QRICH1 (glutamine-rich 1) - Rat Genome Database

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General
Array IDs

Gene: QRICH1 (glutamine-rich 1) Homo sapiens

Symbol:

QRICH1

Name:

glutamine-rich 1

Description:

INVOLVED IN regulation of apoptotic process (inferred); FOUND IN intracellular (inferred); INTERACTS WITH genistein; nocodazole; paclitaxel

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

FLJ20259; glutamine-rich protein 1; MGC131838; OTTHUMP00000210558; OTTHUMP00000210559; OTTHUMP00000210560

Orthologs:

Mus musculus : Qrich1 (glutamine-rich 1) MGI
Rattus norvegicus : Qrich1 (glutamine-rich 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	48,999,451 - 49,063,811	-	NCBI
Human Genome Assembly HuRef	3	49,125,007 - 49,190,034	-	NCBI
Human Genome Assembly GRCh37	3	49,067,142 - 49,131,504	-	NCBI
Human Celera Assembly	3	49,023,864 - 49,088,466	-	NCBI
Human Genome Assembly Build 36	3	49,042,146 - 49,106,508	-	NCBI
Human Cytogenetic Map	3	p21.31		NCBI

Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1332052	6480464	Tetrachlorodibenzodioxin affects the expression of QRICH1 mRNA	CTD	PMID:21570461
4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1332052	6480464	4,4'-diaminodiphenylmethane results in increased expression of QRICH1 mRNA	CTD	PMID:18648102
benzo[a]pyrene	multiple interactions	ISO	RGD:1332052	6480464	[Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of QRICH1 mRNA	CTD	PMID:21715664
genistein	multiple interactions	EXP		6480464	Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein]	CTD	PMID:17510977
indole-3-methanol	affects expression	ISO	RGD:1311095	6480464	indole-3-carbinol affects the expression of RGD1311095 mRNA; more ...	CTD	PMID:21396975
nocodazole	multiple interactions	EXP		6480464	Genistein inhibits the reaction [Nocodazole results in increased phosphorylation of QRICH1 protein]	CTD	PMID:17510977
nocodazole	increases phosphorylation	EXP		6480464	Nocodazole results in increased phosphorylation of QRICH1 protein	CTD	PMID:17510977
paclitaxel	increases phosphorylation	EXP		6480464	Paclitaxel results in increased phosphorylation of QRICH1 protein	CTD	PMID:17510977
paracetamol	affects expression	ISO	RGD:1332052	6480464	Acetaminophen affects the expression of QRICH1 mRNA	CTD	PMID:17562736
valproic acid	affects expression	ISO	RGD:1332052	6480464	Valproic Acid affects the expression of QRICH1 mRNA	CTD	PMID:17292431
vincaleukoblastine	increases phosphorylation	EXP		6480464	Vinblastine results in increased phosphorylation of QRICH1 protein	CTD	PMID:17510977
vincristine	increases phosphorylation	EXP		6480464	Vincristine results in increased phosphorylation of QRICH1 protein	CTD	PMID:17510977

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
biological_process		ND		2290271	GO_REF:0000015	UniProtKB	GO_REF:0000015
regulation of apoptotic process		IEA	InterPro:IPR001315	2290271	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
cellular_component		ND		2290271	GO_REF:0000015	UniProtKB	GO_REF:0000015
intracellular		IEA	InterPro:IPR001315	2290271	GO_REF:0000002	InterPro	GO_REF:0000002

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
molecular_function		ND		2290271	GO_REF:0000015	UniProtKB	GO_REF:0000015

Gene-Chemical Interaction Annotations

	2,3,7,8-tetrachlorodibenzodioxine (ISO)
	4,4'-diaminodiphenylmethane (ISO)
	benzo[a]pyrene (ISO)
	genistein (EXP)

	indole-3-methanol (ISO)
	nocodazole (EXP)
	paclitaxel (EXP)
	paracetamol (ISO)

	valproic acid (ISO)
	vincaleukoblastine (EXP)
	vincristine (EXP)

Gene Ontology Annotations

Biological Process

	biological_process (ND)
	regulation of apoptotic process (IEA)

Cellular Component

cellular_component (ND)

intracellular (IEA)

Molecular Function

molecular_function (ND)

References - curated

1.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

PubMed	12477932
	14702039
	15231748
	15489334
	16713569
	19471022
	21139048
	21252943
	21693764
	21890473
	21906983
	21987572
	22863883

RGD Disease Portals

QRICH1 has been annotated in the following RGD Disease Portals.

