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Gene: Lin28a (lin-28 RNA binding posttranscriptional regulator A) Rattus norvegicus

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Symbol:

Lin28a

Name:

lin-28 RNA binding posttranscriptional regulator A (Ensembl:lin-28 homolog A)

RGD ID:

1566408

Description:

Predicted to enable RNA binding activity; protein-RNA adaptor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of intracellular signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; nucleolus; and rough endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human LIN28A (lin-28 RNA binding posttranscriptional regulator A); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

lin-28 homolog; lin-28 homolog (C. elegans); lin-28 homolog A; lin-28 homolog A (C. elegans); Lin28; LOC500562; LOC503116; RGD1566408; similar to lin-28 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

Lin28c

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,510,891 - 151,527,884 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	151,510,891 - 151,527,884 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,227,119 - 146,244,122 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,227,119 - 146,244,122 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	148,930,214 - 148,947,205 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,699,834 - 150,716,825 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,686,401 - 150,703,397 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	5	151,134,890 - 151,151,882 (-)	NCBI
Lyon_Normotensive	5	153,124,763 - 153,141,758 (-)	NCBI
Lyon_Hypertensive	5	152,299,783 - 152,316,776 (-)	NCBI
F344_StmMcwi	5	145,871,599 - 145,888,589 (-)	NCBI
Rnor_6.0	5	152,230,343 - 152,247,873 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,230,343 - 152,247,332 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	5	155,917,438 - 155,935,517 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	152,730,997 - 152,766,317 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	144,647,207 - 144,664,072 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

cervical cancer (ISO)

disease of cellular proliferation (ISO)

high grade glioma (ISO)

melanoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplastic Cell Transformation (ISO)

nephroblastoma (ISS)

ovarian serous cystadenocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-deoxy-D-glucose (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetic acid (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

carbamazepine (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

dioxygen (ISO)

folic acid (ISO)

FR900359 (ISO)

hexadecanoic acid (ISO)

imidacloprid (ISO)

lamotrigine (ISO)

LDN-193189 (ISO)

lead diacetate (EXP)

methimazole (EXP)

methylmercury chloride (ISO)

perfluorononanoic acid (ISO)

propiconazole (EXP)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

T-2 toxin (ISO)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (ISO)

vinclozolin (EXP)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to glucose stimulus (ISO)

germ cell development (ISO)

miRNA catabolic process (IEA,ISO)

miRNA metabolic process (ISO)

negative regulation of glial cell differentiation (ISO)

negative regulation of pre-miRNA processing (ISO)

negative regulation of translation (ISO)

positive regulation of cell proliferation involved in kidney development (ISO)

positive regulation of cytoplasmic translation (ISO)

positive regulation of neuron differentiation (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of TOR signaling (ISO)

positive regulation of translation (ISO)

post-transcriptional regulation of gene expression (IEA)

pre-miRNA processing (IEA,ISO)

regulation of miRNA-mediated gene silencing (IEA,ISO)

RNA 3'-end processing (ISO)

stem cell differentiation (ISO)

stem cell population maintenance (ISO)

Cellular Component

cytoplasm (ISO)

cytoplasmic stress granule (IEA,ISO)

cytosol (ISO)

nucleolus (IEA,ISO)

nucleus (ISO)

P-body (IEA,ISO)

rough endoplasmic reticulum (IEA,ISO)

Molecular Function

G-quadruplex RNA binding (ISO)

miRNA binding (ISO)

mRNA binding (ISO)

nucleic acid binding (IEA)

pre-miRNA binding (ISO)

protein-RNA adaptor activity (ISO)

RNA binding (ISO)

sequence-specific mRNA binding (ISO)

translation initiation factor binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12798299	PMID:17473174	PMID:17617744	PMID:18292307	PMID:18604195	PMID:18951094	PMID:19578360	PMID:19703396	PMID:19898466	PMID:20014101	PMID:20179095	PMID:21247876
PMID:21962509	PMID:23102813	PMID:24700281	PMID:24732380	PMID:26045559	PMID:28671666	PMID:32710472	PMID:33691905	PMID:33749722	PMID:36106579	PMID:37572229

Genomics

Comparative Map Data

Lin28a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,510,891 - 151,527,884 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	151,510,891 - 151,527,884 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,227,119 - 146,244,122 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,227,119 - 146,244,122 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	148,930,214 - 148,947,205 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,699,834 - 150,716,825 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,686,401 - 150,703,397 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	5	151,134,890 - 151,151,882 (-)	NCBI
Lyon_Normotensive	5	153,124,763 - 153,141,758 (-)	NCBI
Lyon_Hypertensive	5	152,299,783 - 152,316,776 (-)	NCBI
F344_StmMcwi	5	145,871,599 - 145,888,589 (-)	NCBI
Rnor_6.0	5	152,230,343 - 152,247,873 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,230,343 - 152,247,332 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	5	155,917,438 - 155,935,517 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	152,730,997 - 152,766,317 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	144,647,207 - 144,664,072 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

