DONSON (DNA replication fork stabilization factor DONSON) - Rat Genome Database

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Gene: DONSON (DNA replication fork stabilization factor DONSON) Chlorocebus sabaeus
Analyze
Symbol: DONSON
Name: DNA replication fork stabilization factor DONSON
RGD ID: 18343195
Description: INVOLVED IN DNA damage checkpoint signaling (inferred); DNA replication (inferred); mitotic DNA replication checkpoint signaling (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); Colorectal Neoplasms (ortholog); FOUND IN nucleus (inferred); replication fork (inferred); replisome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: downstream neighbor of SON; protein downstream neighbor of Son
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,598,341 - 58,627,279 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,598,967 - 58,609,316 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660711,100,313 - 1,128,775 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DONSON
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,598,341 - 58,627,279 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,598,967 - 58,609,316 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660711,100,313 - 1,128,775 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DONSON
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,577,551 - 33,588,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2133,559,542 - 33,588,706 (-)EnsemblGRCh38hg38GRCh38
GRCh372134,949,857 - 34,960,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,872,081 - 33,882,884 (-)NCBINCBI36Build 36hg18NCBI36
Celera2120,149,845 - 20,160,634 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,428,274 - 20,439,407 (-)NCBIHuRef
CHM1_12134,512,501 - 34,523,651 (-)NCBICHM1_1
T2T-CHM13v2.02131,959,392 - 31,970,473 (-)NCBIT2T-CHM13v2.0
Donson
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,463,744 - 91,485,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,473,696 - 91,485,658 (-)EnsemblGRCm39 Ensembl
GRCm381691,666,856 - 91,688,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,676,808 - 91,688,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371691,679,510 - 91,688,973 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,568,124 - 91,577,587 (-)NCBIMGSCv36mm8
Celera1692,757,855 - 92,767,320 (-)NCBICelera
Cytogenetic Map16C3.3- C4NCBI
cM Map1653.25NCBI
Donson
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,405,794 - 44,419,099 (-)NCBIGRCr8
mRatBN7.21130,919,834 - 30,933,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,923,239 - 30,932,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,613,755 - 39,626,757 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,285,188 - 32,298,190 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,450,393 - 31,463,308 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,834,608 - 31,847,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,837,839 - 31,847,490 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,443,360 - 35,456,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,652,219 - 31,661,872 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,691,277 - 31,700,929 (-)NCBI
Celera1130,590,666 - 30,600,291 (-)NCBICelera
Cytogenetic Map11q11NCBI
Donson
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,007,257 - 33,015,039 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,007,257 - 33,014,600 (-)NCBIChiLan1.0ChiLan1.0
DONSON
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22229,695,344 - 29,706,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12124,553,559 - 24,564,583 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02119,944,692 - 19,956,140 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12133,317,147 - 33,328,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,317,841 - 33,328,132 (-)Ensemblpanpan1.1panPan2
DONSON
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,192,338 - 28,209,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,190,358 - 28,207,190 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,397,647 - 28,414,510 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,404,214 - 28,414,516 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,264,474 - 28,281,296 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,284,547 - 28,295,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,778,176 - 28,794,943 (-)NCBIUU_Cfam_GSD_1.0
Donson
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,746,902 - 28,755,645 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,712,205 - 8,739,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,712,168 - 8,720,728 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DONSON
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,193,658 - 197,203,932 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,192,661 - 197,204,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,004,438 - 207,014,637 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Donson
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,798,075 - 21,807,556 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474521,798,712 - 21,807,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 52
Low 20 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007912   ⟹   ENSCSAP00000006071
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl258,598,967 - 58,609,316 (+)Ensembl
RefSeq Acc Id: XM_007964446   ⟹   XP_007962637
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,598,341 - 58,627,279 (+)NCBI
Vero_WHO_p1.0NW_0236660711,100,324 - 1,128,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007964449   ⟹   XP_007962640
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1258,598,341 - 58,610,006 (+)NCBI
Vero_WHO_p1.0NW_0236660711,100,313 - 1,111,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990816   ⟹   XP_037846744
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660711,100,320 - 1,111,521 (+)NCBI
RefSeq Acc Id: XM_037990817   ⟹   XP_037846745
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660711,100,314 - 1,111,521 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007962637 (Get FASTA)   NCBI Sequence Viewer  
  XP_007962640 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846744 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006071.1
Reference Protein Sequences
RefSeq Acc Id: XP_007962637   ⟸   XM_007964446
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RBT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007962640   ⟸   XM_007964449
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000006071   ⟸   ENSCSAT00000007912
RefSeq Acc Id: XP_037846745   ⟸   XM_037990817
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037846744   ⟸   XM_037990816
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009862 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007912.1 UniProtKB/TrEMBL
InterPro Donson UniProtKB/TrEMBL
KEGG Report csab:103216712 UniProtKB/TrEMBL
NCBI Gene DONSON ENTREZGENE
PANTHER PROTEIN DOWNSTREAM NEIGHBOR OF SON UniProtKB/TrEMBL
  PTHR12972 UniProtKB/TrEMBL
PRINTS DONSON UniProtKB/TrEMBL
UniProt A0A0D9RBT2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-04 DONSON  DNA replication fork stabilization factor DONSON  DONSON  downstream neighbor of SON  Symbol and/or name change 5135510 APPROVED