TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) - Rat Genome Database

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Gene: TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3) Sus scrofa
Analyze
Symbol: TCIRG1
Name: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
RGD ID: 14009626
Description: ENCODES a protein that exhibits ATPase binding (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN apoptotic process (ortholog); autophagosome assembly (ortholog); autophagy (ortholog); ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal recessive osteopetrosis 1 (ortholog); choreaacanthocytosis (ortholog); FOUND IN apical plasma membrane (inferred); late endosome (inferred); lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: V-type proton ATPase 116 kDa subunit a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,844,637 - 4,860,498 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,844,627 - 4,860,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,476,372 - 3,488,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
autophagosome assembly  (IEA,ISO)
autophagy  (IEA,ISO)
B cell differentiation  (IEA,ISO)
bone resorption  (IEA,ISO)
cellular response to cytokine stimulus  (IEA,ISO)
dentin mineralization  (IEA,ISO)
enamel mineralization  (IEA,ISO)
establishment of cell polarity  (IEA,ISO)
establishment of vesicle localization  (IEA,ISO)
gene expression  (IEA,ISO)
hematopoietic stem cell homeostasis  (IEA,ISO)
homeostasis of number of cells  (IEA,ISO)
immunoglobulin mediated immune response  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular pH reduction  (IEA,ISO)
macroautophagy  (IEA,ISO)
memory T cell activation  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
odontogenesis  (IEA,ISO)
optic nerve development  (IEA,ISO)
ossification  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
osteoclast proliferation  (IEA,ISO)
pH reduction  (IEA,ISO)
phagosome acidification  (IEA,ISO)
protein catabolic process in the vacuole  (IEA,ISO)
protein localization to organelle  (IEA,ISO)
proton transmembrane transport  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of osteoblast differentiation  (IEA,ISO)
regulation of proton transport  (IEA,ISO)
response to silver ion  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
ruffle organization  (IEA,ISO)
T cell differentiation  (IEA,ISO)
T cell homeostasis  (IEA,ISO)
T-helper 1 cell activation  (IEA,ISO)
tooth eruption  (IEA,ISO)
vacuolar acidification  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TCIRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,844,637 - 4,860,498 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,844,627 - 4,860,562 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,476,372 - 3,488,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCIRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,039,025 - 68,053,762 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,039,025 - 68,050,895 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,806,492 - 67,818,362 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,563,059 - 67,574,942 (+)NCBINCBI36Build 36hg18NCBI36
Celera1165,140,155 - 65,152,040 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,141,805 - 64,153,709 (+)NCBIHuRef
CHM1_11167,690,218 - 67,702,120 (+)NCBICHM1_1
T2T-CHM13v2.01168,042,666 - 68,057,403 (+)NCBIT2T-CHM13v2.0
Tcirg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,946,050 - 3,957,717 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,946,050 - 3,957,133 (-)EnsemblGRCm39 Ensembl
GRCm38193,896,050 - 3,907,133 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,896,050 - 3,907,133 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,896,050 - 3,907,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,896,053 - 3,905,230 (-)NCBIMGSCv36mm8
Celera193,776,425 - 3,787,508 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.62NCBI
Tcirg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,556,270 - 210,568,021 (-)NCBIGRCr8
mRatBN7.21201,127,034 - 201,138,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,127,034 - 201,138,742 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,500,301 - 209,509,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,589,084 - 216,598,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,263,286 - 209,272,675 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,126,687 - 219,139,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,127,602 - 219,139,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,999,292 - 226,012,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,420,106 - 206,429,495 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,573,497 - 206,585,222 (-)NCBI
Celera1198,679,648 - 198,689,037 (-)NCBICelera
Cytogenetic Map1q43NCBI
Tcirg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,768,469 - 17,779,003 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,768,469 - 17,778,976 (-)NCBIChiLan1.0ChiLan1.0
TCIRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,989,593 - 69,001,506 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,032,855 - 70,044,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,120,913 - 63,132,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,429,435 - 66,441,327 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,429,435 - 66,441,327 (+)Ensemblpanpan1.1panPan2
TCIRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,784,480 - 49,794,361 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,784,490 - 49,794,317 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,393,818 - 48,403,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,705,711 - 50,715,580 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,703,574 - 50,715,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,919,281 - 49,929,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,494,101 - 49,503,970 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,287,643 - 50,297,518 (-)NCBIUU_Cfam_GSD_1.0
Tcirg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,627,790 - 5,636,842 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,066,847 - 2,079,206 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,070,211 - 2,079,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCIRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,484,469 - 6,497,008 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,484,474 - 6,494,719 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038103,762,696 - 103,775,284 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcirg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,809,689 - 18,820,390 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476718,809,626 - 18,820,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TCIRG1
634 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2
Low 9 4 3 4 2 13 2 3 1
Below cutoff 1 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014092   ⟹   ENSSSCP00000013706
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,844,637 - 4,860,498 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046758   ⟹   ENSSSCP00000039295
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,844,637 - 4,858,370 (-)Ensembl
RefSeq Acc Id: XM_003122433   ⟹   XP_003122481
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,844,627 - 4,860,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005660613   ⟹   XP_005660670
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,844,627 - 4,860,562 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005660614   ⟹   XP_005660671
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,844,627 - 4,860,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082733   ⟹   XP_020938392
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,844,627 - 4,860,514 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005660670   ⟸   XM_005660613
- Peptide Label: isoform X2
- UniProtKB: A0A8D1XVC1 (UniProtKB/TrEMBL),   K9J6L7 (UniProtKB/TrEMBL),   A0A287A5S2 (UniProtKB/TrEMBL),   A0A5K1VS82 (UniProtKB/TrEMBL),   F1RVP8 (UniProtKB/TrEMBL),   A0A8D1D0A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003122481   ⟸   XM_003122433
- Peptide Label: isoform X3
- UniProtKB: A0A8D1D0A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938392   ⟸   XM_021082733
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SV87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660671   ⟸   XM_005660614
- Peptide Label: isoform X2
- UniProtKB: A0A8D1XVC1 (UniProtKB/TrEMBL),   K9J6L7 (UniProtKB/TrEMBL),   A0A287A5S2 (UniProtKB/TrEMBL),   A0A5K1VS82 (UniProtKB/TrEMBL),   F1RVP8 (UniProtKB/TrEMBL),   A0A8D1D0A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000039295   ⟸   ENSSSCT00000046758
RefSeq Acc Id: ENSSSCP00000013706   ⟸   ENSSSCT00000014092


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035060593 UniProtKB/TrEMBL
  ENSSSCG00065021886 UniProtKB/TrEMBL
  ENSSSCG00070004032 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014092 ENTREZGENE
  ENSSSCT00000014092.5 UniProtKB/TrEMBL
  ENSSSCT00000046758.3 UniProtKB/TrEMBL
  ENSSSCT00035081384.1 UniProtKB/TrEMBL
  ENSSSCT00065029131.1 UniProtKB/TrEMBL
  ENSSSCT00070007638.1 UniProtKB/TrEMBL
InterPro V-ATPase_116kDa_su UniProtKB/TrEMBL
  V-type_ATPase_116kDa_su_euka UniProtKB/TrEMBL
NCBI Gene TCIRG1 ENTREZGENE
PANTHER PTHR11629 UniProtKB/TrEMBL
  V-TYPE PROTON ATPASE 116 KDA SUBUNIT A3 UniProtKB/TrEMBL
Pfam V_ATPase_I UniProtKB/TrEMBL
PIRSF ATP6V0A1 UniProtKB/TrEMBL
UniProt A0A287A5S2 ENTREZGENE
  A0A4X1SV87 ENTREZGENE, UniProtKB/TrEMBL
  A0A5K1VS82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1D0A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XVC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8X9AEU4_PIG UniProtKB/TrEMBL
  F1RVP8 ENTREZGENE
  K9J6L7 ENTREZGENE
UniProt Secondary A0A287A5S2 UniProtKB/TrEMBL
  F1RVP8 UniProtKB/TrEMBL
  K9J6L7 UniProtKB/TrEMBL
VGNC ID VGNC:93828 ENTREZGENE