GLCE (glucuronic acid epimerase) - Rat Genome Database

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Gene: GLCE (glucuronic acid epimerase) Sus scrofa
Analyze
Symbol: GLCE
Name: glucuronic acid epimerase
RGD ID: 13997419
Description: ENCODES a protein that exhibits calcium ion binding (inferred); heparosan-N-sulfate-glucuronate 5-epimerase activity (inferred); protein homodimerization activity (inferred); INVOLVED IN negative regulation of cell projection organization (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); cerebrovascular disease (ortholog); colorectal cancer (ortholog); FOUND IN Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D-glucuronyl C5-epimerase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,007,939 - 167,122,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,007,930 - 167,122,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,978,725 - 185,090,175 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi apparatus  (IEA,ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GLCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,007,939 - 167,122,186 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,007,930 - 167,122,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,978,725 - 185,090,175 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381569,160,635 - 69,272,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1569,160,584 - 69,272,217 (+)EnsemblGRCh38hg38GRCh38
GRCh371569,452,974 - 69,564,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361567,240,027 - 67,351,598 (+)NCBINCBI36Build 36hg18NCBI36
Celera1546,342,293 - 46,453,794 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1546,285,927 - 46,397,426 (+)NCBIHuRef
CHM1_11569,571,150 - 69,682,613 (+)NCBICHM1_1
T2T-CHM13v2.01566,983,187 - 67,094,669 (+)NCBIT2T-CHM13v2.0
Glce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39961,964,526 - 62,029,891 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl961,964,530 - 62,029,937 (-)EnsemblGRCm39 Ensembl
GRCm38962,057,244 - 62,122,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,057,248 - 62,122,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv37961,905,055 - 61,918,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36961,855,254 - 61,868,612 (-)NCBIMGSCv36mm8
Celera959,282,349 - 59,295,707 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map933.56NCBI
Glce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,441,607 - 71,507,639 (-)NCBIGRCr8
mRatBN7.2862,546,104 - 62,612,144 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,546,107 - 62,612,040 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0867,006,588 - 67,073,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,006,592 - 67,040,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0866,742,121 - 66,808,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4866,199,172 - 66,268,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera861,964,353 - 62,030,080 (-)NCBICelera
Cytogenetic Map8q24NCBI
Glce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,149,721 - 7,227,524 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554507,149,721 - 7,226,835 (-)NCBIChiLan1.0ChiLan1.0
GLCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21658,424,114 - 58,535,662 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11562,588,654 - 62,700,148 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01548,110,725 - 48,222,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11566,884,203 - 66,995,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1566,979,271 - 66,995,646 (+)Ensemblpanpan1.1panPan2
GLCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13033,093,318 - 33,208,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3033,110,947 - 33,206,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3033,026,823 - 33,141,852 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03033,292,160 - 33,407,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3033,292,130 - 33,407,353 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13033,218,466 - 33,333,109 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03033,280,176 - 33,394,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03033,527,094 - 33,642,556 (+)NCBIUU_Cfam_GSD_1.0
Glce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640111,137,374 - 111,187,803 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647128,985,406 - 29,035,870 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647128,984,777 - 29,035,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12614,181,625 - 14,295,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2614,184,606 - 14,295,372 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048127,179,011 - 127,301,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glce
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,135,122 - 4,206,270 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247814,135,829 - 4,228,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GLCE
2943 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 1 3 3 14 3 2
Low 1 3 2 2 9 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000022924   ⟹   ENSSSCP00000019174
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1167,007,939 - 167,122,186 (+)Ensembl
RefSeq Acc Id: XM_001927959   ⟹   XP_001927994
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11167,007,930 - 167,122,196 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_001927994   ⟸   XM_001927959
- UniProtKB: F1SIU0 (UniProtKB/TrEMBL),   A0A4X1T674 (UniProtKB/TrEMBL),   A0A0B8RZK0 (UniProtKB/TrEMBL),   A0A8D0UAN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019174   ⟸   ENSSSCT00000022924
Protein Domains
D-glucuronyl C5-epimerase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026078 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005031345 UniProtKB/TrEMBL
  ENSSSCG00015067802 UniProtKB/TrEMBL
  ENSSSCG00025048823 UniProtKB/TrEMBL
  ENSSSCG00030010909 UniProtKB/TrEMBL
  ENSSSCG00035022326 UniProtKB/TrEMBL
  ENSSSCG00040071064 UniProtKB/TrEMBL
  ENSSSCG00045016955 UniProtKB/TrEMBL
  ENSSSCG00050067350 UniProtKB/TrEMBL
  ENSSSCG00055001256 UniProtKB/TrEMBL
  ENSSSCG00060015447 UniProtKB/TrEMBL
  ENSSSCG00065038781 UniProtKB/TrEMBL
  ENSSSCG00070006725 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022924 ENTREZGENE
  ENSSSCT00000022924.4 UniProtKB/TrEMBL
  ENSSSCT00005050030.1 UniProtKB/TrEMBL
  ENSSSCT00005050052.1 UniProtKB/TrEMBL
  ENSSSCT00015090848.1 UniProtKB/TrEMBL
  ENSSSCT00025066468.1 UniProtKB/TrEMBL
  ENSSSCT00030014973.1 UniProtKB/TrEMBL
  ENSSSCT00035029137.1 UniProtKB/TrEMBL
  ENSSSCT00040097643.1 UniProtKB/TrEMBL
  ENSSSCT00045028836.1 UniProtKB/TrEMBL
  ENSSSCT00050091876.1 UniProtKB/TrEMBL
  ENSSSCT00055002247.1 UniProtKB/TrEMBL
  ENSSSCT00060020566.1 UniProtKB/TrEMBL
  ENSSSCT00065052998.1 UniProtKB/TrEMBL
  ENSSSCT00070012897.1 UniProtKB/TrEMBL
InterPro C5-epim_C UniProtKB/TrEMBL
  C5-epimerase UniProtKB/TrEMBL
KEGG Report ssc:100154444 UniProtKB/TrEMBL
NCBI Gene GLCE ENTREZGENE
PANTHER D-GLUCURONYL C5-EPIMERASE UniProtKB/TrEMBL
  PTHR13174 UniProtKB/TrEMBL
Pfam C5-epim_C UniProtKB/TrEMBL
  Glce_b_sandwich UniProtKB/TrEMBL
UniProt A0A0B8RZK0 ENTREZGENE
  A0A4X1T674 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UAN7 ENTREZGENE, UniProtKB/TrEMBL
  F1SIU0 ENTREZGENE
UniProt Secondary F1SIU0 UniProtKB/TrEMBL
VGNC ID VGNC:88477 ENTREZGENE