CELA2A (chymotrypsin like elastase 2A) - Rat Genome Database

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Gene: CELA2A (chymotrypsin like elastase 2A) Homo sapiens
Analyze
Symbol: CELA2A
Name: chymotrypsin like elastase 2A
RGD ID: 1602468
HGNC Page HGNC:24609
Description: Enables endopeptidase activity and serine hydrolase activity. Involved in several processes, including insulin catabolic process; regulation of insulin secretion; and response to insulin. Located in extracellular region and keratohyalin granule. Implicated in abdominal obesity-metabolic syndrome 4.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AOMS4; chymotrypsin like elastase family member 2A; chymotrypsin-like elastase family member 2A; chymotrypsin-like elastase family, member 2A; ELA2A; elastase 2A; elastase-2A; pancreatic elastase 2; pancreatic elastase IIA; PE-1
RGD Orthologs
Mouse
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,456,732 - 15,472,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,456,728 - 15,472,091 (+)EnsemblGRCh38hg38GRCh38
GRCh37115,783,227 - 15,798,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,655,811 - 15,671,170 (+)NCBINCBI36Build 36hg18NCBI36
Celera114,266,097 - 14,281,458 (+)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,303,023 - 14,318,355 (+)NCBIHuRef
CHM1_1115,581,888 - 15,597,250 (+)NCBICHM1_1
T2T-CHM13v2.0114,901,450 - 14,916,792 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2307232   PMID:2834346   PMID:3427074   PMID:3646943   PMID:11729383   PMID:12477932   PMID:14702039   PMID:15342556   PMID:15489334   PMID:16247445   PMID:16327289   PMID:16710414  
PMID:17207965   PMID:19913121   PMID:20179351   PMID:20628086   PMID:20932654   PMID:21873635   PMID:27358403   PMID:31358993   PMID:33674762   PMID:33961781  


Genomics

Comparative Map Data
CELA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,456,732 - 15,472,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,456,728 - 15,472,091 (+)EnsemblGRCh38hg38GRCh38
GRCh37115,783,227 - 15,798,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,655,811 - 15,671,170 (+)NCBINCBI36Build 36hg18NCBI36
Celera114,266,097 - 14,281,458 (+)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,303,023 - 14,318,355 (+)NCBIHuRef
CHM1_1115,581,888 - 15,597,250 (+)NCBICHM1_1
T2T-CHM13v2.0114,901,450 - 14,916,792 (+)NCBIT2T-CHM13v2.0
Cela2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,542,265 - 141,553,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,542,273 - 141,553,471 (-)EnsemblGRCm39 Ensembl
GRCm384141,814,954 - 141,826,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,814,962 - 141,826,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,370,878 - 141,381,918 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364141,087,039 - 141,098,079 (-)NCBIMGSCv36mm8
Celera4143,639,909 - 143,650,953 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.75NCBI
Cela2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85159,409,900 - 159,420,282 (-)NCBIGRCr8
mRatBN7.25154,126,879 - 154,136,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5154,126,878 - 154,136,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,811,783 - 156,821,667 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,585,079 - 158,594,963 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,574,229 - 158,584,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,374,031 - 160,383,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,374,031 - 160,383,782 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05164,085,554 - 164,106,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,722,053 - 160,731,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,732,240 - 160,741,992 (-)NCBI
Celera5152,478,974 - 152,488,731 (-)NCBICelera
