LAYN (layilin) - Rat Genome Database

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Gene: LAYN (layilin) Homo sapiens
Analyze
Symbol: LAYN
Name: layilin
RGD ID: 1604525
HGNC Page HGNC:29471
Description: Enables hyaluronic acid binding activity. Located in focal adhesion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ30977; FLJ31092
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,540,280 - 111,561,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,540,280 - 111,561,745 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,411,005 - 111,432,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,916,443 - 110,936,998 (+)NCBINCBI36Build 36hg18NCBI36
Celera11108,564,419 - 108,584,973 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,335,428 - 107,356,671 (+)NCBIHuRef
CHM1_111111,294,325 - 111,315,557 (+)NCBICHM1_1
T2T-CHM13v2.011111,550,425 - 111,571,891 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISS)
focal adhesion  (HDA,ISS)
membrane  (IEA)
ruffle  (ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9786953   PMID:11294894   PMID:12477932   PMID:12975309   PMID:14702039   PMID:15489334   PMID:15913605   PMID:16344560   PMID:21423176   PMID:21873635   PMID:23048036   PMID:23251661  
PMID:24706805   PMID:25150153   PMID:26410531   PMID:26598620   PMID:30761122   PMID:32296183   PMID:32393512   PMID:32539073   PMID:33676182   PMID:36398067   PMID:37335337   PMID:37642473  


Genomics

Comparative Map Data
LAYN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,540,280 - 111,561,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,540,280 - 111,561,745 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,411,005 - 111,432,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,916,443 - 110,936,998 (+)NCBINCBI36Build 36hg18NCBI36
Celera11108,564,419 - 108,584,973 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,335,428 - 107,356,671 (+)NCBIHuRef
CHM1_111111,294,325 - 111,315,557 (+)NCBICHM1_1
T2T-CHM13v2.011111,550,425 - 111,571,891 (+)NCBIT2T-CHM13v2.0
Layn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,966,323 - 50,988,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,965,940 - 50,988,394 (-)EnsemblGRCm39 Ensembl
GRCm38951,055,023 - 51,077,209 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,054,640 - 51,077,094 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,864,885 - 50,885,199 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,809,526 - 50,829,324 (-)NCBIMGSCv36mm8
Celera948,343,167 - 48,363,553 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.79NCBI
Layn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,261,325 - 60,280,797 (-)NCBIGRCr8
mRatBN7.2851,363,928 - 51,384,748 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,367,091 - 51,384,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,914,525 - 56,931,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0855,193,448 - 55,210,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,057,712 - 53,075,039 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,447,203 - 55,469,420 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,447,709 - 55,467,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,044,547 - 54,064,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,379,434 - 54,396,580 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera850,913,524 - 50,930,695 (-)NCBICelera
Cytogenetic Map8q23NCBI
Layn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,280,327 - 13,297,833 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,282,871 - 13,298,214 (+)NCBIChiLan1.0ChiLan1.0
LAYN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,286,747 - 112,321,858 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,378,821 - 113,413,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,423,134 - 106,443,237 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,267,428 - 110,287,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,267,762 - 110,287,935 (+)Ensemblpanpan1.1panPan2
LAYN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,509,143 - 21,531,390 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,512,026 - 21,531,641 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,431,419 - 21,452,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,535,081 - 21,556,912 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,535,007 - 21,556,895 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,596,321 - 21,618,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,496,724 - 21,518,168 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,544,917 - 21,566,929 (-)NCBIUU_Cfam_GSD_1.0
