Fah<sup>em10Dlli-/-</sup> (fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 10, Dlli) - Rat Genome Database

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Gene: Fahem10Dlli-/- (fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 10, Dlli) Rattus norvegicus
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Symbol: Fahem10Dlli-/-
Name: fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 10, Dlli
RGD ID: 14398829
Description: This mutation was produced by injecting Sprague Dawley embryo with CRISP/Case9 system targeting the exon 2 of rat Fah gene. The resulting mutation is a 10-bp deletion in exon 2 caused premature stop in the Fah protein.
ASSOCIATED WITH tyrosinemia type I
Type: allele  of Fah  
Previously known as: Fah^[em10Dlli-/-]
Is Marker For: Strains:   SD-Fahem10Dlli-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats. Shao Y, etal., J Biol Chem. 2018 May 4;293(18):6883-6892. doi: 10.1074/jbc.RA117.000347. Epub 2018 Mar 5.

Genomics


Related Rat Strains
The following Strains have been annotated to Fahem10Dlli-/-
SD-Fahem10Dlli-/-    


Expression


Sequence

Nucleotide Sequences


Additional Information