FFAR1 (free fatty acid receptor 1)

Gene: FFAR1 (free fatty acid receptor 1) Sus scrofa

Analyze

Symbol:

FFAR1

Name:

free fatty acid receptor 1

RGD ID:

14119659

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); dystonia (ortholog); hereditary spastic paraplegia 75 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G protein-coupled receptor 40; GPR40

RGD Orthologs

Human

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	44,837,764 - 44,841,518 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,339,498 - 40,342,218 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brugada syndrome 5 (ISO)

dystonia (ISO)

hereditary spastic paraplegia 75 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fatty acid (IBA)

G protein-coupled receptor signaling pathway (IBA,IEA,ISO)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of insulin secretion (IEA)

response to fatty acid (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

bioactive lipid receptor activity (IEA)

G protein-coupled receptor activity (IBA,IEA,ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FFAR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	44,837,764 - 44,841,518 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,339,498 - 40,342,218 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR42
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	35,371,068 - 35,372,962 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	35,371,068 - 35,372,962 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	35,861,970 - 35,863,864 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,554,102 - 40,555,142 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	40,554,101 - 40,555,142	NCBI
Celera	19	32,575,706 - 32,576,746 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
CHM1_1	19	35,863,858 - 35,864,898 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	37,915,808 - 37,917,703 (+)	NCBI		T2T-CHM13v2.0

Variants

Variants in FFAR1
61 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	nervous system
High
Medium
Low	2
Below cutoff	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001278783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013998289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU366318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01097910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JQ768802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001278783 ⟹ NP_001265712

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	44,838,544 - 44,839,560 (+)	NCBI

Sequence:

show sequence

CCTCAGGGATCTGAGGGCAGGGAGCAGGGGGGGCAGGGGCGGCCCCATGGACCTGCCCCCGCAG
CTCTCCTTCGCCCTCTACGTGGCCGCCTTCGCACTGGGCTTCCCCCTCAACTGCCTGGCCATCG
CAGGCGCCGTGTCCCAGGCCCGGCTCCGCCTCACCCCCAGCCTCGTCTACGCCCTCCACCTGGG
CTGCTCTGACCTCCTGCTGGCCACCTCTCTGCCGCTAAAGGCGGCGGAGGTCCTGGCAGGGGGA
GCCTGGCCCCTGCCGGCCGTGCTCTGTCCCATCTTGGCCCTGGCCCACTTTGCCCCCCTCTACA
CAGGTGGGAGCTTCCTGGCTGCCCTGAGTGTCGGCCGCTACCTAGGAGCCGCCTTCCCCTTGGG
CTACCAGGCTGCCCGGAGGCCACGCTATTCCTGGGGGGTGTGTGTGGCCATATGGGCCCTTGTC
CTCTGTCACCTGGGGCTGGTTTTTGGGTTGGAGGCTCCTGGAGGCTGGCTGGACAATACTACCA
GCTCCCTGGGCATCAACACGCCAGTCAATGGCTCTCCAGTCTGCCTGGAGGCCTGGGACCCGGC
CTCTGTGGGCCCCGCTCGCCTAAGCCTCTCTCTCCTGTTCTTCTTTCTGCCTCTGATCATCACG
GCCTTCTGCTATGTGGGCTGCCTCCGAGCACTGGCCCGCTCAGGCCTGAGCCACAGACGGAAGC
TAAGGGCGGCCTGGGTGGCTGGTGGGGCTCTGCTCACGCTGCTGCTCTGCCTAGGACCCTACAA
TGCCTCCAATGTGGCTGGCTTCCTGAACCCCAACCTGGGAGGCTACTGGCGGAAGCTGGGGCTC
ATCACAGGTGCTTGGAGCGTGGTGCTCAACCCACTGGTGACCGGCTACCTGGGAGGGGGCACTG
GCCGGGGGACAACATGTGTGGCCAGAACAAAAGGGGGCCCATCCCAGAAGTAGGAGTCACTGCA
GGGGGCAAGCGGCAGGGAGCAGGAGAGCCTGGCTGCTTCTTCAGGCTCCTGGCGGAA

hide sequence

RefSeq Acc Id:

