CLEC18C (C-type lectin domain family 18 member C) - Rat Genome Database

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Gene: CLEC18C (C-type lectin domain family 18 member C) Homo sapiens
Analyze
Symbol: CLEC18C
Name: C-type lectin domain family 18 member C
RGD ID: 1605549
HGNC Page HGNC:28538
Description: Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-type lectin domain family 18, member C; mannose receptor-like 3; mannose receptor-like protein 3; MGC34761; MRCL; MRCL3
RGD Orthologs
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,173,787 - 70,186,895 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,173,322 - 70,187,361 (+)EnsemblGRCh38hg38GRCh38
GRCh371670,207,690 - 70,220,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,765,429 - 68,778,299 (+)NCBINCBI36Build 36hg18NCBI36
Celera1654,500,318 - 54,513,191 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
CHM1_11671,615,599 - 71,627,854 (+)NCBICHM1_1
T2T-CHM13v2.01675,983,920 - 75,997,950 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16336259   PMID:21873635   PMID:21988832   PMID:26170455  


Genomics

Comparative Map Data
CLEC18C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,173,787 - 70,186,895 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,173,322 - 70,187,361 (+)EnsemblGRCh38hg38GRCh38
GRCh371670,207,690 - 70,220,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,765,429 - 68,778,299 (+)NCBINCBI36Build 36hg18NCBI36
Celera1654,500,318 - 54,513,191 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
CHM1_11671,615,599 - 71,627,854 (+)NCBICHM1_1
T2T-CHM13v2.01675,983,920 - 75,997,950 (+)NCBIT2T-CHM13v2.0
Clec18c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,266,162 - 36,276,060 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647523,313,333 - 23,322,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC18C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1613,265,775 - 13,280,353 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,330,500 - 13,345,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLEC18C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,343,524 - 53,368,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604716,141,679 - 16,156,548 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CLEC18C
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2		 pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q22.1-23.1(chr16:69918076-76723348)x1 copy number loss See cases [RCV000053356] Chr16:69918076..76723348 [GRCh38]
Chr16:69951979..76757245 [GRCh37]
Chr16:68509480..75314746 [NCBI36]
Chr16:16q22.1-23.1		 pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1		 pathogenic
GRCh38/hg38 16q22.1-23.1(chr16:68698941-74353205)x1 copy number loss See cases [RCV000053337] Chr16:68698941..74353205 [GRCh38]
Chr16:68732844..74387103 [GRCh37]
Chr16:67290345..72944604 [NCBI36]
Chr16:16q22.1-23.1		 pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1		 pathogenic
GRCh38/hg38 16q22.1(chr16:69144650-70257882)x1 copy number loss See cases [RCV000136580] Chr16:69144650..70257882 [GRCh38]
Chr16:69178553..70291785 [GRCh37]
Chr16:67736054..68849286 [NCBI36]
Chr16:16q22.1		 uncertain significance
GRCh38/hg38 16q22.1-22.2(chr16:69918076-71541872)x3 copy number gain See cases [RCV000137875] Chr16:69918076..71541872 [GRCh38]
Chr16:69951979..71575775 [GRCh37]
Chr16:68509480..70133276 [NCBI36]
Chr16:16q22.1-22.2		 uncertain significance
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q22.1-23.3(chr16:69053457-83274681)x3 copy number gain See cases [RCV000142038] Chr16:69053457..83274681 [GRCh38]
Chr16:69087360..83308286 [GRCh37]
Chr16:67644861..81865787 [NCBI36]
Chr16:16q22.1-23.3		 pathogenic
GRCh38/hg38 16q22.1(chr16:70118880-70203727)x3 copy number gain See cases [RCV000142976] Chr16:70118880..70203727 [GRCh38]
Chr16:70152783..70237630 [GRCh37]
Chr16:68710284..68795131 [NCBI36]
Chr16:16q22.1		 likely benign
