MIR635 (microRNA 635) - Rat Genome Database

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Gene: MIR635 (microRNA 635) Homo sapiens
Analyze
Symbol: MIR635
Name: microRNA 635
RGD ID: 1602918
HGNC Page HGNC:32891
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-635; MIRN635
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381768,424,451 - 68,424,548 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1768,424,451 - 68,424,548 (-)EnsemblGRCh38hg38GRCh38
GRCh371766,420,592 - 66,420,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361763,932,186 - 63,932,283 (-)NCBINCBI36Build 36hg18NCBI36
Celera1762,992,158 - 62,992,255 (-)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,806,428 - 61,806,525 (-)NCBIHuRef
CHM1_11766,485,231 - 66,485,328 (-)NCBICHM1_1
T2T-CHM13v2.01769,300,967 - 69,301,064 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:27810784   PMID:32753405   PMID:33560141   PMID:33982765   PMID:37864285  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q24.2(chr17:67584224-68639875)x1 copy number loss See cases [RCV000138379] Chr17:67584224..68639875 [GRCh38]
Chr17:65580340..66636016 [GRCh37]
Chr17:63010802..64147611 [NCBI36]
Chr17:17q24.2		 pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:68420514-71351235)x1 copy number loss See cases [RCV000143113] Chr17:68420514..71351235 [GRCh38]
Chr17:66416655..69347376 [GRCh37]
Chr17:63928250..66858971 [NCBI36]
Chr17:17q24.2-24.3		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q24.2-24.3(chr17:67833866-70085854)x1 copy number loss See cases [RCV000053452] Chr17:67833866..70085854 [GRCh38]
Chr17:65829982..68081995 [GRCh37]
Chr17:63260444..65593590 [NCBI36]
Chr17:17q24.2-24.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:34549
Count of gene targets:15175
Count of transcripts:30915
Interacting mature miRNAs:hsa-miR-635
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH16580  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371766,421,717 - 66,421,836UniSTSGRCh37
Build 361763,933,312 - 63,933,431RGDNCBI36
Celera1762,993,280 - 62,993,399RGD
Cytogenetic Map17q24.2UniSTS
HuRef1761,807,550 - 61,807,669UniSTS
GeneMap99-GB4 RH Map17432.57UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 91 24 111 70 499 72 128 31 112 184 187 221 3 1 5 2
Low 1879 2169 1428 435 1203 281 3155 1486 2313 204 992 1305 160 1008 1941 2
Below cutoff 261 345 108 74 125 71 524 401 779 22 120 36 3 105 408

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384830
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1768,424,451 - 68,424,548 (-)Ensembl
RefSeq Acc Id: NR_030365
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381768,424,451 - 68,424,548 (-)NCBI
GRCh371766,420,592 - 66,420,689 (-)RGD
Celera1762,992,158 - 62,992,255 (-)RGD
HuRef1761,806,428 - 61,806,525 (-)ENTREZGENE
CHM1_11766,485,231 - 66,485,328 (-)NCBI
T2T-CHM13v2.01769,300,967 - 69,301,064 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR635 COSMIC
Ensembl Genes ENSG00000207561 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384830 ENTREZGENE
GTEx ENSG00000207561 GTEx
HGNC ID HGNC:32891 ENTREZGENE
Human Proteome Map MIR635 Human Proteome Map
miRBase MI0003650 ENTREZGENE
NCBI Gene 693220 ENTREZGENE
PharmGKB PA164722931 PharmGKB
RNAcentral URS000075CD0C RNACentral
  URS000075DC55 RNACentral