LDLRAD1 (low density lipoprotein receptor class A domain containing 1) - Rat Genome Database

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Gene: LDLRAD1 (low density lipoprotein receptor class A domain containing 1) Homo sapiens
Analyze
Symbol: LDLRAD1
Name: low density lipoprotein receptor class A domain containing 1
RGD ID: 1603477
HGNC Page HGNC:32069
Description: Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: low density lipoprotein receptor A domain containing 1; low-density lipoprotein receptor class A domain-containing protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,007,298 - 54,018,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,007,298 - 54,018,186 (-)EnsemblGRCh38hg38GRCh38
GRCh37154,472,971 - 54,483,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36154,247,094 - 54,256,391 (-)NCBINCBI36Build 36hg18NCBI36
Celera152,762,183 - 52,771,480 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef152,588,682 - 52,599,569 (-)NCBIHuRef
CHM1_1154,589,314 - 54,600,202 (-)NCBICHM1_1
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:24722188   PMID:25416956   PMID:29892012   PMID:31515488   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
LDLRAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,007,298 - 54,018,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,007,298 - 54,018,186 (-)EnsemblGRCh38hg38GRCh38
GRCh37154,472,971 - 54,483,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36154,247,094 - 54,256,391 (-)NCBINCBI36Build 36hg18NCBI36
Celera152,762,183 - 52,771,480 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef152,588,682 - 52,599,569 (-)NCBIHuRef
CHM1_1154,589,314 - 54,600,202 (-)NCBICHM1_1
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBIT2T-CHM13v2.0
Ldlrad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394107,066,264 - 107,081,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,066,377 - 107,075,257 (+)EnsemblGRCm39 Ensembl
GRCm384107,209,078 - 107,221,092 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4107,209,180 - 107,218,060 (+)EnsemblGRCm38mm10GRCm38
MGSCv374106,881,785 - 106,890,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364106,707,112 - 106,715,846 (+)NCBIMGSCv36mm8
Celera4105,571,146 - 105,579,973 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.16NCBI
Ldlrad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85127,212,581 - 127,229,753 (+)NCBIGRCr8
mRatBN7.25121,984,245 - 122,000,941 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,991,690 - 122,000,944 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.05126,812,168 - 126,821,437 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,812,187 - 126,821,407 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05130,656,707 - 130,670,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45128,298,413 - 128,307,513 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5120,737,404 - 120,746,763 (+)NCBICelera
Cytogenetic Map5q34NCBI
Ldlrad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554645,233,216 - 5,240,522 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554645,233,134 - 5,243,730 (+)NCBIChiLan1.0ChiLan1.0
LDLRAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21172,818,318 - 172,831,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,959,113 - 171,972,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0153,281,097 - 53,292,010 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1154,875,019 - 54,885,898 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl154,875,019 - 54,885,898 (-)Ensemblpanpan1.1panPan2
LDLRAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,995,125 - 55,004,578 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,000,029 - 55,003,903 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha555,063,468 - 55,071,248 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0555,184,685 - 55,192,457 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1555,179,144 - 55,186,880 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,068,720 - 55,076,494 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0555,458,409 - 55,466,182 (+)NCBIUU_Cfam_GSD_1.0
Ldlrad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505868,264,262 - 68,275,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365227,141,029 - 7,149,097 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365227,140,568 - 7,149,135 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLRAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6158,292,616 - 158,303,012 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16158,292,303 - 158,304,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,892,589 - 145,902,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LDLRAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12078,917,202 - 78,926,800 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603338,355,845 - 38,365,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldlrad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624934493,380 - 501,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624934492,954 - 502,554 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LDLRAD1
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1		 pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:53738212-61439648)x1 copy number loss See cases [RCV000053839] Chr1:53738212..61439648 [GRCh38]
