KLHDC10 (kelch domain containing 10) - Rat Genome Database

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Gene: KLHDC10 (kelch domain containing 10) Homo sapiens
Analyze
Symbol: KLHDC10
Name: kelch domain containing 10
RGD ID: 1602130
HGNC Page HGNC:22194
Description: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in rescue of stalled ribosome and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex and cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch domain-containing protein 10; KIAA0265; PNAS-119; PNAS-138; scruin like at the midline homolog; slim
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,070,534 - 130,135,705 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,070,534 - 130,135,705 (+)EnsemblGRCh38hg38GRCh38
GRCh377129,710,374 - 129,775,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,497,585 - 129,560,829 (+)NCBINCBI36Build 36hg18NCBI36
Celera7124,506,108 - 124,571,332 (+)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7124,072,999 - 124,138,082 (+)NCBIHuRef
CHM1_17129,643,789 - 129,709,160 (+)NCBICHM1_1
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,095,715 - 129,160,935 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9039502   PMID:12477932   PMID:12690205   PMID:20562859   PMID:21145461   PMID:21873635   PMID:22658674   PMID:23102700   PMID:25036637   PMID:26186194   PMID:26389662   PMID:26472337  
PMID:26496610   PMID:26618866   PMID:27565346   PMID:28514442   PMID:28515276   PMID:28581483   PMID:28619731   PMID:29117863   PMID:29298432   PMID:29779948   PMID:31067453   PMID:31253590  
PMID:32513696   PMID:32552912   PMID:33545068   PMID:33909987   PMID:33961781   PMID:35013218   PMID:36307841   PMID:37676773   PMID:37704626  


Genomics

Comparative Map Data
KLHDC10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,070,534 - 130,135,705 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,070,534 - 130,135,705 (+)EnsemblGRCh38hg38GRCh38
GRCh377129,710,374 - 129,775,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,497,585 - 129,560,829 (+)NCBINCBI36Build 36hg18NCBI36
Celera7124,506,108 - 124,571,332 (+)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7124,072,999 - 124,138,082 (+)NCBIHuRef
CHM1_17129,643,789 - 129,709,160 (+)NCBICHM1_1
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,095,715 - 129,160,935 (+)NCBI
Klhdc10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,401,516 - 30,455,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl630,401,867 - 30,455,178 (+)EnsemblGRCm39 Ensembl
GRCm38630,401,517 - 30,455,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,401,868 - 30,455,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37630,351,909 - 30,405,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36630,351,919 - 30,405,184 (+)NCBIMGSCv36mm8
Celera630,411,890 - 30,465,194 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.52NCBI
Klhdc10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,988,710 - 60,046,518 (+)NCBIGRCr8
mRatBN7.2459,021,300 - 59,079,118 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl459,021,310 - 59,074,941 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,999,425 - 64,053,045 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,915,612 - 59,969,232 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,317,528 - 58,371,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,715,982 - 57,773,800 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,715,946 - 57,773,823 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,477,620 - 57,535,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4457,312,274 - 57,365,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1457,588,403 - 57,642,052 (+)NCBI
Celera454,120,564 - 54,174,023 (+)NCBICelera
Cytogenetic Map4q22NCBI
Klhdc10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547910,743,661 - 10,799,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547910,743,658 - 10,826,129 (+)NCBIChiLan1.0ChiLan1.0
KLHDC10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26166,890,888 - 166,957,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1718,901,880 - 18,967,460 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07122,036,564 - 122,101,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17134,555,062 - 134,620,225 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7134,555,062 - 134,620,225 (+)Ensemblpanpan1.1panPan2
