CD177 (CD177 molecule) - Rat Genome Database

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Gene: CD177 (CD177 molecule) Homo sapiens
Analyze
Symbol: CD177
Name: CD177 molecule
RGD ID: 1603627
HGNC Page HGNC:30072
Description: Enables calcium-dependent protein binding activity; integrin binding activity; and protease binding activity. Involved in several processes, including neutrophil extravasation; positive regulation of superoxide anion generation; and regulation of vesicle-mediated transport. Located in plasma membrane raft and tertiary granule membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD177 antigen; cell surface receptor; HNA-2a; HNA2A; human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; polycythemia rubra vera 1; polycythemia rubra vera protein 1; PRV-1; PRV1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CD177P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,353,686 - 43,366,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,353,686 - 43,363,172 (+)EnsemblGRCh38hg38GRCh38
GRCh371943,857,838 - 43,867,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,549,665 - 48,559,320 (+)NCBINCBI36Build 36hg18NCBI36
Celera1940,658,322 - 40,667,941 (+)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,287,517 - 40,297,162 (+)NCBIHuRef
CHM1_11943,859,366 - 43,869,014 (+)NCBICHM1_1
T2T-CHM13v2.01946,174,138 - 46,186,504 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1382544   PMID:5552408   PMID:7974707   PMID:8125298   PMID:8301201   PMID:8488543   PMID:8614969   PMID:8889548   PMID:9675788   PMID:10753836   PMID:11465086   PMID:11846455  
PMID:12010833   PMID:12239154   PMID:12377969   PMID:12477932   PMID:12591276   PMID:12617169   PMID:12623849   PMID:12675722   PMID:12756017   PMID:12901344   PMID:12975309   PMID:14692971  
PMID:14701686   PMID:15043575   PMID:15340161   PMID:15489334   PMID:15572213   PMID:15749675   PMID:15862967   PMID:15951300   PMID:15985544   PMID:16189514   PMID:16344560   PMID:16398742  
PMID:16502591   PMID:16682284   PMID:16867862   PMID:17244676   PMID:17580308   PMID:17898576   PMID:17976520   PMID:17980909   PMID:18156711   PMID:18462208   PMID:18854317   PMID:19185066  
PMID:19695014   PMID:19999391   PMID:20194726   PMID:20491791   PMID:21193407   PMID:21873635   PMID:22266279   PMID:22300941   PMID:22690867   PMID:22776008   PMID:23118879   PMID:23202369  
PMID:23206890   PMID:23445729   PMID:23461681   PMID:23515576   PMID:23521917   PMID:23533145   PMID:23706337   PMID:23822853   PMID:23899160   PMID:23907354   PMID:24124144   PMID:24597828  
PMID:24926686   PMID:25416956   PMID:26024230   PMID:26829180   PMID:27227454   PMID:27568821   PMID:28240246   PMID:28559244   PMID:28807980   PMID:30097533   PMID:30201498   PMID:30377339  
PMID:30674924   PMID:30943984   PMID:31777111   PMID:32042113   PMID:32296183   PMID:32341565   PMID:32531826   PMID:33302660   PMID:33734454   PMID:34599187   PMID:34879110   PMID:35063507  
PMID:36352147   PMID:38474126  


Genomics

Comparative Map Data
CD177
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,353,686 - 43,366,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,353,686 - 43,363,172 (+)EnsemblGRCh38hg38GRCh38
GRCh371943,857,838 - 43,867,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,549,665 - 48,559,320 (+)NCBINCBI36Build 36hg18NCBI36
Celera1940,658,322 - 40,667,941 (+)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,287,517 - 40,297,162 (+)NCBIHuRef
CHM1_11943,859,366 - 43,869,014 (+)NCBICHM1_1
T2T-CHM13v2.01946,174,138 - 46,186,504 (+)NCBIT2T-CHM13v2.0
Cd177
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,443,408 - 24,459,759 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,443,408 - 24,459,736 (-)EnsemblGRCm39 Ensembl
GRCm38724,743,983 - 24,760,334 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,743,983 - 24,760,311 (-)EnsemblGRCm38mm10GRCm38
MGSCv37725,529,002 - 25,545,330 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,452,743 - 24,469,071 (-)NCBIMGSCv36mm8
Celera719,358,481 - 19,374,808 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map712.58NCBI
Cd177
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,467,926 - 89,488,490 (-)NCBIGRCr8