Layn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494793,831,104 - 93,857,972 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,853,633 - 2,872,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,853,354 - 2,872,861 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAYN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,306,300 - 39,327,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,306,276 - 39,326,825 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,120,371 - 44,141,679 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAYN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11102,878,396 - 102,900,814 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1102,879,428 - 102,899,743 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604323,074,627 - 23,095,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Layn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247846,642,728 - 6,662,957 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247846,642,580 - 6,661,043 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LAYN
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_178834.5(LAYN):c.473C>T (p.Pro158Leu) single nucleotide variant not specified [RCV004286178] Chr11:111549707 [GRCh38]
Chr11:111420432 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.433A>T (p.Met145Leu) single nucleotide variant not specified [RCV004323666] Chr11:111549667 [GRCh38]
Chr11:111420392 [GRCh37]
Chr11:11q23.1
uncertain significance
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_178834.5(LAYN):c.130G>A (p.Val44Ile) single nucleotide variant not specified [RCV004314623] Chr11:111543967 [GRCh38]
Chr11:111414692 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.992C>T (p.Ser331Leu) single nucleotide variant not provided [RCV000883342] Chr11:111560325 [GRCh38]
Chr11:111431050 [GRCh37]
Chr11:11q23.1
benign
NM_178834.5(LAYN):c.40G>A (p.Val14Met) single nucleotide variant not provided [RCV000947385] Chr11:111540883 [GRCh38]
Chr11:111411608 [GRCh37]
Chr11:11q23.1
benign
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q23.1-23.3(chr11:110969076-114578509)x1 copy number loss not provided [RCV000848936] Chr11:110969076..114578509 [GRCh37]
Chr11:11q23.1-23.3
uncertain significance
NM_178834.5(LAYN):c.172G>A (p.Glu58Lys) single nucleotide variant not provided [RCV000957002] Chr11:111544009 [GRCh38]
Chr11:111414734 [GRCh37]
Chr11:11q23.1
benign
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
Chr11:11q22.3-23.2
pathogenic
NC_000011.9:g.(?_111171709)_(111965694_?)del deletion Carney-Stratakis syndrome [RCV001032115] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
pathogenic
NC_000011.9:g.(?_111171709)_(111965694_?)dup duplication Carney-Stratakis syndrome [RCV001300223] Chr11:111171709..111965694 [GRCh37]
Chr11:11q23.1
uncertain significance
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic
NC_000011.9:g.104288964_134937416dup duplication Distal trisomy 11q [RCV001250234] Chr11:104288964..134937416 [GRCh37]
Chr11:11q22.3-25
pathogenic
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3
uncertain significance
NM_178834.5(LAYN):c.85+631C>T single nucleotide variant not provided [RCV002132022] Chr11:111541559 [GRCh38]
Chr11:111412284 [GRCh37]
Chr11:11q23.1
benign
NC_000011.9:g.(?_111171709)_(112104278_?)dup duplication 6-Pyruvoyl-tetrahydrobiopterin synthase deficiency [RCV003111003]|Pyruvate dehydrogenase E2 deficiency [RCV003111004] Chr11:111171709..112104278 [GRCh37]
Chr11:11q23.1
uncertain significance
NC_000011.9:g.(?_111171709)_(111959745_?)del deletion Carney-Stratakis syndrome [RCV003113183] Chr11:111171709..111959745 [GRCh37]
Chr11:11q23.1
pathogenic
NC_000011.9:g.(?_111171709)_(111958707_?)del deletion Carney-Stratakis syndrome [RCV003113185] Chr11:111171709..111958707 [GRCh37]
Chr11:11q23.1
pathogenic
NM_178834.5(LAYN):c.500G>A (p.Arg167Gln) single nucleotide variant not specified [RCV004263183] Chr11:111549734 [GRCh38]
Chr11:111420459 [GRCh37]
Chr11:11q23.1
uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
NM_178834.5(LAYN):c.593C>A (p.Thr198Lys) single nucleotide variant not specified [RCV004307981] Chr11:111555225 [GRCh38]
Chr11:111425950 [GRCh37]
Chr11:11q23.1
uncertain significance
GRCh37/hg19 11q22.3-23.3(chr11:109328787-116414966)x1 copy number loss not provided [RCV002474547] Chr11:109328787..116414966 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
NM_178834.5(LAYN):c.631G>A (p.Ala211Thr) single nucleotide variant not specified [RCV004090047] Chr11:111555263 [GRCh38]
Chr11:111425988 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.308G>A (p.Arg103His) single nucleotide variant not specified [RCV004200455] Chr11:111544145 [GRCh38]
Chr11:111414870 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.35T>G (p.Leu12Arg) single nucleotide variant not specified [RCV004132815] Chr11:111540878 [GRCh38]
Chr11:111411603 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.856G>A (p.Val286Ile) single nucleotide variant not specified [RCV004118022] Chr11:111560189 [GRCh38]
Chr11:111430914 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.721G>A (p.Val241Ile) single nucleotide variant not specified [RCV004202815] Chr11:111557603 [GRCh38]