KLHDC10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,750,269 - 6,771,690 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,755,070 - 6,781,604 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha146,436,275 - 6,498,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0146,511,577 - 6,573,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl146,511,580 - 6,573,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1146,721,799 - 6,778,993 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0146,460,981 - 6,522,979 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,604,954 - 6,667,138 (-)NCBIUU_Cfam_GSD_1.0
Klhdc10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511824,954,264 - 25,010,407 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365795,087,028 - 5,142,253 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365795,082,221 - 5,143,004 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHDC10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,667,365 - 18,723,067 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,667,377 - 18,723,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,582,868 - 19,629,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHDC10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12198,702,411 - 98,773,299 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2198,702,451 - 98,768,343 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660424,631,111 - 4,699,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhdc10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247836,118,829 - 6,188,611 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247836,118,814 - 6,188,198 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLHDC10
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3		 pathogenic
GRCh38/hg38 7q32.1-33(chr7:128747478-134018250)x3 copy number gain See cases [RCV000051072] Chr7:128747478..134018250 [GRCh38]
Chr7:128387532..133703003 [GRCh37]
Chr7:128174768..133353543 [NCBI36]
Chr7:7q32.1-33		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q31.33-32.3(chr7:126859732-132750936)x1 copy number loss See cases [RCV000054171] Chr7:126859732..132750936 [GRCh38]
Chr7:126499786..132435696 [GRCh37]
Chr7:126287022..132086236 [NCBI36]
Chr7:7q31.33-32.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33		 pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3		 pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3		 pathogenic
GRCh38/hg38 7q31.33-33(chr7:124170657-134163594)x1 copy number loss See cases [RCV000142552] Chr7:124170657..134163594 [GRCh38]
Chr7:123810711..133848346 [GRCh37]
Chr7:123597947..133498886 [NCBI36]
Chr7:7q31.33-33		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34		 pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_014997.4(KLHDC10):c.515C>T (p.Thr172Met) single nucleotide variant not specified [RCV004313652] Chr7:130120788 [GRCh38]
Chr7:129760628 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
Single allele complex Renal transitional cell carcinoma [RCV000754611] Chr7:129367205..140482957 [GRCh37]
Chr7:7q32.2-34		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
GRCh37/hg19 7q32.1-33(chr7:129147455-132777678)x1 copy number loss not provided [RCV002473525] Chr7:129147455..132777678 [GRCh37]
Chr7:7q32.1-33		 uncertain significance
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3		 pathogenic
GRCh37/hg19 7q32.2-33(chr7:129605827-133093756)x3 copy number gain not provided [RCV001258971] Chr7:129605827..133093756 [GRCh37]
Chr7:7q32.2-33		 uncertain significance
GRCh37/hg19 7q31.33-33(chr7:124103982-134693590) copy number loss not specified [RCV002053726] Chr7:124103982..134693590 [GRCh37]
Chr7:7q31.33-33		 pathogenic
GRCh37/hg19 7q31.33-33(chr7:123967475-132729981) copy number loss not specified [RCV002053723] Chr7:123967475..132729981 [GRCh37]
Chr7:7q31.33-33		 pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358) copy number loss not specified [RCV002053727] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34		 pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_014997.4(KLHDC10):c.1051T>C (p.Phe351Leu) single nucleotide variant not specified [RCV004097957] Chr7:130129508 [GRCh38]
Chr7:129769348 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.437C>T (p.Thr146Ile) single nucleotide variant not specified [RCV004111659] Chr7:130116628 [GRCh38]
Chr7:129756468 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7q32.2(chr7:129442838-129877274)x3 copy number gain not provided [RCV002475636] Chr7:129442838..129877274 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.85G>C (p.Gly29Arg) single nucleotide variant not specified [RCV004233943] Chr7:130070728 [GRCh38]
Chr7:129710568 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.1172G>A (p.Arg391Gln) single nucleotide variant not specified [RCV004099043] Chr7:130130589 [GRCh38]
