KCNK4 (potassium two pore domain channel subfamily K member 4) - Rat Genome Database

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Gene: KCNK4 (potassium two pore domain channel subfamily K member 4) Sus scrofa
Analyze
Symbol: KCNK4
Name: potassium two pore domain channel subfamily K member 4
RGD ID: 14188426
Description: ENCODES a protein that exhibits identical protein binding (ortholog); potassium channel activity (ortholog); temperature-gated cation channel activity (ortholog); INVOLVED IN cellular response to alkaline pH (ortholog); cellular response to temperature stimulus (ortholog); detection of mechanical stimulus involved in sensory perception of touch (ortholog); ASSOCIATED WITH epilepsy (ortholog); Facial Dysmorphism, Hypertrichosis, Epilepsy, Intellectual/Developmental Delay, and Gingival Overgrowth Syndrome (ortholog); high grade glioma (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); potassium channel complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel subfamily K member 4; potassium channel, subfamily K, member 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,817,342 - 7,823,927 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,817,062 - 7,824,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,883,684 - 6,892,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,817,342 - 7,823,927 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,817,062 - 7,824,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,883,684 - 6,892,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,291,302 - 64,300,031 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,291,302 - 64,300,031 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,058,774 - 64,067,503 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,815,369 - 63,824,079 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,816,706 - 63,824,053NCBI
Celera1161,385,692 - 61,394,405 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,386,517 - 60,395,232 (+)NCBIHuRef
CHM1_11163,941,791 - 63,950,504 (+)NCBICHM1_1
T2T-CHM13v2.01164,281,266 - 64,289,999 (+)NCBIT2T-CHM13v2.0
Kcnk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,903,030 - 6,912,261 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,901,334 - 6,911,883 (-)EnsemblGRCm39 Ensembl
GRCm38196,925,662 - 6,934,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,923,966 - 6,934,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,000,180 - 7,009,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36196,992,734 - 7,001,559 (-)NCBIMGSCv36mm8
Celera196,702,625 - 6,711,599 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.08NCBI
Kcnk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,547,577 - 213,558,706 (-)NCBIGRCr8
mRatBN7.21204,117,941 - 204,129,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,114,572 - 204,125,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,468,837 - 212,475,145 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,563,911 - 219,570,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,254,963 - 212,261,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,182,997 - 222,192,139 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,183,276 - 222,189,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,173,229 - 229,182,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,602,228 - 209,608,521 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,760,657 - 209,766,951 (-)NCBI
Celera1201,652,646 - 201,658,974 (-)NCBICelera
Cytogenetic Map1q43NCBI
Kcnk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,780,765 - 20,788,836 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,780,765 - 20,788,988 (-)NCBIChiLan1.0ChiLan1.0
KCNK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,518,153 - 65,527,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,563,313 - 66,572,274 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,648,374 - 59,657,083 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,994,158 - 63,001,342 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,994,544 - 63,001,229 (+)Ensemblpanpan1.1panPan2
KCNK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,767,151 - 52,775,053 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,767,414 - 52,773,369 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,373,981 - 51,382,488 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,812,317 - 53,820,826 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,812,440 - 53,820,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,914,667 - 52,923,062 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,490,731 - 52,499,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,274,639 - 53,283,144 (-)NCBIUU_Cfam_GSD_1.0
Kcnk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,468,434 - 8,476,795 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,910,723 - 4,918,229 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,910,783 - 4,917,355 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,934,174 - 9,942,815 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,934,597 - 9,941,609 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,274,409 - 107,284,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,011,187 - 22,019,370 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,011,745 - 22,020,980 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNK4
158 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium
Low 1 18
Below cutoff 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014244   ⟹   ENSSSCP00000013858
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl27,817,342 - 7,823,927 (-)Ensembl
RefSeq Acc Id: XM_013994155   ⟹   XP_013849609
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.127,817,062 - 7,824,390 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013849609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000013858
  ENSSSCP00000013858.4
  ENSSSCP00070039566.1
Reference Protein Sequences
RefSeq Acc Id: XP_013849609   ⟸   XM_013994155
- UniProtKB: A0A4X1VD02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000013858   ⟸   ENSSSCT00000014244
Protein Domains
Potassium channel


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013031 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023529 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014244 ENTREZGENE
  ENSSSCT00000014244.4 UniProtKB/TrEMBL
  ENSSSCT00070046900.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TRAAK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
KEGG Report ssc:100524785 UniProtKB/TrEMBL
NCBI Gene KCNK4 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TRAAKCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A4X1VD02 ENTREZGENE, UniProtKB/TrEMBL
  F1RQN9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89371 ENTREZGENE