HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) - Rat Genome Database

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Gene: HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) Sus scrofa
Analyze
Symbol: HSD17B4
Name: hydroxysteroid 17-beta dehydrogenase 4
RGD ID: 13939962
Description: ENCODES a protein that exhibits 17-beta-hydroxysteroid dehydrogenase (NAD+) activity (ortholog); 3-hydroxyacyl-CoA dehydratase activity (ortholog); estradiol 17-beta-dehydrogenase [NAD(P)] activity (ortholog); INVOLVED IN androgen metabolic process (ortholog); cellular response to organic cyclic compound (ortholog); estrogen metabolic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH COVID-19 (ortholog); D-bifunctional protein deficiency (ortholog); familial adenomatous polyposis 1 (ortholog); FOUND IN peroxisome (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17beta-estradiol dehydrogenase; peroxisomal multifunctional enzyme type 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2123,313,448 - 123,402,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12123,313,445 - 123,401,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22128,752,284 - 128,841,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:8200347   PMID:14681463   PMID:17145712   PMID:22217853   PMID:22301074   PMID:22950857   PMID:23580952   PMID:30032202  


Genomics

Comparative Map Data
HSD17B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2123,313,448 - 123,402,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12123,313,445 - 123,401,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22128,752,284 - 128,841,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385119,452,497 - 119,542,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5119,452,465 - 119,637,199 (+)EnsemblGRCh38hg38GRCh38
GRCh375118,788,192 - 118,878,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365118,816,122 - 118,905,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 345118,816,123 - 118,905,923NCBI
Celera5114,741,869 - 114,831,759 (+)NCBICelera
Cytogenetic Map5q23.1NCBI
HuRef5113,983,371 - 114,073,268 (+)NCBIHuRef
CHM1_15118,221,090 - 118,311,127 (+)NCBICHM1_1
T2T-CHM13v2.05119,973,333 - 120,063,188 (+)NCBIT2T-CHM13v2.0
Hsd17b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391850,261,268 - 50,329,337 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1850,261,268 - 50,329,336 (+)EnsemblGRCm39 Ensembl
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBIMGSCv36mm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
cM Map1827.24NCBI
Hsd17b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81845,515,427 - 45,604,467 (+)NCBIGRCr8
mRatBN7.21843,328,903 - 43,417,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1843,328,824 - 43,417,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1845,372,258 - 45,461,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01846,093,452 - 46,184,056 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01843,878,165 - 43,967,210 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01844,810,462 - 44,897,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01844,032,347 - 44,119,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41845,157,435 - 45,251,606 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11845,194,975 - 45,281,963 (+)NCBI
Celera1841,553,644 - 41,635,741 (+)NCBICelera
Cytogenetic Map18q11NCBI
Hsd17b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540839,040,840 - 39,138,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540839,041,028 - 39,136,867 (+)NCBIChiLan1.0ChiLan1.0
HSD17B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24114,729,320 - 114,816,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15112,882,983 - 112,970,447 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05114,842,892 - 114,928,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15120,628,605 - 120,713,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5120,628,605 - 120,713,860 (+)Ensemblpanpan1.1panPan2
HSD17B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,717,182 - 8,810,716 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,717,349 - 8,824,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,845,728 - 9,939,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0118,803,421 - 8,896,940 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,803,454 - 8,911,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,674,773 - 8,768,177 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0118,731,175 - 8,824,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,988,828 - 9,082,305 (+)NCBIUU_Cfam_GSD_1.0
Hsd17b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213131,797,848 - 131,887,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367152,357,274 - 2,446,271 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367152,357,215 - 2,446,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12322,674,059 - 22,761,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2322,674,072 - 22,762,056 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603455,546,291 - 55,636,123 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247332,124,825 - 2,205,378 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247332,126,124 - 2,204,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSD17B4
2872 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000025027   ⟹   ENSSSCP00000022446
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2123,313,448 - 123,402,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037522   ⟹   ENSSSCP00000038448
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2123,313,449 - 123,401,296 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061615   ⟹   ENSSSCP00000045203
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2123,313,552 - 123,402,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075989   ⟹   ENSSSCP00000067157
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2123,313,448 - 123,402,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000097174   ⟹   ENSSSCP00000075447
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2123,326,864 - 123,401,296 (+)Ensembl
RefSeq Acc Id: NM_214306   ⟹   NP_999471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12123,313,483 - 123,401,297 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021081510   ⟹   XP_020937169
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12123,313,851 - 123,401,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021081514   ⟹   XP_020937173
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12123,313,445 - 123,401,386 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020937173   ⟸   XM_021081514
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UBD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999471   ⟸   NM_214306
- UniProtKB: Q28956 (UniProtKB/TrEMBL),   A0A480PUC2 (UniProtKB/TrEMBL),   A0A4X1UAJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020937169   ⟸   XM_021081510
- Peptide Label: isoform X1
- UniProtKB: A0A8D1RL60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022446   ⟸   ENSSSCT00000025027
RefSeq Acc Id: ENSSSCP00000067157   ⟸   ENSSSCT00000075989
RefSeq Acc Id: ENSSSCP00000038448   ⟸   ENSSSCT00000037522
RefSeq Acc Id: ENSSSCP00000045203   ⟸   ENSSSCT00000061615
RefSeq Acc Id: ENSSSCP00000075447   ⟸   ENSSSCT00000097174
Protein Domains
MaoC-like   SCP2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028431 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015078072 UniProtKB/TrEMBL
  ENSSSCG00025044566 UniProtKB/TrEMBL
  ENSSSCG00030053754 UniProtKB/TrEMBL
  ENSSSCG00035075588 UniProtKB/TrEMBL
  ENSSSCG00055021383 UniProtKB/TrEMBL
  ENSSSCG00065067051 UniProtKB/TrEMBL
  ENSSSCG00070015260 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025027 ENTREZGENE
  ENSSSCT00000025027.4 UniProtKB/TrEMBL
  ENSSSCT00000037522.3 UniProtKB/TrEMBL
  ENSSSCT00000061615.3 UniProtKB/TrEMBL
  ENSSSCT00000075989.2 UniProtKB/TrEMBL
  ENSSSCT00000097174 ENTREZGENE
  ENSSSCT00000097174.1 UniProtKB/TrEMBL
  ENSSSCT00015105926.1 UniProtKB/TrEMBL
  ENSSSCT00015105952.1 UniProtKB/TrEMBL
  ENSSSCT00015105985.1 UniProtKB/TrEMBL
  ENSSSCT00025061182.1 UniProtKB/TrEMBL
  ENSSSCT00025061470.1 UniProtKB/TrEMBL
  ENSSSCT00025061692.1 UniProtKB/TrEMBL
  ENSSSCT00030075033.1 UniProtKB/TrEMBL
  ENSSSCT00030075086.1 UniProtKB/TrEMBL
  ENSSSCT00035103219.1 UniProtKB/TrEMBL
  ENSSSCT00035103314.1 UniProtKB/TrEMBL
  ENSSSCT00035103773.1 UniProtKB/TrEMBL
  ENSSSCT00055042944.1 UniProtKB/TrEMBL
  ENSSSCT00055043117.1 UniProtKB/TrEMBL
  ENSSSCT00055043386.1 UniProtKB/TrEMBL
  ENSSSCT00055043557.1 UniProtKB/TrEMBL
  ENSSSCT00065092744.1 UniProtKB/TrEMBL
  ENSSSCT00065092761.1 UniProtKB/TrEMBL
  ENSSSCT00065092795.1 UniProtKB/TrEMBL
  ENSSSCT00070030189.1 UniProtKB/TrEMBL
  ENSSSCT00070030234.1 UniProtKB/TrEMBL
  ENSSSCT00070030242.1 UniProtKB/TrEMBL
  ENSSSCT00070030315.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.4290 UniProtKB/TrEMBL
  3.30.1050.10 UniProtKB/TrEMBL
  Hotdog Thioesterase UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro HotDog_dom_sf UniProtKB/TrEMBL
  MaoC-like_dom UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
  SCP2_sterol-bd_dom UniProtKB/TrEMBL
  SCP2_sterol-bd_dom_sf UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
KEGG Report ssc:397574 UniProtKB/TrEMBL
NCBI Gene HSD17B4 ENTREZGENE
PANTHER DEHYDROGENASES, SHORT CHAIN UniProtKB/TrEMBL
  PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2 UniProtKB/TrEMBL
  PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED UniProtKB/TrEMBL
  SCP2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  MaoC_dehydratas UniProtKB/TrEMBL
  SCP2 UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
SMART PKS_KR UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF54637 UniProtKB/TrEMBL
  SSF55718 UniProtKB/TrEMBL
UniProt A0A287A3B5_PIG UniProtKB/TrEMBL
  A0A287AMG9_PIG UniProtKB/TrEMBL
  A0A480PUC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U679_PIG UniProtKB/TrEMBL
  A0A4X1UAJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UAP4_PIG UniProtKB/TrEMBL
  A0A4X1UBD7 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QQI1_PIG UniProtKB/TrEMBL
  A0A8D1RL60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F822_PIG UniProtKB/TrEMBL
  I3LEF8_PIG UniProtKB/TrEMBL
  Q28956 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:99760 ENTREZGENE