LLGL1 (LLGL scribble cell polarity complex component 1) - Rat Genome Database

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Gene: LLGL1 (LLGL scribble cell polarity complex component 1) Sus scrofa
Analyze
Symbol: LLGL1
Name: LLGL scribble cell polarity complex component 1
RGD ID: 14018864
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN axonogenesis (ortholog); maintenance of apical/basal cell polarity (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); Breast Neoplasms (ortholog); FOUND IN axon (ortholog); basolateral plasma membrane (ortholog); cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lethal(2) giant larvae protein homolog 1; LLGL1, scribble cell polarity complex component
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,487,337 - 60,500,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LLGL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,487,337 - 60,500,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LLGL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,225,635 - 18,244,875 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,225,635 - 18,244,875 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,128,949 - 18,148,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,069,661 - 18,088,914 (+)NCBINCBI36Build 36hg18NCBI36
Build 341718,069,715 - 18,087,963NCBI
Celera1719,074,368 - 19,089,303 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,886,506 - 17,901,442 (+)NCBIHuRef
CHM1_11718,137,711 - 18,156,955 (+)NCBICHM1_1
T2T-CHM13v2.01718,172,434 - 18,191,679 (+)NCBIT2T-CHM13v2.0
Llgl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,590,501 - 60,605,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,590,549 - 60,605,012 (+)EnsemblGRCm39 Ensembl
GRCm381160,699,672 - 60,714,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,699,723 - 60,714,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,513,192 - 60,527,690 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,130,925 - 61,145,271 (+)NCBIMGSCv36mm8
MGSCv361160,516,035 - 60,530,381 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Llgl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,878,936 - 45,893,609 (+)NCBIGRCr8
mRatBN7.21045,379,423 - 45,394,096 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,379,515 - 45,394,094 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,080,221 - 50,094,720 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,570,609 - 49,585,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,074,208 - 45,088,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,940,873 - 46,955,524 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,940,965 - 46,954,674 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,713,910 - 46,728,515 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,845,810 - 46,859,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,859,432 - 46,872,723 (+)NCBI
Celera1044,634,872 - 44,649,254 (+)NCBICelera
Cytogenetic Map10q22NCBI
Llgl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,075,399 - 11,089,839 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,075,399 - 11,089,818 (-)NCBIChiLan1.0ChiLan1.0
LLGL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,021,328 - 53,040,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,732,297 - 57,751,542 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,770,511 - 32,789,756 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11737,966,100 - 37,982,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1737,966,100 - 37,985,103 (-)Ensemblpanpan1.1panPan2
LLGL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,314,807 - 41,332,687 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,315,152 - 41,332,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,454,283 - 41,472,092 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,421,547 - 41,439,311 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,421,553 - 41,439,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,389,367 - 41,407,168 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,336,840 - 41,354,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,528,638 - 41,546,442 (-)NCBIUU_Cfam_GSD_1.0
Llgl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,082,262 - 61,099,934 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,770,620 - 1,788,356 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,770,797 - 1,784,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LLGL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,266,648 - 17,285,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,266,684 - 17,284,076 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,617,199 - 3,638,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Llgl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,227,758 - 3,245,118 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,227,518 - 3,245,137 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LLGL1
179 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 4 3 2 5 2 21 2 2 3
Below cutoff 5 1 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000060744   ⟹   ENSSSCP00000039542
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067330   ⟹   ENSSSCP00000070213
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000091055   ⟹   ENSSSCP00000069383
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000095005   ⟹   ENSSSCP00000077733
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000106041   ⟹   ENSSSCP00000074828
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,487,343 - 60,500,447 (-)Ensembl
RefSeq Acc Id: XM_021067985   ⟹   XP_020923644
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11260,487,337 - 60,500,423 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020923644 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000039542
  ENSSSCP00000039542.3
  ENSSSCP00000069383.2
  ENSSSCP00000070213.2
  ENSSSCP00000074828.1
  ENSSSCP00000077733.1
  ENSSSCP00035041203.1
  ENSSSCP00070006628.1
Reference Protein Sequences
RefSeq Acc Id: XP_020923644   ⟸   XM_021067985
- UniProtKB: A0A480IQW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000039542   ⟸   ENSSSCT00000060744
RefSeq Acc Id: ENSSSCP00000069383   ⟸   ENSSSCT00000091055
RefSeq Acc Id: ENSSSCP00000070213   ⟸   ENSSSCT00000067330
RefSeq Acc Id: ENSSSCP00000077733   ⟸   ENSSSCT00000095005
RefSeq Acc Id: ENSSSCP00000074828   ⟸   ENSSSCT00000106041
Protein Domains
Lethal giant larvae (Lgl)-like C-terminal   Lethal giant larvae homologue


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035072154 UniProtKB/TrEMBL
  ENSSSCG00070004271 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060744 ENTREZGENE
  ENSSSCT00000060744.3 UniProtKB/TrEMBL
  ENSSSCT00000067330.2 UniProtKB/TrEMBL
  ENSSSCT00000091055.2 UniProtKB/TrEMBL
  ENSSSCT00000095005.1 UniProtKB/TrEMBL
  ENSSSCT00000106041.1 UniProtKB/TrEMBL
  ENSSSCT00035097625.1 UniProtKB/TrEMBL
  ENSSSCT00070008053.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Lethal2_giant UniProtKB/TrEMBL
  Lgl_C_dom UniProtKB/TrEMBL
  LLGL2 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene LLGL1 ENTREZGENE
PANTHER LETHAL 2 GIANT LARVAE PROTEIN UniProtKB/TrEMBL
  LETHAL(2) GIANT LARVAE PROTEIN HOMOLOG 1 UniProtKB/TrEMBL
Pfam Lgl_C UniProtKB/TrEMBL
  LLGL UniProtKB/TrEMBL
PRINTS LETHAL2GIANT UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A287A6Z8_PIG UniProtKB/TrEMBL
  A0A480IQW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SW54_PIG UniProtKB/TrEMBL
  A0A5G2QZ13_PIG UniProtKB/TrEMBL
  A0A5G2QZ99_PIG UniProtKB/TrEMBL
  A0A8W4F7S8_PIG UniProtKB/TrEMBL
  A0A8W4FE85_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89746 ENTREZGENE