Mrgprb2 (MAS-related GPR, member B2) - Rat Genome Database

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Gene: Mrgprb2 (MAS-related GPR, member B2) Rattus norvegicus
Analyze
Symbol: Mrgprb2
Name: MAS-related GPR, member B2
RGD ID: 1591915
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; and response to chloroquine. Predicted to be active in plasma membrane. Orthologous to human MRGPRX1 (MAS related GPR family member X1) and MRGPRX2 (MAS related GPR family member X2); INTERACTS WITH ammonium chloride; paracetamol; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC502338; MAS related GPR family member X1; Mas-related G protein-coupled receptor g10; MAS-related G protein-coupled receptor, member B6; mas-related G-protein coupled receptor member B2; MAS-related gene B6; MAS-related GPR, member X1; Mgrg10; MrgB6; Mrgprb6; Mrgprx1; similar to MAS-related GPR, member B2
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,537,410 - 107,539,432 (-)NCBIGRCr8
mRatBN7.2198,401,140 - 98,403,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,401,538 - 98,415,284 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01104,023,700 - 104,049,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,023,738 - 104,024,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,085,669 - 105,086,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,479,104 - 98,480,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,557,417 - 98,558,155 (-)NCBI
Celera192,612,181 - 92,638,270 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12909716   PMID:20004959   PMID:24583173   PMID:26582731  


Genomics

Comparative Map Data
Mrgprb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,537,410 - 107,539,432 (-)NCBIGRCr8
mRatBN7.2198,401,140 - 98,403,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,401,538 - 98,415,284 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01104,023,700 - 104,049,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,023,738 - 104,024,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,085,669 - 105,086,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,479,104 - 98,480,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,557,417 - 98,558,155 (-)NCBI
Celera192,612,181 - 92,638,270 (-)NCBICelera
Cytogenetic Map1q22NCBI
MRGPRX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,933,499 - 18,939,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,933,499 - 18,939,414 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,955,046 - 18,960,961 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,911,936 - 18,913,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,087,796 - 19,088,985 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,639,412 - 18,640,601 (-)NCBIHuRef
CHM1_11118,954,694 - 18,955,883 (-)NCBICHM1_1
T2T-CHM13v2.01119,031,499 - 19,037,414 (-)NCBIT2T-CHM13v2.0
LOC100972004
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,239,227 - 21,245,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,199,544 - 21,205,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,960,202 - 18,961,386 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,874,205 - 18,879,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,874,205 - 18,875,173 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Mrgprb2
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000056081
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 15 15 15 21
Below cutoff 2 1 18 10 7 10 1 1 8 6 15 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056081   ⟹   ENSRNOP00000052932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl198,401,538 - 98,415,284 (-)Ensembl
Rnor_6.0 Ensembl1104,023,738 - 104,024,682 (-)Ensembl
RefSeq Acc Id: NM_001408774   ⟹   NP_001395703
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81107,537,410 - 107,539,432 (-)NCBI
mRatBN7.2198,401,140 - 98,403,162 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395703 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ08316 (Get FASTA)   NCBI Sequence Viewer  
  CDG86249 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052932
  ENSRNOP00000052932.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000052932   ⟸   ENSRNOT00000056081
RefSeq Acc Id: NP_001395703   ⟸   NM_001408774
- UniProtKB: W8W3M7 (UniProtKB/TrEMBL),   E9PTZ2 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTZ2-F1-model_v2 AlphaFold E9PTZ2 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591915 AgrOrtholog
BioCyc Gene G2FUF-59574 BioCyc
Ensembl Genes ENSRNOG00000037156 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056081 ENTREZGENE
  ENSRNOT00000056081.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/TrEMBL
NCBI Gene 502338 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED UniProtKB/TrEMBL
  PTHR11334 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Mrgprb2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037156 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt E9PTZ2 ENTREZGENE, UniProtKB/TrEMBL
  W8W3M7 ENTREZGENE
UniProt Secondary W8W3M7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-07 Mrgprb2  MAS-related GPR, member B2  Mrgprx1  MAS related GPR family member X1  Name and Symbol changed 629549 APPROVED
2018-02-12 Mrgprx1  MAS related GPR family member X1  Mrgprx1  MAS-related GPR, member X1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-20 Mrgprx1  MAS-related GPR, member X1  Mrgprb6  MAS-related G protein-coupled receptor, member B6  Data merged from RGD:738046 737654 APPROVED
2012-10-05 Mrgprx1  MAS-related GPR, member X1  Mrgprb2  MAS-related GPR, member B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-21 Mrgprb2  MAS-related GPR, member B2  LOC502338  similar to MAS-related GPR, member B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC502338  similar to MAS-related GPR, member B2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 Mrgprb6  MAS-related G protein-coupled receptor, member B6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_evolution genome comparisons with mouse and gerbil suggest Mrgprb genes diverged from a single ancestral gene 65-70 million years ago 737883
gene_expression expressed in nociceptive sensory neurons and in newborn dorsal root ganglia 737883
gene_mapping Mrgpra, Mrgprb and Mrgprc are located within a 760-kb cluster on chr 1 737883
gene_product member of the Mas-related gene (Mrg) family, based on ligand which activates the receptor 737883