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Gene: Rap2c (RAP2C, member of RAS oncogene family) Rattus norvegicus

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Symbol:

Rap2c

Name:

RAP2C, member of RAS oncogene family (Ensembl:RAP2C, member of RAS onco family)

RGD ID:

1588562

Description:

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including Rap protein signal transduction; establishment of endothelial intestinal barrier; and regulation of protein tyrosine kinase activity. Predicted to act upstream of or within positive regulation of protein autophosphorylation. Predicted to be located in several cellular components, including bicellular tight junction; cell-cell contact zone; and recycling endosome membrane. Predicted to be active in plasma membrane. Orthologous to human RAP2C (RAP2C, member of RAS oncogene family); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical LOC302495; LOC302495; ras-related protein Rap-2c

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAP2C (RAP2C, member of RAS oncogene family)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rap2c (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rap2c (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAP2C (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAP2C (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rap2c (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAP2C (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAP2C (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rap2c (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rap2c (RAP2C, member of RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RAP2B (RAP2B, member of RAS oncogene family)	HGNC	OrthoDB
Homo sapiens (human):	RAP2A (RAP2A, member of RAS oncogene family)	HGNC	OrthoDB
Homo sapiens (human):	PDXK (pyridoxal kinase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RAP2C (RAP2C, member of RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rap2c (RAP2C, member of RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rap2c (RAP2C, member of RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rap2l	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rap-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RSR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rap2c	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	135,388,881 - 135,401,998 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	135,388,882 - 135,401,998 (-)	Ensembl				GRCr8
mRatBN7.2	X	130,504,554 - 130,517,671 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	130,504,698 - 130,518,328 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	132,624,793 - 132,637,910 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	136,206,689 - 136,219,806 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	133,781,696 - 133,794,808 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	138,224,039 - 138,237,157 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	138,224,040 - 138,237,157 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	X	138,277,498 - 138,290,616 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	137,743,296 - 137,756,412 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	129,422,499 - 129,435,616 (-)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Cancer, Familial (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian cancer (ISO)

ovarian serous cystadenocarcinoma (ISO)

sarcoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

1,3,5-trinitro-1,3,5-triazinane (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2-bromohexadecanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt dichloride (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

finasteride (EXP)

florfenicol (ISO)

flutamide (EXP)

folic acid (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

nitrates (ISO)

ochratoxin A (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zinc protoporphyrin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of endothelial intestinal barrier (IEA,ISO)

negative regulation of cell migration (IBA,IEA,ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of protein autophosphorylation (ISO)

Rap protein signal transduction (IBA,IEA,ISO)

regulation of protein tyrosine kinase activity (ISO)

signal transduction (IEA)

Cellular Component

bicellular tight junction (IEA,ISO)

cell-cell contact zone (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

membrane (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

recycling endosome (IEA,ISO)

recycling endosome membrane (IEA,ISO)

Molecular Function

G protein activity (IEA)

GDP binding (IEA,ISO)

GTP binding (IEA,ISO)

GTPase activity (IBA,IEA)

transcription coactivator activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:16213650	PMID:17447155	PMID:19056867	PMID:19061864	PMID:20458337	PMID:22797597	PMID:23885123	PMID:28714326

Genomics

Comparative Map Data

Rap2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	135,388,881 - 135,401,998 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	135,388,882 - 135,401,998 (-)	Ensembl				GRCr8
mRatBN7.2	X	130,504,554 - 130,517,671 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	130,504,698 - 130,518,328 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	132,624,793 - 132,637,910 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	136,206,689 - 136,219,806 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	133,781,696 - 133,794,808 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	138,224,039 - 138,237,157 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	138,224,040 - 138,237,157 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	X	138,277,498 - 138,290,616 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	137,743,296 - 137,756,412 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	129,422,499 - 129,435,616 (-)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

RAP2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	132,203,025 - 132,219,447 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	132,202,882 - 132,219,627 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	X	131,337,053 - 131,353,475 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	131,164,734 - 131,179,870 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	131,062,587 - 131,077,724	NCBI
Celera	X	131,723,459 - 131,738,593 (-)	NCBI		Celera
Cytogenetic Map	X	q26.2	NCBI
HuRef	X	120,741,042 - 120,773,945 (-)	NCBI		HuRef
CHM1_1	X	131,248,623 - 131,265,070 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	130,527,262 - 130,543,665 (-)	NCBI		T2T-CHM13v2.0

