GIP (gastric inhibitory polypeptide) - Rat Genome Database

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Gene: GIP (gastric inhibitory polypeptide) Sus scrofa
Analyze
Symbol: GIP
Name: gastric inhibitory polypeptide
RGD ID: 14086633
Description: ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; gastric inhibitory peptide signaling pathway; adult locomotory behavior (ortholog); ASSOCIATED WITH Anorexia (ortholog); autonomic nervous system disease (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glucose-dependent insulinotropic polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,160,789 - 25,167,940 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,160,783 - 25,167,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,126,659 - 25,133,815 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7227513   PMID:8375398   PMID:15679890   PMID:20433877   PMID:22301074   PMID:25378285   PMID:26572091   PMID:28242256   PMID:30032202  


Genomics

Comparative Map Data
GIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,160,789 - 25,167,940 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,160,783 - 25,167,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,126,659 - 25,133,815 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,958,554 - 48,968,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,958,554 - 48,968,596 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,035,916 - 47,045,958 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,390,917 - 44,400,954 (-)NCBINCBI36Build 36hg18NCBI36
Build 341744,390,916 - 44,400,954NCBI
Celera1743,490,595 - 43,500,198 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,403,606 - 42,413,192 (-)NCBIHuRef
CHM1_11747,101,692 - 47,111,260 (-)NCBICHM1_1
T2T-CHM13v2.01749,822,260 - 49,831,965 (-)NCBIT2T-CHM13v2.0
Gip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,915,358 - 95,921,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,915,371 - 95,921,657 (+)EnsemblGRCm39 Ensembl
GRCm381196,024,532 - 96,030,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,024,545 - 96,030,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,885,859 - 95,892,142 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,840,635 - 95,846,918 (+)NCBIMGSCv36mm8
Celera11105,675,017 - 105,681,265 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.21NCBI
Gip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,465,070 - 81,473,216 (+)NCBIGRCr8
mRatBN7.21080,968,360 - 80,976,506 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,968,352 - 80,976,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,916,682 - 85,924,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,414,718 - 85,422,832 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,807,160 - 80,815,278 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,835,080 - 83,848,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,840,303 - 83,848,396 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,645,328 - 83,653,501 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,732,705 - 84,740,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,747,074 - 84,755,168 (+)NCBI
Celera1079,736,495 - 79,744,591 (+)NCBICelera
Cytogenetic Map10q26NCBI
Gip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545112,390,938 - 12,396,599 (+)NCBIChiLan1.0ChiLan1.0
GIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,135,817 - 16,144,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,101,423 - 18,110,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,573,104 - 8,580,424 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,554,736 - 8,561,849 (+)NCBIpanpan1.1PanPan1.1panPan2
GIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,167,938 - 25,174,402 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,167,926 - 25,174,575 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,630,394 - 24,634,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,964,527 - 25,968,409 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1924,732,107 - 24,736,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,990,580 - 24,994,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,119,509 - 25,123,597 (-)NCBIUU_Cfam_GSD_1.0
Gip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,581,725 - 24,588,955 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,487,025 - 12,492,214 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,487,025 - 12,492,214 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,367,030 - 69,377,563 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,367,207 - 69,377,155 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,470,887 - 40,480,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,332,071 - 5,333,992 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,331,214 - 5,333,425 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GIP
391 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium 2
Low 2 2
Below cutoff 3 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030856   ⟹   ENSSSCP00000023744
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1225,160,789 - 25,167,940 (-)Ensembl
RefSeq Acc Id: NM_001287408   ⟹   NP_001274337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11225,160,832 - 25,166,270 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653967   ⟹   XP_005654024
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11225,160,783 - 25,167,952 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013980014   ⟹   XP_013835468
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11225,162,252 - 25,167,952 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005654024   ⟸   XM_005653967
- Peptide Label: isoform X1
- UniProtKB: I3LI45 (UniProtKB/TrEMBL),   A0A4X1URI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274337   ⟸   NM_001287408
- Peptide Label: precursor
- UniProtKB: I3RLE6 (UniProtKB/TrEMBL),   A0A8D0PC84 (UniProtKB/TrEMBL),   A0A8D1I9K0 (UniProtKB/TrEMBL),   A0A8D0XSE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835468   ⟸   XM_013980014
- Peptide Label: isoform X2
- UniProtKB: A0A4X1URI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000023744   ⟸   ENSSSCT00000030856
Protein Domains
Glucagon / GIP / secretin / VIP family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005003911 UniProtKB/TrEMBL
  ENSSSCG00015058572 UniProtKB/TrEMBL
  ENSSSCG00025005693 UniProtKB/TrEMBL
  ENSSSCG00030060343 UniProtKB/TrEMBL
  ENSSSCG00035006624 UniProtKB/TrEMBL
  ENSSSCG00040065180 UniProtKB/TrEMBL
  ENSSSCG00045026234 UniProtKB/TrEMBL
  ENSSSCG00050053911 UniProtKB/TrEMBL
  ENSSSCG00055006657 UniProtKB/TrEMBL
  ENSSSCG00060050988 UniProtKB/TrEMBL
  ENSSSCG00065050475 UniProtKB/TrEMBL
  ENSSSCG00070018714 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030856 ENTREZGENE
  ENSSSCT00000030856.3 UniProtKB/TrEMBL
  ENSSSCT00005005779.1 UniProtKB/TrEMBL
  ENSSSCT00015078242.1 UniProtKB/TrEMBL
  ENSSSCT00025007619.1 UniProtKB/TrEMBL
  ENSSSCT00030084260.1 UniProtKB/TrEMBL
  ENSSSCT00035008242.1 UniProtKB/TrEMBL
  ENSSSCT00040088993.1 UniProtKB/TrEMBL
  ENSSSCT00045044628.1 UniProtKB/TrEMBL
  ENSSSCT00050073491.1 UniProtKB/TrEMBL
  ENSSSCT00055012867.1 UniProtKB/TrEMBL
  ENSSSCT00060069365.1 UniProtKB/TrEMBL
  ENSSSCT00065069139.1 UniProtKB/TrEMBL
  ENSSSCT00070036889.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.590 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100621117 UniProtKB/TrEMBL
NCBI Gene GIP ENTREZGENE
PANTHER GASTRIC INHIBITORY POLYPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLUCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1URI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PC84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0XSE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1I9K0 ENTREZGENE, UniProtKB/TrEMBL
  GIP_PIG UniProtKB/Swiss-Prot
  I3LI45 ENTREZGENE, UniProtKB/TrEMBL
  I3RLE6 ENTREZGENE
  P01281 ENTREZGENE
UniProt Secondary I3RLE6 UniProtKB/TrEMBL
VGNC ID VGNC:98995 ENTREZGENE