mRatBN7.2180,340,034 - 80,360,599 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,340,034 - 80,360,621 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,732,422 - 85,752,957 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,283,444 - 94,303,961 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,488,184 - 87,508,719 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,964,683 - 82,987,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,964,683 - 82,987,253 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,206,101 - 84,244,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,033,098 - 80,053,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera174,789,612 - 74,809,869 (-)NCBICelera
Cytogenetic Map1q21NCBI
Cd177
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555551,106,722 - 1,120,756 (+)NCBIChiLan1.0ChiLan1.0
CD177
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,504,794 - 49,515,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,304,519 - 51,382,077 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,287,083 - 40,295,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD177
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,693,234 - 111,698,879 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,693,005 - 111,698,742 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,172,751 - 111,178,674 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,303,259 - 112,309,197 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11111,891,326 - 111,897,264 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,525,114 - 111,531,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,409,530 - 112,415,468 (+)NCBIUU_Cfam_GSD_1.0
Cd177
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,282,723 - 16,290,450 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936706630,098 - 637,775 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD177
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,246,365 - 50,255,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,246,165 - 50,255,935 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,102,450 - 46,115,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD177
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,900,948 - 36,929,987 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,900,795 - 36,911,758 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607316,437,805 - 16,466,746 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd177
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624907943,027 - 964,077 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CD177
40 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.31(chr19:43303334-43576458)x3 copy number gain See cases [RCV000054150] Chr19:43303334..43576458 [GRCh38]
Chr19:43807486..44080610 [GRCh37]
Chr19:48499326..48772450 [NCBI36]
Chr19:19q13.31		 uncertain significance
GRCh38/hg38 19q13.31(chr19:43338231-43853163)x3 copy number gain See cases [RCV000054151] Chr19:43338231..43853163 [GRCh38]
Chr19:43842383..44357315 [GRCh37]
Chr19:48534223..49049155 [NCBI36]
Chr19:19q13.31		 uncertain significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q13.31(chr19:43338231-43570437)x3 copy number gain See cases [RCV000135231] Chr19:43338231..43570437 [GRCh38]
Chr19:43842383..44074589 [GRCh37]
Chr19:48534223..48766429 [NCBI36]
Chr19:19q13.31		 likely benign
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1 copy number loss See cases [RCV000240182] Chr19:43013365..47241534 [GRCh37]
Chr19:19q13.2-13.32		 pathogenic
GRCh37/hg19 19q13.2-13.31(chr19:42891150-43922624)x3 copy number gain See cases [RCV000446399] Chr19:42891150..43922624 [GRCh37]
Chr19:19q13.2-13.31		 uncertain significance
NM_020406.4(CD177):c.1006T>A (p.Ser336Thr) single nucleotide variant not specified [RCV004325116] Chr19:43361504 [GRCh38]
Chr19:43865656 [GRCh37]
Chr19:19q13.31		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_020406.4(CD177):c.253C>A (p.Arg85Ser) single nucleotide variant not specified [RCV004305128] Chr19:43354266 [GRCh38]
Chr19:43858418 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.713G>A (p.Cys238Tyr) single nucleotide variant not specified [RCV004319811] Chr19:43360358 [GRCh38]
Chr19:43864510 [GRCh37]
Chr19:19q13.31		 uncertain significance
GRCh37/hg19 19q13.31(chr19:43846269-44055858)x4 copy number gain not provided [RCV000684072] Chr19:43846269..44055858 [GRCh37]
Chr19:19q13.31		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
