ATF6 (activating transcription factor 6) - Rat Genome Database

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Gene: ATF6 (activating transcription factor 6) Sus scrofa
Analyze
Symbol: ATF6
Name: activating transcription factor 6
RGD ID: 14265968
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of autophagy (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; ASSOCIATED WITH achromatopsia (ortholog); achromatopsia 7 (ortholog); asbestosis (ortholog); FOUND IN RNA polymerase II transcription regulator complex (ortholog); INTERACTS WITH 3-acetyldeoxynivalenol; 4-phenylbutyric acid; benzo[a]pyrene
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclic AMP-dependent transcription factor ATF-6 alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,591,288 - 88,805,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,591,279 - 88,806,156 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,614,364 - 96,821,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202   PMID:31539773  


Genomics

Comparative Map Data
ATF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,591,288 - 88,805,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,591,279 - 88,806,156 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,614,364 - 96,821,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,766,320 - 161,964,070 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,766,298 - 161,977,574 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,736,110 - 161,933,860 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,002,708 - 160,195,476 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,467,741 - 158,660,510NCBI
Celera1134,839,502 - 135,032,269 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,980,970 - 133,178,653 (+)NCBIHuRef
CHM1_11163,157,827 - 163,355,630 (+)NCBICHM1_1
T2T-CHM13v2.01161,110,648 - 161,308,347 (+)NCBIT2T-CHM13v2.0
Atf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,532,026 - 170,696,414 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,532,243 - 170,695,340 (-)EnsemblGRCm39 Ensembl
GRCm381170,704,457 - 170,868,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,704,674 - 170,867,771 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,634,588 - 172,797,902 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,541,132 - 172,710,564 (-)NCBIMGSCv36mm8
Celera1173,146,825 - 173,324,073 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map176.96NCBI
Atf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,460,312 - 85,639,959 (-)NCBIGRCr8
mRatBN7.21382,927,579 - 83,106,381 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1382,930,034 - 83,107,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,558,613 - 85,732,374 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01386,852,287 - 87,025,840 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,083,880 - 84,257,664 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,053,457 - 89,242,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,055,983 - 89,242,443 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,668,054 - 93,854,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,543,773 - 86,718,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11386,559,136 - 86,734,174 (-)NCBI
Celera1382,588,612 - 82,760,829 (-)NCBICelera
Cytogenetic Map13q24NCBI
Atf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,357,945 - 14,548,543 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,352,956 - 14,553,299 (-)NCBIChiLan1.0ChiLan1.0
ATF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2187,820,564 - 88,020,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,484,878 - 87,688,569 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,178,629 - 137,382,256 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,977,750 - 141,181,837 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,977,750 - 141,176,725 (+)Ensemblpanpan1.1panPan2
ATF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,705,167 - 20,903,852 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3820,709,038 - 20,903,814 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,758,598 - 20,956,710 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03820,788,925 - 20,987,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,788,924 - 20,987,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,761,253 - 20,959,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,114,892 - 21,313,427 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,406,602 - 21,593,774 (-)NCBIUU_Cfam_GSD_1.0
Atf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,651,241 - 7,833,831 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937131170,649 - 183,942 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,112,819 - 2,304,063 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,117,982 - 2,304,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,151,751 - 1,344,350 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624826190,131 - 412,197 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624826189,899 - 412,540 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATF6
4373 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006954   ⟹   ENSSSCP00000006765
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,592,588 - 88,797,757 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000043085   ⟹   ENSSSCP00000039015
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,591,280 - 88,805,250 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000052399   ⟹   ENSSSCP00000043666
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,593,206 - 88,806,129 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086014   ⟹   ENSSSCP00000062851
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,651,370 - 88,805,267 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088090   ⟹   ENSSSCP00000060683
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,591,288 - 88,805,304 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090069   ⟹   ENSSSCP00000071499
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl488,591,288 - 88,805,233 (-)Ensembl
RefSeq Acc Id: XM_021089510   ⟹   XP_020945169
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,591,279 - 88,805,427 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089512   ⟹   XP_020945171
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,591,279 - 88,805,428 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089513   ⟹   XP_020945172
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,592,396 - 88,805,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089514   ⟹   XP_020945173
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,591,279 - 88,805,425 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089515   ⟹   XP_020945174
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,591,279 - 88,806,156 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021089516   ⟹   XP_020945175
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1488,592,396 - 88,806,146 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020945174   ⟸   XM_021089515
- Peptide Label: isoform X5
- UniProtKB: A0A8D1FUL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945171   ⟸   XM_021089512
- Peptide Label: isoform X2
- UniProtKB: A0A8D1NCQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945169   ⟸   XM_021089510
- Peptide Label: isoform X1
- UniProtKB: A0A8D1NCQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945173   ⟸   XM_021089514
- Peptide Label: isoform X4
- UniProtKB: A0A8D1BBG0 (UniProtKB/TrEMBL),   A0A8D1J416 (UniProtKB/TrEMBL),   A0A8D1YMK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945175   ⟸   XM_021089516
- Peptide Label: isoform X6
- UniProtKB: A0A8D1BAD7 (UniProtKB/TrEMBL),   F1S1C8 (UniProtKB/TrEMBL),   A0A8D0QC08 (UniProtKB/TrEMBL),   A0A8D1YHH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945172   ⟸   XM_021089513
- Peptide Label: isoform X3
- UniProtKB: K9J4P5 (UniProtKB/TrEMBL),   A0A8D1PY36 (UniProtKB/TrEMBL),   A0A8D0JEG8 (UniProtKB/TrEMBL),   A0A8D0S9U5 (UniProtKB/TrEMBL),   A0A8D1J2T6 (UniProtKB/TrEMBL),   A0A8D1J416 (UniProtKB/TrEMBL),   A0A8D1YMK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060683   ⟸   ENSSSCT00000088090
RefSeq Acc Id: ENSSSCP00000071499   ⟸   ENSSSCT00000090069
RefSeq Acc Id: ENSSSCP00000006765   ⟸   ENSSSCT00000006954
RefSeq Acc Id: ENSSSCP00000043666   ⟸   ENSSSCT00000052399
RefSeq Acc Id: ENSSSCP00000062851   ⟸   ENSSSCT00000086014
RefSeq Acc Id: ENSSSCP00000039015   ⟸   ENSSSCT00000043085
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006346 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005023067 UniProtKB/TrEMBL
  ENSSSCG00015077602 UniProtKB/TrEMBL
  ENSSSCG00025049278 UniProtKB/TrEMBL
  ENSSSCG00035077181 UniProtKB/TrEMBL
  ENSSSCG00040068993 UniProtKB/TrEMBL
  ENSSSCG00045034737 UniProtKB/TrEMBL
  ENSSSCG00050061354 UniProtKB/TrEMBL
  ENSSSCG00055007602 UniProtKB/TrEMBL
  ENSSSCG00065036742 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006954 ENTREZGENE
  ENSSSCT00000006954.5 UniProtKB/TrEMBL
  ENSSSCT00000086014 ENTREZGENE
  ENSSSCT00000086014.1 UniProtKB/TrEMBL
  ENSSSCT00000088090 ENTREZGENE
  ENSSSCT00000088090.2 UniProtKB/TrEMBL
  ENSSSCT00000090069.2 UniProtKB/TrEMBL
  ENSSSCT00005036579.1 UniProtKB/TrEMBL
  ENSSSCT00015104844.1 UniProtKB/TrEMBL
  ENSSSCT00015104892.1 UniProtKB/TrEMBL
  ENSSSCT00015105004.1 UniProtKB/TrEMBL
  ENSSSCT00025067290.1 UniProtKB/TrEMBL
  ENSSSCT00025067534.1 UniProtKB/TrEMBL
  ENSSSCT00035105173.1 UniProtKB/TrEMBL
  ENSSSCT00035105221.1 UniProtKB/TrEMBL
  ENSSSCT00040094564.1 UniProtKB/TrEMBL
  ENSSSCT00045059678.1 UniProtKB/TrEMBL
  ENSSSCT00045059847.1 UniProtKB/TrEMBL
  ENSSSCT00045060001.1 UniProtKB/TrEMBL
  ENSSSCT00045060121.1 UniProtKB/TrEMBL
  ENSSSCT00050083606.1 UniProtKB/TrEMBL
  ENSSSCT00050083612.1 UniProtKB/TrEMBL
  ENSSSCT00055014844.1 UniProtKB/TrEMBL
  ENSSSCT00055014951.1 UniProtKB/TrEMBL
  ENSSSCT00065050105.1 UniProtKB/TrEMBL
  ENSSSCT00065050108.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
NCBI Gene ATF6 ENTREZGENE
PANTHER ATF6, ISOFORM C UniProtKB/TrEMBL
  PTHR46164:SF1 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt A0A5G2Q9P8_PIG UniProtKB/TrEMBL
  A0A5G2QXC7_PIG UniProtKB/TrEMBL
  A0A5G2R5A4_PIG UniProtKB/TrEMBL
  A0A8D0JEG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QC08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S9U5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BAD7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BBG0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1FUL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1J2T6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1J416 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1J6Q4_PIG UniProtKB/TrEMBL
  A0A8D1NCQ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PY36 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YHH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1YMK9 ENTREZGENE, UniProtKB/TrEMBL
  C8ZL57_PIG UniProtKB/TrEMBL
  F1S1C8 ENTREZGENE, UniProtKB/TrEMBL
  K9J4P5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85609 ENTREZGENE