Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | LAYN | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LAYN mRNA | CTD | PMID:22574217 | LAYN | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LAYN mRNA | CTD | PMID:33387578 and PMID:34747641 | LAYN | Human | 4,4'-sulfonyldiphenol | increases expression | ISO | Layn (Mus musculus) | 6480464 | bisphenol S results in increased expression of LAYN mRNA | CTD | PMID:30951980 | LAYN | Human | 4,4'-sulfonyldiphenol | affects methylation | ISO | Layn (Mus musculus) | 6480464 | bisphenol S affects the methylation of LAYN gene | CTD | PMID:31683443 | LAYN | Human | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Layn (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of LAYN mRNA | CTD | PMID:36041667 | LAYN | Human | acetamide | increases expression | ISO | Layn (Rattus norvegicus) | 6480464 | acetamide results in increased expression of LAYN mRNA | CTD | PMID:31881176 | LAYN | Human | aflatoxin B1 | decreases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in decreased expression of LAYN mRNA | CTD | PMID:33354967 | LAYN | Human | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of LAYN mRNA | CTD | PMID:23724009 | LAYN | Human | arsenite(3-) | increases methylation | EXP | | 6480464 | arsenite results in increased methylation of LAYN promoter | CTD | PMID:23974009 | LAYN | Human | benzo[a]pyrene | increases expression | ISO | Layn (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of LAYN mRNA | CTD | PMID:32417428 | LAYN | Human | benzo[b]fluoranthene | increases expression | ISO | Layn (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of LAYN mRNA | CTD | PMID:26377693 | LAYN | Human | bisphenol A | affects expression | ISO | Layn (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of LAYN mRNA | CTD | PMID:25181051 | LAYN | Human | bisphenol A | decreases expression | ISO | Layn (Mus musculus) | 6480464 | bisphenol A results in decreased expression of LAYN protein | CTD | PMID:35999755 | LAYN | Human | bisphenol A | multiple interactions | ISO | Layn (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of LAYN mRNA | CTD | PMID:36041667 | LAYN | Human | bisphenol A | decreases expression | ISO | Layn (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LAYN mRNA | CTD | PMID:30816183 and PMID:32528016 | LAYN | Human | bisphenol A | increases expression | ISO | Layn (Mus musculus) | 6480464 | bisphenol A results in increased expression of LAYN mRNA | CTD | PMID:30951980 | LAYN | Human | bisphenol F | increases expression | ISO | Layn (Mus musculus) | 6480464 | bisphenol F results in increased expression of LAYN mRNA | CTD | PMID:30951980 | LAYN | Human | bisphenol F | multiple interactions | ISO | Layn (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of LAYN mRNA | CTD | PMID:36041667 | LAYN | Human | butanal | increases expression | EXP | | 6480464 | butyraldehyde results in increased expression of LAYN mRNA | CTD | PMID:26079696 | LAYN | Human | calcitriol | decreases expression | EXP | | 6480464 | Calcitriol results in decreased expression of LAYN mRNA | CTD | PMID:16002434 | LAYN | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LAYN gene] | CTD | PMID:28238834 | LAYN | Human | cisplatin | multiple interactions | ISO | Layn (Mus musculus) | 6480464 | [Cisplatin co-treated with RELB mutant form] results in decreased expression of LAYN mRNA | CTD | PMID:23625948 | LAYN | Human | dextran sulfate | decreases expression | ISO | Layn (Mus musculus) | 6480464 | Dextran Sulfate results in decreased expression of LAYN protein | CTD | PMID:35999755 | LAYN | Human | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | LAYN | Human | entinostat | increases expression | EXP | | 6480464 | entinostat results in increased expression of LAYN mRNA | CTD | PMID:26272509 and PMID:27188386 | LAYN | Human | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | gentamycin | decreases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of LAYN mRNA | CTD | PMID:33387578 | LAYN | Human | indole-3-methanol | multiple interactions | ISO | Layn (Rattus norvegicus) | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of LAYN mRNA | CTD | PMID:22129741 | LAYN | Human | lead(0) | decreases expression | EXP | | 6480464 | Lead results in decreased expression of LAYN mRNA | CTD | PMID:19921347 | LAYN | Human | mercury dibromide | increases