XM_013998289 ⟹ XP_013853743

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	44,837,764 - 44,841,518 (+)	NCBI

Sequence:

show sequence

CTGCTCATCCAGGCTGCGAGTGCCTCCGGCTAATGGCCCCGCCACCCCGCCTTCTCTCCCTTCC
AGCTCACTGCCCATCGCGGCCACCCTCCCTCGGGGACTCCTGAGCCTCAGAGACATCCGGCAGC
ACCCAGAGAGGCTCGGAAATCACGAGGGCTTCCTCTTCTGGGACCTGCATGCTCCTGTTCCATC
TCCTGCTGTTACACGGCCATCGTGTGCTTTCCATTTAAGGGTGGGGGAAAGAAAACAGGGGACT
CAGGGCCAGAGGTCCTGTCCTGGCGTCTAATCCAGTCTCCTCCACCCTCTGGGGGCGTCCTTCT
CCTCCACTATCCCATTAGATGGCTTCTCGGGGCCCTGAGTGGTGCTGAAACCAGTCTGTGGCTC
CCAGAGCTCACTTCCCCGCCTCAGGGATCTGAGGGCAGGGAGCAGGGGGGGCAGGGGCGGCCCC
ATGGACCTGCCCCCGCAGCTCTCCTTCGCCCTCTACGTGGCCGCCTTCGCACTGGGCTTCCCCC
TCAACTGCCTGGCCATCGCAGGCGCCGTGTCCCAGGCCCGGCTCCGCCTCACCCCCAGCCTCGT
CTACGCCCTCCACCTGGGCTGCTCTGACCTCCTGCTGGCCACCTCTCTGCCGCTAAAGGCGGCG
GAGGTCCTGGCAGGGGGAGCCTGGCCCCTGCCGGCCGTGCTCTGTCCCATCTTGGCCCTGGCCC
ACTTTGCCCCCCTCTACACAGGTGGGAGCTTCCTGGCTGCCCTGAGTGTCGGCCGCTACCTAGG
AGCCGCCTTCCCCTTGGGCTACCAGGCTGCCCGGAGGCCACGCTATTCCTGGGGGGTGTGTGTG
GCCATATGGGCCCTTGTCCTCTGTCACCTGGGGCTGGTTTTTGGGTTGGAGGCTCCTGGAGGCT
GGCTGGACAATACTACCAGCTCCCTGGGCATCAACACGCCAGTCAATGGCTCTCCAGTCTGCCT
GGAGGCCTGGGACCCGGCCTCTGTGGGCCCCGCTCGCCTAAGCCTCTCTCTCCTGTTCTTCTTT
CTGCCTCTGATCATCACGGCCTTCTGCTATGTGGGCTGCCTCCGAGCACTGGCCCGCTCAGGCC
TGAGCCACAGACGGAAGCTAAGGGCGGCCTGGGTGGCTGGTGGGGCTCTGCTCACGCTGCTGCT
CTGCCTAGGACCCTACAATGCCTCCAATGTGGCTGGCTTCCTGAACCCCAACCTGGGAGGCTAC
TGGCGGAAGCTGGGGCTCATCACAGGTGCTTGGAGCGTGGTGCTCAACCCACTGGTGACCGGCT
ACCTGGGAGGGGGCACTGGCCGGGGGACAACATGTGTGGCCAGAACAAAAGGGGGCCCATCCCA
GAAGTAGGAGTCACTGCAGGGGGCAAGCGGCAGGGAGCAGGAGAGCCTGGCTGCTTCTTCAGGC
TCCTGGCGGAAGCTGCTCCAAAGGAACTGTGGGCTGGCCTTGCCTGGGGGCATCCATGGAGCCA
CTTAGGGAAAGAACTGAGCCTGGCAGAAGACGGCATCCCAGAGGGGGAGAAGAATGGAGGCCTG
GAGCTGGGTCACAGGGGAAGGTAAGCTGCCGCATTTCATCAAATCATCAGCCTGATTTCCACCT
CTACCTGTCTCTCTTCTGAGTCCTGGCAGGCCTGACTGCCAGTGCGCCACATAGGGAAGGAGGG
AGACAGTTTTCTTCTAAGCTGAAGGAACTGCCACTCTGACAGGGCACACTGGGAGATGTTACTC
CAAAATCATTCCCTAGGAAAGAGCATTTACATTTCTGAATAAGGGGCAGGAGGCCAGCGAATGA
GAGTTATACCACTTTACCCCACAAGGGGGCAGCAGTGGAACTGTGAACAGGAACTGTGAATTGG
