HAAO (3-hydroxyanthranilate 3,4-dioxygenase) - Rat Genome Database

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Gene: HAAO (3-hydroxyanthranilate 3,4-dioxygenase) Sus scrofa
Analyze
Symbol: HAAO
Name: 3-hydroxyanthranilate 3,4-dioxygenase
RGD ID: 14232263
Description: ENCODES a protein that exhibits 3-hydroxyanthranilate 3,4-dioxygenase activity (ortholog); iron ion binding (ortholog); oxygen binding (ortholog); INVOLVED IN quinolinate metabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH atherosclerosis (ortholog); genetic disease (ortholog); Huntington's disease (ortholog); FOUND IN mitochondrial membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl397,580,851 - 97,595,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1397,580,756 - 97,595,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HAAO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl397,580,851 - 97,595,021 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1397,580,756 - 97,595,033 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAAO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38242,767,089 - 42,792,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl242,767,089 - 42,792,593 (-)EnsemblGRCh38hg38GRCh38
GRCh37242,994,229 - 43,019,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,847,734 - 42,873,219 (-)NCBINCBI36Build 36hg18NCBI36
Build 34242,905,880 - 42,931,366NCBI
Celera242,833,485 - 42,858,995 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef242,728,505 - 42,754,300 (-)NCBIHuRef
CHM1_1242,923,585 - 42,949,123 (-)NCBICHM1_1
T2T-CHM13v2.0242,772,378 - 42,797,833 (-)NCBIT2T-CHM13v2.0
Haao
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391784,138,777 - 84,157,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1784,138,585 - 84,155,392 (-)EnsemblGRCm39 Ensembl
GRCm381783,831,348 - 83,848,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1783,831,156 - 83,847,963 (-)EnsemblGRCm38mm10GRCm38
MGSCv371784,230,694 - 84,246,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361783,739,421 - 83,756,289 (-)NCBIMGSCv36mm8
Celera1788,186,650 - 88,204,249 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1754.85NCBI
Haao
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8616,598,325 - 16,617,590 (+)NCBIGRCr8
mRatBN7.2610,845,235 - 10,864,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl610,845,771 - 10,864,877 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx611,140,636 - 11,153,719 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0611,449,968 - 11,463,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0610,962,770 - 10,975,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.067,045,145 - 7,059,227 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,045,152 - 7,058,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.066,994,168 - 7,008,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.467,197,352 - 7,210,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.167,197,351 - 7,210,456 (-)NCBI
Celera610,553,178 - 10,565,875 (+)NCBICelera
Cytogenetic Map6q12NCBI
Haao
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,110,380 - 10,129,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544110,114,863 - 10,128,948 (-)NCBIChiLan1.0ChiLan1.0
HAAO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21283,605,885 - 83,652,485 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A83,606,853 - 83,657,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A42,857,216 - 42,882,738 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A43,704,468 - 43,729,886 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A43,704,468 - 43,729,887 (-)Ensemblpanpan1.1panPan2
HAAO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11045,368,157 - 45,379,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1045,368,178 - 45,379,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1045,234,849 - 45,243,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01046,244,310 - 46,257,893 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11045,953,712 - 45,967,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01046,242,070 - 46,255,650 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01046,426,251 - 46,439,827 (-)NCBIUU_Cfam_GSD_1.0
Haao
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629237,521,284 - 37,557,728 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365088,971,477 - 8,986,404 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365088,971,516 - 8,987,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAAO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11464,460,553 - 64,485,731 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1464,460,703 - 64,485,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604547,421,217 - 47,446,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Haao
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473824,407,551 - 24,421,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473824,409,531 - 24,421,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HAAO
303 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 1
Low 6 2 3 5 15 2 3
Below cutoff 1 2 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000060035   ⟹   ENSSSCP00000032423
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl397,580,851 - 97,595,021 (+)Ensembl
RefSeq Acc Id: NM_001244941   ⟹   NP_001231870
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1397,580,853 - 97,595,033 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021085670   ⟹   XP_020941329
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1397,580,756 - 97,595,033 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020941329   ⟸   XM_021085670
- Peptide Label: isoform X1
- UniProtKB: A0A8D0IQT3 (UniProtKB/TrEMBL),   A0A8D1HYN4 (UniProtKB/TrEMBL),   A0A286ZLU2 (UniProtKB/TrEMBL),   A0A8D0INK0 (UniProtKB/TrEMBL),   A0A8D1V2I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231870   ⟸   NM_001244941
- UniProtKB: A0A8D0IQT3 (UniProtKB/TrEMBL),   A0A8D0INK0 (UniProtKB/TrEMBL),   A0A8D1V2I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032423   ⟸   ENSSSCT00000060035


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005013028 UniProtKB/TrEMBL
  ENSSSCG00015076736 UniProtKB/TrEMBL
  ENSSSCG00025025073 UniProtKB/TrEMBL
  ENSSSCG00030030667 UniProtKB/TrEMBL
  ENSSSCG00035052230 UniProtKB/TrEMBL
  ENSSSCG00040009493 UniProtKB/TrEMBL
  ENSSSCG00045022539 UniProtKB/TrEMBL
  ENSSSCG00050024921 UniProtKB/TrEMBL
  ENSSSCG00060030395 UniProtKB/TrEMBL
  ENSSSCG00065047572 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060035 ENTREZGENE
  ENSSSCT00000060035.2 UniProtKB/TrEMBL
  ENSSSCT00005020527.1 UniProtKB/TrEMBL
  ENSSSCT00005020567.1 UniProtKB/TrEMBL
  ENSSSCT00015103586.1 UniProtKB/TrEMBL
  ENSSSCT00015103639.1 UniProtKB/TrEMBL
  ENSSSCT00025033849.1 UniProtKB/TrEMBL
  ENSSSCT00025033980.1 UniProtKB/TrEMBL
  ENSSSCT00030042563.1 UniProtKB/TrEMBL
  ENSSSCT00035069602.1 UniProtKB/TrEMBL
  ENSSSCT00035069612.1 UniProtKB/TrEMBL
  ENSSSCT00035069617.1 UniProtKB/TrEMBL
  ENSSSCT00040012283.1 UniProtKB/TrEMBL
  ENSSSCT00040012310.1 UniProtKB/TrEMBL
  ENSSSCT00045038466.1 UniProtKB/TrEMBL
  ENSSSCT00045038541.1 UniProtKB/TrEMBL
  ENSSSCT00050033530.1 UniProtKB/TrEMBL
  ENSSSCT00050033545.1 UniProtKB/TrEMBL
  ENSSSCT00060041064.1 UniProtKB/TrEMBL
  ENSSSCT00060041075.1 UniProtKB/TrEMBL
  ENSSSCT00065065083.1 UniProtKB/TrEMBL
  ENSSSCT00065065092.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
InterPro 3hydroanth_dOase UniProtKB/TrEMBL
  3hydroanth_dOase_met UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/TrEMBL
NCBI Gene HAAO ENTREZGENE
PANTHER 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE UniProtKB/TrEMBL
  PTHR15497 UniProtKB/TrEMBL
Pfam 3-HAO UniProtKB/TrEMBL
PIRSF 3hydroanth_dOase_animal UniProtKB/TrEMBL
Superfamily-SCOP SSF51182 UniProtKB/TrEMBL
UniProt A0A286ZLU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480ZZ23_PIG UniProtKB/TrEMBL
  A0A481BC34_PIG UniProtKB/TrEMBL
  A0A8D0INK0 ENTREZGENE
  A0A8D0IQT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Q8M3_PIG UniProtKB/TrEMBL
  A0A8D1A3R6_PIG UniProtKB/TrEMBL
  A0A8D1HYN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TAU2_PIG UniProtKB/TrEMBL
  A0A8D1V1E4_PIG UniProtKB/TrEMBL
  A0A8D1V2I9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8D0INK0 UniProtKB/TrEMBL
VGNC ID VGNC:88765 ENTREZGENE