Single allele duplication Schizophrenia [RCV000754211] Chr19:41608672..44315856 [GRCh38]
Chr19:19q13.2-13.31		 likely pathogenic
GRCh37/hg19 19q13.31(chr19:43666697-43858317)x1 copy number loss not provided [RCV000740173] Chr19:43666697..43858317 [GRCh37]
Chr19:19q13.31		 benign
NM_020406.4(CD177):c.622T>G (p.Phe208Val) single nucleotide variant not provided [RCV000882522] Chr19:43360267 [GRCh38]
Chr19:43864419 [GRCh37]
Chr19:19q13.31		 benign
NM_020406.4(CD177):c.1097A>G (p.Lys366Arg) single nucleotide variant not provided [RCV000967889] Chr19:43362103 [GRCh38]
Chr19:43866255 [GRCh37]
Chr19:19q13.31		 benign
GRCh37/hg19 19q13.31(chr19:43818072-44100076)x3 copy number gain not provided [RCV000848508] Chr19:43818072..44100076 [GRCh37]
Chr19:19q13.31		 uncertain significance
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
GRCh37/hg19 19q13.31(chr19:43803157-44105375)x3 copy number gain not provided [RCV000845850] Chr19:43803157..44105375 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1090T>A (p.Ser364Thr) single nucleotide variant not provided [RCV000967888] Chr19:43362096 [GRCh38]
Chr19:43866248 [GRCh37]
Chr19:19q13.31		 benign
NM_020406.4(CD177):c.629C>T (p.Thr210Ile) single nucleotide variant not provided [RCV000957462] Chr19:43360274 [GRCh38]
Chr19:43864426 [GRCh37]
Chr19:19q13.31		 benign|likely benign
GRCh37/hg19 19q13.2-13.31(chr19:43084067-44096910)x3 copy number gain not provided [RCV002472871] Chr19:43084067..44096910 [GRCh37]
Chr19:19q13.2-13.31		 uncertain significance
NM_020406.4(CD177):c.1291G>A (p.Gly431Arg) single nucleotide variant not provided [RCV001654400] Chr19:43362297 [GRCh38]
Chr19:43866449 [GRCh37]
Chr19:19q13.31		 benign
GRCh37/hg19 19q13.31(chr19:43834305-44004721)x1 copy number loss not provided [RCV001259941] Chr19:43834305..44004721 [GRCh37]
Chr19:19q13.31		 uncertain significance
GRCh37/hg19 19q13.2-13.31(chr19:43082847-44100076) copy number gain not specified [RCV002052685] Chr19:43082847..44100076 [GRCh37]
Chr19:19q13.2-13.31		 uncertain significance
NM_020406.4(CD177):c.1116C>G (p.Cys372Trp) single nucleotide variant not specified [RCV004090231] Chr19:43362122 [GRCh38]
Chr19:43866274 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.35T>A (p.Phe12Tyr) single nucleotide variant not specified [RCV004149582] Chr19:43353749 [GRCh38]
Chr19:43857901 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1156C>A (p.Gln386Lys) single nucleotide variant not specified [RCV004147473] Chr19:43362162 [GRCh38]
Chr19:43866314 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.361G>A (p.Ala121Thr) single nucleotide variant not specified [RCV004227024] Chr19:43354374 [GRCh38]
Chr19:43858526 [GRCh37]
Chr19:19q13.31		 likely benign
NM_020406.4(CD177):c.415A>G (p.Met139Val) single nucleotide variant not specified [RCV004171736] Chr19:43355696 [GRCh38]
Chr19:43859848 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.798C>A (p.Ser266Arg) single nucleotide variant not specified [RCV004172092] Chr19:43361180 [GRCh38]
Chr19:43865332 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1178G>A (p.Arg393His) single nucleotide variant not specified [RCV004232021] Chr19:43362184 [GRCh38]
Chr19:43866336 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.638G>A (p.Arg213Gln) single nucleotide variant not specified [RCV004126307] Chr19:43360283 [GRCh38]
Chr19:43864435 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.727G>C (p.Val243Leu) single nucleotide variant not specified [RCV004077338] Chr19:43360372 [GRCh38]
Chr19:43864524 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1259T>G (p.Val420Gly) single nucleotide variant not specified [RCV004210206] Chr19:43362265 [GRCh38]
Chr19:43866417 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1111G>A (p.Gly371Ser) single nucleotide variant not specified [RCV004078973] Chr19:43362117 [GRCh38]
Chr19:43866269 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.168G>C (p.Gln56His) single nucleotide variant not specified [RCV004206239] Chr19:43353968 [GRCh38]
Chr19:43858120 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.728T>C (p.Val243Ala) single nucleotide variant not specified [RCV004137485] Chr19:43360373 [GRCh38]
Chr19:43864525 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.500G>A (p.Gly167Glu) single nucleotide variant not specified [RCV004197809] Chr19:43355781 [GRCh38]
