EID3 (EP300 interacting inhibitor of differentiation 3)

Gene: EID3 (EP300 interacting inhibitor of differentiation 3) Homo sapiens

Analyze

Symbol:

EID3

Name:

EP300 interacting inhibitor of differentiation 3

RGD ID:

1603793

HGNC Page

HGNC:32961

Description:

Predicted to be involved in DNA repair. Located in nucleolus and nucleoplasm. Part of Smc5-Smc6 complex.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; EP300-interacting inhibitor of differentiation 3; FLJ25832; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B; NS4EB; NSE4 homolog B; NSE4B; NSMCE4B; testis tissue sperm-binding protein Li 96mP

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	104,303,739 - 104,305,205 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	104,303,739 - 104,305,205 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	104,697,517 - 104,698,983 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	103,221,679 - 103,223,113 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	104,361,247 - 104,362,681 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	101,757,788 - 101,759,261 (+)	NCBI		HuRef
CHM1_1	12	104,663,356 - 104,664,829 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	104,265,457 - 104,266,923 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (EXP)

4,4'-sulfonyldiphenol (EXP)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (EXP)

amitrole (ISO)

andrographolide (ISO)

aristolochic acid A (EXP)

azathioprine (EXP)

benzo[a]pyrene (EXP)

beta-naphthoflavone (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (EXP)

crotonaldehyde (EXP)

cyclosporin A (EXP)

dexamethasone (EXP)

dorsomorphin (EXP)

fluoranthene (ISO)

formaldehyde (EXP)

glycidol (ISO)

hydroquinone (EXP)

indometacin (EXP)

iron dichloride (EXP)

lipopolysaccharide (EXP)

mercury dibromide (EXP)

N-methyl-4-phenylpyridinium (ISO)

p-chloromercuribenzoic acid (EXP)

paracetamol (ISO)

potassium dichromate (ISO)

quercetin (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

SB 431542 (EXP)

silver atom (EXP)

silver(0) (EXP)

sodium arsenite (EXP)

sulforaphane (EXP)

sunitinib (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (EXP)

urethane (EXP)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin looping (NAS)

DNA recombination (IEA)

DNA repair (IBA,IEA)

double-strand break repair via homologous recombination (NAS)

protein sumoylation (NAS)

regulation of telomere maintenance (NAS)

Cellular Component

chromosome (IEA)

chromosome, telomeric region (IEA,NAS)

cytoplasm (IEA)

intracellular non-membrane-bounded organelle (IEA)

nucleolus (IDA)

nucleoplasm (IDA,TAS)

nucleus (IBA,IEA)

protein-containing complex (IEA)

Smc5-Smc6 complex (IBA,IDA,IEA,NAS)

Molecular Function

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15752197	PMID:15970276	PMID:15987788	PMID:16189514	PMID:16810316	PMID:17589526	PMID:18086888	PMID:21364888	PMID:21873635	PMID:23940030	PMID:24528284
PMID:25590999	PMID:26186194	PMID:28074931	PMID:28514442	PMID:30114644	PMID:32389690	PMID:33660365	PMID:33961781	PMID:36071872	PMID:38216090

Genomics

Comparative Map Data

EID3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	104,303,739 - 104,305,205 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	104,303,739 - 104,305,205 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	104,697,517 - 104,698,983 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	103,221,679 - 103,223,113 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	104,361,247 - 104,362,681 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	101,757,788 - 101,759,261 (+)	NCBI		HuRef
CHM1_1	12	104,663,356 - 104,664,829 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	104,265,457 - 104,266,923 (+)	NCBI		T2T-CHM13v2.0

Eid3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	82,702,460 - 82,703,764 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	82,702,460 - 82,703,764 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	82,866,626 - 82,867,930 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	82,866,626 - 82,867,930 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	82,329,371 - 82,330,675 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	82,296,457 - 82,297,726 (+)	NCBI		MGSCv36	mm8
Celera	10	84,851,342 - 84,852,646 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	40.66	NCBI