Rap2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	50,093,163 - 50,108,966 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	50,092,789 - 50,107,627 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	51,003,912 - 51,020,091 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	51,003,912 - 51,018,018 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	X	48,357,089 - 48,371,195 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	47,248,539 - 47,262,645 (-)	NCBI		MGSCv36	mm8
Celera	X	38,422,576 - 38,436,521 (-)	NCBI		Celera
Cytogenetic Map	X	A5	NCBI
cM Map	X	28.03	NCBI

Rap2c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	2,709,407 - 2,723,756 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955473	2,709,407 - 2,723,453 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAP2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	131,628,001 - 131,644,370 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	131,631,610 - 131,647,977 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	121,334,292 - 121,350,658 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	131,641,193 - 131,657,751 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	131,641,193 - 131,656,447 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

RAP2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	103,134,752 - 103,150,900 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	103,145,635 - 103,150,934 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	89,307,731 - 89,323,889 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	104,994,806 - 105,010,965 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	104,996,344 - 105,010,985 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	102,405,723 - 102,421,878 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	104,281,475 - 104,297,616 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	104,053,006 - 104,069,156 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rap2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	X	19,522,926 - 19,539,447 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	X	101,312,224 - 101,328,819 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936691	2,628,579 - 2,645,268 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936691	2,628,563 - 2,645,133 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAP2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	108,332,628 - 108,348,396 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	X	108,332,623 - 108,348,432 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	124,342,558 - 124,358,353 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAP2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	X	21,650,951 - 21,665,370 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666065	44,807,990 - 44,823,025 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	X	107,347,404 - 107,363,687 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	107,347,119 - 107,362,076 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Rap2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624797	11,882,443 - 11,899,940 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rap2c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	114,830,402 - 114,844,073 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	565
Count of miRNA genes:	268
Interacting mature miRNAs:	348
Transcripts:	ENSRNOT00000003414
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	97528096	142528096	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	120028026	141353710	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	120028026	141353710	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	105359969	157758123	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	118973754	157758123	Rat
2302047	Pia34	Pristane induced arthritis QTL 34	5.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	19	96916163	141916163	Rat

Markers in Region

RH133900

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	130,509,768 - 130,509,985 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	138,229,254 - 138,229,470	NCBI	Rnor6.0
Rnor_5.0	X	138,282,713 - 138,282,929	UniSTS	Rnor5.0
RGSC_v3.4	X	137,748,511 - 137,748,727	UniSTS	RGSC3.4
Celera	X	129,427,714 - 129,427,930	UniSTS
Cytogenetic Map	X	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
275	156	729	1591	4065	1008	1725	133	871	488	853	156	5385	2589	448	3978	38	1392	741	909	160	158

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA957047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF563611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP503228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK842860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003414 ⟹ ENSRNOP00000003414

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	135,388,882 - 135,401,998 (-)	Ensembl
mRatBN7.2 Ensembl	X	130,504,698 - 130,518,328 (-)	Ensembl
Rnor_6.0 Ensembl	X	138,224,040 - 138,237,157 (-)	Ensembl

RefSeq Acc Id:

NM_001106950 ⟹ NP_001100420

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	135,388,881 - 135,401,998 (-)	NCBI
mRatBN7.2	X	130,504,554 - 130,517,671 (-)	NCBI
Rnor_6.0	X	138,224,039 - 138,237,157 (-)	NCBI
Rnor_5.0	X	138,277,498 - 138,290,616 (-)	NCBI
RGSC_v3.4	X	137,743,296 - 137,756,412 (-)	RGD
Celera	X	129,422,499 - 129,435,616 (-)	RGD

