MIR29A (microRNA mir-29a) - Rat Genome Database

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Gene: MIR29A (microRNA mir-29a) Sus scrofa
Analyze
Symbol: MIR29A (Ensembl: ssc-mir-29a)
Name: microRNA mir-29a (Ensembl:ssc-mir-29a)
RGD ID: 14181314
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 29a; ssc-mir-29a
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,040,032 - 18,040,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,040,032 - 18,040,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,035,225 - 19,035,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
epigenetic regulation of gene expression  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of circulating fibrinogen levels  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
sensory perception of sound  (ISO)
tissue remodeling  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:19917043   PMID:20180025   PMID:21312241   PMID:24499489   PMID:25230983   PMID:25934266   PMID:28280141  


Genomics

Comparative Map Data
MIR29A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,040,032 - 18,040,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,040,032 - 18,040,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,035,225 - 19,035,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIR29A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,876,747 - 130,876,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,876,747 - 130,876,810 (-)EnsemblGRCh38hg38GRCh38
GRCh377130,561,506 - 130,561,569 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367130,212,045 - 130,212,108 (-)NCBINCBI36Build 36hg18NCBI36
Celera7125,312,587 - 125,312,650 (-)NCBICelera
Cytogenetic Map7q32.3NCBI
HuRef7124,876,998 - 124,877,061 (-)NCBIHuRef
CHM1_17130,495,162 - 130,495,225 (-)NCBICHM1_1
T2T-CHM13v2.07132,194,239 - 132,194,302 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,901,214 - 129,901,277 (-)NCBI
Mir29a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39631,039,595 - 31,039,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl631,039,595 - 31,039,682 (-)EnsemblGRCm39 Ensembl
GRCm38631,062,660 - 31,062,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl631,062,660 - 31,062,747 (-)EnsemblGRCm38mm10GRCm38
MGSCv37631,012,660 - 31,012,747 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera631,048,423 - 31,048,510 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.55NCBI
Mir29a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,617,955 - 60,618,042 (-)NCBIGRCr8
mRatBN7.2459,650,608 - 59,650,695 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx464,621,101 - 64,621,188 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,537,282 - 60,537,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,939,224 - 58,939,311 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,343,931 - 58,344,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0458,099,674 - 58,099,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera454,744,230 - 54,744,317 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR29A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,184,844 - 6,184,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,184,830 - 6,184,916 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,845,114 - 5,845,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0145,919,035 - 5,919,094 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1146,124,590 - 6,124,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,869,856 - 5,869,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,013,045 - 6,013,104 (+)NCBIUU_Cfam_GSD_1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 4 2 7
Low 5 2 1 4 2 16 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000020436
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1818,040,032 - 18,040,118 (+)Ensembl
RefSeq Acc Id: NR_038524
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11818,040,032 - 18,040,117 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000018841 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000020436 ENTREZGENE
miRBase MI0013090 ENTREZGENE
NCBI Gene MIR29A ENTREZGENE
RNAcentral URS0000076995 RNACentral
  URS00005ABB2B RNACentral
  URS000075F04A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR29A  microRNA mir-29a    microRNA 29a  Symbol and/or name change 5135510 APPROVED