Biological Process

Genomics

Comparative Map Data

QRICH1 (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	48,999,451 - 49,063,811	-	NCBI
Human Genome Assembly HuRef	3	49,125,007 - 49,190,034	-	NCBI
Human Genome Assembly GRCh37	3	49,067,142 - 49,131,504	-	NCBI
Human Celera Assembly	3	49,023,864 - 49,088,466	-	NCBI
Human Genome Assembly Build 36	3	49,042,146 - 49,106,508	-	NCBI
Human Cytogenetic Map	3	p21.31		NCBI

Qrich1 (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	9	108,517,087 - 108,560,167	+	NCBI
Mouse cM Map	9		+	NCBI
Mouse Celera Assembly	9	108,126,784 - 108,171,369	+	NCBI
Mouse Genome Assembly Build 37	9	108,419,418 - 108,462,498	+	NCBI
Mouse Genome Assembly Build 36.1	9	108,419,434 - 108,447,667	+	NCBI
Mouse Cytogenetic Map	9	F2		NCBI

Qrich1 (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	8	q32		NCBI
RGSC Genome Assembly v5.0	8	116,652,041 - 116,691,239	+	NCBI
RGSC Genome Assembly v3.4	8	113,564,863 - 113,606,732	+	NCBI
Rat Celera Assembly	8	108,513,880 - 108,552,244	+	NCBI
Genome Assembly 3.1	8	113,595,328 - 113,614,144	+	NCBI

Position Markers

RH80406

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	49,171,537 - 49,171,775	UniSTS
Human Genome Assembly GRCh37	3	49,114,054 - 49,114,292	UniSTS
Human Celera Assembly	3	49,070,813 - 49,071,051	RGD
Human Genome Assembly Build 36	3	49,089,058 - 49,089,296	RGD
Human Cytogenetic Map	3	p21.31	UniSTS

RH93145

Map	Chr	Position	Source
Human GeneMap99-GB4 RH Map	3	157.44	UniSTS
Human Genome Assembly HuRef	3	49,181,642 - 49,181,810	UniSTS
Human Genome Assembly GRCh37	3	49,124,161 - 49,124,329	UniSTS
Human Genome Assembly Build 36	3	49,099,165 - 49,099,333	RGD
Human Cytogenetic Map	3	p21.31	UniSTS

RH122928

Map	Chr	Position	Source
Human TNG Radiation Hybrid Map	3	30995.0	UniSTS
Human Genome Assembly HuRef	3	49,188,668 - 49,188,967	UniSTS
Human Genome Assembly GRCh37	3	49,130,138 - 49,130,437	UniSTS
Human Celera Assembly	3	49,087,100 - 49,087,399	RGD
Human Genome Assembly Build 36	3	49,105,142 - 49,105,441	RGD
Human Cytogenetic Map	3	p21.31	UniSTS

D3S2759E

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	49,125,757 - 49,125,837	UniSTS
Human Genome Assembly GRCh37	3	49,067,892 - 49,067,972	UniSTS
Human Celera Assembly	3	49,024,614 - 49,024,694	RGD
Human Genome Assembly Build 36	3	49,042,896 - 49,042,976	RGD
Human Cytogenetic Map	3	p21.31	UniSTS

D3S4029

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	49,156,897 - 49,157,021	UniSTS
Human Genome Assembly GRCh37	3	49,099,366 - 49,099,490	UniSTS
Human Celera Assembly	3	49,056,074 - 49,056,198	RGD
Human Genome Assembly Build 36	3	49,074,370 - 49,074,494	RGD

