CARNS1 (carnosine synthase 1) - Rat Genome Database

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Gene: CARNS1 (carnosine synthase 1) Chlorocebus sabaeus
Analyze
Symbol: CARNS1
Name: carnosine synthase 1
RGD ID: 18411533
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); carnosine synthase activity (inferred); INVOLVED IN carnosine biosynthetic process (ortholog); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); genetic disease (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,838,960 - 6,849,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,839,950 - 6,847,124 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,124,030 - 104,133,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CARNS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,838,960 - 6,849,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,839,950 - 6,847,124 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,124,030 - 104,133,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CARNS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,415,678 - 67,425,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,414,968 - 67,425,607 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,183,149 - 67,193,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,939,725 - 66,949,654 (+)NCBINCBI36Build 36hg18NCBI36
Celera1164,516,258 - 64,526,190 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,511,202 - 63,521,145 (+)NCBIHuRef
CHM1_11167,066,219 - 67,076,148 (+)NCBICHM1_1
T2T-CHM13v2.01167,409,793 - 67,419,719 (+)NCBIT2T-CHM13v2.0
Carns1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,214,323 - 4,227,390 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,214,323 - 4,225,478 (-)EnsemblGRCm39 Ensembl
GRCm38194,164,324 - 4,175,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,164,324 - 4,175,479 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,164,324 - 4,175,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,165,338 - 4,170,381 (-)NCBIMGSCv36mm8
Celera194,035,463 - 4,046,618 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.86NCBI
Carns1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,888,520 - 210,899,311 (-)NCBIGRCr8
mRatBN7.21201,459,061 - 201,470,019 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,459,076 - 201,469,845 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01219,413,897 - 219,424,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,414,915 - 219,422,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,284,548 - 226,295,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,749,680 - 206,763,019 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,903,132 - 206,912,713 (-)NCBI
Celera1199,003,426 - 199,014,063 (-)NCBICelera
Cytogenetic Map1q43NCBI
Carns1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,051,721 - 18,061,487 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,051,721 - 18,061,500 (-)NCBIChiLan1.0ChiLan1.0
CARNS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,642,318 - 68,652,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,684,919 - 69,695,179 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,774,027 - 62,784,066 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,085,343 - 66,098,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,085,594 - 66,097,970 (+)Ensemblpanpan1.1panPan2
CARNS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,041,545 - 50,050,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,042,465 - 50,050,949 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,651,956 - 48,660,828 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,963,489 - 50,972,316 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,963,480 - 50,972,849 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,176,790 - 50,185,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,751,477 - 49,760,381 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,545,795 - 50,554,673 (-)NCBIUU_Cfam_GSD_1.0
Carns1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,880,436 - 5,889,580 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,322,815 - 2,331,599 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,322,797 - 2,331,604 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARNS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,097,243 - 5,105,696 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,097,238 - 5,105,697 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,814,999 - 3,823,462 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Carns1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,097,944 - 19,107,665 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,097,963 - 19,108,078 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 6
Low 14 17 48
Below cutoff 22 3 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006620   ⟹   ENSCSAP00000004823
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl16,839,950 - 6,847,124 (-)Ensembl
RefSeq Acc Id: XM_007966619   ⟹   XP_007964810
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.116,838,960 - 6,848,837 (-)NCBI
Vero_WHO_p1.0NW_023666038104,124,030 - 104,133,905 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007964810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004823
  ENSCSAP00000004823.1
Reference Protein Sequences
RefSeq Acc Id: XP_007964810   ⟸   XM_007966619
- UniProtKB: A0A0D9R884 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004823   ⟸   ENSCSAT00000006620


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006620.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.20 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/TrEMBL
  BL00235/CARNS1_N UniProtKB/TrEMBL
  CARNS1 UniProtKB/TrEMBL
NCBI Gene CARNS1 ENTREZGENE
PANTHER CARNOSINE SYNTHASE 1 UniProtKB/TrEMBL
  PTHR48066 UniProtKB/TrEMBL
Pfam ATPgrasp_N UniProtKB/TrEMBL
  ATPgrasp_Ter UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt A0A0D9R884 ENTREZGENE, UniProtKB/TrEMBL