MIR17HG (miR-17-92a-1 cluster host gene) - Rat Genome Database

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Gene: MIR17HG (miR-17-92a-1 cluster host gene) Homo sapiens
Analyze
Symbol: MIR17HG
Name: miR-17-92a-1 cluster host gene
RGD ID: 1604139
HGNC Page HGNC:23564
Description: Involved in miRNA-mediated post-transcriptional gene silencing and positive regulation of muscle hyperplasia. Predicted to be located in membrane. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: REVIEWED
Previously known as: C13orf25; FGLDS2; FLJ14178; LINC00048; MGC126270; MIHG1; miR-17-92; miR-17-92 cluster host gene; MIRH1; MIRHG1; NCRNA00048
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,347,820 - 91,354,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,347,686 - 91,397,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,000,074 - 92,006,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,800,444 - 90,800,656 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,847,045 - 72,853,800 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,595,711 - 72,602,664 (+)NCBIHuRef
CHM1_11391,968,712 - 91,975,469 (+)NCBICHM1_1
T2T-CHM13v2.01390,550,394 - 90,557,151 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
RISC complex  (IEA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
Additional References at PubMed
PMID:11991713   PMID:12477932   PMID:14702039   PMID:15126345   PMID:15944707   PMID:15944709   PMID:16077067   PMID:16266980   PMID:17210683   PMID:19597473   PMID:19696742   PMID:20008935  
PMID:20167088   PMID:20300951   PMID:20305691   PMID:21145484   PMID:21664042   PMID:21796614   PMID:21892160   PMID:21897363   PMID:22022595   PMID:22024720   PMID:22116552   PMID:22343732  
PMID:22383169   PMID:22451425   PMID:22665768   PMID:22731656   PMID:22969266   PMID:22995834   PMID:23271053   PMID:23288173   PMID:23438603   PMID:23532756   PMID:23546593   PMID:23550645  
PMID:23551855   PMID:23759744   PMID:23825564   PMID:23858035   PMID:23921550   PMID:24068957   PMID:24145352   PMID:24145403   PMID:24169826   PMID:24280866   PMID:24305714   PMID:24378993  
PMID:24469837   PMID:24583285   PMID:24625819   PMID:24645838   PMID:25140305   PMID:25239565   PMID:25359779   PMID:25415674   PMID:25634356   PMID:25732734   PMID:25870038   PMID:25887381  
PMID:26233958   PMID:26360630   PMID:26545119   PMID:26760575   PMID:26804174   PMID:26837962   PMID:26891588   PMID:27044389   PMID:27080303   PMID:27229531   PMID:27498867   PMID:27501757  
PMID:27609421   PMID:27650539   PMID:27720936   PMID:27869313   PMID:28030800   PMID:28187958   PMID:28222938   PMID:28461114   PMID:28827775   PMID:29255972   PMID:29333091   PMID:29752469  
PMID:30055570   PMID:30170406   PMID:30226589   PMID:30431147   PMID:30854399   PMID:30941921   PMID:31186404   PMID:31238254   PMID:31290724   PMID:31409641   PMID:31703587   PMID:31706574  
PMID:31802000   PMID:32046383   PMID:32068173   PMID:32466856   PMID:32478334   PMID:32558936   PMID:32748943   PMID:32843613   PMID:32933626   PMID:33036577   PMID:33293632   PMID:33299861  
PMID:33430425   PMID:33803955   PMID:33818875   PMID:34274472   PMID:34598688   PMID:34781979   PMID:35051418   PMID:35063745   PMID:35137671   PMID:35232666   PMID:35253975   PMID:35272588  
PMID:35288592   PMID:35328059   PMID:35872559   PMID:36327576   PMID:36461008   PMID:36675221   PMID:36943627   PMID:37269748   PMID:38321787  


Genomics

Comparative Map Data
MIR17HG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,347,820 - 91,354,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,347,686 - 91,397,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371392,000,074 - 92,006,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,800,444 - 90,800,656 (+)NCBINCBI36Build 36hg18NCBI36
Celera1372,847,045 - 72,853,800 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,595,711 - 72,602,664 (+)NCBIHuRef
CHM1_11391,968,712 - 91,975,469 (+)NCBICHM1_1
T2T-CHM13v2.01390,550,394 - 90,557,151 (+)NCBIT2T-CHM13v2.0
Mir17hg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,822 - 115,284,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,280,311 - 115,284,159 (+)EnsemblGRCm39 Ensembl
GRCm3814115,044,390 - 115,046,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,042,879 - 115,046,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714115,443,612 - 115,445,950 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera14113,634,958 - 113,637,296 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI

Variants

.
