PGPEP1L (pyroglutamyl-peptidase I like) - Rat Genome Database

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Gene: PGPEP1L (pyroglutamyl-peptidase I like) Sus scrofa
Analyze
Symbol: PGPEP1L
Name: pyroglutamyl-peptidase I like
RGD ID: 14040337
Description: ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); pyroglutamyl-peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH chromosome 15q26-qter deletion syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyroglutamyl-peptidase 1-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,308,438 - 137,380,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,307,784 - 137,384,465 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,438,767 - 153,511,366 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PGPEP1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1137,308,438 - 137,380,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11137,307,784 - 137,384,465 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,438,767 - 153,511,366 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGPEP1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,968,229 - 99,007,792 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1598,968,229 - 99,007,792 (-)EnsemblGRCh38hg38GRCh38
GRCh371599,511,458 - 99,551,021 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,329,032 - 97,366,314 (-)NCBINCBI36Build 36hg18NCBI36
Celera1575,928,408 - 75,967,924 (-)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1575,638,931 - 75,678,446 (-)NCBIHuRef
CHM1_11599,352,875 - 99,392,437 (-)NCBICHM1_1
T2T-CHM13v2.01596,732,626 - 96,772,141 (-)NCBIT2T-CHM13v2.0
Pgpep1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39767,881,154 - 67,914,232 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl767,886,358 - 67,913,981 (-)EnsemblGRCm39 Ensembl
GRCm38768,235,521 - 68,264,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl768,236,610 - 68,264,233 (-)EnsemblGRCm38mm10GRCm38
MGSCv37775,381,494 - 75,409,119 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36768,110,123 - 68,137,746 (-)NCBIMGSCv36mm8
Celera765,693,201 - 65,721,158 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map737.47NCBI
Pgpep1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81131,247,280 - 131,278,481 (-)NCBIGRCr8
mRatBN7.21121,835,243 - 121,868,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1121,840,697 - 121,869,407 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01129,216,221 - 129,244,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,216,152 - 129,217,058 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01130,273,933 - 130,302,611 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41122,999,105 - 123,010,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1114,038,502 - 114,067,153 (-)NCBICelera
Cytogenetic Map1q22NCBI
Pgpep1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541626,069,466 - 26,094,419 (+)NCBIChiLan1.0ChiLan1.0
PGPEP1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21688,509,202 - 88,548,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11592,206,720 - 92,350,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01577,651,265 - 77,791,570 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11596,836,590 - 96,877,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1596,836,590 - 96,839,587 (-)Ensemblpanpan1.1panPan2
PGPEP1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1342,101,055 - 42,150,367 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl342,098,609 - 42,146,623 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,791,584 - 44,850,067 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0342,500,856 - 42,559,442 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1342,025,366 - 42,083,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0342,256,272 - 42,310,921 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0342,476,154 - 42,534,677 (-)NCBIUU_Cfam_GSD_1.0
PGPEP1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12917,537,895 - 17,587,521 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605929,023,255 - 29,048,453 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgpep1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247685,691,436 - 5,707,956 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PGPEP1L
1674 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1
Low 10 4 3 5 2 23 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005310   ⟹   ENSSSCP00000005180
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1137,308,438 - 137,380,851 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087550   ⟹   ENSSSCP00000068483
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1137,344,985 - 137,379,830 (+)Ensembl
RefSeq Acc Id: XM_005659773   ⟹   XP_005659830
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,307,787 - 137,384,465 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005659775   ⟹   XP_005659832
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11137,307,784 - 137,384,465 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005659832   ⟸   XM_005659775
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005659830   ⟸   XM_005659773
- Peptide Label: isoform X1
- UniProtKB: A0A8D0QJ06 (UniProtKB/TrEMBL),   F1SRY2 (UniProtKB/TrEMBL),   A0A8D1VSL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005180   ⟸   ENSSSCT00000005310
RefSeq Acc Id: ENSSSCP00000068483   ⟸   ENSSSCT00000087550


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025004221 UniProtKB/TrEMBL
  ENSSSCG00030057258 UniProtKB/TrEMBL
  ENSSSCG00045023743 UniProtKB/TrEMBL
  ENSSSCG00060048996 UniProtKB/TrEMBL
  ENSSSCG00065026141 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005310 ENTREZGENE
  ENSSSCT00000005310.5 UniProtKB/TrEMBL
  ENSSSCT00025005594.1 UniProtKB/TrEMBL
  ENSSSCT00030079834.1 UniProtKB/TrEMBL
  ENSSSCT00045040589.1 UniProtKB/TrEMBL
  ENSSSCT00060066532.1 UniProtKB/TrEMBL
  ENSSSCT00065035108.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.20 UniProtKB/TrEMBL
InterPro Peptidase_C15 UniProtKB/TrEMBL
  Peptidase_C15-like UniProtKB/TrEMBL
  Peptidase_C15-like_sf UniProtKB/TrEMBL
KEGG Report ssc:100518709 UniProtKB/TrEMBL
NCBI Gene PGPEP1L ENTREZGENE
PANTHER PTHR23402 UniProtKB/TrEMBL
  PYROGLUTAMYL-PEPTIDASE 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Peptidase_C15 UniProtKB/TrEMBL
PIRSF Prld-crbxl_pptds UniProtKB/TrEMBL
PRINTS PYROGLUPTASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53182 UniProtKB/TrEMBL
UniProt A0A8D0QJ06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1VSL7 ENTREZGENE, UniProtKB/TrEMBL
  F1SRY2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91361 ENTREZGENE