ZMPSTE24 (zinc metallopeptidase STE24) - Rat Genome Database

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Gene: ZMPSTE24 (zinc metallopeptidase STE24) Sus scrofa
Analyze
Symbol: ZMPSTE24
Name: zinc metallopeptidase STE24
RGD ID: 13884662
Description: ENCODES a protein that exhibits double-stranded DNA binding (inferred); endopeptidase activity (inferred); metal ion binding (inferred); INVOLVED IN adult walking behavior (ortholog); bone mineralization (ortholog); calcium ion import into sarcoplasmic reticulum (ortholog); ASSOCIATED WITH Acro-Osteolysis (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CAAX prenyl protease 1 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,008,455 - 96,062,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,129,860 - 89,133,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (IEA,ISO)
bone mineralization  (IEA,ISO)
CAAX-box protein processing  (IBA,IEA)
calcium ion import into sarcoplasmic reticulum  (IEA,ISO)
CAMKK-AMPK signaling cascade  (IEA,ISO)
cardiac conduction  (IEA,ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac ventricle development  (IEA,ISO)
cellular lipid metabolic process  (IEA,ISO)
cellular response to gamma radiation  (IEA,ISO)
chromatin organization  (IEA,ISO)
chromosome organization  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
DNA damage response  (IEA,ISO)
DNA repair  (IEA,ISO)
epidermis development  (IEA,ISO)
epigenetic regulation of gene expression  (IEA,ISO)
growth plate cartilage development  (IEA,ISO)
hair follicle development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
inflammatory cell apoptotic process  (IEA,ISO)
kidney morphogenesis  (IEA,ISO)
liver development  (IEA,ISO)
maintenance of rDNA  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of miRNA processing  (IEA,ISO)
neuromuscular process  (IEA,ISO)
nuclear envelope organization  (IEA,ISO)
nucleus organization  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of gene expression via chromosomal CpG island demethylation  (IEA,ISO)
prenylated protein catabolic process  (IEA,ISO)
protein maturation  (IEA)
protein processing  (IEA,ISO)
proteolysis  (IEA)
regulation of autophagy  (IEA,ISO)
regulation of blood circulation  (IEA,ISO)
regulation of bone mineralization  (IEA,ISO)
regulation of cell shape  (IEA,ISO)
regulation of cellular senescence  (IEA,ISO)
regulation of defense response to virus  (IEA,ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fibroblast proliferation  (IEA,ISO)
regulation of glucose metabolic process  (IEA,ISO)
regulation of heart contraction  (IEA,ISO)
regulation of hormone metabolic process  (IEA,ISO)
regulation of lipid metabolic process  (IEA,ISO)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of mitotic cell cycle DNA replication  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of stress-activated protein kinase signaling cascade  (IEA,ISO)
regulation of termination of RNA polymerase I transcription  (IEA,ISO)
regulation of TOR signaling  (IEA,ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
response to DNA damage checkpoint signaling  (IEA,ISO)
thymus development  (IEA,ISO)
ventricular cardiac muscle tissue development  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZMPSTE24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl696,008,455 - 96,062,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2689,129,860 - 89,133,461 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZMPSTE24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,258,236 - 40,294,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,258,041 - 40,294,180 (+)EnsemblGRCh38hg38GRCh38
GRCh37140,723,908 - 40,759,852 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,496,320 - 40,532,443 (+)NCBINCBI36Build 36hg18NCBI36
Build 34140,392,871 - 40,428,944NCBI
Celera139,006,122 - 39,042,251 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,842,523 - 38,878,354 (+)NCBIHuRef
CHM1_1140,839,331 - 40,875,788 (+)NCBICHM1_1
T2T-CHM13v2.0140,127,713 - 40,163,687 (+)NCBIT2T-CHM13v2.0
Zmpste24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,916,434 - 120,955,452 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,916,434 - 120,955,438 (-)EnsemblGRCm39 Ensembl
GRCm384121,059,237 - 121,098,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4121,059,237 - 121,098,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv374120,731,843 - 120,770,848 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364120,556,873 - 120,595,878 (-)NCBIMGSCv36mm8
Celera4119,770,178 - 119,809,143 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map456.8NCBI
Zmpste24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,912,395 - 139,945,532 (-)NCBIGRCr8
mRatBN7.25134,627,218 - 134,660,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,627,229 - 134,660,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5137,355,779 - 137,387,791 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,112,274 - 139,144,282 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,132,865 - 139,164,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05139,982,404 - 140,015,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,983,680 - 140,015,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05143,777,121 - 143,808,982 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45141,644,119 - 141,677,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15141,649,218 - 141,682,222 (-)NCBI