Cytogenetic Map5q36NCBI
LOC100992916
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21211,451,372 - 211,473,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,699,826 - 210,721,553 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,595,218 - 14,606,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1115,589,914 - 15,604,924 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,589,878 - 15,604,926 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in CELA2A
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.21-36.12(chr1:15385267-20980349)x1 copy number loss See cases [RCV000051146] Chr1:15385267..20980349 [GRCh38]
Chr1:15711763..21306842 [GRCh37]
Chr1:15584350..21179429 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6853513-17326813)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]|See cases [RCV000051795] Chr1:6853513..17326813 [GRCh38]
Chr1:6913573..17685411 [GRCh37]
Chr1:6836160..17557998 [NCBI36]
Chr1:1p36.31-36.13		 pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3 copy number gain See cases [RCV000051797] Chr1:13110797..20670207 [GRCh38]
Chr1:13178269..20996700 [GRCh37]
Chr1:13100856..20869287 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:13619979-18466172)x3 copy number gain See cases [RCV000051799] Chr1:13619979..18466172 [GRCh38]
Chr1:13946474..18792666 [GRCh37]
Chr1:13819061..18665253 [NCBI36]
Chr1:1p36.21-36.13		 pathogenic
GRCh38/hg38 1p36.32-36.13(chr1:3006193-17688934)x1 copy number loss See cases [RCV000053714] Chr1:3006193..17688934 [GRCh38]
Chr1:2922757..18015429 [GRCh37]
Chr1:2912617..17888016 [NCBI36]
Chr1:1p36.32-36.13		 pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1 copy number loss See cases [RCV000053760] Chr1:10556797..22557907 [GRCh38]
Chr1:10616854..22884400 [GRCh37]
Chr1:10539441..22756987 [NCBI36]
Chr1:1p36.22-36.12		 pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10621776-16520709)x1 copy number loss See cases [RCV000053763] Chr1:10621776..16520709 [GRCh38]
Chr1:10681833..16847204 [GRCh37]
Chr1:10604420..16719791 [NCBI36]
Chr1:1p36.22-36.13		 pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10809039-16422500)x1 copy number loss See cases [RCV000053765] Chr1:10809039..16422500 [GRCh38]
Chr1:10869096..16748995 [GRCh37]
Chr1:10791683..16621582 [NCBI36]
Chr1:1p36.22-36.13		 pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:11121625-16324498)x1 copy number loss See cases [RCV000053766] Chr1:11121625..16324498 [GRCh38]
Chr1:11181682..16650993 [GRCh37]
Chr1:11104269..16523580 [NCBI36]
Chr1:1p36.22-36.13		 pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:15173497-18242678)x1 copy number loss See cases [RCV000053769] Chr1:15173497..18242678 [GRCh38]
Chr1:15499993..18569172 [GRCh37]
Chr1:15372580..18441759 [NCBI36]
Chr1:1p36.21-36.13		 pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:15173497-17019576)x1 copy number loss See cases [RCV000053771] Chr1:15173497..17019576 [GRCh38]
Chr1:15499993..17346071 [GRCh37]
Chr1:15372580..17218658 [NCBI36]
Chr1:1p36.21-36.13		 pathogenic
GRCh38/hg38 1p36.23-36.13(chr1:9034671-16441465)x1 copy number loss See cases [RCV000053756] Chr1:9034671..16441465 [GRCh38]
Chr1:9094730..16767960 [GRCh37]
Chr1:9017317..16640547 [NCBI36]
Chr1:1p36.23-36.13		 pathogenic
NM_033440.2(CELA2A):c.792+1296C>T single nucleotide variant Lung cancer [RCV000089799] Chr1:15468834 [GRCh38]
Chr1:15795329 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.568G>A (p.Ala190Thr) single nucleotide variant not specified [RCV004254285] Chr1:15466073 [GRCh38]
Chr1:15792568 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.791C>T (p.Ser264Leu) single nucleotide variant not specified [RCV004257974] Chr1:15467537 [GRCh38]
Chr1:15794032 [GRCh37]
