S100A12 (S100 calcium binding protein A12) - Rat Genome Database

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Gene: S100A12 (S100 calcium binding protein A12) Sus scrofa
Analyze
Symbol: S100A12
Name: S100 calcium binding protein A12
RGD ID: 14033619
Description: ENCODES a protein that exhibits calcium ion binding; zinc ion binding; INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (inferred); defense response to fungus (inferred); inflammatory response (inferred); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); immunodeficiency 42 (ortholog); MHC class II deficiency (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); extracellular region (inferred); INTERACTS WITH deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CAGC; calgranulin-C; EN-RAGE; extracellular newly identified RAGE-binding protein; protein S100-A12
RGD Orthologs
Human
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,225,691 - 96,227,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,225,691 - 96,227,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24105,075,389 - 105,076,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7961855   PMID:14681463   PMID:17145712   PMID:20189650   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
S100A12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,225,691 - 96,227,127 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,225,691 - 96,227,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24105,075,389 - 105,076,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S100A12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,373,711 - 153,375,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,373,711 - 153,375,621 (-)EnsemblGRCh38hg38GRCh38
GRCh371153,346,187 - 153,348,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,612,808 - 151,614,699 (-)NCBINCBI36Build 36hg18NCBI36
Build 341150,159,256 - 150,161,148NCBI
Celera1126,417,439 - 126,419,330 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,709,595 - 124,711,486 (-)NCBIHuRef
CHM1_11154,741,897 - 154,743,788 (-)NCBICHM1_1
T2T-CHM13v2.01152,510,935 - 152,512,845 (-)NCBIT2T-CHM13v2.0
S100A12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,462,114 - 96,464,031 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,197,768 - 96,199,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,725,102 - 128,727,021 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,354,132 - 132,356,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,354,132 - 132,356,085 (-)Ensemblpanpan1.1panPan2
S100A12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,554,078 - 43,555,470 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,554,146 - 43,555,475 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha743,046,910 - 43,048,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,503,704 - 43,505,146 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,503,822 - 43,505,151 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,206,024 - 43,207,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,259,932 - 43,261,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,543,469 - 43,544,911 (+)NCBIUU_Cfam_GSD_1.0
S100A12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,377,418 - 10,379,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660389,847,458 - 9,848,394 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in S100A12
41 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 1 1 2
Medium 1
Low 2 4 2 4 2 7 2 1
Below cutoff 7 1 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000066217   ⟹   ENSSSCP00000032082
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl496,225,691 - 96,227,127 (+)Ensembl
RefSeq Acc Id: NM_001160272   ⟹   NP_001153744
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1496,225,691 - 96,227,030 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001153744   ⟸   NM_001160272
- UniProtKB: P80310 (UniProtKB/Swiss-Prot),   C3S7K4 (UniProtKB/TrEMBL),   A0A4X1W1C0 (UniProtKB/TrEMBL),   A0A5S6H0X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032082   ⟸   ENSSSCT00000066217
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005017529 UniProtKB/Swiss-Prot
  ENSSSCG00015021486 UniProtKB/Swiss-Prot
  ENSSSCG00025058600 UniProtKB/TrEMBL
  ENSSSCG00030041199 UniProtKB/TrEMBL
  ENSSSCG00035005883 UniProtKB/TrEMBL
  ENSSSCG00040066184 UniProtKB/TrEMBL
  ENSSSCG00045009918 UniProtKB/TrEMBL
  ENSSSCG00050007804 UniProtKB/TrEMBL
  ENSSSCG00055025041 UniProtKB/TrEMBL
  ENSSSCG00060052818 UniProtKB/TrEMBL
  ENSSSCG00065066186 UniProtKB/TrEMBL
  ENSSSCG00070027991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000066217 ENTREZGENE
  ENSSSCT00000066217.3 UniProtKB/TrEMBL
  ENSSSCT00005027709.1 UniProtKB/Swiss-Prot
  ENSSSCT00015028578.1 UniProtKB/Swiss-Prot
  ENSSSCT00015028675.1 UniProtKB/Swiss-Prot
  ENSSSCT00025080220.1 UniProtKB/TrEMBL
  ENSSSCT00030057234.1 UniProtKB/TrEMBL
  ENSSSCT00035007350.1 UniProtKB/TrEMBL
  ENSSSCT00040090420.1 UniProtKB/TrEMBL
  ENSSSCT00045016817.1 UniProtKB/TrEMBL
  ENSSSCT00050010660.1 UniProtKB/TrEMBL
  ENSSSCT00055049505.1 UniProtKB/TrEMBL
  ENSSSCT00060071882.1 UniProtKB/TrEMBL
  ENSSSCT00065090840.1 UniProtKB/TrEMBL
  ENSSSCT00070056169.1 UniProtKB/Swiss-Prot
  ENSSSCT00070056170.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100301483 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene S100A12 ENTREZGENE
PANTHER PROTEIN S100-A12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_CABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1W1C0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S6H0X2 ENTREZGENE, UniProtKB/TrEMBL
  C3S7K4 ENTREZGENE, UniProtKB/TrEMBL
  P80310 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:92538 ENTREZGENE