Eid3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	22,747,645 - 22,748,967 (-)	NCBI		GRCr8
mRatBN7.2	7	20,860,073 - 20,861,395 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	7	22,824,046 - 22,825,371 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	24,986,818 - 24,988,143 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	24,763,829 - 24,765,154 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	26,976,154 - 26,977,479 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	27,095,849 - 27,097,174 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	23,085,569 - 23,086,894 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	18,039,933 - 18,041,258 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

Eid3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955405	38,897,494 - 38,898,057 (+)	NCBI	ChiLan1.0	ChiLan1.0

EID3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	33,955,843 - 33,957,527 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	33,876,053 - 33,877,730 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	34,799,214 - 34,800,900 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	10	34,534,042 - 34,535,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	34,817,607 - 34,819,293 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	35,012,442 - 35,014,128 (-)	NCBI		UU_Cfam_GSD_1.0

Eid3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	17,220,912 - 17,223,142 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	10,232,335 - 10,233,438 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	10,232,140 - 10,233,557 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EID3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	80,221,334 - 80,234,567 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	83,725,886 - 83,727,438 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EID3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666037	145,489,833 - 145,492,863 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eid3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	4,478,911 - 4,479,872 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	4,478,753 - 4,482,276 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in EID3
13 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1	copy number loss	See cases [RCV000051320]	Chr12:100670616..108583607 [GRCh38] Chr12:101064394..108977383 [GRCh37] Chr12:99588525..107501512 [NCBI36] Chr12:12q23.1-23.3	pathogenic
GRCh38/hg38 12q23.3(chr12:103500125-104726872)x1	copy number loss	See cases [RCV000138809]	Chr12:103500125..104726872 [GRCh38] Chr12:103893903..105120650 [GRCh37] Chr12:102418033..103644780 [NCBI36] Chr12:12q23.3	uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3	copy number gain	See cases [RCV000142447]	Chr12:91044318..109133210 [GRCh38] Chr12:91438095..109571015 [GRCh37] Chr12:89962226..108055398 [NCBI36] Chr12:12q21.33-24.11	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805)x1	copy number loss	See cases [RCV000445832]	Chr12:103044333..111639805 [GRCh37] Chr12:12q23.2-24.11	likely pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)x3	copy number gain	See cases [RCV000445929]	Chr12:100580198..105804075 [GRCh37] Chr12:12q23.1-23.3	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
NM_001008394.3(EID3):c.269C>T (p.Ala90Val)	single nucleotide variant	not specified [RCV004297093]	Chr12:104304203 [GRCh38] Chr12:104697981 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12q23.3(chr12:104635115-104904496)x3	copy number gain	not provided [RCV000683415]	Chr12:104635115..104904496 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12q23.3(chr12:104539647-104873021)x3	copy number gain	not provided [RCV000683422]	Chr12:104539647..104873021 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12q23.3(chr12:104477393-104842357)x3	copy number gain	not provided [RCV000750540]	Chr12:104477393..104842357 [GRCh37] Chr12:12q23.3	benign
GRCh37/hg19 12q23.3(chr12:104517152-104778154)x3	copy number gain	not provided [RCV000750541]	Chr12:104517152..104778154 [GRCh37] Chr12:12q23.3	benign
GRCh37/hg19 12q23.2-23.3(chr12:102414522-105845768)x1	copy number loss	not provided [RCV000846678]	Chr12:102414522..105845768 [GRCh37] Chr12:12q23.2-23.3	uncertain significance