G16539

Map	Chr	Position	Source
Human Genome Assembly HuRef	3	49,163,407 - 49,163,629	UniSTS
Human Genome Assembly HuRef	6	138,126,593 - 138,126,646	UniSTS
Human Genome Assembly GRCh37	3	49,105,879 - 49,106,100	UniSTS
Human Genome Assembly GRCh37	6	140,563,329 - 140,563,382	UniSTS
Human Celera Assembly	6	141,304,198 - 141,304,251	RGD
Human Genome Assembly Build 36	3	49,080,883 - 49,081,104	RGD

QTLs in Region (Human Genome Assembly GRCh37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316061	GLUCO194_H	Glucose level QTL 194 (human)		.02	Glucose level		3	21949504	51018984	Human
2314752	GLUCO73_H	Glucose level QTL 73 (human)	.97	.005	Glucose level	non-insulin dependent	3	25869836	51869836	Human
1298487	BFD1_H	Body fluid distribution QTL 1 (human)	3.94		Body fluid distribution	impedance ratio	3	32165239	73258698	Human
1298497	BW10_H	Body weight QTL 10 (human)	1.8	.002	Body weight	body mass index	3	32338465	58338465	Human
1298489	RA4_H	Rheumatoid arthritis QTL 4 (human)		.0283	Joint/bone inflammation	rheumatoid arthritis	3	34624405	64211885	Human
1331638	COPD14_H	Chronic obstructive pulmonary disease QTL 14 (human)	1.5		Chronic airflow obstruction	post-BD FEV1 minus pre-BD FEV1	3	36484119	175785038	Human

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_017730	(Get FASTA)	Search GEO for Microarray Profiles
	NM_198880	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	ABBA01024612	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024613	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024614	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024615	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024616	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024617	(Get FASTA)	Search GEO for Microarray Profiles
	ABBA01024618	(Get FASTA)	Search GEO for Microarray Profiles
	AC135506	(Get FASTA)	Search GEO for Microarray Profiles
	AC137630	(Get FASTA)	Search GEO for Microarray Profiles
	AK000266	(Get FASTA)	Search GEO for Microarray Profiles
	AK022524	(Get FASTA)	Search GEO for Microarray Profiles
	AK025013	(Get FASTA)	Search GEO for Microarray Profiles
	AK074313	(Get FASTA)	Search GEO for Microarray Profiles
	AK093259	(Get FASTA)	Search GEO for Microarray Profiles
	AK124205	(Get FASTA)	Search GEO for Microarray Profiles
	AK292536	(Get FASTA)	Search GEO for Microarray Profiles
	AMYH01013155	(Get FASTA)	Search GEO for Microarray Profiles
	AW673597	(Get FASTA)	Search GEO for Microarray Profiles
	BC000978	(Get FASTA)	Search GEO for Microarray Profiles
	BC098375	(Get FASTA)	Search GEO for Microarray Profiles
	BC110855	(Get FASTA)	Search GEO for Microarray Profiles
	BC130340	(Get FASTA)	Search GEO for Microarray Profiles
	BC130342	(Get FASTA)	Search GEO for Microarray Profiles
	BI459089	(Get FASTA)	Search GEO for Microarray Profiles
	CH471055	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_017730

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_060200

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	48,999,451 - 49,063,811	-	NCBI
Human Genome Assembly HuRef	3	49,125,007 - 49,190,034	-	ENTREZGENE
Human Genome Assembly GRCh37	3	49,067,142 - 49,131,504	-	RGD
Human Celera Assembly	3	49,023,864 - 49,088,466	-	RGD
Human Genome Assembly Build 36	3	49,042,146 - 49,106,508	-	NCBI Archive

RefSeq Acc Id:

NM_198880

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_942581

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	3	48,999,451 - 49,063,811	-	NCBI
Human Genome Assembly HuRef	3	49,125,007 - 49,190,034	-	ENTREZGENE
Human Genome Assembly GRCh37	3	49,067,142 - 49,131,504	-	RGD
Human Celera Assembly	3	49,023,864 - 49,088,466	-	RGD
Human Genome Assembly Build 36	3	49,042,146 - 49,106,508	-	NCBI Archive