Chr1:54203885..61905320 [GRCh37]
Chr1:53976473..61677908 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
NM_001010978.3(LDLRAD1):c.200C>T (p.Pro67Leu) single nucleotide variant Malignant melanoma [RCV000060216] Chr1:54014238 [GRCh38]
Chr1:54479911 [GRCh37]
Chr1:54252499 [NCBI36]
Chr1:1p32.3		 not provided
NM_001010978.3(LDLRAD1):c.181G>A (p.Gly61Arg) single nucleotide variant Malignant melanoma [RCV000060217] Chr1:54014257 [GRCh38]
Chr1:54479930 [GRCh37]
Chr1:54252518 [NCBI36]
Chr1:1p32.3		 not provided
GRCh38/hg38 1p32.3-31.3(chr1:53627272-64248854)x1 copy number loss See cases [RCV000139470] Chr1:53627272..64248854 [GRCh38]
Chr1:54092945..64714537 [GRCh37]
Chr1:53865533..64487125 [NCBI36]
Chr1:1p32.3-31.3		 pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:52787503-67339873)x3 copy number gain See cases [RCV000141758] Chr1:52787503..67339873 [GRCh38]
Chr1:53253175..67805556 [GRCh37]
Chr1:53025763..67578144 [NCBI36]
Chr1:1p32.3-31.3		 likely pathogenic
GRCh38/hg38 1p32.3(chr1:53823735-54328113)x3 copy number gain See cases [RCV000142034] Chr1:53823735..54328113 [GRCh38]
Chr1:54289408..54793786 [GRCh37]
Chr1:54061996..54566374 [NCBI36]
Chr1:1p32.3		 uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p32.3(chr1:51729573-55164001)x1 copy number loss See cases [RCV000447334] Chr1:51729573..55164001 [GRCh37]
Chr1:1p32.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NM_001010978.4(LDLRAD1):c.16C>T (p.Pro6Ser) single nucleotide variant not specified [RCV004302230] Chr1:54018097 [GRCh38]
Chr1:54483770 [GRCh37]
Chr1:1p32.3		 uncertain significance
GRCh37/hg19 1p32.3(chr1:54002963-54575440)x3 copy number gain not provided [RCV000846106] Chr1:54002963..54575440 [GRCh37]
Chr1:1p32.3		 uncertain significance
GRCh37/hg19 1p32.3-31.3(chr1:53675707-66644963)x1 copy number loss Chromosome 1p32-p31 deletion syndrome [RCV001263218] Chr1:53675707..66644963 [GRCh37]
Chr1:1p32.3-31.3		 pathogenic
GRCh37/hg19 1p32.3-32.2(chr1:51941877-56688514) copy number loss Abnormality of the kidney [RCV001352641] Chr1:51941877..56688514 [GRCh37]
Chr1:1p32.3-32.2		 pathogenic
NM_001010978.4(LDLRAD1):c.467C>T (p.Pro156Leu) single nucleotide variant not specified [RCV004134182] Chr1:54010284 [GRCh38]
Chr1:54475957 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.514T>C (p.Ser172Pro) single nucleotide variant not specified [RCV004140443] Chr1:54009086 [GRCh38]
Chr1:54474759 [GRCh37]
Chr1:1p32.3		 likely benign
NM_001010978.4(LDLRAD1):c.134T>G (p.Leu45Arg) single nucleotide variant not specified [RCV004208182] Chr1:54014304 [GRCh38]
Chr1:54479977 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.560G>A (p.Arg187His) single nucleotide variant not specified [RCV004075120] Chr1:54009040 [GRCh38]
Chr1:54474713 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.506G>A (p.Arg169His) single nucleotide variant not specified [RCV004184405] Chr1:54009094 [GRCh38]
Chr1:54474767 [GRCh37]
Chr1:1p32.3		 likely benign
NM_001010978.4(LDLRAD1):c.16C>G (p.Pro6Ala) single nucleotide variant not specified [RCV004259977] Chr1:54018097 [GRCh38]
Chr1:54483770 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.442G>A (p.Gly148Arg) single nucleotide variant not specified [RCV004337592] Chr1:54010309 [GRCh38]
Chr1:54475982 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.554T>C (p.Leu185Pro) single nucleotide variant not specified [RCV004343788] Chr1:54009046 [GRCh38]
Chr1:54474719 [GRCh37]
Chr1:1p32.3		 uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
GRCh37/hg19 1p33-32.2(chr1:47493178-57042671)x3 copy number gain not specified [RCV003986484] Chr1:47493178..57042671 [GRCh37]
Chr1:1p33-32.2		 likely pathogenic
NM_001010978.4(LDLRAD1):c.32G>T (p.Gly11Val) single nucleotide variant not specified [RCV004412647] Chr1:54017417 [GRCh38]
Chr1:54483090 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.431C>T (p.Thr144Ile) single nucleotide variant not specified [RCV004412648] Chr1:54010320 [GRCh38]
Chr1:54475993 [GRCh37]
Chr1:1p32.3		 likely benign
NM_001010978.4(LDLRAD1):c.440G>A (p.Cys147Tyr) single nucleotide variant not specified [RCV004412649] Chr1:54010311 [GRCh38]
Chr1:54475984 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.597G>C (p.Glu199Asp) single nucleotide variant not specified [RCV004412651] Chr1:54009003 [GRCh38]
Chr1:54474676 [GRCh37]
Chr1:1p32.3		 uncertain significance
NM_001010978.4(LDLRAD1):c.82G>A (p.Gly28Ser) single nucleotide variant not specified [RCV004412652] Chr1:54014356 [GRCh38]
Chr1:54480029 [GRCh37]
Chr1:1p32.3		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:728
Count of miRNA genes:290
Interacting mature miRNAs:307
Transcripts:ENST00000371360, ENST00000371362, ENST00000420619, ENST00000545928
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage pharyngeal arch
High
Medium 2 1 16 24 1 17 71 183 8
Low 75 2 310 211 3 72 4 5 1 19 524 452 142 1 1 1
Below cutoff 975 594 788 197 306 185 1539 449 865 89 520 529 18 247 959

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001010978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054336521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL353898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC140760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC171743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM977091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF887342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000371360   ⟹   ENSP00000360411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl154,007,298 - 54,018,186 (-)Ensembl