NM_001008394.3(EID3):c.952G>C (p.Val318Leu)	single nucleotide variant	not specified [RCV004301138]	Chr12:104304886 [GRCh38] Chr12:104698664 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.31G>A (p.Gly11Ser)	single nucleotide variant	not specified [RCV004305493]	Chr12:104303965 [GRCh38] Chr12:104697743 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12q23.3(chr12:104576197-104795306)x3	copy number gain	not provided [RCV002473641]	Chr12:104576197..104795306 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12q23.3-24.12(chr12:104230462-111984801)x1	copy number loss	not provided [RCV001834231]	Chr12:104230462..111984801 [GRCh37] Chr12:12q23.3-24.12	pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)	copy number gain	not specified [RCV002053014]	Chr12:100580198..105804075 [GRCh37] Chr12:12q23.1-23.3	uncertain significance
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805)	copy number loss	not specified [RCV002053016]	Chr12:103044333..111639805 [GRCh37] Chr12:12q23.2-24.11	likely pathogenic
GRCh37/hg19 12q23.2-23.3(chr12:103588380-105161579)x3	copy number gain	not provided [RCV002472838]	Chr12:103588380..105161579 [GRCh37] Chr12:12q23.2-23.3	uncertain significance
NM_001008394.3(EID3):c.47T>G (p.Leu16Arg)	single nucleotide variant	not specified [RCV004223752]	Chr12:104303981 [GRCh38] Chr12:104697759 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.361G>T (p.Asp121Tyr)	single nucleotide variant	not specified [RCV004200102]	Chr12:104304295 [GRCh38] Chr12:104698073 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.581A>G (p.Lys194Arg)	single nucleotide variant	not specified [RCV004091158]	Chr12:104304515 [GRCh38] Chr12:104698293 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.638A>T (p.Tyr213Phe)	single nucleotide variant	not specified [RCV004124874]	Chr12:104304572 [GRCh38] Chr12:104698350 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.215A>T (p.Glu72Val)	single nucleotide variant	not specified [RCV004080783]	Chr12:104304149 [GRCh38] Chr12:104697927 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.426T>G (p.Cys142Trp)	single nucleotide variant	Inborn genetic diseases [RCV002674320]	Chr12:104304360 [GRCh38] Chr12:104698138 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.7A>G (p.Met3Val)	single nucleotide variant	not specified [RCV004286929]	Chr12:104303941 [GRCh38] Chr12:104697719 [GRCh37] Chr12:12q23.3	likely benign
NM_001008394.3(EID3):c.796G>T (p.Val266Leu)	single nucleotide variant	not specified [RCV004355839]	Chr12:104304730 [GRCh38] Chr12:104698508 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.25G>C (p.Ala9Pro)	single nucleotide variant	not specified [RCV004348083]	Chr12:104303959 [GRCh38] Chr12:104697737 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.32G>A (p.Gly11Asp)	single nucleotide variant	not specified [RCV004358592]	Chr12:104303966 [GRCh38] Chr12:104697744 [GRCh37] Chr12:12q23.3	uncertain significance
GRCh37/hg19 12q23.3(chr12:104548295-104807478)x3	copy number gain	not provided [RCV003484877]	Chr12:104548295..104807478 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.101A>G (p.Glu34Gly)	single nucleotide variant	not specified [RCV004377668]	Chr12:104304035 [GRCh38] Chr12:104697813 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.255A>T (p.Glu85Asp)	single nucleotide variant	not specified [RCV004377671]	Chr12:104304189 [GRCh38] Chr12:104697967 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.339C>A (p.Phe113Leu)	single nucleotide variant	not specified [RCV004377672]	Chr12:104304273 [GRCh38] Chr12:104698051 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.758C>A (p.Ser253Tyr)	single nucleotide variant	not specified [RCV004377673]	Chr12:104304692 [GRCh38] Chr12:104698470 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.942G>T (p.Trp314Cys)	single nucleotide variant	not specified [RCV004377675]	Chr12:104304876 [GRCh38] Chr12:104698654 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.949A>G (p.Ile317Val)	single nucleotide variant	not specified [RCV004377676]	Chr12:104304883 [GRCh38] Chr12:104698661 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.143T>G (p.Met48Arg)	single nucleotide variant	not specified [RCV004377669]	Chr12:104304077 [GRCh38] Chr12:104697855 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.214G>A (p.Glu72Lys)	single nucleotide variant	not specified [RCV004377670]	Chr12:104304148 [GRCh38] Chr12:104697926 [GRCh37] Chr12:12q23.3	uncertain significance
NM_001008394.3(EID3):c.880G>A (p.Gly294Arg)	single nucleotide variant	not specified [RCV004377674]	Chr12:104304814 [GRCh38] Chr12:104698592 [GRCh37] Chr12:12q23.3	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	41
Interacting mature miRNAs:	41
Transcripts:	ENST00000527879
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH103907

