CH25H (cholesterol 25-hydroxylase) - Rat Genome Database

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Gene: CH25H (cholesterol 25-hydroxylase) Sus scrofa
Analyze
Symbol: CH25H
Name: cholesterol 25-hydroxylase
RGD ID: 14090844
Description: ENCODES a protein that exhibits cholesterol 25-hydroxylase activity (ortholog); INVOLVED IN B cell chemotaxis (ortholog); cholesterol metabolic process (ortholog); negative regulation of fusion of virus membrane with host plasma membrane (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome (ortholog); Familial Thoracic Aortic Aneurysm 6 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cholesterol 25-monooxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,123,398 - 101,125,593 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,122,318 - 101,128,622 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,108,096 - 110,110,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:28631596   PMID:30032202   PMID:30955800   PMID:38140647  


Genomics

Comparative Map Data
CH25H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,123,398 - 101,125,593 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,122,318 - 101,128,622 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,108,096 - 110,110,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CH25H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,205,629 - 89,207,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,205,629 - 89,207,317 (-)EnsemblGRCh38hg38GRCh38
GRCh371090,965,386 - 90,967,074 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,955,674 - 90,957,051 (-)NCBINCBI36Build 36hg18NCBI36
Build 341090,955,673 - 90,957,051NCBI
Celera1084,712,523 - 84,713,900 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,600,155 - 84,601,532 (-)NCBIHuRef
CHM1_11091,247,750 - 91,249,127 (-)NCBICHM1_1
T2T-CHM13v2.01090,089,526 - 90,091,214 (-)NCBIT2T-CHM13v2.0
Ch25h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,451,183 - 34,452,548 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,451,178 - 34,452,564 (-)EnsemblGRCm39 Ensembl
GRCm381934,473,783 - 34,475,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,473,778 - 34,475,164 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,548,273 - 34,549,625 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,539,780 - 34,541,132 (-)NCBIMGSCv36mm8
Celera1935,249,457 - 35,250,809 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.69NCBI
Ch25h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,428,048 - 241,429,366 (-)NCBIGRCr8
mRatBN7.21232,014,877 - 232,016,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,014,880 - 232,016,195 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,404,834 - 240,406,152 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,327,664 - 247,328,982 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,165,868 - 240,167,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,807,062 - 252,811,409 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,807,065 - 252,808,380 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,028,706 - 260,035,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,457,017 - 238,458,335 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,620,925 - 238,622,241 (-)NCBI
Celera1229,127,450 - 229,128,768 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ch25h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554253,763,302 - 3,764,432 (+)NCBIChiLan1.0ChiLan1.0
CH25H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,224,225 - 101,225,577 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,229,539 - 101,230,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01085,930,638 - 85,932,065 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,470,908 - 89,472,278 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,471,441 - 89,472,259 (-)Ensemblpanpan1.1panPan2
CH25H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,884,356 - 38,885,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,635,628 - 38,637,001 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02640,468,717 - 40,470,089 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12638,339,014 - 38,340,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,902,557 - 37,903,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02639,172,313 - 39,173,684 (-)NCBIUU_Cfam_GSD_1.0
