ASXL3 (ASXL transcriptional regulator 3) - Rat Genome Database

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Gene: ASXL3 (ASXL transcriptional regulator 3) Sus scrofa
Analyze
Symbol: ASXL3
Name: ASXL transcriptional regulator 3
RGD ID: 14153194
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); metal ion binding (inferred); INVOLVED IN animal organ morphogenesis (inferred); negative regulation of lipid biosynthetic process (inferred); positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); Bainbridge-Ropers syndrome (ortholog); Developmental Disabilities (ortholog); FOUND IN nucleus (inferred); PR-DUB complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: additional sex combs like 3, transcriptional regulator; putative Polycomb group protein ASXL3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6117,334,259 - 117,518,026 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16117,334,177 - 117,518,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26109,712,269 - 109,871,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)
PR-DUB complex  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ASXL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6117,334,259 - 117,518,026 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16117,334,177 - 117,518,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26109,712,269 - 109,871,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASXL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381833,578,219 - 33,751,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1833,578,219 - 33,751,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371831,158,183 - 31,331,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361829,412,539 - 29,581,397 (+)NCBINCBI36Build 36hg18NCBI36
Build 341829,573,152 - 29,581,375NCBI
Celera1827,966,488 - 28,135,348 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1828,018,302 - 28,187,028 (+)NCBIHuRef
CHM1_11831,085,980 - 31,254,835 (+)NCBICHM1_1
T2T-CHM13v2.01833,769,917 - 33,942,920 (+)NCBIT2T-CHM13v2.0
Asxl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391822,477,195 - 22,663,284 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1822,477,303 - 22,663,072 (+)EnsemblGRCm39 Ensembl
GRCm381822,344,077 - 22,530,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1822,344,246 - 22,530,227 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1822,344,883 - 22,530,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371822,503,590 - 22,688,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361822,565,437 - 22,690,209 (+)NCBIMGSCv36mm8
Celera1822,845,226 - 23,023,574 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.96NCBI
Asxl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81813,868,223 - 14,040,867 (+)NCBIGRCr8
mRatBN7.21813,593,529 - 13,766,324 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1813,593,985 - 13,762,427 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01813,322,148 - 13,496,230 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1813,386,133 - 13,491,735 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01813,136,962 - 13,279,378 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41813,969,647 - 14,135,093 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11814,059,261 - 14,161,739 (+)NCBI
Celera1813,635,353 - 13,744,963 (+)NCBICelera
Cytogenetic Map18p12NCBI
Asxl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540220,605,804 - 20,702,054 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540220,571,209 - 20,704,480 (+)NCBIChiLan1.0ChiLan1.0
ASXL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21750,950,630 - 51,123,663 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11836,643,227 - 36,816,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01826,781,382 - 26,953,935 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11830,403,023 - 30,546,237 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1830,403,018 - 30,541,651 (+)Ensemblpanpan1.1panPan2
ASXL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1756,093,897 - 56,251,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl756,097,970 - 56,263,622 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha755,526,349 - 55,713,951 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0756,062,998 - 56,250,637 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl756,064,710 - 56,251,111 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1755,749,141 - 55,936,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0755,770,762 - 55,958,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0756,066,744 - 56,254,382 (-)NCBIUU_Cfam_GSD_1.0
Asxl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494451,735,881 - 51,838,556 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651711,064,987 - 11,165,956 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651711,064,986 - 11,074,992 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASXL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11846,988,038 - 47,160,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605021,511,623 - 21,680,068 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asxl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247798,144,474 - 8,271,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247798,099,434 - 8,270,812 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ASXL3
3429 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High
Medium
Low 3 3 3 1 23 2 3
Below cutoff 4 1 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004136   ⟹   ENSSSCP00000004043
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6117,334,259 - 117,518,026 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000105106   ⟹   ENSSSCP00000079013
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6117,334,259 - 117,518,026 (+)Ensembl
RefSeq Acc Id: XM_021096220   ⟹   XP_020951879
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16117,334,177 - 117,518,589 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020951879   ⟸   XM_021096220
- UniProtKB: A0A8D2CJ36 (UniProtKB/TrEMBL),   F1SAK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000004043   ⟸   ENSSSCT00000004136
RefSeq Acc Id: ENSSSCP00000079013   ⟸   ENSSSCT00000105106
Protein Domains
DEUBAD   HTH HARE-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015068733 UniProtKB/TrEMBL
  ENSSSCG00045005468 UniProtKB/TrEMBL
  ENSSSCG00055024048 UniProtKB/TrEMBL
  ENSSSCG00065078015 UniProtKB/TrEMBL
  ENSSSCG00070024452 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004136 ENTREZGENE
  ENSSSCT00000004136.5 UniProtKB/TrEMBL
  ENSSSCT00000105106.1 UniProtKB/TrEMBL
  ENSSSCT00015092037.1 UniProtKB/TrEMBL
  ENSSSCT00045009078.1 UniProtKB/TrEMBL
  ENSSSCT00045009088.1 UniProtKB/TrEMBL
  ENSSSCT00055047355.1 UniProtKB/TrEMBL
  ENSSSCT00065107975.1 UniProtKB/TrEMBL
  ENSSSCT00070048824.1 UniProtKB/TrEMBL
InterPro ASX-like_PHD UniProtKB/TrEMBL
  ASX/ASX-like UniProtKB/TrEMBL
  ASXH UniProtKB/TrEMBL
  DEUBAD_dom UniProtKB/TrEMBL
  HB1/Asxl_HTH UniProtKB/TrEMBL
NCBI Gene ASXL3 ENTREZGENE
PANTHER PTHR13578 UniProtKB/TrEMBL
  PTHR13578:SF18 UniProtKB/TrEMBL
Pfam ASXH UniProtKB/TrEMBL
  HARE-HTH UniProtKB/TrEMBL
  PHD_3 UniProtKB/TrEMBL
PROSITE DEUBAD UniProtKB/TrEMBL
  HTH_HARE UniProtKB/TrEMBL
UniProt A0A4X1VDD0_PIG UniProtKB/TrEMBL
  A0A8D0PQB8_PIG UniProtKB/TrEMBL
  A0A8D1GLK8_PIG UniProtKB/TrEMBL
  A0A8D1GNK5_PIG UniProtKB/TrEMBL
  A0A8D1RM64_PIG UniProtKB/TrEMBL
  A0A8D2CJ36 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FHU2_PIG UniProtKB/TrEMBL
  F1SAK2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85596 ENTREZGENE