Chr7:129770429 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.598C>T (p.Arg200Trp) single nucleotide variant not specified [RCV004170306] Chr7:130120871 [GRCh38]
Chr7:129760711 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7q31.31-33(chr7:120582003-137699953)x1 copy number loss not specified [RCV003986721] Chr7:120582003..137699953 [GRCh37]
Chr7:7q31.31-33		 pathogenic
NM_014997.4(KLHDC10):c.179T>G (p.Ile60Arg) single nucleotide variant not specified [RCV004406683] Chr7:130096933 [GRCh38]
Chr7:129736773 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.202C>T (p.Arg68Cys) single nucleotide variant not specified [RCV004406684] Chr7:130096956 [GRCh38]
Chr7:129736796 [GRCh37]
Chr7:7q32.2		 uncertain significance
NM_014997.4(KLHDC10):c.851A>T (p.Tyr284Phe) single nucleotide variant not specified [RCV004406685] Chr7:130124522 [GRCh38]
Chr7:129764362 [GRCh37]
Chr7:7q32.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2114
Count of miRNA genes:1002
Interacting mature miRNAs:1226
Transcripts:ENST00000335420, ENST00000463413, ENST00000468226, ENST00000495724
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G62136  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,774,617 - 129,774,772UniSTSGRCh37
Build 367129,561,853 - 129,562,008RGDNCBI36
Celera7124,570,384 - 124,570,539RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,137,137 - 124,137,292UniSTS
CRA_TCAGchr7v27129,159,993 - 129,160,148UniSTS
SHGC-30776  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,774,796 - 129,774,921UniSTSGRCh37
Build 367129,562,032 - 129,562,157RGDNCBI36
Celera7124,570,563 - 124,570,688RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,137,316 - 124,137,441UniSTS
CRA_TCAGchr7v27129,160,172 - 129,160,297UniSTS
TNG Radiation Hybrid Map758456.0UniSTS
GeneMap99-GB4 RH Map7592.35UniSTS
Whitehead-RH Map7557.7UniSTS
NCBI RH Map71179.1UniSTS
GeneMap99-G3 RH Map77503.0UniSTS
SGC35002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,770,835 - 129,770,934UniSTSGRCh37
Build 367129,558,071 - 129,558,170RGDNCBI36
Celera7124,566,602 - 124,566,701RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,133,355 - 124,133,454UniSTS
CRA_TCAGchr7v27129,156,211 - 129,156,310UniSTS
GeneMap99-GB4 RH Map7594.02UniSTS
Whitehead-RH Map7559.5UniSTS
NCBI RH Map71179.1UniSTS
RH36601  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,773,351 - 129,773,549UniSTSGRCh37
Build 367129,560,587 - 129,560,785RGDNCBI36
Celera7124,569,118 - 124,569,316RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,135,871 - 124,136,069UniSTS
CRA_TCAGchr7v27129,158,727 - 129,158,925UniSTS
GeneMap99-GB4 RH Map7591.82UniSTS
A006N09  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,774,634 - 129,774,896UniSTSGRCh37
Build 367129,561,870 - 129,562,132RGDNCBI36
Celera7124,570,401 - 124,570,663RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,137,154 - 124,137,416UniSTS
CRA_TCAGchr7v27129,160,010 - 129,160,272UniSTS
GeneMap99-GB4 RH Map7591.82UniSTS
NCBI RH Map71192.6UniSTS
RH67951  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,775,166 - 129,775,311UniSTSGRCh37
Build 367129,562,402 - 129,562,547RGDNCBI36
Celera7124,570,938 - 124,571,083RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,137,688 - 124,137,833UniSTS
CRA_TCAGchr7v27129,160,541 - 129,160,686UniSTS
GeneMap99-GB4 RH Map7592.56UniSTS
NCBI RH Map71179.1UniSTS
STS-H67652  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377129,775,292 - 129,775,422UniSTSGRCh37
Build 367129,562,528 - 129,562,658RGDNCBI36
Celera7124,571,064 - 124,571,194RGD
Cytogenetic Map7q32.2UniSTS
HuRef7124,137,814 - 124,137,944UniSTS
CRA_TCAGchr7v27129,160,667 - 129,160,797UniSTS
GeneMap99-GB4 RH Map7592.56UniSTS
NCBI RH Map71179.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2268 1572 1583 474 1174 339 4102 1670 3084 365 1435 1591 151 1 1115 2635 4 2
Low 171 1418 143 150 776 126 255 527 650 54 25 22 24 89 153 2
Below cutoff 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_014997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054357639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054357640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054357641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054357642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000335420   ⟹   ENSP00000334140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7130,070,534 - 130,135,705 (+)Ensembl
RefSeq Acc Id: ENST00000463413   ⟹   ENSP00000420083
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7130,070,550 - 130,120,769 (+)Ensembl
