RPIA (ribose 5-phosphate isomerase A) - Rat Genome Database

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Pathways
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Gene: RPIA (ribose 5-phosphate isomerase A) Sus scrofa
Analyze
Symbol: RPIA
Name: ribose 5-phosphate isomerase A
RGD ID: 14236429
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); monosaccharide binding (ortholog); ribose-5-phosphate isomerase activity (ortholog); INVOLVED IN pentose-phosphate shunt (ortholog); pentose-phosphate shunt, non-oxidative branch (ortholog); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - non-oxidative phase; ribose 5-phosphate isomerase deficiency pathway; ASSOCIATED WITH genetic disease (ortholog); Ribose 5-Phosphate Isomerase Deficiency (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: phosphoriboisomerase; ribose 5-phosphate isomerase-like protein; ribose-5-phosphate isomerase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,355,975 - 57,386,939 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,355,973 - 57,386,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,834,039 - 59,864,841 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RPIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,355,975 - 57,386,939 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,355,973 - 57,386,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,834,039 - 59,864,841 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,691,673 - 88,750,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,691,673 - 88,750,929 (+)EnsemblGRCh38hg38GRCh38
GRCh37288,991,191 - 89,050,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,772,291 - 88,831,567 (+)NCBINCBI36Build 36hg18NCBI36
Build 34288,830,465 - 88,889,707NCBI
Celera287,738,845 - 87,795,148 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,913,138 - 87,969,437 (+)NCBIHuRef
CHM1_1288,920,696 - 88,980,049 (+)NCBICHM1_1
T2T-CHM13v2.0288,703,670 - 88,759,952 (+)NCBIT2T-CHM13v2.0
Rpia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39670,742,704 - 70,769,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl670,742,704 - 70,769,216 (-)EnsemblGRCm39 Ensembl
GRCm38670,765,720 - 70,792,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl670,765,720 - 70,792,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv37670,715,714 - 70,742,169 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36670,695,280 - 70,721,734 (-)NCBIMGSCv36mm8
Celera672,851,114 - 72,877,569 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.06NCBI
Rpia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,282,081 - 104,307,732 (-)NCBIGRCr8
mRatBN7.24102,723,712 - 102,749,374 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4102,723,712 - 102,749,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,114,413 - 108,140,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04103,889,488 - 103,915,156 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,493,631 - 102,519,248 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,568,028 - 98,593,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,568,028 - 98,593,664 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,347,716 - 163,373,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44103,934,938 - 103,960,574 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,179,418 - 104,205,030 (-)NCBI
Celera491,899,774 - 91,925,410 (-)NCBICelera
Cytogenetic Map4q32NCBI
Rpia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424106,978 - 135,612 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955424107,297 - 135,577 (-)NCBIChiLan1.0ChiLan1.0
RPIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21238,555,220 - 38,624,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A38,557,979 - 38,617,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,823,741 - 87,880,061 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,731,335 - 89,787,512 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,731,335 - 89,787,512 (+)Ensemblpanpan1.1panPan2
RPIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,640,740 - 37,671,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,491,846 - 37,522,341 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,539,274 - 38,569,568 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,539,842 - 38,569,664 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,705,845 - 37,736,309 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,742,287 - 37,772,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,091,779 - 38,122,295 (-)NCBIUU_Cfam_GSD_1.0
Rpia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629278,496,444 - 78,523,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367122,334,744 - 2,362,036 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367122,335,255 - 2,362,004 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,015,873 - 18,071,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,016,740 - 18,071,013 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,707,353 - 1,762,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474915,780,539 - 15,810,752 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474915,783,289 - 15,810,795 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RPIA
847 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 4 5 2 1 3
Low 1 3 23 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008988   ⟹   ENSSSCP00000008762
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl357,355,975 - 57,386,939 (-)Ensembl
RefSeq Acc Id: NM_001097495   ⟹   NP_001090964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1357,356,552 - 57,386,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021085537   ⟹   XP_020941196
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1357,355,973 - 57,386,948 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021085538   ⟹   XP_020941197
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1357,355,973 - 57,385,400 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020941196   ⟸   XM_021085537
- Peptide Label: isoform X1
- UniProtKB: A0A8D0VA97 (UniProtKB/TrEMBL),   F1STC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941197   ⟸   XM_021085538
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001090964   ⟸   NM_001097495
- UniProtKB: A2TLM1 (UniProtKB/Swiss-Prot),   A0A8D0VA97 (UniProtKB/TrEMBL),   F1STC1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000008762   ⟸   ENSSSCT00000008988


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008207 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015057476 UniProtKB/TrEMBL
  ENSSSCG00030004847 UniProtKB/TrEMBL
  ENSSSCG00040029129 UniProtKB/TrEMBL
  ENSSSCG00050077269 UniProtKB/TrEMBL
  ENSSSCG00060035263 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008988 ENTREZGENE
  ENSSSCT00000008988.6 UniProtKB/TrEMBL
  ENSSSCT00015076743.1 UniProtKB/TrEMBL
  ENSSSCT00030006529.1 UniProtKB/TrEMBL
  ENSSSCT00040039161.1 UniProtKB/TrEMBL
  ENSSSCT00050106345.1 UniProtKB/TrEMBL
  ENSSSCT00060047811.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribose5P_isomerase_typA UniProtKB/Swiss-Prot
  Ribose5P_isomerase_typA_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribose5P_isomerase_type_A UniProtKB/TrEMBL
KEGG Report ssc:100038014 UniProtKB/Swiss-Prot
NCBI Gene RPIA ENTREZGENE
PANTHER PTHR11934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSE-5-PHOSPHATE ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rib_5-P_isom_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP D-ribose-5-phosphate isomerase (RpiA), lid domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8D0VA97 ENTREZGENE, UniProtKB/TrEMBL
  A2TLM1 ENTREZGENE
  F1STC1 ENTREZGENE, UniProtKB/TrEMBL
  RPIA_PIG UniProtKB/Swiss-Prot
VGNC ID VGNC:109408 ENTREZGENE