TKFC (triokinase and FMN cyclase)

Gene: TKFC (triokinase and FMN cyclase) Sus scrofa

Analyze

Symbol:

TKFC

Name:

triokinase and FMN cyclase

RGD ID:

13888825

Description:

ENCODES a protein that exhibits ATP binding (inferred); FAD-AMP lyase (cyclizing) activity (inferred); glycerone kinase activity (inferred); INVOLVED IN negative regulation of MDA-5 signaling pathway (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); inherited metabolic disorder (ortholog); intellectual disability (ortholog); FOUND IN cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); DAK; dihydroxyacetone kinase 2 homolog; triokinase/FMN cyclase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TKFC (triokinase and FMN cyclase)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Tkfc (triokinase, FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tkfc (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tkfc (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TKFC (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TKFC (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tkfc (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TKFC (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tkfc (triokinase and FMN cyclase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	10,158,188 - 10,171,449 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	10,158,183 - 10,171,452 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	9,705,516 - 9,717,369 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

inherited metabolic disorder (ISO)

intellectual disability (ISO)

leukocyte adhesion deficiency 3 (ISO)

TRIOKINASE AND FMN CYCLASE DEFICIENCY SYNDROME (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

carbohydrate phosphorylation (IEA)

fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate (IEA)

glycerol catabolic process (IBA,IEA)

glycerol metabolic process (IEA)

negative regulation of MDA-5 signaling pathway (IEA,ISS)

regulation of innate immune response (IEA)

Cellular Component

cytosol (IBA,IEA)

Molecular Function

ATP binding (IEA)

FAD-AMP lyase (cyclizing) activity (IEA)

glycerone kinase activity (IBA,IEA)

kinase activity (IEA)

lyase activity (IEA)

metal ion binding (IEA)

phosphotransferase activity, alcohol group as acceptor (IEA)

protein binding (ISO)

triokinase activity (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TKFC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	10,158,188 - 10,171,449 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	10,158,183 - 10,171,452 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	9,705,516 - 9,717,369 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TKFC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	61,333,228 - 61,353,426 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	61,333,220 - 61,353,295 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	61,100,700 - 61,120,898 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	60,857,230 - 60,872,807 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	11	58,436,381 - 58,451,612 (+)	NCBI		Celera
Cytogenetic Map	11	q12.2	NCBI
HuRef	11	57,428,480 - 57,443,711 (+)	NCBI		HuRef
CHM1_1	11	60,983,674 - 60,998,905 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	61,322,174 - 61,342,034 (+)	NCBI		T2T-CHM13v2.0

Tkfc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	10,565,153 - 10,583,257 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	10,565,155 - 10,583,018 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	10,592,197 - 10,605,482 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	10,587,791 - 10,605,654 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	10,666,687 - 10,678,748 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	10,659,242 - 10,671,303 (-)	NCBI		MGSCv36	mm8
Celera	19	11,288,172 - 11,300,234 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	6.6	NCBI

Tkfc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	216,664,446 - 216,677,815 (-)	NCBI		GRCr8
mRatBN7.2	1	207,238,230 - 207,253,035 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	207,236,557 - 207,252,737 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	215,618,124 - 215,631,306 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	222,673,673 - 222,686,863 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	215,368,669 - 215,381,859 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	226,642,901 - 226,657,698 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	226,644,200 - 226,657,408 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	233,588,830 - 233,603,422 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	213,081,825 - 213,095,034 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	213,240,255 - 213,253,464 (-)	NCBI
Celera	1	204,732,902 - 204,746,111 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

Tkfc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955511	6,200,433 - 6,236,283 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955511	6,200,433 - 6,235,855 (-)	NCBI	ChiLan1.0	ChiLan1.0

TKFC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	62,501,040 - 62,520,960 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	63,544,782 - 63,564,297 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	56,633,046 - 56,648,276 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	59,997,775 - 60,017,666 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	60,002,530 - 60,010,762 (+)	Ensembl	panpan1.1		panPan2