Variants in MIR17HG
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 13q14.12-31.3(chr13:44967523-92738168)x1 copy number loss See cases [RCV000050891] Chr13:44967523..92738168 [GRCh38]
Chr13:45541658..93390421 [GRCh37]
Chr13:44439658..92188422 [NCBI36]
Chr13:13q14.12-31.3		 pathogenic
GRCh38/hg38 13q22.3-32.1(chr13:78349126-94701844)x1 copy number loss See cases [RCV000051379] Chr13:78349126..94701844 [GRCh38]
Chr13:78923261..95354098 [GRCh37]
Chr13:77821262..94152099 [NCBI36]
Chr13:13q22.3-32.1		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:82581008-114327173)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051380]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051380]|See cases [RCV000051380] Chr13:82581008..114327173 [GRCh38]
Chr13:83155143..115085141 [GRCh37]
Chr13:82053144..114110750 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-32.1(chr13:83947821-95128969)x1 copy number loss See cases [RCV000051414] Chr13:83947821..95128969 [GRCh38]
Chr13:84521956..95781223 [GRCh37]
Chr13:83419957..94579224 [NCBI36]
Chr13:13q31.1-32.1		 pathogenic
GRCh38/hg38 13q31.2-32.1(chr13:88260962-97285754)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051415]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051415]|See cases [RCV000051415] Chr13:88260962..97285754 [GRCh38]
Chr13:88913217..97938008 [GRCh37]
Chr13:87711218..96736009 [NCBI36]
Chr13:13q31.2-32.1		 pathogenic
GRCh38/hg38 13q31.2-32.3(chr13:88323009-98888644)x1 copy number loss See cases [RCV000051416] Chr13:88323009..98888644 [GRCh38]
Chr13:88975264..99540898 [GRCh37]
Chr13:87773265..98338899 [NCBI36]
Chr13:13q31.2-32.3		 pathogenic
GRCh38/hg38 13q31.3-32.1(chr13:89549510-96657834)x1 copy number loss See cases [RCV000051417] Chr13:89549510..96657834 [GRCh38]
Chr13:90201764..97310088 [GRCh37]
Chr13:88999765..96108089 [NCBI36]
Chr13:13q31.3-32.1		 pathogenic
GRCh38/hg38 13q31.1-33.2(chr13:82032938-106082542)x3 copy number gain See cases [RCV000051179] Chr13:82032938..106082542 [GRCh38]
Chr13:82607073..106734891 [GRCh37]
Chr13:81505074..105532892 [NCBI36]
Chr13:13q31.1-33.2		 pathogenic
GRCh38/hg38 13q31.3(chr13:90215412-91366486)x1 copy number loss See cases [RCV000051921] Chr13:90215412..91366486 [GRCh38]
Chr13:90867666..92018740 [GRCh37]
Chr13:89665667..90816741 [NCBI36]
Chr13:13q31.3		 uncertain significance
GRCh38/hg38 13q31.3(chr13:90973752-93097331)x1 copy number loss See cases [RCV000051922] Chr13:90973752..93097331 [GRCh38]
Chr13:91626006..93749584 [GRCh37]
Chr13:90424007..92547585 [NCBI36]
Chr13:13q31.3		 uncertain significance
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:43219125-114327314)x3 copy number gain See cases [RCV000053762] Chr13:43219125..114327314 [GRCh38]
Chr13:43793261..115085141 [GRCh37]
Chr13:42691261..114110891 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:44164751-114327173)x3 copy number gain See cases [RCV000053764] Chr13:44164751..114327173 [GRCh38]
Chr13:44738887..115085141 [GRCh37]
Chr13:43636887..114110750 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.12-34(chr13:44733046-114327173)x3 copy number gain See cases [RCV000053767] Chr13:44733046..114327173 [GRCh38]
Chr13:45307182..115085141 [GRCh37]
Chr13:44205182..114110750 [NCBI36]
Chr13:13q14.12-34		 pathogenic
GRCh38/hg38 13q22.1-34(chr13:74345951-114327314)x3 copy number gain See cases [RCV000053770] Chr13:74345951..114327314 [GRCh38]
Chr13:74920088..115085141 [GRCh37]
Chr13:73818089..114110891 [NCBI36]