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q22.1(chr16:69986596-70316676)x3 copy number gain See cases [RCV000239952] Chr16:69986596..70316676 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q22.1(chr16:70024576-70673886)x3 copy number gain See cases [RCV000449413] Chr16:70024576..70673886 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q22.1(chr16:69385913-70336760)x1 copy number loss See cases [RCV000510349] Chr16:69385913..70336760 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q22.1(chr16:69987029-70260895)x3 copy number gain not provided [RCV000751724] Chr16:69987029..70260895 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q22.1(chr16:69992377-70283336)x3 copy number gain not provided [RCV000751725] Chr16:69992377..70283336 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q22.1(chr16:69992377-70283579)x3 copy number gain not provided [RCV000751726] Chr16:69992377..70283579 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q22.1(chr16:70010419-70284784)x3 copy number gain not provided [RCV000751729] Chr16:70010419..70284784 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q22.1(chr16:70032393-70283336)x3 copy number gain not provided [RCV000751730] Chr16:70032393..70283336 [GRCh37]
Chr16:16q22.1		 benign
NM_173619.4(CLEC18C):c.1286G>A (p.Arg429His) single nucleotide variant not specified [RCV004289295] Chr16:70185959 [GRCh38]
Chr16:70219862 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3		 not provided
GRCh37/hg19 16q22.1(chr16:70185757-70416579)x3 copy number gain Abnormal peripheral nervous system morphology [RCV001255182] Chr16:70185757..70416579 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q22.1-23.1(chr16:68971067-74823560)x1 copy number loss See cases [RCV002285074] Chr16:68971067..74823560 [GRCh37]
Chr16:16q22.1-23.1		 pathogenic
NC_000016.9:g.(?_69680960)_(72146396_?)dup duplication Immunodeficiency [RCV001950695] Chr16:69680960..72146396 [GRCh37]
Chr16:16q22.1-22.2		 uncertain significance
GRCh37/hg19 16q22.1(chr16:70024576-70673886) copy number gain not specified [RCV002052534] Chr16:70024576..70673886 [GRCh37]
Chr16:16q22.1		 uncertain significance
NC_000016.9:g.(?_66545871)_(72146396_?)dup duplication Dyskeratosis congenita, autosomal dominant 6 [RCV001900384]|Immunodeficiency [RCV001900385]|not provided [RCV001900386] Chr16:66545871..72146396 [GRCh37]
Chr16:16q21-22.2		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
NC_000016.9:g.(?_65821800)_(72146396_?)del deletion Dyskeratosis congenita, autosomal dominant 6 [RCV003122496] Chr16:65821800..72146396 [GRCh37]
Chr16:16q21-22.2		 uncertain significance
NM_173619.4(CLEC18C):c.1324T>C (p.Trp442Arg) single nucleotide variant not specified [RCV004319389] Chr16:70186503 [GRCh38]
Chr16:70220406 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.34C>T (p.His12Tyr) single nucleotide variant not specified [RCV004315388] Chr16:70174312 [GRCh38]
Chr16:70208215 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.209G>A (p.Arg70Gln) single nucleotide variant not specified [RCV004236590] Chr16:70175031 [GRCh38]
Chr16:70208934 [GRCh37]
Chr16:16q22.1		 likely benign
NM_173619.4(CLEC18C):c.121G>A (p.Gly41Arg) single nucleotide variant not specified [RCV004099841] Chr16:70174399 [GRCh38]
Chr16:70208302 [GRCh37]
Chr16:16q22.1		 likely benign
NM_173619.4(CLEC18C):c.176G>A (p.Arg59His) single nucleotide variant not specified [RCV004100085] Chr16:70174998 [GRCh38]
Chr16:70208901 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.179G>T (p.Ser60Ile) single nucleotide variant not specified [RCV004270557] Chr16:70175001 [GRCh38]
Chr16:70208904 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.427C>T (p.Arg143Cys) single nucleotide variant not specified [RCV004276242] Chr16:70177451 [GRCh38]
Chr16:70211354 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.250G>A (p.Ala84Thr) single nucleotide variant not specified [RCV004249800] Chr16:70177274 [GRCh38]
Chr16:70211177 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.331C>G (p.Gln111Glu) single nucleotide variant not specified [RCV004263496] Chr16:70177355 [GRCh38]
Chr16:70211258 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.82G>T (p.Val28Leu) single nucleotide variant not specified [RCV004347231] Chr16:70174360 [GRCh38]
Chr16:70208263 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.191C>A (p.Pro64His) single nucleotide variant not specified [RCV004337102] Chr16:70175013 [GRCh38]
Chr16:70208916 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q22.1-22.3(chr16:69709450-73535741)x1 copy number loss not provided [RCV003483292] Chr16:69709450..73535741 [GRCh37]
Chr16:16q22.1-22.3		 pathogenic
GRCh37/hg19 16q22.1-22.2(chr16:70179556-71750471)x3 copy number gain not provided [RCV003485119] Chr16:70179556..71750471 [GRCh37]
Chr16:16q22.1-22.2		 uncertain significance
GRCh37/hg19 16q22.1(chr16:70180112-70650383)x3 copy number gain not specified [RCV003987187] Chr16:70180112..70650383 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.106C>G (p.Gln36Glu) single nucleotide variant not specified [RCV004436945] Chr16:70174384 [GRCh38]
Chr16:70208287 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.1322G>A (p.Arg441Gln) single nucleotide variant not specified [RCV004436949] Chr16:70186501 [GRCh38]
Chr16:70220404 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.553A>G (p.Arg185Gly) single nucleotide variant not specified [RCV004436952] Chr16:70181946 [GRCh38]
Chr16:70215849 [GRCh37]
Chr16:16q22.1		 likely benign
NM_173619.4(CLEC18C):c.1225G>A (p.Val409Met) single nucleotide variant not specified [RCV004436946] Chr16:70185898 [GRCh38]
Chr16:70219801 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.340C>T (p.Pro114Ser) single nucleotide variant not specified [RCV004436951] Chr16:70177364 [GRCh38]
Chr16:70211267 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_173619.4(CLEC18C):c.5T>C (p.Leu2Pro) single nucleotide variant not specified [RCV004074633] Chr16:70174283 [GRCh38]
Chr16:70208186 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.1312C>G (p.His438Asp) single nucleotide variant not specified [RCV004436948] Chr16:70186491 [GRCh38]
Chr16:70220394 [GRCh37]
Chr16:16q22.1		 uncertain significance
NM_173619.4(CLEC18C):c.197C>A (p.Ala66Glu) single nucleotide variant not specified [RCV004436950] Chr16:70175019 [GRCh38]
Chr16:70208922 [GRCh37]
Chr16:16q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2839
Count of miRNA genes:801
Interacting mature miRNAs:983
Transcripts:ENST00000314151, ENST00000536907, ENST00000541793, ENST00000561612, ENST00000562923, ENST00000564976, ENST00000565806, ENST00000569201, ENST00000569268, ENST00000569347
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH102328  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map16q22.3UniSTS
GeneMap99-GB4 RH Map16442.72UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 67 4 6
Low 12 110 15 3 64 2 104 11 194 168 432 18 1 2 99
Below cutoff 1508 2070 1221 341 1054 201 2832 1151 3227 96 659 1084 140 724 1877

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011523036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047433992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054380143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054380144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054380145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054380146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054380147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF448856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000314151   ⟹   ENSP00000326538
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,173,898 - 70,186,895 (+)Ensembl
RefSeq Acc Id: ENST00000536907   ⟹   ENSP00000444726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,157 - 70,186,895 (+)Ensembl
RefSeq Acc Id: ENST00000541793   ⟹   ENSP00000444875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,173,787 - 70,186,895 (+)Ensembl
RefSeq Acc Id: ENST00000561612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,385 - 70,182,457 (+)Ensembl
RefSeq Acc Id: ENST00000562923   ⟹   ENSP00000456676
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,173,322 - 70,182,456 (+)Ensembl
RefSeq Acc Id: ENST00000564976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,025 - 70,186,895 (+)Ensembl
RefSeq Acc Id: ENST00000565806   ⟹   ENSP00000457584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,173,919 - 70,177,382 (+)Ensembl
RefSeq Acc Id: ENST00000569201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,086 - 70,187,361 (+)Ensembl
RefSeq Acc Id: ENST00000569268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,100 - 70,183,641 (+)Ensembl
RefSeq Acc Id: ENST00000569347   ⟹   ENSP00000455920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,174,025 - 70,186,895 (+)Ensembl
RefSeq Acc Id: ENST00000618957   ⟹   ENSP00000477846
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1670,173,617 - 70,187,256 (+)Ensembl
RefSeq Acc Id: NM_173619   ⟹   NP_775890
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,173,787 - 70,186,895 (+)NCBI
GRCh371670,207,928 - 70,221,050 (+)NCBI
Build 361668,765,429 - 68,778,299 (+)NCBI Archive
Celera1654,500,318 - 54,513,191 (+)RGD
HuRef1660,201,481 - 60,204,992 (-)RGD
CHM1_11675,854,636 - 75,867,371 (-)NCBI
T2T-CHM13v2.01675,984,837 - 75,997,950 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047433991   ⟹   XP_047289947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,173,993 - 70,185,973 (+)NCBI
RefSeq Acc Id: XM_047433992   ⟹   XP_047289948
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,173,991 - 70,184,988 (+)NCBI
RefSeq Acc Id: XM_054380143   ⟹   XP_054236118
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01675,983,920 - 75,997,950 (+)NCBI
RefSeq Acc Id: XM_054380144   ⟹   XP_054236119
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01675,985,039 - 75,997,028 (+)NCBI
RefSeq Acc Id: XM_054380145   ⟹   XP_054236120
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01675,985,052 - 75,997,950 (+)NCBI
RefSeq Acc Id: XM_054380146   ⟹   XP_054236121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01675,983,925 - 75,997,950 (+)NCBI
RefSeq Acc Id: XM_054380147   ⟹   XP_054236122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01675,985,031 - 75,996,040 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_775890   ⟸   NM_173619
- Peptide Label: precursor
- UniProtKB: Q8IUW8 (UniProtKB/Swiss-Prot),   Q8NCF0 (UniProtKB/Swiss-Prot),   F5H550 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000444875   ⟸   ENST00000541793
RefSeq Acc Id: ENSP00000444726   ⟸   ENST00000536907
RefSeq Acc Id: ENSP00000456676   ⟸   ENST00000562923
RefSeq Acc Id: ENSP00000326538   ⟸   ENST00000314151
RefSeq Acc Id: ENSP00000457584   ⟸   ENST00000565806
RefSeq Acc Id: ENSP00000477846   ⟸   ENST00000618957
RefSeq Acc Id: ENSP00000455920   ⟸   ENST00000569347
RefSeq Acc Id: XP_047289948   ⟸   XM_047433992
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047289947   ⟸   XM_047433991
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054236118   ⟸   XM_054380143
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054236121   ⟸   XM_054380146
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054236122   ⟸   XM_054380147
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054236119   ⟸   XM_054380144
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054236120   ⟸   XM_054380145
- Peptide Label: isoform X5
Protein Domains
C-type lectin   EGF-like   SCP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8NCF0-F1-model_v2 AlphaFold Q8NCF0 1-446 view protein structure

Promoters
RGD ID:7232729
Promoter ID:EPDNEW_H22109
Type:initiation region
Name:CLEC18C_1
Description:C-type lectin domain family 18 member C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,174,092 - 70,174,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:28538 AgrOrtholog
COSMIC CLEC18C COSMIC
Ensembl Genes ENSG00000157335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000314151.12 UniProtKB/Swiss-Prot
  ENST00000536907.2 UniProtKB/TrEMBL
  ENST00000541793 ENTREZGENE
  ENST00000541793.7 UniProtKB/Swiss-Prot
  ENST00000562923.5 UniProtKB/TrEMBL
  ENST00000565806.5 UniProtKB/TrEMBL
  ENST00000569347.6 UniProtKB/Swiss-Prot
  ENST00000618957.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.33.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000157335 GTEx
HGNC ID HGNC:28538 ENTREZGENE
Human Proteome Map CLEC18C Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRISP-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:283971 UniProtKB/Swiss-Prot
NCBI Gene 283971 ENTREZGENE
OMIM 616573 OMIM
PANTHER C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE-RICH SECRETORY PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164718038 PharmGKB
PRINTS V5TPXLIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55797 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CL18C_HUMAN UniProtKB/Swiss-Prot
  F5H550 ENTREZGENE, UniProtKB/TrEMBL
  H3BSF2_HUMAN UniProtKB/TrEMBL
  H3BUD1_HUMAN UniProtKB/TrEMBL
  Q8IUW8 ENTREZGENE
  Q8NCF0 ENTREZGENE
UniProt Secondary Q8IUW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 CLEC18C  C-type lectin domain family 18 member C    C-type lectin domain family 18, member C  Symbol and/or name change 5135510 APPROVED