MIR329-2 (microRNA 329-2) - Rat Genome Database

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Pathways
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Gene: MIR329-2 (microRNA 329-2) Homo sapiens
Analyze
Symbol: MIR329-2
Name: microRNA 329-2
RGD ID: 1603790
HGNC Page HGNC:32051
Description: Enables mRNA base-pairing translational repressor activity. Involved in miRNA-mediated gene silencing by mRNA destabilization; negative regulation of vascular endothelial cell proliferation; and negative regulation of vascular endothelial growth factor signaling pathway. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-329-2; MIRN329-2
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,027,100 - 101,027,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,027,100 - 101,027,183 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,493,437 - 101,493,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,563,189 - 100,563,272 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,549,469 - 81,549,552 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,676,920 - 81,677,003 (+)NCBIHuRef
CHM1_114101,431,573 - 101,431,656 (+)NCBICHM1_1
T2T-CHM13v2.01495,262,544 - 95,262,627 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:15891114   PMID:15965474   PMID:16274478   PMID:16381832   PMID:17604727   PMID:21037258   PMID:23034410   PMID:23878390   PMID:25085941   PMID:25654811   PMID:26320179   PMID:26337669  
PMID:26456956   PMID:26885689   PMID:26909600   PMID:29130516   PMID:29653362   PMID:31219186   PMID:36093435  


Genomics

Comparative Map Data
MIR329-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,027,100 - 101,027,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,027,100 - 101,027,183 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,493,437 - 101,493,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,563,189 - 100,563,272 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,549,469 - 81,549,552 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,676,920 - 81,677,003 (+)NCBIHuRef
CHM1_114101,431,573 - 101,431,656 (+)NCBICHM1_1
T2T-CHM13v2.01495,262,544 - 95,262,627 (+)NCBIT2T-CHM13v2.0
Mir329
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,679,915 - 109,680,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,679,915 - 109,680,011 (+)EnsemblGRCm39 Ensembl
GRCm3812109,713,481 - 109,713,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,713,481 - 109,713,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,951,691 - 110,951,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,910,707 - 110,910,803 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-105987610)x3 copy number gain See cases [RCV000135410] Chr14:100309382..105987610 [GRCh38]
Chr14:100775719..106453697 [GRCh37]
Chr14:99845472..105524742 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97638520-106855263)x3 copy number gain See cases [RCV000135400] Chr14:97638520..106855263 [GRCh38]
Chr14:98104857..107263478 [GRCh37]
Chr14:97174610..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99448012-106850609)x3 copy number gain See cases [RCV000135875] Chr14:99448012..106850609 [GRCh38]
Chr14:99914349..107258824 [GRCh37]
Chr14:98984102..106329869 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:92540983-104863658)x3 copy number gain See cases [RCV000135896] Chr14:92540983..104863658 [GRCh38]
Chr14:93007328..105329995 [GRCh37]
Chr14:92077081..104401040 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:95524407-106879501)x1 copy number loss See cases [RCV000136032] Chr14:95524407..106879501 [GRCh38]
Chr14:95990744..107287708 [GRCh37]
Chr14:95060497..106358753 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.31(chr14:100262836-102500697)x1 copy number loss See cases [RCV000139723] Chr14:100262836..102500697 [GRCh38]
Chr14:100729173..102967034 [GRCh37]
Chr14:99798926..102036787 [NCBI36]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100582059-106877229)x1 copy number loss See cases [RCV000143662] Chr14:100582059..106877229 [GRCh38]
Chr14:101048396..107285437 [GRCh37]
Chr14:100118149..106356482 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
NC_000014.9:g.100806482_101281031del474550 deletion Paternal uniparental disomy of chromosome 14 [RCV000149429] Chr14:100806482..101281031 [GRCh38]
Chr14:101272819..101747368 [GRCh37]
Chr14:14q32.2-32.31		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33		 pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33		 pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33		 pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33		 pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:35292
Count of gene targets:11684
Count of transcripts:23109
Interacting mature miRNAs:hsa-miR-329, hsa-miR-329-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 2 1
Low 4 3 2 4 2 4 3 15 2 8 4 1 1
Below cutoff 3 1 3 2 5 6 11 1 3 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385029
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14101,027,100 - 101,027,183 (+)Ensembl
RefSeq Acc Id: NR_029968
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,027,100 - 101,027,183 (+)NCBI
GRCh3714101,493,437 - 101,493,520 (+)RGD
Celera1481,549,469 - 81,549,552 (+)RGD
HuRef1481,676,920 - 81,677,003 (+)ENTREZGENE
CHM1_114101,431,573 - 101,431,656 (+)NCBI
T2T-CHM13v2.01495,262,544 - 95,262,627 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32051 AgrOrtholog
COSMIC MIR329-2 COSMIC
Ensembl Genes ENSG00000207762 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385029 ENTREZGENE
GTEx ENSG00000207762 GTEx
HGNC ID HGNC:32051 ENTREZGENE
Human Proteome Map MIR329-2 Human Proteome Map
miRBase MI0001726 ENTREZGENE
NCBI Gene 574409 ENTREZGENE
PharmGKB PA164722662 PharmGKB
RNAcentral URS00004C46CF RNACentral
  URS000075BD0A RNACentral
  URS000075D4D9 RNACentral