Chr19:43859933 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.128C>T (p.Thr43Ile) single nucleotide variant not specified [RCV004095696] Chr19:43353928 [GRCh38]
Chr19:43858080 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1177C>T (p.Arg393Cys) single nucleotide variant not specified [RCV004252663] Chr19:43362183 [GRCh38]
Chr19:43866335 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1140G>T (p.Leu380Phe) single nucleotide variant not specified [RCV004274312] Chr19:43362146 [GRCh38]
Chr19:43866298 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1295T>C (p.Val432Ala) single nucleotide variant not specified [RCV004292195] Chr19:43362301 [GRCh38]
Chr19:43866453 [GRCh37]
Chr19:19q13.31		 likely benign
NM_020406.4(CD177):c.1181A>G (p.Glu394Gly) single nucleotide variant not specified [RCV004269676] Chr19:43362187 [GRCh38]
Chr19:43866339 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.16C>G (p.Leu6Val) single nucleotide variant not specified [RCV004319477] Chr19:43353730 [GRCh38]
Chr19:43857882 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.954T>C (p.Pro318=) single nucleotide variant not provided [RCV003425242] Chr19:43361452 [GRCh38]
Chr19:43865604 [GRCh37]
Chr19:19q13.31		 likely benign
NM_020406.4(CD177):c.385G>A (p.Gly129Arg) single nucleotide variant not specified [RCV004346086] Chr19:43355666 [GRCh38]
Chr19:43859818 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.983G>T (p.Cys328Phe) single nucleotide variant not specified [RCV004352019] Chr19:43361481 [GRCh38]
Chr19:43865633 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.380-1G>C single nucleotide variant not provided [RCV003425241] Chr19:43355660 [GRCh38]
Chr19:43859812 [GRCh37]
Chr19:19q13.31		 likely benign
NM_020406.4(CD177):c.699G>T (p.Ser233=) single nucleotide variant not provided [RCV003407022] Chr19:43360344 [GRCh38]
Chr19:43864496 [GRCh37]
Chr19:19q13.31		 likely benign
NM_020406.4(CD177):c.1001C>T (p.Thr334Ile) single nucleotide variant not specified [RCV004433227] Chr19:43361499 [GRCh38]
Chr19:43865651 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.688T>A (p.Trp230Arg) single nucleotide variant not specified [RCV004433238] Chr19:43360333 [GRCh38]
Chr19:43864485 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1034C>T (p.Pro345Leu) single nucleotide variant not specified [RCV004433230] Chr19:43361532 [GRCh38]
Chr19:43865684 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.184A>T (p.Ile62Phe) single nucleotide variant not specified [RCV004433236] Chr19:43353984 [GRCh38]
Chr19:43858136 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1030T>G (p.Cys344Gly) single nucleotide variant not specified [RCV004433229] Chr19:43361528 [GRCh38]
Chr19:43865680 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1261G>A (p.Gly421Arg) single nucleotide variant not specified [RCV004433235] Chr19:43362267 [GRCh38]
Chr19:43866419 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1162G>A (p.Gly388Arg) single nucleotide variant not specified [RCV004433231] Chr19:43362168 [GRCh38]
Chr19:43866320 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1190A>T (p.Asp397Val) single nucleotide variant not specified [RCV004433233] Chr19:43362196 [GRCh38]
Chr19:43866348 [GRCh37]
Chr19:19q13.31		 uncertain significance
NM_020406.4(CD177):c.1238T>A (p.Leu413Gln) single nucleotide variant not specified [RCV004433234] Chr19:43362244 [GRCh38]
Chr19:43866396 [GRCh37]
Chr19:19q13.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2144
Count of miRNA genes:803
Interacting mature miRNAs:919
Transcripts:ENST00000378009, ENST00000378012, ENST00000457794, ENST00000607517, ENST00000607855
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 173 173
Medium 280 595 44 14 772 10 357 14 340 6 209 321 5 102 307
Low 961 943 675 230 167 138 1737 715 1219 166 565 760 106 1 795 919 2
Below cutoff 1122 1141 867 283 226 226 2109 1353 2052 198 623 412 59 304 1454