RefSeq Acc Id: ENST00000371362   ⟹   ENSP00000360413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl154,008,739 - 54,018,172 (-)Ensembl
RefSeq Acc Id: ENST00000420619   ⟹   ENSP00000411017
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl154,007,299 - 54,018,186 (-)Ensembl
RefSeq Acc Id: ENST00000545928   ⟹   ENSP00000445871
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl154,007,299 - 54,018,186 (-)Ensembl
RefSeq Acc Id: NM_001010978   ⟹   NP_001010978
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
GRCh37154,472,971 - 54,483,859 (-)NCBI
Build 36154,247,094 - 54,256,391 (-)NCBI Archive
Celera152,762,183 - 52,771,480 (-)RGD
HuRef152,588,682 - 52,599,569 (-)NCBI
CHM1_1154,589,314 - 54,600,202 (-)NCBI
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276392   ⟹   NP_001263321
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
HuRef152,588,682 - 52,599,569 (-)NCBI
CHM1_1154,589,314 - 54,600,202 (-)NCBI
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276393   ⟹   NP_001263322
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
GRCh37154,472,971 - 54,483,859 (-)NCBI
HuRef152,588,682 - 52,599,569 (-)NCBI
CHM1_1154,589,314 - 54,600,202 (-)NCBI
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276394   ⟹   NP_001263323
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
HuRef152,588,682 - 52,599,569 (-)NCBI
CHM1_1154,589,314 - 54,600,202 (-)NCBI
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276395   ⟹   NP_001263324
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
GRCh37154,472,971 - 54,483,859 (-)NCBI
HuRef152,588,682 - 52,599,569 (-)NCBI
CHM1_1154,589,314 - 54,600,202 (-)NCBI
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541446   ⟹   XP_011539748
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017001264   ⟹   XP_016856753
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,007,298 - 54,018,186 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054336520   ⟹   XP_054192495
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
RefSeq Acc Id: XM_054336521   ⟹   XP_054192496
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0153,890,196 - 53,901,083 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001010978   ⟸   NM_001010978
- Peptide Label: isoform 1
- UniProtKB: B7ZME3 (UniProtKB/Swiss-Prot),   A0PJY0 (UniProtKB/Swiss-Prot),   Q5T6Z9 (UniProtKB/Swiss-Prot),   Q5T700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001263321   ⟸   NM_001276392
- Peptide Label: isoform 2
- UniProtKB: Q5T700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001263323   ⟸   NM_001276394
- Peptide Label: isoform 4
- UniProtKB: Q5T700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001263324   ⟸   NM_001276395
- Peptide Label: isoform 5
- Sequence:
RefSeq Acc Id: NP_001263322   ⟸   NM_001276393
- Peptide Label: isoform 3
- UniProtKB: Q5T700 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011539748   ⟸   XM_011541446
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016856753   ⟸   XM_017001264
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000360411   ⟸   ENST00000371360
RefSeq Acc Id: ENSP00000360413   ⟸   ENST00000371362
RefSeq Acc Id: ENSP00000445871   ⟸   ENST00000545928
RefSeq Acc Id: ENSP00000411017   ⟸   ENST00000420619
RefSeq Acc Id: XP_054192496   ⟸   XM_054336521
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054192495   ⟸   XM_054336520
- Peptide Label: isoform X1
Protein Domains
LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5T700-F1-model_v2 AlphaFold Q5T700 1-205 view protein structure

Promoters
RGD ID:6855618
Promoter ID:EPDNEW_H974
Type:initiation region
Name:LDLRAD1_1
Description:low density lipoprotein receptor class A domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38154,018,186 - 54,018,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32069 AgrOrtholog
COSMIC LDLRAD1 COSMIC
Ensembl Genes ENSG00000203985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000371360 ENTREZGENE
  ENST00000371360.2 UniProtKB/Swiss-Prot
  ENST00000371362 ENTREZGENE
  ENST00000371362.7 UniProtKB/Swiss-Prot
  ENST00000420619 ENTREZGENE
  ENST00000420619.5 UniProtKB/Swiss-Prot
  ENST00000545928 ENTREZGENE
  ENST00000545928.5 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.400.10 UniProtKB/Swiss-Prot
GTEx ENSG00000203985 GTEx
HGNC ID HGNC:32069 ENTREZGENE
Human Proteome Map LDLRAD1 Human Proteome Map
InterPro LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
KEGG Report hsa:388633 UniProtKB/Swiss-Prot
NCBI Gene 388633 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/Swiss-Prot
  PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam Ldl_recept_a UniProtKB/Swiss-Prot
PharmGKB PA142671554 PharmGKB
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
SMART LDLa UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57424 UniProtKB/Swiss-Prot
UniProt A0PJY0 ENTREZGENE
  B7ZME3 ENTREZGENE
  LRAD1_HUMAN UniProtKB/Swiss-Prot
  Q5T6Z9 ENTREZGENE
  Q5T700 ENTREZGENE
UniProt Secondary A0PJY0 UniProtKB/Swiss-Prot
  B7ZME3 UniProtKB/Swiss-Prot
  Q5T6Z9 UniProtKB/Swiss-Prot