Protein Sequences

Protein RefSeqs	NP_060200	(Get FASTA)
	NP_942581	(Get FASTA)
GenBank Protein	AAH00978	(Get FASTA)
	AAH98375	(Get FASTA)
	AAI10856	(Get FASTA)
	AAI30341	(Get FASTA)
	AAI30343	(Get FASTA)
	ADR83401	(Get FASTA)
	BAA91042	(Get FASTA)
	BAB14076	(Get FASTA)
	BAB85047	(Get FASTA)
	BAF85225	(Get FASTA)
	EAW64948	(Get FASTA)
	EAW64949	(Get FASTA)
	EAW64950	(Get FASTA)
	EAW64951	(Get FASTA)
	Q2TAL8	(Get FASTA)

Promoters

RGD ID:

6801495

Promoter ID:

HG_KWN:44986

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

HeLa_S3

Transcripts:

OTTHUMT00000345670, OTTHUMT00000345676, OTTHUMT00000345677

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	49,044,771 - 49,045,271	-	MPROMDB

RGD ID:

6801497

Promoter ID:

HG_KWN:44989

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, Lymphoblastoid

Transcripts:

OTTHUMT00000345678

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	49,069,789 - 49,070,289	-	MPROMDB

RGD ID:

6863584

Promoter ID:

EPDNEW_H4957

Type:

initiation region

Name:

QRICH1_5

Description:

glutamine-rich 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	49,070,602 - 49,070,662		EPDNEW

RGD ID:

6863586

Promoter ID:

EPDNEW_H4958

Type:

initiation region

Name:

QRICH1_4

Description:

glutamine-rich 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	49,081,917 - 49,081,977		EPDNEW

RGD ID:

6801496

Promoter ID:

HG_KWN:44992

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_017730, OTTHUMT00000345669, OTTHUMT00000345674, OTTHUMT00000345679, OTTHUMT00000345680, OTTHUMT00000345681, OTTHUMT00000345682, UC010HKQ.1

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	3	49,105,516 - 49,107,047	-	MPROMDB

RGD ID:

6857528

Promoter ID:

EPDNEW_H1929

Type:

initiation region

Name:

IGSF9_1

Description:

immunoglobulin superfamily, member 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Human Genome Assembly Build 36	1	159,915,401 - 159,915,461		EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
COSMIC	QRICH1	COSMIC
Ensembl Genes	ENSG00000198218	ENTREZGENE
Ensembl Protein	ENSP00000350094	ENTREZGENE
	ENSP00000378830	ENTREZGENE
Ensembl Transcript	ENST00000357496	ENTREZGENE
	ENST00000395443	ENTREZGENE
Entrez Gene	54870	ENTREZGENE
Gene3D-CATH	33.10	UniProtKB/TrEMBL
HGNC ID	24713	ENTREZGENE
HomoloGene Group ID	9803	ENTREZGENE
HPRD ID	13372	ENTREZGENE
InterPro	CARD	UniProtKB/TrEMBL
	DEATH-like_dom	UniProtKB/TrEMBL
	DUF3504	UniProtKB/Swiss-Prot
IPI	IPI00328200	UniProtKB/Swiss-Prot
	IPI00927065	UniProtKB/TrEMBL
	IPI00927294	UniProtKB/TrEMBL
KEGG Report	hsa:54870	ENTREZGENE, UniProtKB/Swiss-Prot
Pfam	CARD	UniProtKB/TrEMBL
	DUF3504	UniProtKB/Swiss-Prot
PharmGKB	PA142671106	PharmGKB
PROSITE	CARD; FALSE_NEG	UniProtKB/Swiss-Prot
UniGene	Hs.297389	ENTREZGENE
UniProt	A1L3Z9_HUMAN	UniProtKB/TrEMBL
	C9JAL2_HUMAN	UniProtKB/TrEMBL
	C9JIA8_HUMAN	UniProtKB/TrEMBL
	QRIC1_HUMAN	UniProtKB/Swiss-Prot

More on QRICH1

Entrez Gene

Ensembl Gene

Genome Browser:

(hg18) (hg19)

RGD Object Information
RGD ID:	1606541
Created:	2007-04-29
Species:	Homo sapiens
Last Modified:	2013-03-06
Status:	ACTIVE