Celera5133,182,210 - 133,213,802 (-)NCBICelera
Cytogenetic Map5q36NCBI
Zmpste24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553781,920 - 134,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553782,724 - 134,609 (+)NCBIChiLan1.0ChiLan1.0
ZMPSTE24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,522,556 - 186,570,943 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,660,166 - 185,708,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,545,264 - 39,589,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,869,076 - 40,912,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,869,076 - 40,912,747 (+)Ensemblpanpan1.1panPan2
ZMPSTE24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,669,546 - 2,708,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,670,326 - 2,709,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,927,171 - 2,965,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0152,756,132 - 2,794,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,756,136 - 2,794,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,663,629 - 2,702,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,723,834 - 2,762,460 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,739,878 - 2,778,521 (-)NCBIUU_Cfam_GSD_1.0
Zmpste24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505856,210,295 - 56,253,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647422,034,801 - 22,077,986 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647422,035,059 - 22,077,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZMPSTE24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,605,495 - 92,648,110 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,605,309 - 92,648,114 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603324,227,800 - 24,273,781 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zmpste24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,723,291 - 22,778,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476422,723,643 - 22,777,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZMPSTE24
456 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 23 2 3 3
Low 1 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025758   ⟹   ENSSSCP00000026562
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl696,008,508 - 96,062,951 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036916   ⟹   ENSSSCP00000044628
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl696,008,455 - 96,057,123 (+)Ensembl
RefSeq Acc Id: XM_021096012   ⟹   XP_020951671
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1696,008,307 - 96,057,131 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021096013   ⟹   XP_020951672
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1696,008,332 - 96,057,131 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020951671   ⟸   XM_021096012
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VVW6 (UniProtKB/TrEMBL),   I3LR30 (UniProtKB/TrEMBL),   A0A8D0LDQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020951672   ⟸   XM_021096013
- Peptide Label: isoform X2
- UniProtKB: A0A8D1G457 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000026562   ⟸   ENSSSCT00000025758
RefSeq Acc Id: ENSSSCP00000044628   ⟸   ENSSSCT00000036916
Protein Domains
CAAX prenyl protease 1 N-terminal   Peptidase M48


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005002552 UniProtKB/TrEMBL
  ENSSSCG00015039387 UniProtKB/TrEMBL
  ENSSSCG00025074118 UniProtKB/TrEMBL
  ENSSSCG00030065415 UniProtKB/TrEMBL
  ENSSSCG00035040968 UniProtKB/TrEMBL
  ENSSSCG00040072310 UniProtKB/TrEMBL
  ENSSSCG00045031185 UniProtKB/TrEMBL
  ENSSSCG00055008586 UniProtKB/TrEMBL
  ENSSSCG00060057462 UniProtKB/TrEMBL
  ENSSSCG00065011257 UniProtKB/TrEMBL
  ENSSSCG00070026708 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025758 ENTREZGENE
  ENSSSCT00000025758.3 UniProtKB/TrEMBL
  ENSSSCT00000036916.3 UniProtKB/TrEMBL
  ENSSSCT00005003912.1 UniProtKB/TrEMBL
  ENSSSCT00015053031.1 UniProtKB/TrEMBL
  ENSSSCT00015053085.1 UniProtKB/TrEMBL
  ENSSSCT00015053240.1 UniProtKB/TrEMBL
  ENSSSCT00025102149.1 UniProtKB/TrEMBL
  ENSSSCT00030091518.1 UniProtKB/TrEMBL
  ENSSSCT00035054453.1 UniProtKB/TrEMBL
  ENSSSCT00035054456.1 UniProtKB/TrEMBL
  ENSSSCT00035054461.1 UniProtKB/TrEMBL
  ENSSSCT00040099549.1 UniProtKB/TrEMBL
  ENSSSCT00040099592.1 UniProtKB/TrEMBL
  ENSSSCT00040099652.1 UniProtKB/TrEMBL
  ENSSSCT00045053491.1 UniProtKB/TrEMBL
  ENSSSCT00045053633.1 UniProtKB/TrEMBL
  ENSSSCT00055016931.1 UniProtKB/TrEMBL
  ENSSSCT00055016991.1 UniProtKB/TrEMBL
  ENSSSCT00060078270.1 UniProtKB/TrEMBL
  ENSSSCT00060078276.1 UniProtKB/TrEMBL
  ENSSSCT00065014962.1 UniProtKB/TrEMBL
  ENSSSCT00070053565.1 UniProtKB/TrEMBL
  ENSSSCT00070053566.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
InterPro CAXX_Prtase_1 UniProtKB/TrEMBL
  Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
NCBI Gene ZMPSTE24 ENTREZGENE
PANTHER CAAX PRENYL PROTEASE 1 UniProtKB/TrEMBL
  CAAX PRENYL PROTEASE 1 HOMOLOG UniProtKB/TrEMBL
Pfam Peptidase_M48 UniProtKB/TrEMBL
  Peptidase_M48_N UniProtKB/TrEMBL
UniProt A0A287AL47_PIG UniProtKB/TrEMBL
  A0A4X1VTQ6_PIG UniProtKB/TrEMBL
  A0A4X1VVW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LDQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1G457 ENTREZGENE, UniProtKB/TrEMBL
  I3LR30 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:95180 ENTREZGENE