Chr11:111428328 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.803C>G (p.Thr268Ser) single nucleotide variant not specified [RCV004122532] Chr11:111560136 [GRCh38]
Chr11:111430861 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.167T>G (p.Phe56Cys) single nucleotide variant not specified [RCV004093818] Chr11:111544004 [GRCh38]
Chr11:111414729 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.1021G>A (p.Val341Met) single nucleotide variant not specified [RCV004233164] Chr11:111560354 [GRCh38]
Chr11:111431079 [GRCh37]
Chr11:11q23.1
likely benign
NM_178834.5(LAYN):c.781C>T (p.Pro261Ser) single nucleotide variant not specified [RCV004201299] Chr11:111560114 [GRCh38]
Chr11:111430839 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.766C>T (p.Arg256Trp) single nucleotide variant not specified [RCV004079001] Chr11:111560099 [GRCh38]
Chr11:111430824 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.998G>A (p.Ser333Asn) single nucleotide variant not specified [RCV004280622] Chr11:111560331 [GRCh38]
Chr11:111431056 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.895C>T (p.Arg299Trp) single nucleotide variant not specified [RCV004347660] Chr11:111560228 [GRCh38]
Chr11:111430953 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.893C>T (p.Thr298Ile) single nucleotide variant not specified [RCV004363050] Chr11:111560226 [GRCh38]
Chr11:111430951 [GRCh37]
Chr11:11q23.1
uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25
pathogenic
NM_178834.5(LAYN):c.1085A>G (p.Lys362Arg) single nucleotide variant not specified [RCV004410284] Chr11:111560418 [GRCh38]
Chr11:111431143 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.307C>T (p.Arg103Cys) single nucleotide variant not specified [RCV004410285] Chr11:111544144 [GRCh38]
Chr11:111414869 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.463A>G (p.Ile155Val) single nucleotide variant not specified [RCV004410286] Chr11:111549697 [GRCh38]
Chr11:111420422 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.59G>A (p.Arg20Gln) single nucleotide variant not specified [RCV004410288] Chr11:111540902 [GRCh38]
Chr11:111411627 [GRCh37]
Chr11:11q23.1
uncertain significance
NM_178834.5(LAYN):c.805A>G (p.Ile269Val) single nucleotide variant not specified [RCV004410289] Chr11:111560138 [GRCh38]
Chr11:111430863 [GRCh37]
Chr11:11q23.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2597
Count of miRNA genes:714
Interacting mature miRNAs:801
Transcripts:ENST00000375614, ENST00000375615, ENST00000436913, ENST00000525126, ENST00000525866, ENST00000528102, ENST00000528924, ENST00000530962, ENST00000533265, ENST00000533999
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1031 1091 721 15 127 13 921 320 699 105 855 1217 13 1 305 821 2
Low 1301 1355 756 374 766 214 3328 1811 3030 287 561 322 161 899 1910 4 2
Below cutoff 23 514 246 233 771 235 76 58 4 14 22 40 57

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001258390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001258391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054367767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK055539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA608521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB006476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC398135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000375614   ⟹   ENSP00000364764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,720 - 111,561,745 (+)Ensembl
RefSeq Acc Id: ENST00000375615   ⟹   ENSP00000364765
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,659 - 111,560,960 (+)Ensembl
RefSeq Acc Id: ENST00000436913   ⟹   ENSP00000392942
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,508 - 111,561,745 (+)Ensembl
RefSeq Acc Id: ENST00000525126   ⟹   ENSP00000434328
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,709 - 111,560,933 (+)Ensembl
RefSeq Acc Id: ENST00000525866   ⟹   ENSP00000434300
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,720 - 111,561,539 (+)Ensembl
RefSeq Acc Id: ENST00000528102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,541,552 - 111,551,416 (+)Ensembl
RefSeq Acc Id: ENST00000528924   ⟹   ENSP00000486561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,541,440 - 111,557,643 (+)Ensembl
RefSeq Acc Id: ENST00000530962   ⟹   ENSP00000431627
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,541,333 - 111,557,641 (+)Ensembl
RefSeq Acc Id: ENST00000533265   ⟹   ENSP00000434972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,730 - 111,560,918 (+)Ensembl
RefSeq Acc Id: ENST00000533999   ⟹   ENSP00000432434
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11111,540,280 - 111,555,212 (+)Ensembl
RefSeq Acc Id: NM_001258390   ⟹   NP_001245319
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,540,720 - 111,561,745 (+)NCBI