Chr13:13q22.1-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:80628584-114327173)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053772]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053772]|See cases [RCV000053772] Chr13:80628584..114327173 [GRCh38]
Chr13:81202719..115085141 [GRCh37]
Chr13:80100720..114110750 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q31.3(chr13:90644219-92557099)x1 copy number loss See cases [RCV000234861] Chr13:90644219..92557099 [GRCh37]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q22.3-31.3(chr13:77061780-92460406)x1 copy number loss See cases [RCV000136886] Chr13:77061780..92460406 [GRCh38]
Chr13:77635915..93112659 [GRCh37]
Chr13:76533916..91910660 [NCBI36]
Chr13:13q22.3-31.3		 pathogenic
GRCh38/hg38 13q31.2-34(chr13:88937651-114327173)x3 copy number gain See cases [RCV000137102] Chr13:88937651..114327173 [GRCh38]
Chr13:89589905..115085141 [GRCh37]
Chr13:88387906..114110750 [NCBI36]
Chr13:13q31.2-34		 pathogenic
GRCh38/hg38 13q31.1-31.3(chr13:84005264-92784013)x1 copy number loss See cases [RCV000137272] Chr13:84005264..92784013 [GRCh38]
Chr13:84579399..93436266 [GRCh37]
Chr13:83477400..92234267 [NCBI36]
Chr13:13q31.1-31.3		 likely pathogenic
GRCh38/hg38 13q14.11-34(chr13:40942298-114340331)x1 copy number loss See cases [RCV000137893] Chr13:40942298..114340331 [GRCh38]
Chr13:41516434..115085141 [GRCh37]
Chr13:40414434..114123908 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:78999318-114327106)x3 copy number gain See cases [RCV000138742] Chr13:78999318..114327106 [GRCh38]
Chr13:79573453..115085141 [GRCh37]
Chr13:78471454..114110683 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:86788927-114340331)x1 copy number loss See cases [RCV000138340] Chr13:86788927..114340331 [GRCh38]
Chr13:87441182..115085141 [GRCh37]
Chr13:86239183..114123908 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q31.2-32.3(chr13:87944479-99866542)x1 copy number loss See cases [RCV000139047] Chr13:87944479..99866542 [GRCh38]
Chr13:88596734..100518796 [GRCh37]
Chr13:87394735..99316797 [NCBI36]
Chr13:13q31.2-32.3		 pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q31.1-34(chr13:78964223-114340331)x3 copy number gain See cases [RCV000141248] Chr13:78964223..114340331 [GRCh38]
Chr13:79538358..115085141 [GRCh37]
Chr13:78436359..114123908 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q31.1-31.3(chr13:84052824-91838339)x3 copy number gain See cases [RCV000141994] Chr13:84052824..91838339 [GRCh38]
Chr13:84626959..92490593 [GRCh37]
Chr13:83524960..91288594 [NCBI36]
Chr13:13q31.1-31.3		 uncertain significance
GRCh38/hg38 13q31.1-34(chr13:83288131-114342258)x3 copy number gain See cases [RCV000141804] Chr13:83288131..114342258 [GRCh38]
Chr13:83862266..115107733 [GRCh37]
Chr13:82760267..114125835 [NCBI36]
Chr13:13q31.1-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q31.3(chr13:91283077-91394459)x1 copy number loss See cases [RCV000143094] Chr13:91283077..91394459 [GRCh38]
Chr13:91935331..92046713 [GRCh37]
Chr13:90733332..90844714 [NCBI36]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q31.3(chr13:91282882-91394459)x1 copy number loss See cases [RCV000143162] Chr13:91282882..91394459 [GRCh38]
Chr13:91935136..92046713 [GRCh37]
Chr13:90733137..90844714 [NCBI36]