Sequence:

show sequence

CCGCACTCTCCTCCCCAGTTCGCACATTTCCGCCCACCTTCCGCCTGGCCTTGCCGCAGCGCAG
CTAGCGGGGTGTTATTTTTCCCCCCTTGGGTAAGGAGTTGGTGAAGGTGAGACTCATGAGGGAA
TACAAGGTAGTGGTGTTAGGGAGCGGAGGGGTTGGCAAATCTGCCCTCACTGTGCAGTTTGTCA
CCGGGACTTTCATTGAGAAATATGACCCCACCATTGAAGATTTCTACCGCAAAGAGATCGAAGT
GGACTCTTCTCCGTCAGTACTGGAAATTCTGGACACCGCGGGAACAGAGCAGTTTGCCTCCATG
AGAGATCTGTACATCAAAAACGGCCAAGGTTTCATCCTGGTGTATAGTTTGGTTAATCAACAGT
CTTTTCAGGATATCAAGCCAATGAGAGATCAGATTGTGAGAGTGAAGAGATACGAGAAAGTTCC
ACTAATCCTAGTAGGAAACAAAGTGGATCTGGAACCAGAAAGAGAGGTTATGTCTTCTGAAGGC
AGAGCTCTGGCTCAAGAATGGGGCTGTCCTTTCATGGAAACATCAGCAAAAAGTAAATCAATGG
TGGATGAACTTTTTGCTGAGATCGTCAGGCAAATGAACTATTCATCCCTACCCGAGAAGCAAGA
TCAGTGTTGTACAACTTGTGTTGTCCAGTAAAAAAGAAAACCTCAAACATGGCCATACCGAGCA
GATAAAAACTCAGAGGAAATTTGCACAGATGCTGCTTTGGAGAACTTTACAACCTGGGTTGCAG
AACTGAGCCTTGGTAAACCTGTCTCTATCACAGCATGTTGCCATACATCTAATGAAGTGCATAA
GGTCTTTGGCCCTCCAGATCCATGGACCTTAACAGTAATGCTTAGCACGTTTACCATACATTTA
AAATCTGTTCTTTATCAATCCGTCCGTTTATAGCTTTTTAAGTTCTTATTGATGGCTAATATGA
AAGGGTTAATTTTAATATGTTAGTTGATTTCGTTAATCAGTTTCTCAACTTGTATTTATTACTC
AAACTCAGTATTACCTACTCAATGCCTTTTAAAAGAAAGATATAATGGAGAAAAAATTGAGCCT
TAAACAAATGGTTACTTCTGTATATTACCTCGTAGCAATGCTTCATCCTATTTGTAAAATCTTT
CTCCTTTAAATGGTTGGTTAATACTTTGAGACTTTGTTTACGTGTGGCAGTGTTGTAAAAAGAA
ACTAAAGATCACGTTTTACCTGTATGGATGGAATATCCCTTTTCTTCAAGTACGGTTTTTGTAA
TTAACAAGTTCTGAAAGTTCCAGGTGATATTGGAGATTGACTGTACAGCATGACTTGAAGAGTT
AAGTATTTGATTCCATCAGGCCTTCACATGTGTTAATCTCATTGACAGCAGTGAATTGCGGCAG
TAACATTTTTCTTTCTGTGAAGTTCTAAACTTAGTTCTGACCTACTTAGCAATGCCTTTGAAAA
GGGATATTGTGTCCATGGTAAATGAATTGTATACCTAAACAGATAGCTCAGCTTTGCCAGTCAG
GCTTGTCATTGACATCTGGGAGACTTCTGCACATGTAAAATTGAATTCAGATAAAACCATGGAC
AATTTCTAGTTCTTAATATTTGTCTTTCTGAATAATAGTTTAAAGCAATATTTGTTAATGTTTT
CTTGCACTATCACAACTGCTTTTTAGTTATTTTTCAAGAAGCATGTTCGTAGTAGAGACAAAAA
TCTGTGTAACAGGAGGGAAAATAGCGCCAAGTCTCTGGCTGGCTGTGTTTTCTTTTTGCAAATG
TGCTTTCTAATAGCCATTGCCTTCCGTGTTGTTTACCTAATCAGCACATTTTGTCTGAATACTT
GAACATTTTACCAATAACGCAGGTATAGTAAAAGAAAAATACTTACAACGAGTAATTTTTGGTT
CAGTTTCAACATCATGATGACGAGTGCTTTTTCTAGCAATTATTTTTCAATTGTGTAAGTTTGA
CAGTATTTTGTTGGGGGTTTTTATTTGGTTTTATTTGTGTGCTTTTAATTTGCAGAAGTTAGTA
ACTGCAGCTCACCTACTGCACCAAAGTTCTCGATTTTAGGAGCCCAGCTTTAGTCGTTTGAACA
TGCTTCTAAATAAAACAAAACCAAAACTATGCTTTGGATCTATAATAATAGCTCAGTAACTTTG
TCAAGAAAAGCTCTATTATATGCAGTGATGGTTTGTGGAAGGGTGTGGCAAGTTTAAATTTGTA
TTGTGTGTGGTGTTCAAATAAAGTGATATCTACATTCATGTGACTTACTGGTCAGCATGGCCAT
TAATTAATGAGTAGAAAATGATTAAACTTTGATTTCCTTTTTTTAAATCGTGTTGCATTTGATT
CCTGATCAGATTCCCTCAAGGTGAGCTCTTGTTCTTAAATTTGGGGTTCAATGGTGAGAGTATA
AGGGTAGAGGCAGCTGAAACATTGGTTCTTCTTTACAAACTGCTTGAAATTCATACTTAGAGTT