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017027022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB237911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ290452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ305326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ310433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM884905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AMYH02036160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU688145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD514938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA728784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB323632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG021197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000378012   ⟹   ENSP00000367251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1943,353,715 - 43,362,372 (+)Ensembl
RefSeq Acc Id: ENST00000607855   ⟹   ENSP00000483817
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1943,353,691 - 43,354,525 (+)Ensembl
RefSeq Acc Id: ENST00000618265   ⟹   ENSP00000479536
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1943,353,686 - 43,363,172 (+)Ensembl
RefSeq Acc Id: NM_020406   ⟹   NP_065139
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381943,353,686 - 43,363,172 (+)NCBI
GRCh371943,857,825 - 43,867,480 (+)ENTREZGENE
Build 361948,549,665 - 48,559,320 (+)NCBI Archive
HuRef1940,287,517 - 40,297,162 (+)ENTREZGENE
CHM1_11943,859,352 - 43,868,858 (+)NCBI
T2T-CHM13v2.01946,174,138 - 46,183,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027021   ⟹   XP_016882510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381943,353,686 - 43,366,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017027022   ⟹   XP_016882511
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381943,353,686 - 43,363,808 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054321510   ⟹   XP_054177485
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01946,174,138 - 46,186,504 (+)NCBI
RefSeq Acc Id: XM_054321511   ⟹   XP_054177486
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01946,174,138 - 46,184,244 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_065139   ⟸   NM_020406
- Peptide Label: precursor
- UniProtKB: Q9HDA5 (UniProtKB/Swiss-Prot),   Q96QH1 (UniProtKB/Swiss-Prot),   Q8NCV9 (UniProtKB/Swiss-Prot),   Q711Q2 (UniProtKB/Swiss-Prot),   Q8N6Q3 (UniProtKB/Swiss-Prot),   A0A087WVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016882510   ⟸   XM_017027021
- Peptide Label: isoform X1
- UniProtKB: Q1T7A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016882511   ⟸   XM_017027022
- Peptide Label: isoform X2
- UniProtKB: Q1T7A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000367251   ⟸   ENST00000378012
RefSeq Acc Id: ENSP00000479536   ⟸   ENST00000618265
RefSeq Acc Id: ENSP00000483817   ⟸   ENST00000607855
RefSeq Acc Id: XP_054177485   ⟸   XM_054321510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054177486   ⟸   XM_054321511
- Peptide Label: isoform X2
Protein Domains
UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8N6Q3-F1-model_v2 AlphaFold Q8N6Q3 1-437 view protein structure

Promoters
RGD ID:7240221
Promoter ID:EPDNEW_H25856
Type:single initiation site
Name:CD177_1
Description:CD177 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25853  EPDNEW_H25855  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381943,353,686 - 43,353,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30072 AgrOrtholog
COSMIC CD177 COSMIC
Ensembl Genes ENSG00000204936 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000378012.3 UniProtKB/Swiss-Prot
  ENST00000607855.5 UniProtKB/TrEMBL
  ENST00000618265 ENTREZGENE
  ENST00000618265.5 UniProtKB/TrEMBL
GTEx ENSG00000204936 GTEx
HGNC ID HGNC:30072 ENTREZGENE
Human Proteome Map CD177 Human Proteome Map
InterPro LY6_UPA_recep-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 57126 ENTREZGENE
OMIM 162860 OMIM
PANTHER CD177 ANTIGEN UniProtKB/Swiss-Prot
  CD177 ANTIGEN UniProtKB/Swiss-Prot
  CD177 ANTIGEN UniProtKB/TrEMBL
  CD177 ANTIGEN UniProtKB/TrEMBL
Pfam UPAR_LY6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA142672147 PharmGKB
Superfamily-SCOP SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WVM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A087X113_HUMAN UniProtKB/TrEMBL
  CD177_HUMAN UniProtKB/Swiss-Prot
  D2N288_HUMAN UniProtKB/TrEMBL
  Q1T7A3 ENTREZGENE, UniProtKB/TrEMBL
  Q711Q2 ENTREZGENE
  Q8N6Q3 ENTREZGENE
  Q8NCV9 ENTREZGENE
  Q96QH1 ENTREZGENE
  Q9HDA5 ENTREZGENE
UniProt Secondary Q711Q2 UniProtKB/Swiss-Prot
  Q8NCV9 UniProtKB/Swiss-Prot
  Q96QH1 UniProtKB/Swiss-Prot
  Q9HDA5 UniProtKB/Swiss-Prot