RHBDL3 (rhomboid like 3) - Rat Genome Database

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Gene: RHBDL3 (rhomboid like 3) Sus scrofa
Analyze
Symbol: RHBDL3
Name: rhomboid like 3
RGD ID: 14058120
Description: ENCODES a protein that exhibits calcium ion binding (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rhomboid, veinlet-like 3; rhomboid-related protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,627,456 - 42,676,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,623,648 - 42,676,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,387,594 - 44,417,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RHBDL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,627,456 - 42,676,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,623,648 - 42,676,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,387,594 - 44,417,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHBDL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381732,265,832 - 32,324,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1732,265,832 - 32,324,659 (+)EnsemblGRCh38hg38GRCh38
GRCh371730,592,851 - 30,651,680 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,617,308 - 27,675,793 (+)NCBINCBI36Build 36hg18NCBI36
Celera1727,503,536 - 27,561,889 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,782,764 - 26,838,459 (+)NCBIHuRef
CHM1_11730,655,694 - 30,714,172 (+)NCBICHM1_1
T2T-CHM13v2.01733,211,602 - 33,270,432 (+)NCBIT2T-CHM13v2.0
Rhbdl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,191,296 - 80,246,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,191,738 - 80,246,781 (+)EnsemblGRCm39 Ensembl
GRCm381180,300,471 - 80,355,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,300,912 - 80,355,955 (+)EnsemblGRCm38mm10GRCm38
MGSCv371180,114,414 - 80,169,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361180,117,271 - 80,172,150 (+)NCBIMGSCv36mm8
Celera1189,937,356 - 89,993,361 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.73NCBI
Rhbdl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,797,145 - 65,851,949 (+)NCBIGRCr8
mRatBN7.21065,299,250 - 65,354,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1065,299,194 - 65,354,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1069,927,814 - 69,982,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01069,433,113 - 69,487,682 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01064,896,807 - 64,951,358 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01067,676,999 - 67,731,670 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,677,071 - 67,731,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01067,333,731 - 67,387,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41068,525,172 - 68,579,955 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11068,538,794 - 68,591,860 (+)NCBI
Celera1064,260,010 - 64,314,177 (+)NCBICelera
Cytogenetic Map10q26NCBI
Rhbdl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554817,232,692 - 7,276,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554817,233,305 - 7,276,085 (+)NCBIChiLan1.0ChiLan1.0
RHBDL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21932,132,495 - 32,191,464 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11734,012,321 - 34,071,337 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,451,483 - 24,510,736 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11724,739,326 - 24,797,155 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1724,739,326 - 24,797,159 (-)Ensemblpanpan1.1panPan2
RHBDL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1940,629,989 - 40,676,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl940,633,277 - 40,675,234 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha939,788,915 - 39,835,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0941,446,671 - 41,493,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,446,696 - 41,493,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,232,275 - 40,279,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,526,390 - 40,573,535 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0940,601,234 - 40,648,166 (-)NCBIUU_Cfam_GSD_1.0
Rhbdl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560239,704,675 - 39,751,527 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365382,583,046 - 2,629,453 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365382,582,598 - 2,629,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHBDL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,835,300 - 25,894,497 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,835,428 - 25,894,871 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660754,151,058 - 4,211,199 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhbdl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624875343,478 - 392,374 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624875343,409 - 392,365 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RHBDL3
2206 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 2 3 2 17
Below cutoff 4 1 2 1 5 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000019301   ⟹   ENSSSCP00000018789
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1242,627,456 - 42,676,900 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000041837   ⟹   ENSSSCP00000035377
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1242,627,456 - 42,675,335 (-)Ensembl
RefSeq Acc Id: XM_021067454   ⟹   XP_020923113
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11242,623,648 - 42,676,312 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067455   ⟹   XP_020923114
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11242,623,648 - 42,676,312 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020923114   ⟸   XM_021067455
- Peptide Label: isoform X2
- UniProtKB: A0A4X1TG87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923113   ⟸   XM_021067454
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TCU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000018789   ⟸   ENSSSCT00000019301
RefSeq Acc Id: ENSSSCP00000035377   ⟸   ENSSSCT00000041837
Protein Domains
EF-hand   Peptidase S54 rhomboid


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017734 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030060739 UniProtKB/TrEMBL
  ENSSSCG00035067481 UniProtKB/TrEMBL
  ENSSSCG00040012599 UniProtKB/TrEMBL
  ENSSSCG00045027638 UniProtKB/TrEMBL
  ENSSSCG00050044675 UniProtKB/TrEMBL
  ENSSSCG00055007178 UniProtKB/TrEMBL
  ENSSSCG00060055769 UniProtKB/TrEMBL
  ENSSSCG00065062029 UniProtKB/TrEMBL
  ENSSSCG00070008826 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019301.5 UniProtKB/TrEMBL
  ENSSSCT00000041837 ENTREZGENE
  ENSSSCT00000041837.3 UniProtKB/TrEMBL
  ENSSSCT00030084837.1 UniProtKB/TrEMBL
  ENSSSCT00035090999.1 UniProtKB/TrEMBL
  ENSSSCT00040016674.1 UniProtKB/TrEMBL
  ENSSSCT00045047205.1 UniProtKB/TrEMBL
  ENSSSCT00050060820.1 UniProtKB/TrEMBL
  ENSSSCT00055013980.1 UniProtKB/TrEMBL
  ENSSSCT00060076017.1 UniProtKB/TrEMBL
  ENSSSCT00065085116.1 UniProtKB/TrEMBL
  ENSSSCT00070017087.1 UniProtKB/TrEMBL
  ENSSSCT00070017093.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1540.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Peptidase_S54_rhomboid_dom UniProtKB/TrEMBL
  Peptidase_S54_rhomboid_met UniProtKB/TrEMBL
  Rhomboid-like_sf UniProtKB/TrEMBL
NCBI Gene RHBDL3 ENTREZGENE
PANTHER RHOMBOID-RELATED PROTEIN UniProtKB/TrEMBL
  RHOMBOID-RELATED PROTEIN 3 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  Rhomboid UniProtKB/TrEMBL
PIRSF Rhomboid UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF144091 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt A0A286ZV51_PIG UniProtKB/TrEMBL
  A0A4X1TCU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TG87 ENTREZGENE, UniProtKB/TrEMBL
  F1RKW5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92279 ENTREZGENE