Adam34 (a disintegrin and metallopeptidase domain 34) - Rat Genome Database

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Gene: Adam34 (a disintegrin and metallopeptidase domain 34) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Adam34
Name: a disintegrin and metallopeptidase domain 34
RGD ID: 1589040
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 26B; Adam26b; LOC685846; similar to a disintegrin and metalloprotease domain 34
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81655,290,008 - 55,294,201 (+)NCBIGRCr8
mRatBN7.21648,557,385 - 48,561,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1648,557,568 - 48,561,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1653,953,912 - 53,956,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01657,329,762 - 57,331,900 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01652,593,328 - 52,595,466 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01651,750,790 - 51,752,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1651,748,970 - 51,752,936 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01651,472,156 - 51,474,305 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41651,876,513 - 51,878,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1646,536,384 - 46,538,522 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Adam34
38 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 7
Low
Below cutoff 1 2 2 5 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059182   ⟹   ENSRNOP00000055955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1648,557,568 - 48,561,733 (+)Ensembl
Rnor_6.0 Ensembl1651,748,970 - 51,752,936 (+)Ensembl
RefSeq Acc Id: NM_001135090   ⟹   NP_001128562
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,290,026 - 55,294,201 (+)NCBI
mRatBN7.21648,557,568 - 48,561,743 (+)NCBI
Rnor_6.01651,750,790 - 51,752,939 (+)NCBI
Rnor_5.01651,472,156 - 51,474,305 (+)NCBI
RGSC_v3.41651,876,513 - 51,878,651 (-)RGD
Celera1646,536,384 - 46,538,522 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094826   ⟹   XP_038950754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81655,290,008 - 55,294,201 (+)NCBI
mRatBN7.21648,557,385 - 48,561,744 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001128562 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950754 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055955
  ENSRNOP00000055955.5
Reference Protein Sequences
RefSeq Acc Id: NP_001128562   ⟸   NM_001135090
- UniProtKB: F1LMB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055955   ⟸   ENSRNOT00000059182
RefSeq Acc Id: XP_038950754   ⟸   XM_039094826
- Peptide Label: isoform X1
- UniProtKB: F1LMB6 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   Peptidase M12B

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589040 AgrOrtholog
BioCyc Gene G2FUF-11297 BioCyc
Ensembl Genes ENSRNOG00000038743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059182 ENTREZGENE
  ENSRNOT00000059182.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:685846 UniProtKB/TrEMBL
NCBI Gene 685846 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 26B-RELATED UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam34 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038743 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt F1LMB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Adam34  a disintegrin and metallopeptidase domain 34  Adam26b  a disintegrin and metallopeptidase domain 26B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Adam34  a disintegrin and metallopeptidase domain 34  LOC685846  similar to a disintegrin and metalloprotease domain 34  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685846  similar to a disintegrin and metalloprotease domain 34      Symbol and Name status set to provisional 70820 PROVISIONAL