Ch25h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,382,065 - 43,384,853 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366015,015,219 - 5,160,908 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366015,015,922 - 5,016,942 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CH25H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,632,151 - 82,634,101 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,633,004 - 82,633,819 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604843,308,387 - 43,309,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ch25h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473739,649 - 41,241 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CH25H
124 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 9 4 2 5 22 2 2 3
Below cutoff 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011435   ⟹   ENSSSCP00000011138
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14101,123,398 - 101,125,335 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000059476   ⟹   ENSSSCP00000058740
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14101,123,398 - 101,125,593 (-)Ensembl
RefSeq Acc Id: XM_005671263   ⟹   XP_005671320
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114101,122,318 - 101,126,233 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073088   ⟹   XP_020928747
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114101,122,318 - 101,126,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021073089   ⟹   XP_020928748
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114101,123,380 - 101,128,622 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005671320   ⟸   XM_005671263
- Peptide Label: isoform X2
- UniProtKB: F1SCY5 (UniProtKB/TrEMBL),   A0A8D0N0L8 (UniProtKB/TrEMBL),   A0A8D1IEP9 (UniProtKB/TrEMBL),   A0A8D1PDH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928747   ⟸   XM_021073088
- Peptide Label: isoform X1
- UniProtKB: A0A287BRJ1 (UniProtKB/TrEMBL),   A0A4X1V547 (UniProtKB/TrEMBL),   A0A8D1I8C4 (UniProtKB/TrEMBL),   A0A8D0QSC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928748   ⟸   XM_021073089
- Peptide Label: isoform X1
- UniProtKB: A0A287BRJ1 (UniProtKB/TrEMBL),   A0A4X1V547 (UniProtKB/TrEMBL),   A0A8D1I8C4 (UniProtKB/TrEMBL),   A0A8D0QSC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011138   ⟸   ENSSSCT00000011435
RefSeq Acc Id: ENSSSCP00000058740   ⟸   ENSSSCT00000059476
Protein Domains
Fatty acid hydroxylase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010449 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005016572 UniProtKB/TrEMBL
  ENSSSCG00015022590 UniProtKB/TrEMBL
  ENSSSCG00025004078 UniProtKB/TrEMBL
  ENSSSCG00030042810 UniProtKB/TrEMBL
  ENSSSCG00035044344 UniProtKB/TrEMBL
  ENSSSCG00040052992 UniProtKB/TrEMBL
  ENSSSCG00045025714 UniProtKB/TrEMBL
  ENSSSCG00050031360 UniProtKB/TrEMBL
  ENSSSCG00055001511 UniProtKB/TrEMBL
  ENSSSCG00060023602 UniProtKB/TrEMBL
  ENSSSCG00065038105 UniProtKB/TrEMBL
  ENSSSCG00070021469 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011435 ENTREZGENE
  ENSSSCT00000011435.4 UniProtKB/TrEMBL
  ENSSSCT00000059476 ENTREZGENE
  ENSSSCT00000059476.2 UniProtKB/TrEMBL
  ENSSSCT00005026062.1 UniProtKB/TrEMBL
  ENSSSCT00005026078.1 UniProtKB/TrEMBL
  ENSSSCT00015029907.1 UniProtKB/TrEMBL
  ENSSSCT00015030001.1 UniProtKB/TrEMBL
  ENSSSCT00025005400.1 UniProtKB/TrEMBL
  ENSSSCT00025005407.1 UniProtKB/TrEMBL
  ENSSSCT00030059659.1 UniProtKB/TrEMBL
  ENSSSCT00030059671.1 UniProtKB/TrEMBL
  ENSSSCT00035058896.1 UniProtKB/TrEMBL
  ENSSSCT00035058900.1 UniProtKB/TrEMBL
  ENSSSCT00040071604.1 UniProtKB/TrEMBL
  ENSSSCT00040071637.1 UniProtKB/TrEMBL
  ENSSSCT00045043787.1 UniProtKB/TrEMBL
  ENSSSCT00045043838.1 UniProtKB/TrEMBL
  ENSSSCT00050042149.1 UniProtKB/TrEMBL
  ENSSSCT00050042154.1 UniProtKB/TrEMBL
  ENSSSCT00055002753.1 UniProtKB/TrEMBL
  ENSSSCT00055002764.1 UniProtKB/TrEMBL
  ENSSSCT00060032007.1 UniProtKB/TrEMBL
  ENSSSCT00060032011.1 UniProtKB/TrEMBL
  ENSSSCT00065052066.1 UniProtKB/TrEMBL
  ENSSSCT00065052073.1 UniProtKB/TrEMBL
  ENSSSCT00070042685.1 UniProtKB/TrEMBL
  ENSSSCT00070042690.1 UniProtKB/TrEMBL
InterPro Fatty_acid_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100157868 UniProtKB/TrEMBL
NCBI Gene CH25H ENTREZGENE
PANTHER CHOLESTEROL 25-HYDROXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROL DESATURASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287BRJ1 ENTREZGENE
  A0A4X1V547 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0N0L8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QSC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1I8C4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IEP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PDH0 ENTREZGENE, UniProtKB/TrEMBL
  CH25H_PIG UniProtKB/Swiss-Prot
  F1SCY5 ENTREZGENE
  Q4G1G8 ENTREZGENE
UniProt Secondary A0A287BRJ1 UniProtKB/TrEMBL
  F1SCY5 UniProtKB/TrEMBL
VGNC ID VGNC:86618 ENTREZGENE