TKFC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	55,051,068 - 55,064,571 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	55,051,097 - 55,064,526 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	53,623,820 - 53,637,316 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	56,098,586 - 56,112,568 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	56,098,590 - 56,112,547 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	55,157,110 - 55,170,596 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	54,778,939 - 54,792,440 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	55,659,103 - 55,673,085 (-)	NCBI		UU_Cfam_GSD_1.0

Tkfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	11,584,139 - 11,596,607 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	1,697,947 - 1,710,738 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	1,697,965 - 1,710,363 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TKFC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	12,495,058 - 12,508,693 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	12,495,477 - 12,507,927 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	109,872,445 - 109,887,877 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tkfc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624926	862,339 - 869,926 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624926	862,339 - 870,936 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TKFC
571 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	4	1		4			2	1	1
Low	6	3	3	1	2	23		2	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003122641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021082941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK237051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU462918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU896534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01051854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000014305 ⟹ ENSSSCP00000013919

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	10,158,189 - 10,171,449 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000040177 ⟹ ENSSSCP00000042088

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	10,158,189 - 10,171,389 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000041826 ⟹ ENSSSCP00000034559

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	10,158,188 - 10,165,068 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000102978 ⟹ ENSSSCP00000081251

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	10,158,190 - 10,165,676 (-)	Ensembl

RefSeq Acc Id:

XM_003122641 ⟹ XP_003122689

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	10,158,183 - 10,170,124 (-)	NCBI

Sequence:

show sequence

TCAGCCCCACGCTCTTCTCCATCCCCAGCCCACGTTCTAGAGTTTGGACCTGGATCAAAGTCTG
GGGCAGCTCCCTAATTACTAAGGGCCCTGGAAGCACGATTGCACCAGTAGGCTGCAAGTGCCTT
CGCAGCTCATGTTGTTACCCCCTCCTGCAGGCACTGCTTGCCGCTCAGGCCCCGTCGGATTGCC
TGTCCTCCGGCAGCTCAGCGCGAAGGTGTGAACTCAGCTTCCTTCAGAGCCTCCCCGCCATGAC
CTCCAAGAAGCTGGTGAACTCAGTGGCAGGCTGTGCCGACGATGCCCTTGCTGGCCTGGTGGCC
TGCAACCCCAGCCTGCAGCTCCTGCAAGGCCACCGAGTGGCCCTCCGTTCTGACCTGGACAGTC
TCAAGGGCCGGGTGGCCCTACTGTCGGGTGGGGGCTCTGGCCATGAGCCTGCCCATGCCGGGTT
CATAGGGAAGGGCATGCTCACAGGGGTCATCGCAGGAGCCGTGTTCACCTCCCCGGCAGTGGGC
AGCATCCTGGCGGCCATCAGGGCAGTGGCCCAGGCGGGCACAGTGGGGACCCTCCTCATCGTGA
AGAACTACACTGGGGATCGGCTCAACTTCGGCCTGGCCCGGGAGCAGGCCCGGGCAGAGGGCAT
CCCCGTGGAGATGGTGGTCGTTGGGGACGACAGCGCCTTCACCGTCCTGAAGAAGGCGGGCCGG
CGGGGGCTCTGTGGCACGGTGCTCATACACAAGGTGGCAGGTGCCCTGGCTGAGGCAGGTGTGG
GGCTGGAGGAGATCACGAATCGGGTGAGCGTGGTCGCCAAGGCCATGGGAACCCTGGGAGTGAG
CCTGTCCTCCTGCAGCGTCCCCGGTTCCAGACCCACCTTTGAGCTCTCAGCCGATGAGGTGGAG
CTGGGCCTGGGGATCCACGGGGAGGCTGGCGTGCTCCGGATAAAGATGGCAACCGCCGACGAGA
TTGTGGCGCACATGCTGAACCACATGACAGACTCCTCCAATGTGTCCCACGTGCCCGTGCAGTC
TGGCTCCTCAGTGGTGCTGATGGTCAACAACCTGGGTGGCCTCTCATACCTGGAACTGGGCATC
ATAGCCGACGCCGCTGTCCGCTTTCTGGAGGGCCGCGGGGTGAAGATTGCCCGTGCCCTAGTGG
GCACCTTCATGTCAGCCCTGGAGATGCCTGGCGTCTCTCTCACCCTTCTGCTGGTGGACGAGCC
CCTCCTGAAACTGATAGATGCCGAAACCACCGCAGCAGCCTGGCCTAACGTGGCCAAGGTCTCT
GTGACTGGGCGGAAGCGGAGCCGGGCCGCCCCTGCCGAGCCCCCGGAGGCTCCTGATGCCACTG
CTGCAGGAGGCGCGACCTCGAAGCAGATGGTGCGTGTGCTGGAGCGGGTGTGCACCACCCTCCT
GGGCCTGGAGGACCAGCTGAATGCCCTGGACCGCGCTGCCGGCGACGGGGACTGCGGCACCACC
CACAGCCGTGCTGCCAGAGCGATTCAGGGCTGGCTGAAGGAGAGCCCACCACCCGCCAGTCCTG
CCCAGCTACTCTCCAAATTGTCCCTCCTGCTACTGGAGAAGATGGGAGGCTCATCCGGGGCACT
CTATGGCCTGTTCCTGACTGCGGCGGCCCAGCCGCTCAAGGCCAAGACTGACCTCGCAGCCTGG
TCTGCTGCCATGGATGCCGGCCTGGAGGCCATGCAGAAGTACGGAAAGGCTGCCCCAGGGGACA
GGACTATGCTGGATTCCCTGTGGGCAGCAGGACAGGAGCTCCAAGCCTGGAAGAGCCCGGGGGC
TAACCTGCTCCCAGTCCTGACCAAGGCAGTCAAGAACGCAGAGGCTGCAGCTGAAGCCACCAAG
AACATGGAAGCTGGAGCTGGAAGAGCCAGTTATATCAGCTCTGCGCGGCTGGATCAGCCAGACC
CCGGGGCAGTGGCGGCCGCTGCCATTCTCCGCGCCATCCTGGAGGTTCTGCAGAGCCAGGGGGC
ATGAAAGCCTCCCTGGGGCTCAGTGCCTCCCATTGCTGTGCACAGTGGCCACTGTCACTTATTT
CTGCCTTCCAACTGTCGCCCTCCCCTGCCTACCCTCAGGGCCAGTCCTCTGAGTTCAGCAGGAA
TCCCTCAGGCAGCGTCCAGAATTACTCCACTGTAGACACTGCAGGCTCCAGTAGGTCACTACCC
CTTCCCTCTTCAGGCAGGGTGGAGTCCTTGGGTCACCCGGCTGTCCCCAGCCAACCCTGGGCTT
CCGTGATAAGGCCTTTCTGTGGGTGACAGCACAGCCCTTAACGGGCAACGCGAATTTGGTTTTA
AGACTCCCCGTGAAAGGCCTTCTGTACCTGAGCTGAGCCAGTGTGGAAAAGCAAGTCAATAAAC
ACACGGAAGCCAAAGA

hide sequence

RefSeq Acc Id:

XM_021082941 ⟹ XP_020938600

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	10,158,183 - 10,171,452 (-)	NCBI

Sequence:

show sequence

CGCCCCCTCCTACCGCCGGAGCCCCGAGAACCCGGATGAGGGCGCCCTGTTGGGGCGTCTTTGA
GAAGCGGTGGCGGGTGCTGAGGTGGTGGATGCGGGCGTGAGCGGGTAGCGGAAGTGTGCGGACG
TCCCCTCCTCCCCCGAAGCTGATCTGCGGATCTCATCCCCGGGCCTCGCCCCTCGCCTTCCCCA
AACCCCGTCCACTCCCCTTTCATTGCTCCGGGAGCCGTCGGGGCTGTTTCCCCTTTGGGAACGG
AAAGGTACCGCAGAGGCTTAGAGAGGGGAGGAAGGTGACATCAATTTGTGCATCTCCCAGACTA
GCACCGAGGCACTGCTTGCCGCTCAGGCCCCGTCGGATTGCCTGTCCTCCGGCAGCTCAGCGCG
AAGGTGTGAACTCAGCTTCCTTCAGAGCCTCCCCGCCATGACCTCCAAGAAGCTGGTGAACTCA
GTGGCAGGCTGTGCCGACGATGCCCTTGCTGGCCTGGTGGCCTGCAACCCCAGCCTGCAGCTCC
TGCAAGGCCACCGAGTGGCCCTCCGTTCTGACCTGGACAGTCTCAAGGGCCGGGTGGCCCTACT
GTCGGGTGGGGGCTCTGGCCATGAGCCTGCCCATGCCGGGTTCATAGGGAAGGGCATGCTCACA
GGGGTCATCGCAGGAGCCGTGTTCACCTCCCCGGCAGTGGGCAGCATCCTGGCGGCCATCAGGG
CAGTGGCCCAGGCGGGCACAGTGGGGACCCTCCTCATCGTGAAGAACTACACTGGGGATCGGCT
CAACTTCGGCCTGGCCCGGGAGCAGGCCCGGGCAGAGGGCATCCCCGTGGAGATGGTGGTCGTT
GGGGACGACAGCGCCTTCACCGTCCTGAAGAAGGCGGGCCGGCGGGGGCTCTGTGGCACGGTGC
TCATACACAAGGTGGCAGGTGCCCTGGCTGAGGCAGGTGTGGGGCTGGAGGAGATCACGAATCG
GGTGAGCGTGGTCGCCAAGGCCATGGGAACCCTGGGAGTGAGCCTGTCCTCCTGCAGCGTCCCC
GGTTCCAGACCCACCTTTGAGCTCTCAGCCGATGAGGTGGAGCTGGGCCTGGGGATCCACGGGG
AGGCTGGCGTGCTCCGGATAAAGATGGCAACCGCCGACGAGATTGTGGCGCACATGCTGAACCA
CATGACAGACTCCTCCAATGTGTCCCACGTGCCCGTGCAGTCTGGCTCCTCAGTGGTGCTGATG
GTCAACAACCTGGGTGGCCTCTCATACCTGGAACTGGGCATCATAGCCGACGCCGCTGTCCGCT
TTCTGGAGGGCCGCGGGGTGAAGATTGCCCGTGCCCTAGTGGGCACCTTCATGTCAGCCCTGGA
GATGCCTGGCGTCTCTCTCACCCTTCTGCTGGTGGACGAGCCCCTCCTGAAACTGATAGATGCC
GAAACCACCGCAGCAGCCTGGCCTAACGTGGCCAAGGTCTCTGTGACTGGGCGGAAGCGGAGCC
GGGCCGCCCCTGCCGAGCCCCCGGAGGCTCCTGATGCCACTGCTGCAGGAGGCGCGACCTCGAA
GCAGATGGTGCGTGTGCTGGAGCGGGTGTGCACCACCCTCCTGGGCCTGGAGGACCAGCTGAAT
GCCCTGGACCGCGCTGCCGGCGACGGGGACTGCGGCACCACCCACAGCCGTGCTGCCAGAGCGA
TTCAGGGCTGGCTGAAGGAGAGCCCACCACCCGCCAGTCCTGCCCAGCTACTCTCCAAATTGTC
CCTCCTGCTACTGGAGAAGATGGGAGGCTCATCCGGGGCACTCTATGGCCTGTTCCTGACTGCG
GCGGCCCAGCCGCTCAAGGCCAAGACTGACCTCGCAGCCTGGTCTGCTGCCATGGATGCCGGCC
TGGAGGCCATGCAGAAGTACGGAAAGGCTGCCCCAGGGGACAGGACTATGCTGGATTCCCTGTG
GGCAGCAGGACAGGAGCTCCAAGCCTGGAAGAGCCCGGGGGCTAACCTGCTCCCAGTCCTGACC
AAGGCAGTCAAGAACGCAGAGGCTGCAGCTGAAGCCACCAAGAACATGGAAGCTGGAGCTGGAA
GAGCCAGTTATATCAGCTCTGCGCGGCTGGATCAGCCAGACCCCGGGGCAGTGGCGGCCGCTGC
CATTCTCCGCGCCATCCTGGAGGTTCTGCAGAGCCAGGGGGCATGAAAGCCTCCCTGGGGCTCA
GTGCCTCCCATTGCTGTGCACAGTGGCCACTGTCACTTATTTCTGCCTTCCAACTGTCGCCCTC
CCCTGCCTACCCTCAGGGCCAGTCCTCTGAGTTCAGCAGGAATCCCTCAGGCAGCGTCCAGAAT
TACTCCACTGTAGACACTGCAGGCTCCAGTAGGTCACTACCCCTTCCCTCTTCAGGCAGGGTGG
AGTCCTTGGGTCACCCGGCTGTCCCCAGCCAACCCTGGGCTTCCGTGATAAGGCCTTTCTGTGG
GTGACAGCACAGCCCTTAACGGGCAACGCGAATTTGGTTTTAAGACTCCCCGTGAAAGGCCTTC
TGTACCTGAGCTGAGCCAGTGTGGAAAAGCAAGTCAATAAACACACGGAAGCCAAAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003122689	(Get FASTA)	NCBI Sequence Viewer
	XP_020938600	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000013919
	ENSSSCP00000013919.5
	ENSSSCP00000034559.2
	ENSSSCP00000042088.1
	ENSSSCP00000081251
	ENSSSCP00000081251.1
	ENSSSCP00015009465.1
	ENSSSCP00035030469.1
	ENSSSCP00070042785.1
	ENSSSCP00070042786.1
	ENSSSCP00070042788.1
GenBank Protein	F1RKQ4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_020938600 ⟸ XM_021082941

- UniProtKB:

A0A2C9F397 (UniProtKB/TrEMBL), A0A480IXS3 (UniProtKB/TrEMBL), A0A480HRC0 (UniProtKB/TrEMBL), A0A480YP74 (UniProtKB/TrEMBL), A0A8D0TXM2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTSKKLVNSVAGCADDALAGLVACNPSLQLLQGHRVALRSDLDSLKGRVALLSGGGSGHEPAHA
GFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVAQAGTVGTLLIVKNYTGDRLNFGLAREQARAE
GIPVEMVVVGDDSAFTVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEEITNRVSVVAKAMGTLG
VSLSSCSVPGSRPTFELSADEVELGLGIHGEAGVLRIKMATADEIVAHMLNHMTDSSNVSHVPV
QSGSSVVLMVNNLGGLSYLELGIIADAAVRFLEGRGVKIARALVGTFMSALEMPGVSLTLLLVD
EPLLKLIDAETTAAAWPNVAKVSVTGRKRSRAAPAEPPEAPDATAAGGATSKQMVRVLERVCTT
LLGLEDQLNALDRAAGDGDCGTTHSRAARAIQGWLKESPPPASPAQLLSKLSLLLLEKMGGSSG
ALYGLFLTAAAQPLKAKTDLAAWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSP
GANLLPVLTKAVKNAEAAAEATKNMEAGAGRASYISSARLDQPDPGAVAAAAILRAILEVLQSQ
GA

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RefSeq Acc Id:

XP_003122689 ⟸ XM_003122641

- UniProtKB:

A0A2C9F397 (UniProtKB/TrEMBL), A0A480IXS3 (UniProtKB/TrEMBL), A0A480HRC0 (UniProtKB/TrEMBL), A0A480YP74 (UniProtKB/TrEMBL), A0A8D0TXM2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTSKKLVNSVAGCADDALAGLVACNPSLQLLQGHRVALRSDLDSLKGRVALLSGGGSGHEPAHA
GFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVAQAGTVGTLLIVKNYTGDRLNFGLAREQARAE
GIPVEMVVVGDDSAFTVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEEITNRVSVVAKAMGTLG
VSLSSCSVPGSRPTFELSADEVELGLGIHGEAGVLRIKMATADEIVAHMLNHMTDSSNVSHVPV
QSGSSVVLMVNNLGGLSYLELGIIADAAVRFLEGRGVKIARALVGTFMSALEMPGVSLTLLLVD
EPLLKLIDAETTAAAWPNVAKVSVTGRKRSRAAPAEPPEAPDATAAGGATSKQMVRVLERVCTT
LLGLEDQLNALDRAAGDGDCGTTHSRAARAIQGWLKESPPPASPAQLLSKLSLLLLEKMGGSSG
ALYGLFLTAAAQPLKAKTDLAAWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSP
GANLLPVLTKAVKNAEAAAEATKNMEAGAGRASYISSARLDQPDPGAVAAAAILRAILEVLQSQ
GA

hide sequence

RefSeq Acc Id:

ENSSSCP00000042088 ⟸ ENSSSCT00000040177

RefSeq Acc Id:

ENSSSCP00000034559 ⟸ ENSSSCT00000041826

RefSeq Acc Id:

ENSSSCP00000013919 ⟸ ENSSSCT00000014305

RefSeq Acc Id:

ENSSSCP00000081251 ⟸ ENSSSCT00000102978

Protein Domains

DhaK DhaL

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000013087	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015018352	UniProtKB/TrEMBL
	ENSSSCG00035056080	UniProtKB/TrEMBL
	ENSSSCG00070025318	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000014305	ENTREZGENE
	ENSSSCT00000014305.5	UniProtKB/TrEMBL
	ENSSSCT00000040177.3	UniProtKB/TrEMBL
	ENSSSCT00000041826.3	UniProtKB/TrEMBL
	ENSSSCT00000102978	ENTREZGENE
	ENSSSCT00000102978.1	UniProtKB/TrEMBL
	ENSSSCT00015024310.1	UniProtKB/TrEMBL
	ENSSSCT00035074973.1	UniProtKB/TrEMBL
	ENSSSCT00070050617.1	UniProtKB/TrEMBL
	ENSSSCT00070050619.1	UniProtKB/TrEMBL
	ENSSSCT00070050620.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.340	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DhaK_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DhaK_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DhaL_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DhaL_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:100520121	UniProtKB/TrEMBL
NCBI Gene	TKFC	ENTREZGENE
PANTHER	TRIOKINASE/FMN CYCLASE	UniProtKB/Swiss-Prot
	TRIOKINASE/FMN CYCLASE	UniProtKB/Swiss-Prot
	TRIOKINASE/FMN CYCLASE	UniProtKB/TrEMBL
	TRIOKINASE/FMN CYCLASE	UniProtKB/TrEMBL
Pfam	Dak1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dak2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	DHAK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DHAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Dak2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	DAK1/DegV-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF101473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A286ZSK9_PIG	UniProtKB/TrEMBL
	A0A287AE46_PIG	UniProtKB/TrEMBL
	A0A2C9F397	ENTREZGENE
	A0A480HRC0	ENTREZGENE, UniProtKB/TrEMBL
	A0A480IXS3	ENTREZGENE, UniProtKB/TrEMBL
	A0A480YP74	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1VLB8_PIG	UniProtKB/TrEMBL
	A0A4X1VLU0_PIG	UniProtKB/TrEMBL
	A0A4X1VMV0_PIG	UniProtKB/TrEMBL
	A0A8D0TXM2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8W4FRI0_PIG	UniProtKB/TrEMBL
	F1RKQ4	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A0A2C9F397	UniProtKB/TrEMBL
	Q9TR81	UniProtKB/Swiss-Prot
VGNC ID	VGNC:100872	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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