RefSeq Acc Id: ENST00000468226   ⟹   ENSP00000420034
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7130,070,772 - 130,124,534 (+)Ensembl
RefSeq Acc Id: ENST00000495724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7130,116,445 - 130,117,666 (+)Ensembl
RefSeq Acc Id: NM_014997   ⟹   NP_055812
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,135,705 (+)NCBI
GRCh377129,710,349 - 129,775,560 (+)RGD
GRCh377129,710,349 - 129,775,560 (+)NCBI
Build 367129,497,585 - 129,560,829 (+)NCBI Archive
Celera7124,506,108 - 124,571,332 (+)RGD
HuRef7124,072,999 - 124,138,082 (+)ENTREZGENE
CHM1_17129,643,789 - 129,709,160 (+)NCBI
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBI
CRA_TCAGchr7v27129,095,715 - 129,160,935 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_005250233   ⟹   XP_005250290
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,135,705 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047420061   ⟹   XP_047276017
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,135,705 (+)NCBI
RefSeq Acc Id: XM_047420062   ⟹   XP_047276018
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,135,705 (+)NCBI
RefSeq Acc Id: XM_047420063   ⟹   XP_047276019
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,135,705 (+)NCBI
RefSeq Acc Id: XM_054357639   ⟹   XP_054213614
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBI
RefSeq Acc Id: XM_054357640   ⟹   XP_054213615
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBI
RefSeq Acc Id: XM_054357641   ⟹   XP_054213616
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBI
RefSeq Acc Id: XM_054357642   ⟹   XP_054213617
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07131,383,894 - 131,449,088 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_055812   ⟸   NM_014997
- UniProtKB: Q86Y99 (UniProtKB/Swiss-Prot),   Q92554 (UniProtKB/Swiss-Prot),   Q6PID8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005250290   ⟸   XM_005250233
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000420083   ⟸   ENST00000463413
RefSeq Acc Id: ENSP00000334140   ⟸   ENST00000335420
RefSeq Acc Id: ENSP00000420034   ⟸   ENST00000468226
RefSeq Acc Id: XP_047276017   ⟸   XM_047420061
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047276018   ⟸   XM_047420062
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047276019   ⟸   XM_047420063
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054213615   ⟸   XM_054357640
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054213616   ⟸   XM_054357641
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054213617   ⟸   XM_054357642
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054213614   ⟸   XM_054357639
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PID8-F1-model_v2 AlphaFold Q6PID8 1-442 view protein structure

Promoters
RGD ID:6805536
Promoter ID:HG_KWN:59675
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000355818,   NM_014997,   UC003VPK.1,   UC010LMB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 367129,497,189 - 129,497,689 (+)MPROMDB
RGD ID:7211921
Promoter ID:EPDNEW_H11703
Type:initiation region
Name:KLHDC10_1
Description:kelch domain containing 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387130,070,534 - 130,070,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:22194 AgrOrtholog
COSMIC KLHDC10 COSMIC
Ensembl Genes ENSG00000128607 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000335420 ENTREZGENE
  ENST00000335420.10 UniProtKB/Swiss-Prot
  ENST00000463413.1 UniProtKB/TrEMBL
  ENST00000468226.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128607 GTEx
HGNC ID HGNC:22194 ENTREZGENE
Human Proteome Map KLHDC10 Human Proteome Map
InterPro Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:23008 UniProtKB/Swiss-Prot
NCBI Gene 23008 ENTREZGENE
OMIM 615152 OMIM
PANTHER KELCH DOMAIN-CONTAINING PROTEIN 10 UniProtKB/Swiss-Prot
  KELCH DOMAIN-CONTAINING PROTEIN 10 UniProtKB/Swiss-Prot
  KELCH DOMAIN-CONTAINING PROTEIN 10 UniProtKB/TrEMBL
  KELCH DOMAIN-CONTAINING PROTEIN 10 UniProtKB/TrEMBL
Pfam Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164721976 PharmGKB
SMART Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP NHL repeat UniProtKB/Swiss-Prot
  SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9JRT7_HUMAN UniProtKB/TrEMBL
  C9JRX2_HUMAN UniProtKB/TrEMBL
  KLD10_HUMAN UniProtKB/Swiss-Prot
  L8E8L8_HUMAN UniProtKB/TrEMBL
  Q6PID8 ENTREZGENE
  Q86Y99 ENTREZGENE
  Q92554 ENTREZGENE
  Q96G43_HUMAN UniProtKB/TrEMBL
  Q9BZS9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q86Y99 UniProtKB/Swiss-Prot
  Q92554 UniProtKB/Swiss-Prot