SHD (Src homology 2 domain containing transforming protein D) - Rat Genome Database

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Gene: SHD (Src homology 2 domain containing transforming protein D) Sus scrofa
Analyze
Symbol: SHD
Name: Src homology 2 domain containing transforming protein D
RGD ID: 14007099
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2 domain-containing adapter protein D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,497,351 - 74,504,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,496,771 - 74,506,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,990,300 - 74,997,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,497,351 - 74,504,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,496,771 - 74,506,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,990,300 - 74,997,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,279,069 - 4,290,722 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,279,266 - 4,290,722 (+)EnsemblGRCh38hg38GRCh38
GRCh37194,279,066 - 4,290,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,230,659 - 4,241,720 (+)NCBINCBI36Build 36hg18NCBI36
Celera194,217,984 - 4,230,101 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,041,763 - 4,053,879 (+)NCBIHuRef
CHM1_1194,278,213 - 4,290,327 (+)NCBICHM1_1
T2T-CHM13v2.0194,262,345 - 4,273,993 (+)NCBIT2T-CHM13v2.0
Shd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,276,828 - 56,283,624 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,277,467 - 56,283,625 (+)EnsemblGRCm39 Ensembl
GRCm381755,969,828 - 55,976,620 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1755,970,467 - 55,976,625 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,109,905 - 56,116,043 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,563,776 - 55,569,910 (+)NCBIMGSCv36mm8
Celera1759,389,009 - 59,395,147 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.09NCBI
Shd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89888,865 - 895,557 (+)NCBIGRCr8
mRatBN7.29799,652 - 809,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9795,674 - 808,371 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,248,790 - 1,255,476 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,595,976 - 6,602,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,553,828 - 5,560,514 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0911,090,048 - 11,098,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl911,089,106 - 11,096,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0910,075,316 - 10,083,990 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,698,081 - 7,704,778 (-)NCBICelera
Cytogenetic Map9q11NCBI
Shd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,577,178 - 4,586,955 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,579,252 - 4,587,192 (-)NCBIChiLan1.0ChiLan1.0
SHD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,676,614 - 8,687,690 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,906,663 - 7,917,916 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,301,944 - 3,313,769 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,250,630 - 4,261,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,250,630 - 4,261,038 (+)Ensemblpanpan1.1panPan2
SHD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,356,407 - 55,361,675 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,356,169 - 55,361,681 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,084,340 - 55,089,970 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,015,524 - 56,021,165 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,015,513 - 56,020,937 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,075,479 - 55,081,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,556,686 - 55,562,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,755,327 - 55,760,970 (-)NCBIUU_Cfam_GSD_1.0
Shd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,380,272 - 215,388,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,447,947 - 2,454,591 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,447,133 - 2,454,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,021,013 - 4,030,904 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,022,494 - 4,030,812 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,182,012 - 4,193,091 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,368,029 - 5,375,702 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,368,153 - 5,376,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SHD
153 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 19
Below cutoff 8 3 3 3 1 4 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014750   ⟹   ENSSSCP00000014352
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl274,497,351 - 74,504,659 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090739   ⟹   ENSSSCP00000063727
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl274,497,574 - 74,504,659 (-)Ensembl
RefSeq Acc Id: XM_003123062   ⟹   XP_003123110
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1274,496,771 - 74,506,855 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003123110   ⟸   XM_003123062
- UniProtKB: F1S7M3 (UniProtKB/TrEMBL),   A0A8D1EKH3 (UniProtKB/TrEMBL),   A0A4X1VS21 (UniProtKB/TrEMBL),   A0A5G2QG52 (UniProtKB/TrEMBL),   A0A8D0WUH7 (UniProtKB/TrEMBL),   A0A8D1TI01 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000063727   ⟸   ENSSSCT00000090739
RefSeq Acc Id: ENSSSCP00000014352   ⟸   ENSSSCT00000014750
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005036832 UniProtKB/TrEMBL
  ENSSSCG00015039380 UniProtKB/TrEMBL
  ENSSSCG00025023823 UniProtKB/TrEMBL
  ENSSSCG00030042331 UniProtKB/TrEMBL
  ENSSSCG00035017224 UniProtKB/TrEMBL
  ENSSSCG00040043204 UniProtKB/TrEMBL
  ENSSSCG00045018660 UniProtKB/TrEMBL
  ENSSSCG00050049323 UniProtKB/TrEMBL
  ENSSSCG00055027173 UniProtKB/TrEMBL
  ENSSSCG00060005349 UniProtKB/TrEMBL
  ENSSSCG00065027233 UniProtKB/TrEMBL
  ENSSSCG00070026299 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014750 ENTREZGENE
  ENSSSCT00000014750.3 UniProtKB/TrEMBL
  ENSSSCT00000090739.2 UniProtKB/TrEMBL
  ENSSSCT00005058850.1 UniProtKB/TrEMBL
  ENSSSCT00005058894.1 UniProtKB/TrEMBL
  ENSSSCT00015052408.1 UniProtKB/TrEMBL
  ENSSSCT00015052543.1 UniProtKB/TrEMBL
  ENSSSCT00025032253.1 UniProtKB/TrEMBL
  ENSSSCT00025032322.1 UniProtKB/TrEMBL
  ENSSSCT00030058901.1 UniProtKB/TrEMBL
  ENSSSCT00030058918.1 UniProtKB/TrEMBL
  ENSSSCT00035022098.1 UniProtKB/TrEMBL
  ENSSSCT00035022104.1 UniProtKB/TrEMBL
  ENSSSCT00040057823.1 UniProtKB/TrEMBL
  ENSSSCT00040057890.1 UniProtKB/TrEMBL
  ENSSSCT00045031731.1 UniProtKB/TrEMBL
  ENSSSCT00045031781.1 UniProtKB/TrEMBL
  ENSSSCT00050067113.1 UniProtKB/TrEMBL
  ENSSSCT00050067116.1 UniProtKB/TrEMBL
  ENSSSCT00055053696.1 UniProtKB/TrEMBL
  ENSSSCT00055053750.1 UniProtKB/TrEMBL
  ENSSSCT00060006728.1 UniProtKB/TrEMBL
  ENSSSCT00060006733.1 UniProtKB/TrEMBL
  ENSSSCT00065036667.1 UniProtKB/TrEMBL
  ENSSSCT00065036671.1 UniProtKB/TrEMBL
  ENSSSCT00070052711.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SHD_SH2 UniProtKB/TrEMBL
KEGG Report ssc:100523303 UniProtKB/TrEMBL
NCBI Gene SHD ENTREZGENE
PANTHER HEAVYWEIGHT, ISOFORM A UniProtKB/TrEMBL
  PTHR15127:SF33 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
UniProt A0A4X1VS21 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QG52 ENTREZGENE
  A0A8D0WUH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EKH3 ENTREZGENE
  A0A8D1TI01 ENTREZGENE, UniProtKB/TrEMBL
  F1S7M3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A5G2QG52 UniProtKB/TrEMBL
  A0A8D1EKH3 UniProtKB/TrEMBL
VGNC ID VGNC:92841 ENTREZGENE