CAPN14 (calpain 14) - Rat Genome Database

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Gene: CAPN14 (calpain 14) Sus scrofa
Analyze
Symbol: CAPN14
Name: calpain 14
RGD ID: 14084021
Description: ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); eosinophilic esophagitis (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calpain-14
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3108,152,047 - 108,190,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13108,152,053 - 108,191,391 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,886,292 - 114,916,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component
cytoplasm  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPN14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3108,152,047 - 108,190,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13108,152,053 - 108,191,391 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,886,292 - 114,916,149 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPN14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38231,173,056 - 31,233,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl231,173,056 - 31,233,858 (-)EnsemblGRCh38hg38GRCh38
GRCh37231,395,922 - 31,456,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,249,426 - 31,310,228 (-)NCBINCBI36Build 36hg18NCBI36
Celera231,238,630 - 31,283,129 (-)NCBICelera
Cytogenetic Map2p23.1NCBI
HuRef231,133,588 - 31,178,077 (-)NCBIHuRef
CHM1_1231,326,254 - 31,371,020 (-)NCBICHM1_1
T2T-CHM13v2.0231,217,215 - 31,278,121 (-)NCBIT2T-CHM13v2.0
Capn14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546912,899,174 - 12,929,408 (-)NCBIChiLan1.0ChiLan1.0
CAPN14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21295,292,547 - 95,328,325 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A95,296,521 - 95,330,001 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A31,186,027 - 31,245,818 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A31,256,702 - 31,317,389 (-)NCBIpanpan1.1PanPan1.1panPan2
CAPN14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11724,774,603 - 24,812,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1724,775,059 - 24,811,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,568,877 - 24,608,698 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,338,344 - 25,378,171 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,338,801 - 25,393,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11724,641,601 - 24,681,433 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01724,703,580 - 24,743,527 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01724,803,646 - 24,843,487 (-)NCBIUU_Cfam_GSD_1.0
Capn14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629268,886,875 - 68,914,055 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,925,510 - 1,949,585 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,925,510 - 1,949,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11476,271,701 - 76,334,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1476,302,648 - 76,335,341 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604535,741,487 - 35,800,904 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capn14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473812,978,086 - 13,006,327 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473812,975,145 - 13,033,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CAPN14
1611 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 1 1 1
Below cutoff 4 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031281   ⟹   ENSSSCP00000021966
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3108,152,047 - 108,190,047 (+)Ensembl
RefSeq Acc Id: XM_021088409   ⟹   XP_020944068
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13108,152,053 - 108,191,391 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020944068 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000021966
  ENSSSCP00000021966.3
Reference Protein Sequences
RefSeq Acc Id: XP_020944068   ⟸   XM_021088409
- UniProtKB: I3LD38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021966   ⟸   ENSSSCT00000031281
Protein Domains
Calpain catalytic   EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031281 ENTREZGENE
  ENSSSCT00000031281.4 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.380 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Calpain_cysteine_protease UniProtKB/TrEMBL
  Calpain_domain_III UniProtKB/TrEMBL
  Calpain_III UniProtKB/TrEMBL
  Calpain_III_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Peptidase_C2_calpain_cat UniProtKB/TrEMBL
NCBI Gene CAPN14 ENTREZGENE
PANTHER CALPAIN UniProtKB/TrEMBL
  CALPAIN-14 UniProtKB/TrEMBL
Pfam Calpain_III UniProtKB/TrEMBL
  Peptidase_C2 UniProtKB/TrEMBL
PRINTS CALPAIN UniProtKB/TrEMBL
PROSITE CALPAIN_CAT UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
SMART calpain_III UniProtKB/TrEMBL
  CysPc UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF49758 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt I3LD38 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:97043 ENTREZGENE