Chr13:13q31.3		 pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:89796110-115083342)x1 copy number loss See cases [RCV000240161] Chr13:89796110..115083342 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.3(chr13:91209639-94704856)x3 copy number gain See cases [RCV000240035] Chr13:91209639..94704856 [GRCh37]
Chr13:13q31.3		 uncertain significance
GRCh37/hg19 13q31.3(chr13:91284502-92325104)x1 copy number loss See cases [RCV002285045] Chr13:91284502..92325104 [GRCh37]
Chr13:13q31.3		 pathogenic
GRCh37/hg19 13q22.1-31.3(chr13:74459395-93481294)x1 copy number loss See cases [RCV000598789] Chr13:74459395..93481294 [GRCh37]
Chr13:13q22.1-31.3		 pathogenic
GRCh37/hg19 13q14.3-33.3(chr13:53551300-109850651)x1 copy number loss See cases [RCV000449272] Chr13:53551300..109850651 [GRCh37]
Chr13:13q14.3-33.3		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61424168-115107733)x3 copy number gain See cases [RCV000449118] Chr13:61424168..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q31.1-31.3(chr13:86963003-93390362)x3 copy number gain See cases [RCV000446248] Chr13:86963003..93390362 [GRCh37]
Chr13:13q31.1-31.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82221361-115092569)x3 copy number gain See cases [RCV000447429] Chr13:82221361..115092569 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.1-34(chr13:56431743-115107733) copy number gain See cases [RCV000510722] Chr13:56431743..115107733 [GRCh37]
Chr13:13q21.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-33.1(chr13:81851091-102864674)x1 copy number loss See cases [RCV000448988] Chr13:81851091..102864674 [GRCh37]
Chr13:13q31.1-33.1		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:88073140-115107733)x1 copy number loss See cases [RCV000448405] Chr13:88073140..115107733 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
NC_000013.11:g.(?_90698351)_(90699137_?)del deletion Feingold syndrome type 2 [RCV000498711] Chr13:90698351..90699137 [GRCh38]
Chr13:91350605..91351391 [GRCh37]
Chr13:13q31.3		 pathogenic
GRCh37/hg19 13q21.33-34(chr13:71871468-115107733)x4 copy number gain See cases [RCV000510281] Chr13:71871468..115107733 [GRCh37]
Chr13:13q21.33-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:80058840-115107733)x3 copy number gain See cases [RCV000510566] Chr13:80058840..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-33.3(chr13:80572498-108719528)x1 copy number loss See cases [RCV000510890] Chr13:80572498..108719528 [GRCh37]
Chr13:13q31.1-33.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:83435292-115107733)x3 copy number gain See cases [RCV000512605] Chr13:83435292..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q14.3-32.1(chr13:53932358-96586363)x3 copy number gain See cases [RCV000512571] Chr13:53932358..96586363 [GRCh37]
Chr13:13q14.3-32.1		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:85176519-115107733)x3 copy number gain See cases [RCV000512242] Chr13:85176519..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
Single allele duplication not provided [RCV000678035] Chr13:91209639..94704856 [GRCh37]
Chr13:13q31.3		 likely pathogenic
GRCh37/hg19 13q22.3-34(chr13:78590089-115107733)x3 copy number gain not provided [RCV000683571] Chr13:78590089..115107733 [GRCh37]
Chr13:13q22.3-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.1-31.3(chr13:85005334-92461147)x1 copy number loss not provided [RCV000738268] Chr13:85005334..92461147 [GRCh37]
Chr13:13q31.1-31.3		 pathogenic
GRCh37/hg19 13q31.3(chr13:91999737-92001350)x1 copy number loss not provided [RCV000738283] Chr13:91999737..92001350 [GRCh37]
Chr13:13q31.3		 benign
GRCh37/hg19 13q31.3(chr13:91999750-92001350)x3 copy number gain not provided [RCV000738284] Chr13:91999750..92001350 [GRCh37]
Chr13:13q31.3		 benign
GRCh37/hg19 13q31.3(chr13:92000140-92001350)x4 copy number gain not provided [RCV000738285] Chr13:92000140..92001350 [GRCh37]
Chr13:13q31.3		 benign
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.1-31.3(chr13:57058434-94684615)x1 copy number loss not provided [RCV000750731] Chr13:57058434..94684615 [GRCh37]
Chr13:13q21.1-31.3		 pathogenic
GRCh37/hg19 13q31.3(chr13:91460305-92069153)x3 copy number gain not provided [RCV001006582] Chr13:91460305..92069153 [GRCh37]
Chr13:13q31.3		 likely pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61775567-115107733)x3 copy number gain not provided [RCV000848025] Chr13:61775567..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q14.3-34(chr13:53262013-115107733)x1 copy number loss not provided [RCV001006567] Chr13:53262013..115107733 [GRCh37]
Chr13:13q14.3-34		 pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878) copy number gain Complete trisomy 13 syndrome [RCV002280659] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
NC_000013.10:g.(?_92002837)_(103343314_?)del deletion Holoprosencephaly 5 [RCV001388033] Chr13:92002837..103343314 [GRCh37]
Chr13:13q31.3-33.1		 pathogenic
GRCh37/hg19 13q11-34(chr13:19053605-115108528)x3 copy number gain See cases [RCV001353184] Chr13:19053605..115108528 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878)x3 copy number gain See cases [RCV001780076] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-114981726) copy number gain not specified [RCV002053035] Chr13:19436286..114981726 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.11-33.3(chr13:42504540-108206269)x3 copy number gain not provided [RCV001829235] Chr13:42504540..108206269 [GRCh37]
Chr13:13q14.11-33.3		 pathogenic
GRCh37/hg19 13q22.3-34(chr13:78514567-115107733) copy number gain not specified [RCV002053071] Chr13:78514567..115107733 [GRCh37]
Chr13:13q22.3-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:79370012-115107733) copy number loss not specified [RCV002053072] Chr13:79370012..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV001834436] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61424168-115107733) copy number gain not specified [RCV002053063] Chr13:61424168..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:85037147-115107733) copy number gain not specified [RCV002053073] Chr13:85037147..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:88073140-115107733) copy number loss not specified [RCV002053074] Chr13:88073140..115107733 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733) copy number gain not specified [RCV002053036] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q31.2-34(chr13:89490345-115062235)x3 copy number gain See cases [RCV002286354] Chr13:89490345..115062235 [GRCh37]
Chr13:13q31.2-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19253848-115108937)x3 copy number gain not provided [RCV002291540] Chr13:19253848..115108937 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q22.1-34(chr13:75268539-115107733)x3 copy number gain not provided [RCV002472537] Chr13:75268539..115107733 [GRCh37]
Chr13:13q22.1-34		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82131211-115107733)x1 copy number loss not provided [RCV003483192] Chr13:82131211..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.2-34(chr13:61534068-115107733)x3 copy number gain not provided [RCV003484899] Chr13:61534068..115107733 [GRCh37]
