SEMA4A (semaphorin 4A) - Rat Genome Database

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Gene: SEMA4A (semaphorin 4A) Chlorocebus sabaeus
Analyze
Symbol: SEMA4A
Name: semaphorin 4A
RGD ID: 18345067
Description: ENCODES a protein that exhibits chemorepellent activity (inferred); semaphorin receptor binding (inferred); INVOLVED IN axon guidance (inferred); axonogenesis (inferred); cell differentiation (inferred); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colonic Polyps (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: semaphorin-4A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,684,107 - 7,716,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,683,994 - 7,708,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,978,444 - 7,011,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SEMA4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,684,107 - 7,716,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,683,994 - 7,708,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,978,444 - 7,011,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SEMA4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,147,373 - 156,177,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,147,366 - 156,177,752 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,119,735 - 156,147,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,390,012 - 154,414,159 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,936,460 - 152,960,607NCBI
Celera1129,192,724 - 129,220,533 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,481,928 - 127,509,284 (+)NCBIHuRef
CHM1_11157,515,841 - 157,543,516 (+)NCBICHM1_1
T2T-CHM13v2.01155,285,786 - 155,316,193 (+)NCBIT2T-CHM13v2.0
Sema4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,343,266 - 88,368,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,343,266 - 88,368,489 (-)EnsemblGRCm39 Ensembl
GRCm38388,435,959 - 88,461,182 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,435,959 - 88,461,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,239,884 - 88,265,104 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,521,886 - 88,541,606 (-)NCBIMGSCv36mm8
Celera388,475,600 - 88,501,116 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.83NCBI
Sema4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,194,248 - 176,215,752 (-)NCBIGRCr8
mRatBN7.22173,896,432 - 173,917,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,896,439 - 173,914,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,040,481 - 181,058,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,062,844 - 179,080,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,663,030 - 173,681,029 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,799,568 - 187,823,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,799,568 - 187,822,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,201,920 - 207,225,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,552,405 - 180,570,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,502,513 - 180,520,465 (-)NCBI
Celera2167,841,037 - 167,859,037 (-)NCBICelera
Cytogenetic Map2q34NCBI
Sema4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,316,390 - 2,342,233 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,316,402 - 2,341,873 (+)NCBIChiLan1.0ChiLan1.0
SEMA4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,668,571 - 93,698,992 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,400,554 - 93,430,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,489,446 - 131,519,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,321,147 - 135,350,724 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,321,288 - 135,350,724 (+)Ensemblpanpan1.1panPan2
SEMA4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,670,814 - 41,695,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,672,120 - 41,692,460 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,160,653 - 41,184,935 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,537,442 - 41,561,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,537,570 - 41,558,851 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,318,592 - 41,342,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,371,735 - 41,396,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,656,115 - 41,680,364 (-)NCBIUU_Cfam_GSD_1.0
Sema4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,373,899 - 26,400,801 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,406,194 - 5,431,185 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,404,380 - 5,431,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEMA4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,865,057 - 93,886,371 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,865,054 - 93,892,995 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,607,463 - 102,628,790 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sema4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,470,525 - 1,495,369 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,470,666 - 1,493,634 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 11 8
Low 36 9 52
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000000120   ⟹   ENSCSAP00000015932
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl207,683,994 - 7,708,741 (-)Ensembl
RefSeq Acc Id: XM_007976745   ⟹   XP_007974936
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,684,107 - 7,716,047 (-)NCBI
Vero_WHO_p1.0NW_0236660386,978,444 - 7,010,556 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007976746   ⟹   XP_007974937
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,684,107 - 7,713,133 (-)NCBI
Vero_WHO_p1.0NW_0236660386,978,444 - 7,008,613 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007976747   ⟹   XP_007974938
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1207,684,107 - 7,716,866 (-)NCBI
Vero_WHO_p1.0NW_0236660386,978,444 - 7,011,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037997778   ⟹   XP_037853706
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660386,978,444 - 7,011,431 (-)NCBI
RefSeq Acc Id: XM_037997779   ⟹   XP_037853707
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660386,978,444 - 7,002,514 (-)NCBI
RefSeq Acc Id: XM_037997780   ⟹   XP_037853708
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660386,978,444 - 7,011,430 (-)NCBI
RefSeq Acc Id: XP_007974938   ⟸   XM_007976747
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974936   ⟸   XM_007976745
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007974937   ⟸   XM_007976746
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015932   ⟸   ENSCSAT00000000120
RefSeq Acc Id: XP_037853706   ⟸   XM_037997778
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S4Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037853708   ⟸   XM_037997780
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037853707   ⟸   XM_037997779
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002102 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000120.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
InterPro Plexin_repeat UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  Semap_dom UniProtKB/TrEMBL
  Semap_dom_sf UniProtKB/TrEMBL
  Semaphorin UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene SEMA4A ENTREZGENE
PANTHER PTHR11036 UniProtKB/TrEMBL
  SEMAPHORIN-4A UniProtKB/TrEMBL
Pfam PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
PROSITE SEMA UniProtKB/TrEMBL
SMART PSI UniProtKB/TrEMBL
  Sema UniProtKB/TrEMBL
Superfamily-SCOP Plexin repeat UniProtKB/TrEMBL
  SSF101912 UniProtKB/TrEMBL
UniProt A0A0D9S4Z3 ENTREZGENE, UniProtKB/TrEMBL