expression | EXP | | 6480464 | mercuric bromide results in increased expression of LAYN mRNA | CTD | PMID:26272509 | LAYN | Human | mercury dibromide | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of LAYN mRNA | CTD | PMID:28001369 | LAYN | Human | N-nitrosodiethylamine | multiple interactions | ISO | Layn (Rattus norvegicus) | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of LAYN mRNA | CTD | PMID:22129741 | LAYN | Human | ozone | multiple interactions | ISO | Layn (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of LAYN mRNA | CTD | PMID:34911549 | LAYN | Human | p-chloromercuribenzoic acid | increases expression | EXP | | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of LAYN mRNA | CTD | PMID:26272509 | LAYN | Human | p-chloromercuribenzoic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | panobinostat | increases expression | EXP | | 6480464 | panobinostat results in increased expression of LAYN mRNA | CTD | PMID:26272509 | LAYN | Human | panobinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | paracetamol | increases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of LAYN mRNA | CTD | PMID:33387578 | LAYN | Human | pentanal | increases expression | EXP | | 6480464 | pentanal results in increased expression of LAYN mRNA | CTD | PMID:26079696 | LAYN | Human | perfluorohexanesulfonic acid | increases expression | ISO | Layn (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of LAYN mRNA | CTD | PMID:37995155 | LAYN | Human | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of LAYN mRNA | CTD | PMID:26272509 | LAYN | Human | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | propanal | increases expression | EXP | | 6480464 | propionaldehyde results in increased expression of LAYN mRNA | CTD | PMID:26079696 | LAYN | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | LAYN | Human | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide analog results in increased expression of LAYN mRNA | CTD | PMID:25895662 | LAYN | Human | silicon dioxide | increases expression | ISO | Layn (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of LAYN mRNA | CTD | PMID:29203145 | LAYN | Human | silver atom | increases expression | EXP | | 6480464 | Silver results in increased expression of LAYN mRNA | CTD | PMID:28959546 | LAYN | Human | silver atom | increases expression | ISO | Layn (Mus musculus) | 6480464 | Silver results in increased expression of LAYN mRNA | CTD | PMID:27131904 | LAYN | Human | silver(0) | increases expression | EXP | | 6480464 | Silver results in increased expression of LAYN mRNA | CTD | PMID:28959546 | LAYN | Human | silver(0) | increases expression | ISO | Layn (Mus musculus) | 6480464 | Silver results in increased expression of LAYN mRNA | CTD | PMID:27131904 | LAYN | Human | succimer | multiple interactions | ISO | Layn (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of LAYN mRNA | CTD | PMID:21641980 | LAYN | Human | temozolomide | increases expression | EXP | | 6480464 | Temozolomide results in increased expression of LAYN mRNA | CTD | PMID:31758290 | LAYN | Human | tetrachloromethane | decreases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of LAYN mRNA | CTD | PMID:31150632 | LAYN | Human | thioacetamide | increases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of LAYN mRNA | CTD | PMID:34492290 | LAYN | Human | trichloroethene | increases expression | ISO | Layn (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of LAYN mRNA | CTD | PMID:33387578 | LAYN | Human | trichostatin A | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of LAYN mRNA | CTD | PMID:24935251 more ... | LAYN | Human | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of LAYN gene | CTD | PMID:29154799 | LAYN | Human | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of LAYN mRNA | CTD | PMID:25979313 | LAYN | Human | valproic acid | increases expression | ISO | Layn (Mus musculus) | 6480464 | Valproic Acid results in increased expression of LAYN mRNA | CTD | PMID:24896083 | LAYN | Human | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAYN mRNA | CTD | PMID:27188386 | LAYN | Human | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of LAYN mRNA | CTD | PMID:23179753 more ... | LAYN | Human | vorinostat | increases expression | EXP | | 6480464 | vorinostat results in increased expression of LAYN mRNA | CTD | PMID:27188386 | |