Chr13:13q21.2-34		 pathogenic
GRCh37/hg19 13q21.33-33.1(chr13:73132193-104595598)x1 copy number loss not provided [RCV003483190] Chr13:73132193..104595598 [GRCh37]
Chr13:13q21.33-33.1		 pathogenic
GRCh37/hg19 13q31.2-33.2(chr13:89012420-106371634)x1 copy number loss not provided [RCV003483195] Chr13:89012420..106371634 [GRCh37]
Chr13:13q31.2-33.2		 pathogenic
GRCh37/hg19 13q22.1-34(chr13:73488238-115107733)x3 copy number gain not provided [RCV003484901] Chr13:73488238..115107733 [GRCh37]
Chr13:13q22.1-34		 pathogenic
NR_027350.1(MIR17HG):n.1011_1013del deletion MIR17HG-related condition [RCV003391240] Chr13:91350567..91350569 [GRCh38]
Chr13:92002821..92002823 [GRCh37]
Chr13:13q31.3		 uncertain significance
NR_027350.1(MIR17HG):n.192A>C single nucleotide variant MIR17HG-related condition [RCV003408656] Chr13:91349749 [GRCh38]
Chr13:92002003 [GRCh37]
Chr13:13q31.3		 uncertain significance
NR_027350.1(MIR17HG):n.4498T>C single nucleotide variant MIR17HG-related condition [RCV003408732] Chr13:91354055 [GRCh38]
Chr13:92006309 [GRCh37]
Chr13:13q31.3		 uncertain significance
NR_027350.1(MIR17HG):n.3164C>T single nucleotide variant MIR17HG-related condition [RCV003393164] Chr13:91352721 [GRCh38]
Chr13:92004975 [GRCh37]
Chr13:13q31.3		 uncertain significance
NR_027350.1(MIR17HG):n.1956CTTGT[1] microsatellite MIR17HG-related condition [RCV003410652] Chr13:91351512..91351516 [GRCh38]
Chr13:92003766..92003770 [GRCh37]
Chr13:13q31.3		 uncertain significance
GRCh37/hg19 13q31.1-34(chr13:84669397-115107733)x1 copy number loss not specified [RCV003987038] Chr13:84669397..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q21.1-31.3(chr13:56450978-93582180)x1 copy number loss not specified [RCV003987013] Chr13:56450978..93582180 [GRCh37]
Chr13:13q21.1-31.3		 pathogenic
GRCh37/hg19 13q31.1-34(chr13:82876219-115107733)x3 copy number gain not specified [RCV003987023] Chr13:82876219..115107733 [GRCh37]
Chr13:13q31.1-34		 pathogenic
GRCh37/hg19 13q14.2-32.2(chr13:49547974-98214905)x1 copy number loss not specified [RCV003987008] Chr13:49547974..98214905 [GRCh37]
Chr13:13q14.2-32.2		 pathogenic
GRCh37/hg19 13q21.31-33.1(chr13:64825656-103641349)x1 copy number loss not specified [RCV003987009] Chr13:64825656..103641349 [GRCh37]
Chr13:13q21.31-33.1		 pathogenic
NR_027350.1(MIR17HG):n.4526T>G single nucleotide variant MIR17HG-related condition [RCV003893985] Chr13:91354083 [GRCh38]
Chr13:92006337 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.445C>T single nucleotide variant MIR17HG-related condition [RCV003951807] Chr13:91350002 [GRCh38]
Chr13:92002256 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.994A>G single nucleotide variant MIR17HG-related condition [RCV003954312] Chr13:91350551 [GRCh38]
Chr13:92002805 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.3522C>T single nucleotide variant MIR17HG-related condition [RCV003899014] Chr13:91353079 [GRCh38]
Chr13:92005333 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027349.1(MIR17HG):n.284+22dupT duplication MIR17HG-related condition [RCV003951606] Chr13:91350247..91350248 [GRCh38]
Chr13:92002501..92002502 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.1450G>T single nucleotide variant MIR17HG-related condition [RCV003907248] Chr13:91351007 [GRCh38]