LIN28A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,410,817 - 26,429,728 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,410,788 - 26,429,728 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	1	26,737,308 - 26,756,219 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	26,609,856 - 26,628,806 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	26,421,410 - 26,440,350	NCBI
Celera	1	25,134,507 - 25,153,439 (+)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	24,991,870 - 25,010,565 (+)	NCBI		HuRef
CHM1_1	1	26,850,273 - 26,869,222 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	26,248,852 - 26,267,747 (+)	NCBI		T2T-CHM13v2.0

Lin28a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	133,730,641 - 133,746,504 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	133,730,641 - 133,746,173 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	134,003,330 - 134,019,196 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	134,003,330 - 134,018,841 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	4	133,559,245 - 133,574,731 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	133,275,406 - 133,290,892 (-)	NCBI		MGSCv36	mm8
Celera	4	132,180,714 - 132,196,406 (-)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI

Lin28a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	5,793,583 - 5,808,662 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955452	5,793,583 - 5,808,662 (+)	NCBI	ChiLan1.0	ChiLan1.0

LIN28A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	200,439,026 - 200,459,229 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,539,757 - 199,559,961 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	25,674,751 - 25,693,684 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	26,739,267 - 26,758,028 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	26,739,268 - 26,758,028 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

LIN28A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,638,438 - 73,656,841 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,614,531 - 73,628,211 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,614,531 - 73,628,211 (-)	NCBI		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	70,189,783 - 70,233,550 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	74,176,232 - 74,219,851 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	74,177,683 - 74,191,364 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	71,001,039 - 71,044,831 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	72,006,779 - 72,050,518 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	73,035,491 - 73,054,057 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lin28a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	11	17,833,739 - 17,849,584 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405058	45,071,230 - 45,087,075 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	10,896,153 - 10,909,247 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	10,896,153 - 10,909,247 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIN28A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	83,806,056 - 83,818,633 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	6	83,806,178 - 83,818,550 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	77,358,779 - 77,371,149 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LIN28A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	20	110,686,250 - 110,701,455 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666033	10,042,313 - 10,084,107 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	20	106,340,477 - 106,373,081 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	106,342,640 - 106,357,899 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Lin28a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624764	10,426,168 - 10,441,541 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
Naked mole-rat maternal Ensembl	7	23,850,228 - 23,864,028 (-)	Ensembl

Lin28a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	24,222,209 - 24,235,392 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Lin28a
152 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	169
Count of miRNA genes:	134
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000058500
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

BE113056

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	4	162,160,698 - 162,160,901	UniSTS	Rnor5.0
Rnor_5.0	4	161,779,204 - 161,779,407	UniSTS	Rnor5.0
RGSC_v3.4	4	95,842,110 - 95,842,313	UniSTS	RGSC3.4
Celera	5	144,647,246 - 144,647,450	UniSTS
Celera	4	90,141,672 - 90,141,875	UniSTS
Cytogenetic Map	5	q36	UniSTS

BE108055

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	146,212,439 - 146,212,602 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,215,667 - 152,215,829	NCBI	Rnor6.0
Rnor_5.0	5	155,900,595 - 155,900,757	UniSTS	Rnor5.0
RGSC_v3.4	5	172,196,590 - 172,196,752	UniSTS	RGSC3.4
RGSC_v3.4	5	152,732,724 - 152,732,886	UniSTS	RGSC3.4
Celera	5	144,632,531 - 144,632,693	UniSTS
RH 3.4 Map	5	980.0	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH137902

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	146,219,523 - 146,219,651 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,222,750 - 152,222,877	NCBI	Rnor6.0
Rnor_5.0	5	155,907,677 - 155,907,804	UniSTS	Rnor5.0
RGSC_v3.4	5	152,739,806 - 152,739,933	UniSTS	RGSC3.4
Celera	5	144,639,614 - 144,639,741	UniSTS
RH 3.4 Map	5	980.0	UniSTS
Cytogenetic Map	5	q36	UniSTS

