PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1) - Rat Genome Database

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Gene: PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1) Sus scrofa
Analyze
Symbol: PAG1
Name: phosphoprotein membrane anchor with glycosphingolipid microdomains 1
RGD ID: 14265169
Description: ENCODES a protein that exhibits SH2 domain binding (inferred); INVOLVED IN intracellular signal transduction (inferred); negative regulation of T cell activation (inferred); regulation of T cell activation (inferred); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); schizophrenia (ortholog); FOUND IN membrane (inferred); membrane raft (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,506,069 - 55,616,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,450,824 - 55,619,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2460,465,088 - 60,627,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
membrane raft  (IBA,IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,506,069 - 55,616,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,450,824 - 55,619,226 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2460,465,088 - 60,627,627 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38880,967,810 - 81,112,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl880,967,810 - 81,112,068 (-)EnsemblGRCh38hg38GRCh38
GRCh37881,880,045 - 82,024,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,042,600 - 82,186,858 (-)NCBINCBI36Build 36hg18NCBI36
Celera877,885,010 - 78,029,263 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef877,369,813 - 77,514,038 (-)NCBIHuRef
CHM1_1881,932,291 - 82,076,435 (-)NCBICHM1_1
T2T-CHM13v2.0881,399,402 - 81,543,674 (-)NCBIT2T-CHM13v2.0
Pag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3939,752,539 - 9,898,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl39,752,539 - 9,898,739 (-)EnsemblGRCm39 Ensembl
GRCm3839,687,479 - 9,833,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl39,687,479 - 9,833,679 (-)EnsemblGRCm38mm10GRCm38
MGSCv3739,691,898 - 9,833,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3639,674,971 - 9,816,162 (-)NCBIMGSCv36mm8
Celera39,712,657 - 9,857,374 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.47NCBI
Pag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,842,747 - 93,984,314 (+)NCBIGRCr8
mRatBN7.2291,935,378 - 92,076,937 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl292,057,216 - 92,069,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx298,547,791 - 98,560,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,668,798 - 96,681,431 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,725,642 - 91,738,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0294,266,104 - 94,277,680 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl294,266,213 - 94,277,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02114,018,219 - 114,030,544 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera287,649,094 - 87,661,699 (+)NCBICelera
Cytogenetic Map2q23NCBI
Pag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444608,711 - 629,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955444487,028 - 636,440 (+)NCBIChiLan1.0ChiLan1.0
PAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2796,707,238 - 96,851,003 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1872,335,013 - 72,478,833 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0877,492,087 - 77,635,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1879,115,801 - 79,218,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,123,503 - 79,218,100 (-)Ensemblpanpan1.1panPan2
PAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12928,207,445 - 28,340,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2928,211,031 - 28,263,322 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2928,483,198 - 28,621,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02928,333,786 - 28,471,980 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2928,341,507 - 28,402,630 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12928,386,612 - 28,524,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02928,418,572 - 28,556,528 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02928,775,035 - 28,913,070 (-)NCBIUU_Cfam_GSD_1.0
Pag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,820,083 - 50,961,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366563,129,084 - 3,143,449 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366563,010,603 - 3,152,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,404,120 - 76,541,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl876,409,223 - 76,426,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603964,652,588 - 64,793,449 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474410,361,284 - 10,424,207 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474410,286,013 - 10,431,383 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PAG1
5024 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 4 2 5 1 3
Low 6 2 3 2 22 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000037521   ⟹   ENSSSCP00000049251
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl455,593,601 - 55,619,219 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048589   ⟹   ENSSSCP00000048300
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl455,506,069 - 55,616,111 (+)Ensembl
RefSeq Acc Id: XM_021089173   ⟹   XP_020944832
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1455,450,824 - 55,619,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089174   ⟹   XP_020944833
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1455,450,879 - 55,619,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089175   ⟹   XP_020944834
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1455,467,912 - 55,619,226 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020944832   ⟸   XM_021089173
- UniProtKB: A0A8D0IUL7 (UniProtKB/TrEMBL),   F1RXA1 (UniProtKB/TrEMBL),   A0A4X1UCH3 (UniProtKB/TrEMBL),   A0A8D0LK15 (UniProtKB/TrEMBL),   A0A8D0WXW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020944833   ⟸   XM_021089174
- UniProtKB: A0A8D0IUL7 (UniProtKB/TrEMBL),   F1RXA1 (UniProtKB/TrEMBL),   A0A4X1UCH3 (UniProtKB/TrEMBL),   A0A8D0LK15 (UniProtKB/TrEMBL),   A0A8D0WXW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020944834   ⟸   XM_021089175
- UniProtKB: A0A8D0IUL7 (UniProtKB/TrEMBL),   F1RXA1 (UniProtKB/TrEMBL),   A0A4X1UCH3 (UniProtKB/TrEMBL),   A0A8D0LK15 (UniProtKB/TrEMBL),   A0A8D0WXW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000048300   ⟸   ENSSSCT00000048589
RefSeq Acc Id: ENSSSCP00000049251   ⟸   ENSSSCT00000037521


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040208 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005016655 UniProtKB/TrEMBL
  ENSSSCG00025057502 UniProtKB/TrEMBL
  ENSSSCG00030042486 UniProtKB/TrEMBL
  ENSSSCG00035023024 UniProtKB/TrEMBL
  ENSSSCG00045007546 UniProtKB/TrEMBL
  ENSSSCG00050054251 UniProtKB/TrEMBL
  ENSSSCG00055009272 UniProtKB/TrEMBL
  ENSSSCG00060049306 UniProtKB/TrEMBL
  ENSSSCG00070016787 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048589 ENTREZGENE
  ENSSSCT00000048589.3 UniProtKB/TrEMBL
  ENSSSCT00005026164.1 UniProtKB/TrEMBL
  ENSSSCT00005026183.1 UniProtKB/TrEMBL
  ENSSSCT00005026188.1 UniProtKB/TrEMBL
  ENSSSCT00025078708.1 UniProtKB/TrEMBL
  ENSSSCT00030059183.1 UniProtKB/TrEMBL
  ENSSSCT00035030123.1 UniProtKB/TrEMBL
  ENSSSCT00045012618.1 UniProtKB/TrEMBL
  ENSSSCT00050073969.1 UniProtKB/TrEMBL
  ENSSSCT00055018105.1 UniProtKB/TrEMBL
  ENSSSCT00060066964.1 UniProtKB/TrEMBL
  ENSSSCT00070033085.1 UniProtKB/TrEMBL
  ENSSSCT00070033095.1 UniProtKB/TrEMBL
InterPro PAG UniProtKB/TrEMBL
NCBI Gene PAG1 ENTREZGENE
PANTHER PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1 UniProtKB/TrEMBL
  PTHR16322 UniProtKB/TrEMBL
Pfam PAG UniProtKB/TrEMBL
UniProt A0A4X1UCH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IUL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LK15 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0WXW4 ENTREZGENE
  F1RXA1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8D0WXW4 UniProtKB/TrEMBL
VGNC ID VGNC:91154 ENTREZGENE