Chr13:92003261 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.1287A>G single nucleotide variant MIR17HG-related condition [RCV003931841] Chr13:91350844 [GRCh38]
Chr13:92003098 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.1998C>T single nucleotide variant MIR17HG-related condition [RCV003979702] Chr13:91351555 [GRCh38]
Chr13:92003809 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.3326C>T single nucleotide variant MIR17HG-related condition [RCV003984722] Chr13:91352883 [GRCh38]
Chr13:92005137 [GRCh37]
Chr13:13q31.3		 benign
NR_027350.1(MIR17HG):n.5011T>C single nucleotide variant MIR17HG-related condition [RCV003974763] Chr13:91354568 [GRCh38]
Chr13:92006822 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027349.1(MIR17HG):n.213+123A>G single nucleotide variant MIR17HG-related condition [RCV003904424] Chr13:91349893 [GRCh38]
Chr13:92002147 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.836C>G single nucleotide variant MIR17HG-related condition [RCV003911535] Chr13:91350393 [GRCh38]
Chr13:92002647 [GRCh37]
Chr13:13q31.3		 benign
NR_027349.1(MIR17HG):n.285-301A>G single nucleotide variant MIR17HG-related condition [RCV003982726] Chr13:91353632 [GRCh38]
Chr13:92005886 [GRCh37]
Chr13:13q31.3		 uncertain significance
NR_027350.1(MIR17HG):n.3584C>A single nucleotide variant MIR17HG-related condition [RCV003894606] Chr13:91353141 [GRCh38]
Chr13:92005395 [GRCh37]
Chr13:13q31.3		 likely benign
NR_027350.1(MIR17HG):n.3827A>G single nucleotide variant MIR17HG-related condition [RCV003896669] Chr13:91353384 [GRCh38]
Chr13:92005638 [GRCh37]
Chr13:13q31.3		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:215
Interacting mature miRNAs:218
Transcripts:ENST00000400282, ENST00000581816, ENST00000582141
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH45064  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371392,006,677 - 92,006,806UniSTSGRCh37
Build 361390,804,678 - 90,804,807RGDNCBI36
Celera1372,853,648 - 72,853,777RGD
Cytogenetic Map13q31.3UniSTS
HuRef1372,602,512 - 72,602,641UniSTS
GeneMap99-GB4 RH Map13255.96UniSTS
NCBI RH Map13798.9UniSTS
G59670  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371392,006,677 - 92,006,802UniSTSGRCh37
Build 361390,804,678 - 90,804,803RGDNCBI36
Celera1372,853,648 - 72,853,773RGD
Cytogenetic Map13q31.3UniSTS
HuRef1372,602,512 - 72,602,637UniSTS
RH48552  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371392,007,842 - 92,007,922UniSTSGRCh37
Build 361390,805,843 - 90,805,923RGDNCBI36
Celera1372,854,813 - 72,854,893RGD
Cytogenetic Map13q31.3UniSTS
HuRef1372,603,677 - 72,603,757UniSTS
GeneMap99-GB4 RH Map13257.37UniSTS
NCBI RH Map13676.9UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 17 5 2 152 2 126 12 15 28 27 1 19 2
Low 1772 837 1230 432 1083 294 2049 656 883 179 1115 1304 151 1 816 1138 3 2
Below cutoff 641 2014 485 184 631 163 2111 1446 2645 208 307 280 22 367 1585

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000400282
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,820 - 91,354,585 (+)Ensembl
RefSeq Acc Id: ENST00000581816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,942 - 91,352,096 (+)Ensembl
RefSeq Acc Id: ENST00000582141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,820 - 91,355,068 (+)Ensembl
RefSeq Acc Id: ENST00000659898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,349,118 - 91,350,573 (+)Ensembl
RefSeq Acc Id: ENST00000664987
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,352,584 - 91,354,577 (+)Ensembl
RefSeq Acc Id: ENST00000710412