TGCACTTTAAAACCCAACACACATGTCAAGTAGCTTAAGTGGCCGCGGCTCATCATTATTGGCT
CTGTGAAATTCTAGAGGAATCAAATAATTCATGATGGCTTCAACTGTCCGCACATTGATTTTTA
TACAGTTTCTTTCCTAGGAATATTCTTCTGTCCTTCCCTTCTTCGCCTTTTGTCACCTCTCTCT
CTATCACAGTGTTCATTGACATTGACCTCAGCAGCAGATTTCACTTGGATTCACTTAGGATCGC
AGGAATCAGGGGAAAGTGATTTTAAAGGTGGTTTCTCCAGCACATTTTAAGAAAAGGGACCAAA
AGTTATTTTAGCTTCCTCAATAGATTGCATGTTGCTTATTAGGATAAGAAATGAATATTAAATG
CAATATATGTCTTGTCTTTACTACGGCATCTGTTTAGGAGTTGTTCAGATCACTGCAGTAGGGC
TCTGCAAATAAATCATGTAACCTATTATCATGGATCTAATGTACTGTAACATTATCAGTGAACA
GGAAAAGCTCCAATAACAAGTACAAACATTGAACAATTACCTATGAAGATTTGTAAAAGTAAAG
TTTTTCCAATAGATTTCATTCTTGTCATTTTGTAAGACGACCCTGCAGTCCACCTGTTTGTAAC
TTTTTTAATAAAATAGATATCTGTATTATGGAAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001100420	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM10944	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003414
	ENSRNOP00000003414.6

RefSeq Acc Id:	NP_001100420 ⟸ NM_001106950
- UniProtKB:	D3ZK56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQF ASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMS SEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ hide sequence

Ensembl Acc Id:

ENSRNOP00000003414 ⟸ ENSRNOT00000003414

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZK56-F1-model_v2	AlphaFold	D3ZK56	1-183	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13702019

Promoter ID:

EPDNEW_R12542

Type:

initiation region

Name:

Rap2c_1

Description:

RAP2C, member of RAS oncogene family

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	138,237,193 - 138,237,253	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588562	AgrOrtholog
BioCyc Gene	G2FUF-1051	BioCyc
Ensembl Genes	ENSRNOG00000002529	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003414	ENTREZGENE
	ENSRNOT00000003414.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Rap2	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	Ras_small_GTPase	UniProtKB/TrEMBL
	Small_GTP-bd	UniProtKB/TrEMBL
KEGG Report	rno:302495	UniProtKB/TrEMBL
NCBI Gene	302495	ENTREZGENE
PANTHER	PTHR24070	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Rap2c	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002529	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	D3ZK56	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-09-17	Rap2c	RAP2C, member of RAS oncogene family	LOC302495	hypothetical LOC302495	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC302495	hypothetical LOC302495			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar