CISD3 (CDGSH iron sulfur domain 3)

Gene: CISD3 (CDGSH iron sulfur domain 3) Sus scrofa

Analyze

Symbol:

CISD3

Name:

CDGSH iron sulfur domain 3

RGD ID:

13960710

Description:

ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN protein maturation by [2Fe-2S] cluster transfer (inferred); ASSOCIATED WITH genetic disease (ortholog); Turnpenny-Fry Syndrome (ortholog); Wolfram syndrome 2 (ortholog); FOUND IN cytoplasm (inferred); intracellular membrane-bounded organelle (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CDGSH iron-sulfur domain-containing protein 3, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	23,376,002 - 23,379,584 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	23,375,998 - 23,379,587 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Turnpenny-Fry Syndrome (ISO)

Wolfram syndrome 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein maturation by [2Fe-2S] cluster transfer (IBA,IEA)

Cellular Component

cytoplasm (IEA)

intracellular membrane-bounded organelle (IEA)

mitochondrion (IBA,IEA)

Molecular Function

2 iron, 2 sulfur cluster binding (IBA,IEA)

metal ion binding (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

CISD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	23,376,002 - 23,379,584 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	23,375,998 - 23,379,587 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CISD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	38,730,341 - 38,735,605 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	38,730,341 - 38,735,605 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	36,886,594 - 36,891,858 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	34,138,986 - 34,145,383 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	33,547,468 - 33,552,818 (+)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	32,683,132 - 32,687,987 (+)	NCBI		HuRef
CHM1_1	17	37,121,826 - 37,127,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	39,593,426 - 39,598,690 (+)	NCBI		T2T-CHM13v2.0

Cisd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	97,576,291 - 97,579,451 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	97,576,652 - 97,579,447 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	97,685,465 - 97,688,625 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	97,685,826 - 97,688,621 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	97,547,266 - 97,549,939 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	97,501,677 - 97,504,715 (+)	NCBI		MGSCv36	mm8
Celera	11	107,335,758 - 107,338,441 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	61.06	NCBI

Cisd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	83,175,708 - 83,178,739 (+)	NCBI		GRCr8
mRatBN7.2	10	82,679,345 - 82,682,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	82,679,196 - 82,682,550 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	87,627,099 - 87,630,127 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	87,125,190 - 87,128,218 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	82,517,771 - 82,520,799 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	85,628,579 - 85,631,656 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	85,628,491 - 85,631,657 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	85,415,946 - 85,419,003 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	86,434,901 - 86,437,932 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	81,435,130 - 81,438,161 (+)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Cisd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	13,814,135 - 13,817,334 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	13,814,679 - 13,817,334 (+)	NCBI	ChiLan1.0	ChiLan1.0

CISD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	26,216,912 - 26,220,675 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	28,100,485 - 28,103,892 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	18,538,545 - 18,543,374 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	18,815,044 - 18,820,685 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	18,815,044 - 18,817,980 (-)	Ensembl	panpan1.1		panPan2

CISD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	23,501,167 - 23,504,302 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	23,501,168 - 23,504,308 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1

Cisd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	22,936,199 - 22,938,976 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	14,136,640 - 14,138,969 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	14,136,209 - 14,138,940 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CISD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	67,462,038 - 67,465,843 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	67,458,472 - 67,465,572 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	38,459,661 - 38,463,171 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cisd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	3,952,477 - 3,955,127 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	3,952,500 - 3,955,123 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CISD3
49 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021067067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002337143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002337144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01061820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000025319 ⟹ ENSSSCP00000027759

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	12	23,376,002 - 23,379,385 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000048529 ⟹ ENSSSCP00000049586

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	12	23,376,002 - 23,379,584 (-)	Ensembl

RefSeq Acc Id:

XM_021067067 ⟹ XP_020922726

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	12	23,375,998 - 23,379,417 (-)	NCBI

Sequence:

show sequence

CGGCGCGGCGTGGCGGTGGCGGCGGGGCCGGCATGGGCGGCGCGGGGGCGCTCCTGAGGCCGGC
GGCCTGGCTGAACCAGAGGCGGGACATCTCCTCCTGGCTGGCTCGATGGTTCCCCAGAACCCCA
GCCAAGCCTGTGGTGGCCCTGAAAACACCCATCAAGGTGGAGCTGGTGGCTGGGAAAACCTACA
GGTGGTGTGTGTGTGGCCGTAGCAAGAAGCAGCCCTTCTGTGATGGCTCCCACTTCTTCCAACG
CACTGGCCTATCCCCACTCAAGTTCAAGGCCCAGGAGACCCGCGTGGTGGTGCTCTGTACCTGC
AAGGCCACCCAGAAACCCCCGTACTGCGATGGCACCCACAGGAGTGAGCGGGTGCAGAAGGCAG
AAGTGGGCGCCCCACTCTGAGGGGGTGGCTGCTGCCCGGCCCAAGAAGGATCACCCAGGGACCC
CAATACCCATAGCTGGTTTGTGAGCAGCTTGCTCCTGTAACCCAAGGTCTCCAATGTGGGGCAG
CTGGGACCAGGCCCCTGCTTCAGTGCCTGCTGGCGAAGATGGCATTAAAAAAGCATTCCATGCC
ACA

hide sequence

RefSeq Acc Id:

XR_002337143

Type:

NON-CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	12	23,375,998 - 23,379,422 (-)	NCBI

Sequence:

show sequence

GGAGCCGGCGCGGCGTGGCGGTGGCGGCGGGGCCGGCATGGGCGGCGCGGGGGCGCTCCTGAGG
CCGGCGGCCTGGATGACTTCCCTCTGGAAGTCTTTCCACTGACTTTGTATTTCTGTTTCCGAAT
CACCGTCTCGTGACGCCTGGTGGCCTTGAGAAGCTGAACCAGAGGCGGGACATCTCCTCCTGGC
TGGCTCGATGGTTCCCCAGAACCCCAGCCAAGCCTGTGGTGGCCCTGAAAACACCCATCAAGGT
GGAGCTGGTGGCTGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGTAGCAAGAAGCAGCCCTTC
TGTGATGGCTCCCACTTCTTCCAACGCACTGGCCTATCCCCACTCAAGTTCAAGGCCCAGGAGA
CCCGCGTGGTGGTGCTCTGTACCTGCAAGGCCACCCAGAAACCCCCGTACTGCGATGGCACCCA
CAGGAGTGAGCGGGTGCAGAAGGCAGAAGTGGGCGCCCCACTCTGAGGGGGTGGCTGCTGCCCG
GCCCAAGAAGGATCACCCAGGGACCCCAATACCCATAGCTGGTTTGTGAGCAGCTTGCTCCTGT
AACCCAAGGTCTCCAATGTGGGGCAGCTGGGACCAGGCCCCTGCTTCAGTGCCTGCTGGCGAAG
ATGGCATTAAAAAAGCATTCCATGCCACA

hide sequence

RefSeq Acc Id:

XR_002337144

Type:

NON-CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	12	23,375,998 - 23,379,587 (-)	NCBI

Sequence:

show sequence

ACGCCCTCGGGGCCCGAGGCGGCTGCTGGACTCGACTTCCGGCGGCTGGAGCTGGTGTTCGGCC
CCCCGGCCCGCACCCGCGCGAACCCCGTGGCGTCTTCCGGGCCGAGGCGGGGCCGGGCCGCCGG
GAGGCGGGGAAGCGGGAAGATGACTTCCCTCTGGAAGTCTTTCCACTGACTTTGTATTTCTGTT
TCCGAATCACCGTCTCGTGACGCCTGGTGGCCTTGAGAAGCTGAACCAGAGGCGGGACATCTCC
TCCTGGCTGGCTCGATGGTTCCCCAGAACCCCAGCCAAGCCTGTGGTGGCCCTGAAAACACCCA
TCAAGGTGGAGCTGGTGGCTGGGAAAACCTACAGGTGGTGTGTGTGTGGCCGTAGCAAGAAGCA
GCCCTTCTGTGATGGCTCCCACTTCTTCCAACGCACTGGCCTATCCCCACTCAAGTTCAAGGCC
CAGGAGACCCGCGTGGTGGTGCTCTGTACCTGCAAGGCCACCCAGAAACCCCCGTACTGCGATG
GCACCCACAGGAGTGAGCGGGTGCAGAAGGCAGAAGTGGGCGCCCCACTCTGAGGGGGTGGCTG
CTGCCCGGCCCAAGAAGGATCACCCAGGGACCCCAATACCCATAGCTGGTTTGTGAGCAGCTTG
CTCCTGTAACCCAAGGTCTCCAATGTGGGGCAGCTGGGACCAGGCCCCTGCTTCAGTGCCTGCT
GGCGAAGATGGCATTAAAAAAGCATTCCATGCCACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020922726	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000027759.4
	ENSSSCP00000049586
	ENSSSCP00000049586.3
	ENSSSCP00015023113.1
	ENSSSCP00025027112.1
	ENSSSCP00025027220.1
	ENSSSCP00030023916.1
	ENSSSCP00030023927.1
	ENSSSCP00035010412.1
	ENSSSCP00035010418.1
	ENSSSCP00040021204.1
	ENSSSCP00040021243.1
	ENSSSCP00045032088.1
	ENSSSCP00045032155.1
	ENSSSCP00050033959.1
	ENSSSCP00055006871.1
	ENSSSCP00055006879.1
	ENSSSCP00065024860.1
	ENSSSCP00065024864.1
	ENSSSCP00070029093.1
	ENSSSCP00070029095.1

RefSeq Acc Id:	XP_020922726 ⟸ XM_021067067
- UniProtKB:	A0A8D1IAF5 (UniProtKB/TrEMBL), I3LUF9 (UniProtKB/TrEMBL), A0A480XMR2 (UniProtKB/TrEMBL), A0A287AZL4 (UniProtKB/TrEMBL), A0A4X1UGF7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGAGALLRPAAWLNQRRDISSWLARWFPRTPAKPVVALKTPIKVELVAGKTYRWCVCGRSKKQ PFCDGSHFFQRTGLSPLKFKAQETRVVVLCTCKATQKPPYCDGTHRSERVQKAEVGAPL hide sequence

RefSeq Acc Id:

ENSSSCP00000027759 ⟸ ENSSSCT00000025319

RefSeq Acc Id:

ENSSSCP00000049586 ⟸ ENSSSCT00000048529

Protein Domains

Iron-binding zinc finger CDGSH type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000022187	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015043331	UniProtKB/TrEMBL
	ENSSSCG00025046781	UniProtKB/TrEMBL
	ENSSSCG00030037665	UniProtKB/TrEMBL
	ENSSSCG00035020921	UniProtKB/TrEMBL
	ENSSSCG00040038170	UniProtKB/TrEMBL
	ENSSSCG00045027149	UniProtKB/TrEMBL
	ENSSSCG00050057869	UniProtKB/TrEMBL
	ENSSSCG00055004406	UniProtKB/TrEMBL
	ENSSSCG00065041795	UniProtKB/TrEMBL
	ENSSSCG00070017633	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000025319.4	UniProtKB/TrEMBL
	ENSSSCT00000048529	ENTREZGENE
	ENSSSCT00000048529.3	UniProtKB/TrEMBL
	ENSSSCT00015057683.1	UniProtKB/TrEMBL
	ENSSSCT00025063605.1	UniProtKB/TrEMBL
	ENSSSCT00025063849.1	UniProtKB/TrEMBL
	ENSSSCT00030052424.1	UniProtKB/TrEMBL
	ENSSSCT00030052448.1	UniProtKB/TrEMBL
	ENSSSCT00035027233.1	UniProtKB/TrEMBL
	ENSSSCT00035027246.1	UniProtKB/TrEMBL
	ENSSSCT00040051073.1	UniProtKB/TrEMBL
	ENSSSCT00040051172.1	UniProtKB/TrEMBL
	ENSSSCT00045046246.1	UniProtKB/TrEMBL
	ENSSSCT00045046342.1	UniProtKB/TrEMBL
	ENSSSCT00050078931.1	UniProtKB/TrEMBL
	ENSSSCT00055008695.1	UniProtKB/TrEMBL
	ENSSSCT00055008703.1	UniProtKB/TrEMBL
	ENSSSCT00065057176.1	UniProtKB/TrEMBL
	ENSSSCT00065057181.1	UniProtKB/TrEMBL
	ENSSSCT00070034815.1	UniProtKB/TrEMBL
	ENSSSCT00070034818.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.5.90	UniProtKB/TrEMBL
InterPro	FeS-contain_CDGSH-typ	UniProtKB/TrEMBL
	FeS-contain_mitoNEET_C	UniProtKB/TrEMBL
NCBI Gene	CISD3	ENTREZGENE
PANTHER	CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG	UniProtKB/TrEMBL
	CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	zf-CDGSH	UniProtKB/TrEMBL
SMART	ZnF_CDGSH	UniProtKB/TrEMBL
UniProt	A0A287AZL4	ENTREZGENE, UniProtKB/TrEMBL
	A0A480XMR2	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UGF7	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UIQ5_PIG	UniProtKB/TrEMBL
	A0A8D1IAF5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8X9AEK4_PIG	UniProtKB/TrEMBL
	I3LUF9	ENTREZGENE
UniProt Secondary	I3LUF9	UniProtKB/TrEMBL
VGNC ID	VGNC:86708	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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