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,349,109 - 91,353,136 (+)Ensembl
RefSeq Acc Id: ENST00000710413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,351,383 - 91,353,136 (+)Ensembl
RefSeq Acc Id: ENST00000710414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,352,334 - 91,365,107 (+)Ensembl
RefSeq Acc Id: ENST00000710419
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,686 - 91,353,402 (+)Ensembl
RefSeq Acc Id: ENST00000710420
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,687 - 91,354,585 (+)Ensembl
RefSeq Acc Id: ENST00000710421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,697 - 91,397,577 (+)Ensembl
RefSeq Acc Id: ENST00000710422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,697 - 91,397,592 (+)Ensembl
RefSeq Acc Id: ENST00000710423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,347,906 - 91,354,577 (+)Ensembl
RefSeq Acc Id: ENST00000710424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,348,815 - 91,353,136 (+)Ensembl
RefSeq Acc Id: ENST00000710425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,349,393 - 91,354,585 (+)Ensembl
RefSeq Acc Id: ENST00000710426
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1391,351,385 - 91,354,585 (+)Ensembl
RefSeq Acc Id: NR_027349
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381391,347,820 - 91,354,575 (+)NCBI
GRCh371392,000,074 - 92,006,829 (+)ENTREZGENE
HuRef1372,595,711 - 72,602,664 (+)ENTREZGENE
CHM1_11391,968,712 - 91,975,469 (+)NCBI
T2T-CHM13v2.01390,550,394 - 90,557,151 (+)NCBI
Sequence:
RefSeq Acc Id: NR_027350
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381391,347,820 - 91,354,575 (+)NCBI
GRCh371392,000,074 - 92,006,829 (+)ENTREZGENE
HuRef1372,595,711 - 72,602,664 (+)ENTREZGENE
CHM1_11391,968,712 - 91,975,469 (+)NCBI
T2T-CHM13v2.01390,550,394 - 90,557,151 (+)NCBI
Sequence:
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q75NE6-F1-model_v2 AlphaFold Q75NE6 1-70 view protein structure

Promoters
RGD ID:6790987
Promoter ID:HG_KWN:18252
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000400280,   NR_027350,   OTTHUMT00000045448
Position:
Human AssemblyChrPosition (strand)Source
Build 361390,797,501 - 90,798,077 (+)MPROMDB
RGD ID:6815055
Promoter ID:HG_MRA:4403
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AK024240
Position:
Human AssemblyChrPosition (strand)Source
Build 361390,802,221 - 90,802,721 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23564 AgrOrtholog
COSMIC MIR17HG COSMIC
Ensembl Genes ENSG00000215417 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000400282 ENTREZGENE
  ENST00000582141 ENTREZGENE
GTEx ENSG00000215417 GTEx
HGNC ID HGNC:23564 ENTREZGENE
Human Proteome Map MIR17HG Human Proteome Map
NCBI Gene 407975 ENTREZGENE
OMIM 609415 OMIM
PharmGKB PA165505138 PharmGKB
RNAcentral URS000075DA42 RNACentral
  URS000075DE64 RNACentral
UniProt MIRH1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A4QMU7 UniProtKB/Swiss-Prot
  Q75NE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 MIR17HG  miR-17-92a-1 cluster host gene    miR-17-92 cluster host gene  Symbol and/or name change 5135510 APPROVED
2015-02-24 MIR17HG  miR-17-92 cluster host gene    miR-17-92 cluster host gene (non-protein coding)  Symbol and/or name change 5135510 APPROVED
2011-07-27 MIR17HG  miR-17-92 cluster host gene (non-protein coding)  MIR17HG  MIR17 host gene (non-protein coding)  Symbol and/or name change 5135510 APPROVED