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	104,698,835 - 104,698,932	UniSTS	GRCh37
Build 36	12	103,222,965 - 103,223,062	RGD	NCBI36
Celera	12	104,362,533 - 104,362,630	RGD
Cytogenetic Map	12	q23.3	UniSTS
Cytogenetic Map	12	q23-q24.1	UniSTS
HuRef	12	101,759,113 - 101,759,210	UniSTS
GeneMap99-GB4 RH Map	12	400.64	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

110

143

515

121

Low

2251

2624

1587

524

1555

364

3805

1476

3584

399

925

1473

169

1187

2290

Below cutoff

329

237

520

631

114

488

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_029392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001008394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC090107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK098698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC027612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI461575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HM005376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000527879 ⟹ ENSP00000435619

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	104,303,739 - 104,305,205 (+)	Ensembl

RefSeq Acc Id:

NM_001008394 ⟹ NP_001008395

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	104,303,739 - 104,305,205 (+)	NCBI
GRCh37	12	104,697,510 - 104,698,983 (+)	NCBI
Build 36	12	103,221,679 - 103,223,113 (+)	NCBI Archive
Celera	12	104,361,247 - 104,362,681 (+)	RGD
HuRef	12	101,757,788 - 101,759,261 (+)	NCBI
CHM1_1	12	104,663,356 - 104,664,829 (+)	NCBI
T2T-CHM13v2.0	12	104,265,457 - 104,266,923 (+)	NCBI

Sequence:

show sequence

ATGGGCGGGCGTCCTCGGCTCTAACTGCCGCCACTTTCCACACGCTGGGAGGGCCGTTACCTCA
GAGATACCCGTGGCCGGCATGTTGGTTGAAAAAGCTTCCCGGAAGGGAGACGAAGAGAAAGGAG
AGGAGCAGCTCGTGATCATCCCCGGTAGCGAGTACGCGGCGAAGTAGGCGGCGGCGGAGGGAGC
GCTGATGAAGATGGATGTGTCAGTGAGGGCCGCGGGCTGCTCCGACGACCTCAGCTCTGGGGAG
GCCGACGTAGACCCAAAGCTCCTGGAGCTCACCGCTGACGAGGAGAAGTGCCGCAGCATCCGCA
GGCAGTACCGGCAGCTCATGTACTGCGTGCGGCAGAACCGGGAGGACATCGTGAGCTCGGCGAA
CAACTCCTTAACCGAGGCTCTGGAGGAAGCCAACGTCCTCTTTGATGGCGTGAGCCGAACCAGA
GAAGCAGCCCTCGACGCCCGGTTTCTTGTTATGGCTTCTGATTTGGGTAAAGAAAAGGCAAAGC
AGTTAAACTCAGATATGAACTTCTTTAATCAGTTAGCATTTTGTGACTTTCTGTTTCTGTTCGT
GGGTCTGAATTGGATGGAAGGCGATCCTGACAAGTTGAGTGATTGTGATGATAGCATAGCTCTT
TCCTTCTGGAAGGCAATAGAAAAGGAAGCAACATCCTGGATGGTAAAAGCTGAGACATTCCATT
TTGTTTTTGGTTCATTCAAGCTAGAACGTTCTGCACCAAAGCCCCGACTTGAACACCAGAAAAA
AGTTCGCAAGATGGAAGAAAATGGCAACATGCCTACAAAGTTGCAGAAGTTGGACCTGAGTAGT
TATCCAGAAGCGACAGAAAAAAACGTAGAAAGGATTTTGGGATTGTTGCAAACCTACTTTCGAA
AGTATCCTGATACTCCTGTGTCCTATTTTGAGTTTGTGATTGATCCAAACTCTTTTTCTCGTAC
TGTGGAGAATATATTTTATGTTTCTTTTATTGTAAGAGATGGTTTTGCAAGAATAAGGCTTGAT
GAAGACAGGCTGCCAATATTAGAGCCGATGAATGTTAACCAAATGGGTGAGGGAAATGATTCCA
GTTGCCATGGCAGGAAACAGGGAGTTATATCTTTGACTTTACAGGAGTGGAAAAACATTGTGGC
AGCTTTTGAAATTTCTGAGGCTATGATTACATACTCCTCATACTAAAGATTTCTTAGTATAGCA
TCCTTTTTGTGTTTTTTTTCTGAAGTTAGATGGAGAGTAAAATGTAAACTGAAGCACATATTGT
ATCTCTTGTAAAGTGAAAAAGTATTTTCAAGAACATCAGACATTGTTTTACTGTGCAGCATATT
TTTCTTAGTAATTTATAAGGTCATGATCTTCTGTTATTAAAACAAATTCACTGGCATATTTATG
GGAACGTTTTATTGAATGCCCTTTAAGACTATTAATAAAAACAAGTTTTGGATACCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008395	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH27612	(Get FASTA)	NCBI Sequence Viewer
	AEE60976	(Get FASTA)	NCBI Sequence Viewer
	BAC05385	(Get FASTA)	NCBI Sequence Viewer
	EAW97747	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000435619
	ENSP00000435619.1
GenBank Protein	Q8N140	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008395 ⟸ NM_001008394

- UniProtKB:

Q8N140 (UniProtKB/Swiss-Prot), A0A140VJI9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKMDVSVRAAGCSDDLSSGEADVDPKLLELTADEEKCRSIRRQYRQLMYCVRQNREDIVSSANN
SLTEALEEANVLFDGVSRTREAALDARFLVMASDLGKEKAKQLNSDMNFFNQLAFCDFLFLFVG
LNWMEGDPDKLSDCDDSIALSFWKAIEKEATSWMVKAETFHFVFGSFKLERSAPKPRLEHQKKV
RKMEENGNMPTKLQKLDLSSYPEATEKNVERILGLLQTYFRKYPDTPVSYFEFVIDPNSFSRTV
ENIFYVSFIVRDGFARIRLDEDRLPILEPMNVNQMGEGNDSSCHGRKQGVISLTLQEWKNIVAA
FEISEAMITYSSY

hide sequence

RefSeq Acc Id:

ENSP00000435619 ⟸ ENST00000527879

Protein Domains

Non-structural maintenance of chromosome element Nse4/EID protein Nse3/MAGE-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8N140-F1-model_v2	AlphaFold	Q8N140	1-333	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:32961	AgrOrtholog
COSMIC	EID3	COSMIC
Ensembl Genes	ENSG00000255150	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000527879	ENTREZGENE
	ENST00000527879.2	UniProtKB/Swiss-Prot
GTEx	ENSG00000255150	GTEx
HGNC ID	HGNC:32961	ENTREZGENE
Human Proteome Map	EID3	Human Proteome Map
InterPro	Nse4/EID	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nse4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nse4_Nse3-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:493861	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	493861	ENTREZGENE
OMIM	612986	OMIM
PANTHER	EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR16140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Nse4-Nse3_bdg	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nse4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA162384552	PharmGKB
UniProt	A0A140VJI9	ENTREZGENE, UniProtKB/TrEMBL
	EID3_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar