GPN2 (GPN-loop GTPase 2) - Rat Genome Database

Name: GPN2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: GPN2 (GPN-loop GTPase 2) Sus scrofa

Analyze

Symbol:

GPN2

Name:

GPN-loop GTPase 2

RGD ID:

14107105

Description:

ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); hydrolase activity (inferred); ASSOCIATED WITH genetic disease (ortholog); retinitis pigmentosa 59 (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPN2 (GPN-loop GTPase 2)	HGNC	NCBI
Mus musculus (house mouse):	Gpn2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gpn2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpn2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPN2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPN2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpn2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPN2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpn2 (GPN-loop GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,200,652 - 84,209,668 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	84,200,152 - 84,209,729 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

retinitis pigmentosa 59 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

Molecular Function

GTP binding (IEA)

GTPase activity (IBA,IEA)

hydrolase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:30032202

Genomics

Comparative Map Data

GPN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,200,652 - 84,209,668 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	84,200,152 - 84,209,729 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GPN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,876,132 - 26,890,283 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,876,132 - 26,890,283 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	27,202,623 - 27,216,774 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	27,078,460 - 27,089,456 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	25,602,968 - 25,613,964 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	25,459,450 - 25,470,451 (-)	NCBI		HuRef
CHM1_1	1	27,319,224 - 27,330,229 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	26,714,196 - 26,728,346 (-)	NCBI		T2T-CHM13v2.0

Gpn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	133,311,684 - 133,319,046 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	133,311,673 - 133,319,046 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	133,584,373 - 133,591,735 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	133,584,362 - 133,591,735 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	133,140,288 - 133,147,650 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,856,456 - 132,863,810 (+)	NCBI		MGSCv36	mm8
MGSCv36	4	131,152,460 - 131,159,814 (+)	NCBI		MGSCv36	mm8
Celera	4	131,745,277 - 131,755,807 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.25	NCBI

Gpn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,093,279 - 151,101,114 (+)	NCBI		GRCr8
mRatBN7.2	5	145,809,455 - 145,817,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	145,809,651 - 145,817,252 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	148,512,174 - 148,519,668 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,281,778 - 150,289,270 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,268,334 - 150,275,828 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	151,806,458 - 151,813,954 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	151,806,458 - 151,813,954 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	155,495,838 - 155,503,334 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,489,863 - 151,497,359 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,500,230 - 151,507,398 (-)	NCBI
Celera	5	144,230,311 - 144,237,793 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Gpn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	6,227,126 - 6,234,143 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	6,227,126 - 6,234,143 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,979,741 - 199,990,731 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,083,722 - 199,094,839 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,141,959 - 26,152,948 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,198,382 - 27,209,795 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,198,382 - 27,209,795 (-)	Ensembl	panpan1.1		panPan2

GPN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,251,139 - 73,261,806 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,251,303 - 73,259,636 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,829,145 - 69,839,847 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,814,872 - 73,825,579 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,814,881 - 73,825,574 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	70,639,859 - 70,650,561 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	71,645,290 - 71,655,987 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	72,648,481 - 72,659,177 (+)	NCBI		UU_Cfam_GSD_1.0

Gpn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	45,465,175 - 45,473,657 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	11,290,998 - 11,298,627 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	11,291,093 - 11,298,520 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,873,376 - 105,884,304 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,873,666 - 105,884,572 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	10,545,657 - 10,556,677 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	10,872,054 - 10,879,213 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	10,872,054 - 10,879,182 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GPN2
218 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003127718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK236386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000102327 ⟹ ENSSSCP00000080430

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	84,200,652 - 84,209,668 (-)	Ensembl

RefSeq Acc Id:

XM_003127718 ⟹ XP_003127766

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	84,200,152 - 84,209,729 (-)	NCBI

Sequence:

show sequence

CGGCCCTCGCTGTTTCCGGCGTTGTACGGAAGTCGGGTGCTGGTCTGGTCAGTGCCTGGCCATT
TGGTCCCCTTACAGCGCGCCTTTTCCAGCTCTCTCTCCTTAGGCGGCTTCCGGGTATCGCTGCC
AGTCCCCAGCCAAGTGCAGTTAGGGGAACCCATTGCCCTCGGCTCTTGTCTGCGGTGCGGCTCC
CCCCTTGCTTCCTCTCTGAACTTGTCTGCTACGCACTTCCTCTCACTTGTCTGAGCCGTGTGCC
GCCCATGGCAGGGGCCGCTCAGACCACGGCCTTTGGGCAAGCGGTGATCGGCCCGCCGGGCTCG
GGGAAGACCACGTACTGCCTGGGCATGAGTGAGTTTCTGCGAGCGCTGGGCCGGCGCGTGGCGG
TGGTGAACCTGGACCCGGCCAACGAGGGGCTGCCATATGAGTGCGCCGTAGATGTGGGCGAGCT
GGTGGGCCTGAGCGACGTTATGGACGAGCTGCAGCTGGGGCCCAACGGCGGTCTGCTGTACTGC
ATGGAGTACCTAGAGGCCAACCTGGACTGGCTGCGCGCGAAACTCGACCCCCTTCGCGGCCACT
ACTTCCTCTTTGACTGCCCTGGTCAAGTGGAGCTCTGCACGCACCACGGAGCCCTGCGCAGCAT
CTTCTCCCAGATGACGCAGTGGGACCTCAGGCTGACTGCTGTCCACCTGGTGGATTCTCACTAT
TGCACAGACCCTGCCAAGTTCATTTCAGTACTGTGTACCTCCCTAGCCACCATGCTGCATGTGG
AGCTCCCCCATGTCAACCTCCTCTCCAAGATGGACCTCATTGAACACTATGGGAAGCTGGCCTT
CAACCTGGACTACTACACAGAGGTCCTGGACCTCTCCTACCTGCTTGACCACCTGGCTTCTGAT
CCTTTCTTCCGCCACTATCGTCAGCTCAATGAGAAACTCGTGCAGCTCATCGAAGACTACAGCC
TGGTCTCCTTCATCCCTCTCAACATCCAGGACAAGGAGAGCATCCAGCGGGTCCTGCAGGCTGT
GGATAAAGCCAATGGCTACTGCTTCGGGGTCCAGGAGCAGCGGAGCCTGGAGGCCATGATGTCT
GCCGCTGTGGGAGCGGACTTCCACTTCTCCTCCACCCTGGGCCTCCAGGAGAAGTACCTGGCAC
CCTCAGACCAGCCAGTGGAGCAGGAGGCCATGCAGCTCTAGCAACAAGCTGGGCTCTTGTTGGA
GGAGGACGCACAACCCAGCGCTGGGTAGCATGGTGGCTTCCAGAGCAGCAGACTGCGCGGCAGG
CTGCAGATCCAAGAGCAGCCCTCACAGGGGGAGACTGGCAAGGGGATACACAGCCCTGCAGAGG
AGTTCGGCCAGATCCAGACCTGTCACCAAGCAGAGCACTCTCAGTGCTCTGGGCGCTGCCAGCA
GGAATCCAGCACTGGCCCCGCTTGGGCTGTGATGGAACATGGTACAATACAAGAGTTTATTTTC
TACTTTTTGTGGCTTCCAAACTTTTCTTCAACCATCCGGGCCGAGGAATTTGGGAACATGAGAA
TGTCACCTTTCCTCAGAAGAGTCCTGTTGCCTTTTTTTTTTTTCTTCTTCTTTTTTTGGCTGCC
CCTCTGCATATGGAGTTCCCGGACCAGGGATCAGATCCAAGTCGCAGTTGTGACCTAAGCCGAA
GCTGCGGCAACGCCAGATCCTTAACTCACTGTGCTGGACCAGGGCTGGAACCTGCGACCCAGCA
CTCCCAAGACAACACCAATTCCATTGCACCACAGCAGGAACTCCAGAAGAGTCCTGTTTCTTCA
CACAGGGCAGTGGTTTCCCCCTAAACCACAGGATCATAGTAGAGGGTTGACTCTCAAGTCTCAA
GTTGTGTGCTTTTGTTAATCTTCAGTTTTAACAATGAGGCTCAAGCTTGAGCTTTCCTCACAGA
TCTTATATTTTATTTTCATTGTATTTATTTCAGGGTTTTATTCTTGGGGGGGGGCAAGTGTTAA
CTAGTTTTCCATTTATAGTAGTGATTAGAAGTTGACTTTAAAATAAAATTTATTGGGAGTTCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003127766	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000080430
	ENSSSCP00000080430.1
	ENSSSCP00070031126.1

RefSeq Acc Id:

XP_003127766 ⟸ XM_003127718

- UniProtKB:

Q58DD9 (UniProtKB/Swiss-Prot), A0A4X1URF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGAAQTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELV
GLSDVMDELQLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIF
SQMTQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHVNLLSKMDLIEHYGKLAFN
LDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAVD
KANGYCFGVQEQRSLEAMMSAAVGADFHFSSTLGLQEKYLAPSDQPVEQEAMQL

hide sequence

RefSeq Acc Id:

ENSSSCP00000080430 ⟸ ENSSSCT00000102327

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000053928	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSSSCG00070018843	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000102327	ENTREZGENE
	ENSSSCT00000102327.1	UniProtKB/Swiss-Prot
	ENSSSCT00070037226.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Gpn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gpn2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:110255194	UniProtKB/Swiss-Prot
NCBI Gene	GPN2	ENTREZGENE
PANTHER	GPN-LOOP GTPASE 2	UniProtKB/TrEMBL
	PTHR21231	UniProtKB/Swiss-Prot
	PTHR21231:SF3	UniProtKB/Swiss-Prot
	XPA-BINDING PROTEIN 1-RELATED	UniProtKB/TrEMBL
Pfam	ATP_bind_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	P-loop containing nucleoside triphosphate hydrolases	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A0A4X1URF1	ENTREZGENE, UniProtKB/TrEMBL
	GPN2_PIG	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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