AU049987

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	151,518,742 - 151,518,905 (+)	Marker Load Pipeline
mRatBN7.2	5	146,234,973 - 146,235,136 (-)	MAPPER	mRatBN7.2
mRatBN7.2	5	146,234,973 - 146,235,136 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,238,193 - 152,238,355	NCBI	Rnor6.0
Rnor_6.0	7	6,044,603 - 6,044,765	NCBI	Rnor6.0
Rnor_5.0	7	6,152,061 - 6,152,223	UniSTS	Rnor5.0
Rnor_5.0	5	155,926,355 - 155,926,517	UniSTS	Rnor5.0
RGSC_v3.4	5	152,756,504 - 152,756,666	UniSTS	RGSC3.4
Celera	5	144,654,933 - 144,655,095	UniSTS
Cytogenetic Map	5	q36	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
144	106	180	493	2391	436	648	115	299	309	287	58	2440	1187	386	2321	4	881	601	356	153	153

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077165 ⟹ ENSRNOP00000071200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	152,230,343 - 152,247,332 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100729 ⟹ ENSRNOP00000085321

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	146,227,119 - 146,244,122 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000141154 ⟹ ENSRNOP00000108329

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	151,510,891 - 151,527,884 (-)	Ensembl

RefSeq Acc Id:

NM_001109269 ⟹ NP_001102739

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,510,891 - 151,527,884 (-)	NCBI
mRatBN7.2	5	146,227,119 - 146,244,122 (-)	NCBI
Dahl_SR_JrHsd	5	151,134,890 - 151,151,882 (-)	NCBI
Lyon_Normotensive	5	153,124,763 - 153,141,758 (-)	NCBI
Lyon_Hypertensive	5	152,299,783 - 152,316,776 (-)	NCBI
F344_StmMcwi	5	145,871,599 - 145,888,589 (-)	NCBI
Rnor_6.0	5	152,230,343 - 152,247,332 (-)	NCBI
Rnor_5.0	5	155,917,438 - 155,935,517 (-)	NCBI
RGSC_v3.4	5	152,730,997 - 152,766,317 (-)	RGD
Celera	5	144,647,207 - 144,664,072 (-)	RGD

Sequence:

show sequence

CCTTTGCCTCCGGACTTCTCTGGGGCCAGCAGCCGCCCGACCTGGGGCCCGGGGCCACGGGCTC
AGCCGACGACCATGGGCTCGGTGTCCAACCAGCAGTTTGCAGGTGGCTGCGCCAAGGCAGCGGA
GAAGGCGCCAGAAGAGGCGCCGGCTGACGCGGCCCGAGCGGCAGACGAGCCGCAGCTGCTGCAC
GGGGCCGGCATCTGTAAGTGGTTCAACGTGCGCATGGGGTTCGGCTTCCTGTCTATGACCGCCC
GTGCCGGGGTCGCGCTCGACCCCCCGGTGGACGTCTTTGTGCACCAGAGCAAGCTGCACATGGA
AGGTTTCCGAAGCCTCAAGGAGGGTGAGGCAGTGGAGTTCACCTTTAAGAAGTCTGCCAAGGGT
CTAGAGTCCATCCGCGTCACTGGCCCTGGTGGCGTGTTCTGTATTGGGAGTGAGCGACGGCCAA
AGGGGAAGAGCATGCAGAAACGAAGATCCAAAGGAGACAGGTGCTACAACTGTGGTGGGCTAGA
CCACCATGCCAAGGAATGCAAGCTGCCACCCCAGCCCAAGAAGTGCCACTTTTGCCAAAGCATC
AGCCATATGGTGGCCTCATGTCCACTGAAGGCCCAGCAGGGCCCCAGTTCTCAGGGAAAACCTG
TCTACTTCCGGGAGGAGGAAGAAGAGATCCACAGCCCTACCCTGCTCCCAGAAGCCCAGAATTG
AGGCCCAGGAGTAGGGGTTATTCTTTGGCTAATGGGGAGTTTCAGGGAGGAGGCATCAATCCGC
AGAGTGGAGAAAGTGGGAATCGGGTGGGTTGCGTGGGTAGCTTGCACTGTCATATGACATCTCA
GGCCGGGGTTCCCAGTGTCACCCTGTCTTTCCTTGGAGGGAAGGAAAGGGTGAGGCAAAGGAAC
TCCTACCACGCTCCATCTAGAAGCAAGTGAAAGCTTTTGTGGGGAACCACCCTAGAATCTGCAT
GCTTTATCTGAGGCTCTAATGGGCTCTGCTGAGTGGCTGTTACAGGGGAGAAGCCCTTCTGTAG
AAGGCTGTGTGACAGTTCCCTTGCTAGACAGGATGTGAAACAAGTGTCAAACCAAGATTAATGA
ACCTAACCCTCCAGCTTCTATGTTCTGTAGAAGAGACTCTCAGGTTATTTCCACAGGGCGCTTC
CTCATAACCCAGTCCTGCCATGCTGTGCTGGGAAGAGTCCCTAGCAACGGGTTGTGATCACAGG
CAAAGAGGGTGGTTGGGGGGACAACTGCAGACCTGCTGCTCCCACCTCACTCCCAGCCCTTTCT
GGGCCAATGGGATTTTAATTTATTTGCTCCCTTGGGTAACTGCACCTTGGGTCCCACTTTCTCC
AGGATGCCAACTGCACTATCTATGTGCGAATGACGTATCTTGTGCGTTTTTTTTTCCTTAATAT
AAATATTGGGTTTGTATTTTTGTATATTTTAATCTTAAGGCCCTCATTCCTGCACTGTGTTCTC
AGGTACATGAGCAATCTCAGGGATAAGTCCGTAGCAGCTCCAGGTCTGCACAGCAGGAATACTT
AACTTTGTTTTGATCACCATGGAGACCAACCATTTGGAGTGCACAGCCTGTTGAACTACCTCAT
TTTTGCCGATTACAGCTGCCTTTTCTGCCATAGCGTCCTTGAAAAATGTCTCACAGGTTTTGAT
TGAGCTGCCCCGAGACTTGATCTGGTTTTGGCAAAACATAGGAAATCAGTCTAAACCGGAAAGG
GTGGTACAGAGACATTAAAAAGCCGGGCCAGGGATTGGGGATTTAGCTCAGTGGTAGAGCGCTT
GCCTAGGAAGCGCAAGGCCCTGGGTTAGGTCCCCAGCTCTGGAAAAAAAAGAACCAAAAAAAAA
AAAAAAAAAAAAAAAAGCTGGGCCAGTGAAAGGCGCAAGAGTAACTTTCCATACCAAATTCATC
CTTTTGCCAGATTAATCTAAGCCTGCCATGCACAGCAGGGTGTGTTTGTGTGTGTGTATGTTGA
TTTTTTTTCAATGCAAATTTATGAGGAAGAGGTGTTTTTTTATTGTTTGATTGCTTTTTTTATA
CTGGGGATTGAACCATGGGCTTCATTTATGCTAGGAAGTACCCTGCCACTGAGTTATCCTGGTA
AGGATGCAATTTAAGACCAATATCTTATTCCCACATTGTGCTGTCCAGGTATGGGAACATGAGG
CAAGGACTCAAATCCTTAGCCTTTCACAATCTTGGCTTCCAGAGAGACTCAACGAGTGTGGGCC
TCTGTGGCAAGTGTCCTGCCCTGCTGTAGTGTGATGGTTGATAGCTAACGAGGGGGGGGGGGTA
AAGTTTCGTTTACGTACTTAGAGATCACCACAAACCTACCTCACTGTGTTGAAACGGGACAAAT
GCAATAGAACACATTGGGAGGTGTGTGTGTGTCTGATCCTGGTTTCTTGTTTCCCCCAAATGCT
GCCCCCACCCCTAGTTAATTGTATTCGTCTGGCCTTTGTAGGACTTTACTGTCTGAGTTGGTGA
CTGCTAGGTGGTCTAGTTGTGTAAATATAAATGTGTTGGTCTTCATGTTCTTTTGGGGTTTTAT
TGTTTACAAAACTTTTGTCGTATTGAGAGAAAAATAGGCAAAGCATCTTTGACAGAAAGTTCTG
CACCAGACTACACCATCTGAAACCGAAATGTGGGGTCCTCTTCCCAAAGTGAGCATCTGGGAAC
CAATGGCTTTCCCTCCTGTGATCCTTCTGTCTCCCACTCTGGACCACAATGACCTTACAACCAG
CCCCTCTTCTCCCTCATAAGAAAACTCAGGCTCAGTTACTTCTTTGAGCTTCTCTACAGCTTTT
GAAAGACCTATGTAAAAGTTCTGAAGAAGCCATGAACTTCATACTCTCTCCCCCTTGTTCCCTA
ACTCAGTGAGGAGTTTTGGTTGGTGCTTTTGAGACCGGGTCTCAGGTTCCTGGCTATCCTCCGG
CCTCAGACTCCTCTGTGCAGGGACTGCAGGTGAGCCCCTTCTCCCTGGCAAGACCATTTCATGG
TGTGATTTACCTTTGGACAGATCCAACCAACGTAATCTGTCACCCTTAGGTAGAGAGAAGCAGT
TGTGGGGCCTTCCATGTAGAAGGTGGAATTCAAAGTTCAGGAAGGGACTATGAATGTACGTAAA
GTTGAGACACTCAGGAACTTAATGCCGGTGCAAGAAACTTATGTCAAAGTGGCCACAAGATTGT
TACTAGGAGACGGACGAATGTATCTCCATGTTTACTGCTAGAAACCAAAGCTTTGTGAGAAATC
TTGAATTTATGGGGAGGGTGGGAAAGTGTGTACTTGCCTGTCCTTTCCCTGATATCTTTCCTGA
ACTGCAGGAGACTAAGCCCCCTGGGGCTTTGGTGACCCCACCCCTGGGGTGTTTTATTTCATGG
TTGAGTTTTGCTGTCCCCGGGTACTTATATTCCTATCGTATAATCATTTTGTAACACATGCTGA
CTTTACCTTCCCTTCTCTTCCCTGGGAAAAATAAAGACTTATTGGTACTCCAAAATTGGTACTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102739	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80696	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000108329
	ENSRNOP00000108329.1