Chr1:1p36.21		 uncertain significance
GRCh38/hg38 1p36.21-36.13(chr1:15052047-16499873)x1 copy number loss See cases [RCV000135597] Chr1:15052047..16499873 [GRCh38]
Chr1:15378543..16826368 [GRCh37]
Chr1:15251130..16698955 [NCBI36]
Chr1:1p36.21-36.13		 likely pathogenic|uncertain significance
GRCh38/hg38 1p36.21-36.13(chr1:12724785-16034788)x1 copy number loss See cases [RCV000137720] Chr1:12724785..16034788 [GRCh38]
Chr1:12784752..16361283 [GRCh37]
Chr1:12707339..16233870 [NCBI36]
Chr1:1p36.21-36.13		 pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1 copy number loss See cases [RCV000137948] Chr1:6303641..15799093 [GRCh38]
Chr1:6363701..16125588 [GRCh37]
Chr1:6286288..15998175 [NCBI36]
Chr1:1p36.31-36.21		 pathogenic|likely benign
GRCh38/hg38 1p36.22-36.21(chr1:9428538-15815791)x1 copy number loss See cases [RCV000140873] Chr1:9428538..15815791 [GRCh38]
Chr1:9488597..16142286 [GRCh37]
Chr1:9411184..16014873 [NCBI36]
Chr1:1p36.22-36.21		 pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:10264397-15780840)x1 copy number loss See cases [RCV000141438] Chr1:10264397..15780840 [GRCh38]
Chr1:10324455..16107335 [GRCh37]
Chr1:10247042..15979922 [NCBI36]
Chr1:1p36.22-36.21		 pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3 copy number gain See cases [RCV000142906] Chr1:6554885..16056011 [GRCh38]
Chr1:6614945..16382506 [GRCh37]
Chr1:6537532..16255093 [NCBI36]
Chr1:1p36.31-36.13		 pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:5363826-18360302)x1 copy number loss See cases [RCV000142771] Chr1:5363826..18360302 [GRCh38]
Chr1:5423886..18686796 [GRCh37]
Chr1:5323746..18559383 [NCBI36]
Chr1:1p36.31-36.13		 pathogenic
Single allele deletion Normal pregnancy [RCV000161155] Chr1:15457276..15470313 [GRCh38]
Chr1:15783771..15796808 [GRCh37]
Chr1:1p36.21		 not provided
Single allele deletion Normal pregnancy [RCV000161156] Chr1:15467516..15487691 [GRCh38]
Chr1:15794011..15814186 [GRCh37]
Chr1:1p36.21		 not provided
Single allele complex Breast ductal adenocarcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11		 uncertain significance
chr1:909238-16736132 complex variant complex Breast ductal adenocarcinoma [RCV000207094] Chr1:909238..16736132 [GRCh37]
Chr1:1p36.33-36.13		 uncertain significance
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
GRCh37/hg19 1p36.21-36.13(chr1:13178371-19961858)x1 copy number loss See cases [RCV000447987] Chr1:13178371..19961858 [GRCh37]
Chr1:1p36.21-36.13		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.23-36.13(chr1:8850514-16272383)x1 copy number loss See cases [RCV000512226] Chr1:8850514..16272383 [GRCh37]
Chr1:1p36.23-36.13		 likely pathogenic
NC_000001.10:g.(?_15764961)_(16063358_?)del deletion Hereditary pancreatitis [RCV000708522] Chr1:15764961..16063358 [GRCh37]
Chr1:1p36.21		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.21(chr1:15782147-15797670)x1 copy number loss not provided [RCV000748911] Chr1:15782147..15797670 [GRCh37]
Chr1:1p36.21		 benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NM_033440.3(CELA2A):c.253C>A (p.Leu85Met) single nucleotide variant Abdominal obesity-metabolic syndrome 4 [RCV002508145]|Coronary artery disorder [RCV000853072] Chr1:15462758 [GRCh38]
Chr1:15789253 [GRCh37]
Chr1:1p36.21		 pathogenic
NM_033440.3(CELA2A):c.639+1G>C single nucleotide variant Abdominal obesity-metabolic syndrome 4 [RCV002508146]|Coronary artery disorder [RCV000853073] Chr1:15466145 [GRCh38]
Chr1:15792640 [GRCh37]
Chr1:1p36.21		 pathogenic
NM_033440.3(CELA2A):c.104C>T (p.Ala35Val) single nucleotide variant not specified [RCV004289350] Chr1:15457149 [GRCh38]
Chr1:15783644 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.209C>T (p.Thr70Met) single nucleotide variant Abdominal obesity-metabolic syndrome 4 [RCV002249481]|CELA2A-related condition [RCV003965579]|Coronary artery disorder [RCV000853074] Chr1:15461640 [GRCh38]
Chr1:15788135 [GRCh37]
Chr1:1p36.21		 pathogenic|likely pathogenic
NM_033440.3(CELA2A):c.361G>A (p.Asp121Asn) single nucleotide variant Abdominal obesity-metabolic syndrome 4 [RCV002508144]|Coronary artery disorder [RCV000853071] Chr1:15463390 [GRCh38]
Chr1:15789885 [GRCh37]
Chr1:1p36.21		 pathogenic
NM_033440.3(CELA2A):c.697G>A (p.Gly233Ser) single nucleotide variant not provided [RCV003322112] Chr1:15467443 [GRCh38]
Chr1:15793938 [GRCh37]
Chr1:1p36.21		 uncertain significance
GRCh37/hg19 1p36.33-36.13(chr1:849466-17525065)x1 copy number loss not provided [RCV001832902] Chr1:849466..17525065 [GRCh37]
Chr1:1p36.33-36.13		 pathogenic
NC_000001.11:g.10115497_16283149dup duplication not specified [RCV002286386] Chr1:10115497..16283149 [GRCh38]
Chr1:1p36.22-36.13		 likely pathogenic
NC_000001.10:g.4481271_20530242del deletion Chromosome 1p36 deletion syndrome [RCV003159574] Chr1:4481271..20530242 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
GRCh37/hg19 1p36.31-36.13(chr1:6758933-19287770)x1 copy number loss not provided [RCV002474779] Chr1:6758933..19287770 [GRCh37]
Chr1:1p36.31-36.13		 pathogenic
NM_033440.3(CELA2A):c.235A>G (p.Arg79Gly) single nucleotide variant not specified [RCV004238057] Chr1:15462740 [GRCh38]
Chr1:15789235 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.496A>T (p.Asn166Tyr) single nucleotide variant not specified [RCV004167568] Chr1:15466001 [GRCh38]
Chr1:15792496 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.157A>C (p.Lys53Gln) single nucleotide variant not specified [RCV004071402] Chr1:15461588 [GRCh38]
Chr1:15788083 [GRCh37]
Chr1:1p36.21		 likely benign
NM_033440.3(CELA2A):c.247G>A (p.Val83Met) single nucleotide variant not specified [RCV004105193] Chr1:15462752 [GRCh38]
Chr1:15789247 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.500G>A (p.Gly167Glu) single nucleotide variant not specified [RCV004279244] Chr1:15466005 [GRCh38]
Chr1:15792500 [GRCh37]
Chr1:1p36.21		 uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
GRCh37/hg19 1p36.21(chr1:13922015-16013972)x1 copy number loss not specified [RCV003986640] Chr1:13922015..16013972 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.638A>G (p.Asn213Ser) single nucleotide variant not specified [RCV004431248] Chr1:15466143 [GRCh38]
Chr1:15792638 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.751G>A (p.Val251Ile) single nucleotide variant not specified [RCV004431250] Chr1:15467497 [GRCh38]
Chr1:15793992 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.319G>A (p.Val107Met) single nucleotide variant not specified [RCV004431244] Chr1:15462824 [GRCh38]
Chr1:15789319 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.683G>A (p.Arg228Gln) single nucleotide variant not specified [RCV004431249] Chr1:15467429 [GRCh38]
Chr1:15793924 [GRCh37]
Chr1:1p36.21		 likely benign
NM_033440.3(CELA2A):c.530G>A (p.Arg177Gln) single nucleotide variant not specified [RCV004431246] Chr1:15466035 [GRCh38]
Chr1:15792530 [GRCh37]
Chr1:1p36.21		 uncertain significance
NM_033440.3(CELA2A):c.632G>C (p.Ser211Thr) single nucleotide variant not specified [RCV004431247] Chr1:15466137 [GRCh38]
Chr1:15792632 [GRCh37]
Chr1:1p36.21		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:788
Count of miRNA genes:533
Interacting mature miRNAs:623
Transcripts:ENST00000359621, ENST00000459653, ENST00000497590
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-36104  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37115,816,231 - 15,816,358UniSTSGRCh37
GRCh37115,796,940 - 15,797,066UniSTSGRCh37
Build 36115,669,527 - 15,669,653RGDNCBI36
Celera114,279,812 - 14,279,938RGD
Celera114,299,101 - 14,299,228UniSTS
Cytogenetic Map1p36.21UniSTS
HuRef114,316,708 - 14,316,834UniSTS
HuRef114,335,633 - 14,335,760UniSTS
GeneMap99-G3 RH Map1810.0UniSTS
RH67819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37115,816,219 - 15,816,355UniSTSGRCh37
GRCh37115,796,928 - 15,797,063UniSTSGRCh37
Build 36115,669,515 - 15,669,650RGDNCBI36
Celera114,279,800 - 14,279,935RGD
Celera114,299,089 - 14,299,225UniSTS
Cytogenetic Map1p36.21UniSTS
HuRef114,316,696 - 14,316,831UniSTS
HuRef114,335,621 - 14,335,757UniSTS
GeneMap99-GB4 RH Map156.77UniSTS
RH71372  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37115,792,592 - 15,793,979UniSTSGRCh37
Celera114,275,464 - 14,276,851UniSTS
Cytogenetic Map1p36.21UniSTS
HuRef114,312,361 - 14,313,748UniSTS
GeneMap99-GB4 RH Map156.67UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 2 1 1 1
Medium 30 26 15 5 9 4 36 24 13 1 13 9 1 20 23 2
Low 899 837 713 164 433 107 1127 542 1227 47 803 456 56 366 759
Below cutoff 1019 1388 644 237 706 163 2203 1003 2151 182 434 730 77 575 1407 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000359621   ⟹   ENSP00000352639
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl115,456,732 - 15,472,091 (+)Ensembl
RefSeq Acc Id: ENST00000459653
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl115,456,728 - 15,463,011 (+)Ensembl
RefSeq Acc Id: ENST00000497590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl115,456,747 - 15,457,623 (+)Ensembl
RefSeq Acc Id: NM_033440   ⟹   NP_254275
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38115,456,732 - 15,472,091 (+)NCBI
GRCh37115,783,223 - 15,798,586 (+)RGD
Build 36115,655,811 - 15,671,170 (+)NCBI Archive
Celera114,266,097 - 14,281,458 (+)RGD
HuRef114,303,023 - 14,318,355 (+)ENTREZGENE
CHM1_1115,581,888 - 15,597,250 (+)NCBI
T2T-CHM13v2.0114,901,450 - 14,916,792 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_254275   ⟸   NM_033440
- Peptide Label: preproprotein
- UniProtKB: B2R5I4 (UniProtKB/Swiss-Prot),   Q14243 (UniProtKB/Swiss-Prot),   P08217 (UniProtKB/Swiss-Prot),   Q6ICV2 (UniProtKB/TrEMBL),   Q6ISN8 (UniProtKB/TrEMBL),   Q6ISU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000352639   ⟸   ENST00000359621
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08217-F1-model_v2 AlphaFold P08217 1-269 view protein structure

Promoters
RGD ID:6854196
Promoter ID:EPDNEW_H263
Type:multiple initiation site
Name:CELA2A_1
Description:chymotrypsin like elastase family member 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38115,456,732 - 15,456,792EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24609 AgrOrtholog
COSMIC CELA2A COSMIC
Ensembl Genes ENSG00000142615 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000359621 ENTREZGENE
  ENST00000359621.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000142615 GTEx
HGNC ID HGNC:24609 ENTREZGENE
Human Proteome Map CELA2A Human Proteome Map
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:63036 UniProtKB/Swiss-Prot
NCBI Gene 63036 ENTREZGENE
OMIM 609443 OMIM
PANTHER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA165750794 PharmGKB
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R5I4 ENTREZGENE
  CEL2A_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q14243 ENTREZGENE
  Q6ICV2 ENTREZGENE, UniProtKB/TrEMBL
  Q6ISN8 ENTREZGENE, UniProtKB/TrEMBL
  Q6ISU5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R5I4 UniProtKB/Swiss-Prot
  Q14243 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-12 CELA2A  chymotrypsin like elastase 2A  CELA2A  chymotrypsin like elastase family member 2A  Symbol and/or name change 5135510 APPROVED
2015-11-24 CELA2A  chymotrypsin like elastase family member 2A  CELA2A  chymotrypsin-like elastase family, member 2A  Symbol and/or name change 5135510 APPROVED