TAGGAGAGGATGCTGGGGGTGGGACGCTGGGGCGGGGGGGTGTCCCCGCAGTTGGGGGGAATAC
TAGCAACACCAAAAACAGTCGCAAACAAATATACGTGACTGTCACCATGCCTTCAAGTGCTTTA
CAAGTGGTGTCTCATTTCATCTTCCCACATCCTTCTGATTTAGCCATGTGACTGCTGTACAGAT
GAGTGGGCTGCTCACTGCACAGGGGTGTCAGGCAGAGGGGCACACAAAGATTCAATTCTAGCTT
GTGCTTTGCCCACCAAGGCCTGTGCCTGGCATGGAGCTGCTTCAATCCAGGGAAAAGAGCACCT
TGTTCTAATCGGAAAAAGACACCACCCCACTCCTCAAGCAGTGCACCTTGGTGCAGGGCTGTGC
TCACCTGCAGGGGGTGCCTTTCCCTAACCTGCACTAAGGCACCACATGCCTTACTTAGTTGCAG
TGCTGGAACCAGGTATTCTTACCACCTTCATCCTGTGGCGTTAAGAAATTTGCCCGAGGCCCTA
CAGCAAGGAAGGGGTAGGTGTAGGAGGTCATCGGTCAAAGAAGACTCCCAAGGATTGGGGAACA
CTTGGGAAACGCGGGGTATTGGGGTTAATGCCTGTCCTTGTGGTGCCTTTTGCGAAAGTAAATG
AACCTTCACCTTGAACCTGTGAGAGGGTGGGCAGAGAGTGGCCAAGGCCTGGGCATCTGCTCTG
AGGGGAGGTGTAGGAAGCAGACTTGTTCCTCTAATGATGACAGATAATGAGGTGAGTACTCAGA
AAGAAAAAAAAAAAAAAAAAAGCAGTGGCTACGTGCCTGGTGTGCACAGGTTGGTTTATGCAAG
TTATCTCTTTTCATAGGAAAGTGACCCCAAGGGCAAGAATTTTTGTCGTATCTGTGGATCTATC
CCCAGCAACCAGAAGAGAGCTGAGCACACAGTAGGCTTATAATAAATATTTGTTGAGTGGATGA
ATGCCCATAACAGCCCTCCAGAGGAAGTTTTATTACCCTGTTTATAAACATGGGATCAGGCCAG
AGAAGTTAAGTTACTTGCCCAAGGCTCCCCCGAAGCGAGAAACAAGTTTCTGCTCAGTGCTGAC
ACCAGAGAATTTTTGTCAAAGCCTGGACTCCAGCCCAGGTGGCCCCACTGCTGCTCCCGTAGCA
CTGTAACCATTCTCCCTCCCACTTGTGGGTTCGGGGCCACCTCTTCCAGTTACTTGTGCCTCCT
CCGCTTAGGGAAGATTTCAGTTCCTCCCTGGGGCCACCAGTGCTCAGCATGGTCTGCCTCCAGC
ATCCTCTGGCGACCCTTGCCCTTTGGGCCCCAAACCTTCCACCAGCACCCCCAGCAGGTCAAGC
CTGTGCACCCCCACGCCCTCTGCACTGTTTCCTCCAGGAGTTCTCTGCCTCTGTATTATTTATT
ATCCTCCTACCACTCAACCCCCCACCAAATGTCAGCACCAGGACAGTGAAAACTTTTTTTTTTT
TTTACGGCTGCATCTGTGGCATATGGAAGTTTCCAGGCGAGGGGTTGTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001265712	(Get FASTA)	NCBI Sequence Viewer
	XP_013853743	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABY66127	(Get FASTA)	NCBI Sequence Viewer
	AFK25173	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000003114.4
	ENSSSCP00000059833
	ENSSSCP00000059833.1
	ENSSSCP00005032199.1
	ENSSSCP00025019548.1
	ENSSSCP00035019579.1
	ENSSSCP00045039368.1
	ENSSSCP00070016294.1

RefSeq Acc Id:	XP_013853743 ⟸ XM_013998289
- Peptide Label:	isoform X1
- UniProtKB:	F1RM69 (UniProtKB/TrEMBL), A0A4X1TJT4 (UniProtKB/TrEMBL), A0A8D1L752 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLPPQLSFALYVAAFALGFPLNCLAIAGAVSQARLRLTPSLVYALHLGCSDLLLATSLPLKAA EVLAGGAWPLPAVLCPILALAHFAPLYTGGSFLAALSVGRYLGAAFPLGYQAARRPRYSWGVCV AIWALVLCHLGLVFGLEAPGGWLDNTTSSLGINTPVNGSPVCLEAWDPASVGPARLSLSLLFFF LPLIITAFCYVGCLRALARSGLSHRRKLRAAWVAGGALLTLLLCLGPYNASNVAGFLNPNLGGY WRKLGLITGAWSVVLNPLVTGYLGGGTGRGTTCVARTKGGPSQK hide sequence

RefSeq Acc Id:

NP_001265712 ⟸ NM_001278783

- UniProtKB:

F1RM69 (UniProtKB/TrEMBL), A0A4X1TJT4 (UniProtKB/TrEMBL), A0A8D1L752 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLPPQLSFALYVAAFALGFPLNCLAIAGAVSQARLRLTPSLVYALHLGCSDLLLATSLPLKAA
EVLAGGAWPLPAVLCPILALAHFAPLYTGGSFLAALSVGRYLGAAFPLGYQAARRPRYSWGVCV
AIWALVLCHLGLVFGLEAPGGWLDNTTSSLGINTPVNGSPVCLEAWDPASVGPARLSLSLLFFF
LPLIITAFCYVGCLRALARSGLSHRRKLRAAWVAGGALLTLLLCLGPYNASNVAGFLNPNLGGY
WRKLGLITGAWSVVLNPLVTGYLGGGTGRGTTCVARTKGGPSQK

hide sequence

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000002891	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005032608	UniProtKB/TrEMBL
	ENSSSCG00025033651	UniProtKB/TrEMBL
	ENSSSCG00035036929	UniProtKB/TrEMBL
	ENSSSCG00045033057	UniProtKB/TrEMBL
	ENSSSCG00070010096	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000003195.5	UniProtKB/TrEMBL
	ENSSSCT00000074167	ENTREZGENE
	ENSSSCT00000074167.2	UniProtKB/TrEMBL
	ENSSSCT00005052085.1	UniProtKB/TrEMBL
	ENSSSCT00025045796.1	UniProtKB/TrEMBL
	ENSSSCT00035048956.1	UniProtKB/TrEMBL
	ENSSSCT00045056412.1	UniProtKB/TrEMBL
	ENSSSCT00070019593.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	GPR40-rel_orph	UniProtKB/TrEMBL
	GPR40_recept_FA	UniProtKB/TrEMBL
KEGG Report	ssc:100135676	UniProtKB/TrEMBL
NCBI Gene	FFAR1	ENTREZGENE
PANTHER	FREE FATTY ACID RECEPTOR 1	UniProtKB/TrEMBL
	FREE FATTY ACID RECEPTOR 2-RELATED	UniProtKB/TrEMBL
	FREE FATTY ACID RECEPTOR 3-RELATED	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	FATTYACIDR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	GPR40FAMILY	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A4X1TJT4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0JQ17_PIG	UniProtKB/TrEMBL
	A0A8D1L752	ENTREZGENE, UniProtKB/TrEMBL
	F1RM69	ENTREZGENE, UniProtKB/TrEMBL
	F1RM70_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:111802	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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