RefSeq Acc Id:

NP_001102739 ⟸ NM_001109269

- UniProtKB:

A0ABK0LT56 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSVSNQQFAGGCAKAAEKAPEEAPADAARAADEPQLLHGAGICKWFNVRMGFGFLSMTARAGV
ALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGSERRPKGKS
MQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQGPSSQGKPVYFR
EEEEEIHSPTLLPEAQN

hide sequence

Ensembl Acc Id:

ENSRNOP00000071200 ⟸ ENSRNOT00000077165

Ensembl Acc Id:

ENSRNOP00000085321 ⟸ ENSRNOT00000100729

Ensembl Acc Id:

ENSRNOP00000108329 ⟸ ENSRNOT00000141154

Protein Domains

CCHC-type CSD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZA6-F1-model_v2	AlphaFold	D3ZZA6	1-209	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566408	AgrOrtholog
BioCyc Gene	G2FUF-39601	BioCyc
Ensembl Genes	ENSRNOG00000060320	Ensembl
	ENSRNOG00000069459	Ensembl
	ENSRNOG00000082489	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000141154	ENTREZGENE
	ENSRNOT00000141154.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.140	UniProtKB/TrEMBL
	Zinc finger, CCHC-type	UniProtKB/TrEMBL
InterPro	Cold_shock_prot	UniProtKB/TrEMBL
	CSP_DNA-bd	UniProtKB/TrEMBL
	Lin-28_RNA-binding	UniProtKB/TrEMBL
	Lin-28A-like_Znf-CCHC_2	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	Znf_CCHC	UniProtKB/TrEMBL
	Znf_CCHC_sf	UniProtKB/TrEMBL
KEGG Report	rno:500562	UniProtKB/TrEMBL
NCBI Gene	500562	ENTREZGENE
PANTHER	PROTEIN LIN-28	UniProtKB/TrEMBL
	PROTEIN LIN-28 HOMOLOG A	UniProtKB/TrEMBL
Pfam	CSD	UniProtKB/TrEMBL
	Lin-28A-like_zf-CCHC_2	UniProtKB/TrEMBL
	zf-CCHC	UniProtKB/TrEMBL
PhenoGen	Lin28a	PhenoGen
PRINTS	COLDSHOCK	UniProtKB/TrEMBL
PROSITE	CSD_2	UniProtKB/TrEMBL
	ZF_CCHC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060320	RatGTEx
	ENSRNOG00000069459	RatGTEx
	ENSRNOG00000082489	RatGTEx
SMART	CSP	UniProtKB/TrEMBL
	ZnF_C2HC	UniProtKB/TrEMBL
Superfamily-SCOP	Nucleic_acid_OB	UniProtKB/TrEMBL
	SSF57756	UniProtKB/TrEMBL
UniProt	A0ABK0LT56	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Lin28a	lin-28 RNA binding posttranscriptional regulator A	Lin28a	lin-28 homolog A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2021-03-09	Lin28a	lin-28 homolog A	LOC503116	similar to lin-28 homolog	Data merged from RGD:1598183	737654	PROVISIONAL
2016-03-01	Lin28a	lin-28 homolog A	Lin28a	lin-28 homolog A (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Lin28a	lin-28 homolog A (C. elegans)	Lin28	lin-28 homolog (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Lin28	lin-28 homolog (C. elegans)	RGD1566408_predicted	similar to lin-28 homolog (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC503116	similar to lin-28 homolog			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1566408_predicted	similar to lin-28 homolog (predicted)	LOC500562	similar to lin-28 homolog	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500562	similar to lin-28 homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

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