HuRef11107,335,428 - 107,356,671 (+)NCBI
CHM1_111111,294,325 - 111,315,557 (+)NCBI
T2T-CHM13v2.011111,550,865 - 111,571,891 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001258391   ⟹   NP_001245320
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,540,720 - 111,561,745 (+)NCBI
GRCh3711111,411,233 - 111,432,470 (+)NCBI
HuRef11107,335,428 - 107,356,671 (+)NCBI
CHM1_111111,294,325 - 111,315,557 (+)NCBI
T2T-CHM13v2.011111,550,865 - 111,571,891 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318799   ⟹   NP_001305728
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,540,280 - 111,561,745 (+)NCBI
CHM1_111111,294,097 - 111,315,557 (+)NCBI
T2T-CHM13v2.011111,550,425 - 111,571,891 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178834   ⟹   NP_849156
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,540,720 - 111,561,745 (+)NCBI
GRCh3711111,411,233 - 111,432,470 (+)NCBI
Build 3611110,916,443 - 110,936,998 (+)NCBI Archive
Celera11108,564,419 - 108,584,973 (+)RGD
HuRef11107,335,428 - 107,356,671 (+)NCBI
CHM1_111111,294,325 - 111,315,557 (+)NCBI
T2T-CHM13v2.011111,550,865 - 111,571,891 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006718769   ⟹   XP_006718832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,541,334 - 111,561,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054367767   ⟹   XP_054223742
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011111,551,641 - 111,571,891 (+)NCBI
RefSeq Acc Id: NP_849156   ⟸   NM_178834
- Peptide Label: isoform 2 precursor
- UniProtKB: B4DP26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001245319   ⟸   NM_001258390
- Peptide Label: isoform 1 precursor
- UniProtKB: Q96NC5 (UniProtKB/Swiss-Prot),   Q8TAY8 (UniProtKB/Swiss-Prot),   B4DJU0 (UniProtKB/Swiss-Prot),   A6NJB0 (UniProtKB/Swiss-Prot),   Q96NF3 (UniProtKB/Swiss-Prot),   Q6UX15 (UniProtKB/Swiss-Prot),   B4DP26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001245320   ⟸   NM_001258391
- Peptide Label: isoform 3
- UniProtKB: Q6UX15 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006718832   ⟸   XM_006718769
- Peptide Label: isoform X1
- UniProtKB: B4DDS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305728   ⟸   NM_001318799
- Peptide Label: isoform 4
- UniProtKB: B4DDS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000431627   ⟸   ENST00000530962
RefSeq Acc Id: ENSP00000364764   ⟸   ENST00000375614
RefSeq Acc Id: ENSP00000364765   ⟸   ENST00000375615
RefSeq Acc Id: ENSP00000434972   ⟸   ENST00000533265
RefSeq Acc Id: ENSP00000432434   ⟸   ENST00000533999
RefSeq Acc Id: ENSP00000434300   ⟸   ENST00000525866
RefSeq Acc Id: ENSP00000434328   ⟸   ENST00000525126
RefSeq Acc Id: ENSP00000486561   ⟸   ENST00000528924
RefSeq Acc Id: ENSP00000392942   ⟸   ENST00000436913
RefSeq Acc Id: XP_054223742   ⟸   XM_054367767
- Peptide Label: isoform X1
- UniProtKB: B4DDS5 (UniProtKB/TrEMBL)
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6UX15-F1-model_v2 AlphaFold Q6UX15 1-382 view protein structure

Promoters
RGD ID:7222069
Promoter ID:EPDNEW_H16780
Type:initiation region
Name:LAYN_1
Description:layilin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811111,540,722 - 111,540,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29471 AgrOrtholog
COSMIC LAYN COSMIC
Ensembl Genes ENSG00000204381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000375614 ENTREZGENE
  ENST00000375614.7 UniProtKB/Swiss-Prot
  ENST00000375615 ENTREZGENE
  ENST00000375615.7 UniProtKB/Swiss-Prot
  ENST00000436913 ENTREZGENE
  ENST00000436913.6 UniProtKB/Swiss-Prot
  ENST00000525126.5 UniProtKB/TrEMBL
  ENST00000525866.5 UniProtKB/TrEMBL
  ENST00000528924.4 UniProtKB/TrEMBL
  ENST00000530962.5 UniProtKB/TrEMBL
  ENST00000533265.5 UniProtKB/TrEMBL
  ENST00000533999.5 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204381 GTEx
HGNC ID HGNC:29471 ENTREZGENE
Human Proteome Map LAYN Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:143903 UniProtKB/Swiss-Prot
NCBI Gene 143903 ENTREZGENE
OMIM 618843 OMIM
PANTHER CHONDROLECTIN VARIANT CHODLFDELTAE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAYILIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142671570 PharmGKB
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0D9SFG0_HUMAN UniProtKB/TrEMBL
  A6NJB0 ENTREZGENE
  B4DDS5 ENTREZGENE, UniProtKB/TrEMBL
  B4DJU0 ENTREZGENE
  B4DP26 ENTREZGENE, UniProtKB/TrEMBL
  E9PK64_HUMAN UniProtKB/TrEMBL
  E9PMI0_HUMAN UniProtKB/TrEMBL
  E9PQU7_HUMAN UniProtKB/TrEMBL
  E9PQY8_HUMAN UniProtKB/TrEMBL
  E9PR90_HUMAN UniProtKB/TrEMBL
  LAYN_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8TAY8 ENTREZGENE
  Q96NC5 ENTREZGENE
  Q96NF3 ENTREZGENE
UniProt Secondary A6NJB0 UniProtKB/Swiss-Prot
  B4DJU0 UniProtKB/Swiss-Prot
  Q8TAY8 UniProtKB/Swiss-Prot
  Q96NC5 UniProtKB/Swiss-Prot
  Q96NF3 UniProtKB/Swiss-Prot