NKG7 (natural killer cell granule protein 7)

Gene: NKG7 (natural killer cell granule protein 7) Sus scrofa

Analyze

Symbol:

NKG7

Name:

natural killer cell granule protein 7

RGD ID:

13866134

Description:

INVOLVED IN CD4-positive, alpha-beta T cell activation (ortholog); granzyme-mediated programmed cell death signaling pathway (ortholog); natural killer cell degranulation (ortholog); ASSOCIATED WITH multiple acyl-CoA dehydrogenase deficiency (ortholog); FOUND IN cytolytic granule (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

natural killer cell group 7 sequence; protein NKG7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	58,496,089 - 58,497,827 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	58,496,089 - 58,497,827 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	51,692,516 - 51,694,254 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

multiple acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CD4-positive, alpha-beta T cell activation (ISO)

defense response to protozoan (IEA)

granzyme-mediated programmed cell death signaling pathway (ISO)

natural killer cell degranulation (ISO)

natural killer cell mediated cytotoxicity (ISO)

natural killer cell mediated cytotoxicity directed against tumor cell target (ISO)

positive regulation of inflammatory response (ISO)

Cellular Component

cytolytic granule (ISO)

cytolytic granule membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:12226715	PMID:14681463	PMID:17145712	PMID:30032202

Genomics

Comparative Map Data

NKG7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	58,496,089 - 58,497,827 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	58,496,089 - 58,497,827 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	51,692,516 - 51,694,254 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NKG7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,371,620 - 51,372,654 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,371,606 - 51,372,701 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	51,874,874 - 51,875,908 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,566,686 - 56,567,772 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	56,566,685 - 56,567,772	NCBI
Celera	19	48,925,955 - 48,927,041 (-)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	48,206,847 - 48,207,933 (-)	NCBI		HuRef
CHM1_1	19	51,876,835 - 51,877,921 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,460,261 - 54,461,295 (-)	NCBI		T2T-CHM13v2.0

Nkg7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	43,086,562 - 43,087,670 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	43,086,497 - 43,087,673 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	43,437,138 - 43,438,246 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	43,437,073 - 43,438,249 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	50,692,508 - 50,693,616 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	43,305,058 - 43,306,166 (+)	NCBI		MGSCv36	mm8
Celera	7	38,903,800 - 38,904,909 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	28.25	NCBI

Nkg7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	102,981,497 - 102,982,564 (+)	NCBI		GRCr8
mRatBN7.2	1	93,844,748 - 93,845,975 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	93,844,902 - 93,845,983 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	99,230,257 - 99,231,324 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	107,702,931 - 107,703,998 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	100,995,511 - 100,996,578 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	98,492,873 - 98,493,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	98,492,828 - 98,493,978 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	99,569,678 - 99,570,745 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	93,813,123 - 93,814,190 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	93,891,233 - 93,892,299 (+)	NCBI
Celera	1	88,122,019 - 88,123,086 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Nkg7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955558	1,028,425 - 1,029,161 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955558	1,027,682 - 1,029,338 (+)	NCBI	ChiLan1.0	ChiLan1.0

NKG7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,408,922 - 57,409,958 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	59,330,407 - 59,331,538 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	48,306,714 - 48,307,961 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	57,192,778 - 57,193,882 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	57,192,788 - 57,193,882 (-)	Ensembl	panpan1.1		panPan2

NKG7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,607,558 - 105,608,870 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	105,180,162 - 105,181,513 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	106,117,006 - 106,118,357 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	106,117,043 - 106,119,057 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	105,788,654 - 105,790,005 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,429,503 - 105,430,854 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	106,225,044 - 106,226,395 (+)	NCBI		UU_Cfam_GSD_1.0

Nkg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	23,069,735 - 23,070,976 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937378	42,066 - 43,156 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937378	42,083 - 43,068 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKG7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	44,291,219 - 44,292,338 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	44,291,134 - 44,292,310 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	24,340,409 - 24,341,501 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkg7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	3,501,973 - 3,504,773 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	3,501,924 - 3,502,750 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NKG7
24 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	4	2		4					2
Low	6	2	1	1	2	21		3	1
Below cutoff			2			2	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001244529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK237343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK348727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AW483192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB476480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ027613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU694842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01036686	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000003590 ⟹ ENSSSCP00000003507

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	58,496,089 - 58,497,827 (+)	Ensembl

RefSeq Acc Id:

NM_001244529 ⟹ NP_001231458

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	58,496,089 - 58,497,827 (+)	NCBI

Sequence:

show sequence

AAGCCAGACCAATCTGATCTGAAGGAGTGCGGTCCGACCTCCTCCTCCACCCCCAGCCACCCCT
ACTGCCGCCTGGTTTCTCTTTCTTGAGCTCAGTGGACCCAGGTGTCTAGGGGGGCCCAGCCTCC
TCCCCTCTCTGAGACCCGGAAGCCTGGATCGCCAGCCTCTTCATCACCCAGGACCCAGAAACCC
AGCCTCCACCACCAGCCATGGAGCCCTGTCGGTCCCTGGCCCTGCTCACGAGCTCCCTGGGCCT
GATGTCTGTCTTGGTTGCCCTGAGCACAAATTTCTGGTTCGAGGCCCAGGGGCCCCACTTCTCA
TCTCACTCAGGCCTCTGGCCAAGTGGGGATGAGGGCTCCATAGAAGGCTACATCCATGTGACCC
AGAGCTTTGGCATCCTGGCCGCCCTGTGGGGCCTGGTCTCTGTGAGCTTCCTGGTCATGTCCTG
CATACCCTCGCTGTCCGCGCCTGGCCGTGGCCCCCTGGTCTCAACTTTCACAGCCTTTGGTGCA
GCTCTCTCTCTGATGGTGGCTATGACCGTCTACACTGTTGAGCGCTGGAACCAGCCCAGACACT
CCCAGATCCAGAGGAGCTTCTCCTGGTCCTTCTACCTGGGCTGGGTTTCAACAGTCCTCTTTCT
CTGTACAGGTGGCCTGAGTCTGGGCGCTCACTTTGGTGCCCCTCGGGCCGGCTATGACAGCGTG
TGACCTGCGCGCTGGCTTTGGGGCTCCCTTCTCGGAAGGCATCATCAGGGACCTCGGGAACAGC
CAGCTCCCTTTCCAGCCCAGACTCCCAGCCTCCACAGCCTCCTCCCTTGGTGTCTTTATTCTTT
CAACAAACATTTGCTGGAATCTGGTTATTCCCCCCCCCATTTATGCAGCCGCCACATAAGTCAA
CAACTGGCTAGCTCCACGGTAGGTGACACGGTGCCCAGAGAGGAGTCAGACCTGTCACCTGCCC
TGCCCCCAAGGTGCTTCCCACCCCGTGTGGGCTCGGGCACGACCCCAGGGCTTTCTCTCCCCTC
CGTCTGGCCCTTGGCTCTCTTCTTCGTCCTTTTACCTCTATTTTTCAGTGTCTTTCTCCTTGTA
GCCCTTTTCTTCTTGCTCCTTCTCTGACTTTGTCACCTTCACCTCAGTCCTCCTTGCTCATTTC
ATTAATAAATGCACTCCTTCAAGGCTTCAAAGTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001231458	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000003507
	ENSSSCP00000003507.2
	ENSSSCP00005002424.1
	ENSSSCP00015013247.1
	ENSSSCP00025011903.1
	ENSSSCP00030000148.1
	ENSSSCP00035029233.1
	ENSSSCP00040012470.1
	ENSSSCP00045009986.1
	ENSSSCP00050030639.1
	ENSSSCP00055009107.1
	ENSSSCP00060010385.1
	ENSSSCP00065048158.1
	ENSSSCP00070042694.1

RefSeq Acc Id:	NP_001231458 ⟸ NM_001244529
- UniProtKB:	F1RP91 (UniProtKB/TrEMBL), A0A4X1VLK1 (UniProtKB/TrEMBL), A0A8D1H4U7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPCRSLALLTSSLGLMSVLVALSTNFWFEAQGPHFSSHSGLWPSGDEGSIEGYIHVTQSFGIL AALWGLVSVSFLVMSCIPSLSAPGRGPLVSTFTAFGAALSLMVAMTVYTVERWNQPRHSQIQRS FSWSFYLGWVSTVLFLCTGGLSLGAHFGAPRAGYDSV hide sequence

RefSeq Acc Id:

ENSSSCP00000003507 ⟸ ENSSSCT00000003590

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000003231	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005002695	UniProtKB/TrEMBL
	ENSSSCG00015025047	UniProtKB/TrEMBL
	ENSSSCG00025020723	UniProtKB/TrEMBL
	ENSSSCG00030000086	UniProtKB/TrEMBL
	ENSSSCG00035053947	UniProtKB/TrEMBL
	ENSSSCG00040022227	UniProtKB/TrEMBL
	ENSSSCG00045008568	UniProtKB/TrEMBL
	ENSSSCG00050052311	UniProtKB/TrEMBL
	ENSSSCG00055005903	UniProtKB/TrEMBL
	ENSSSCG00060018391	UniProtKB/TrEMBL
	ENSSSCG00065077982	UniProtKB/TrEMBL
	ENSSSCG00070025264	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000003590	ENTREZGENE
	ENSSSCT00000003590.3	UniProtKB/TrEMBL
	ENSSSCT00005004104.1	UniProtKB/TrEMBL
	ENSSSCT00015033286.1	UniProtKB/TrEMBL
	ENSSSCT00025028135.1	UniProtKB/TrEMBL
	ENSSSCT00030000172.1	UniProtKB/TrEMBL
	ENSSSCT00035071993.1	UniProtKB/TrEMBL
	ENSSSCT00040029823.1	UniProtKB/TrEMBL
	ENSSSCT00045014416.1	UniProtKB/TrEMBL
	ENSSSCT00050071250.1	UniProtKB/TrEMBL
	ENSSSCT00055011511.1	UniProtKB/TrEMBL
	ENSSSCT00060024688.1	UniProtKB/TrEMBL
	ENSSSCT00065107922.1	UniProtKB/TrEMBL
	ENSSSCT00070050513.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.140.150	UniProtKB/TrEMBL
InterPro	PMP22/EMP/MP20/Claudin	UniProtKB/TrEMBL
KEGG Report	ssc:100513287	UniProtKB/TrEMBL
NCBI Gene	NKG7	ENTREZGENE
PANTHER	EPITHELIAL MEMBRANE PROTEIN-RELATED	UniProtKB/TrEMBL
	PROTEIN NKG7	UniProtKB/TrEMBL
Pfam	PMP22_Claudin	UniProtKB/TrEMBL
UniProt	A0A4X1VLK1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1H4U7	ENTREZGENE, UniProtKB/TrEMBL
	F1RP91	ENTREZGENE
UniProt Secondary	F1RP91	UniProtKB/TrEMBL
VGNC ID	VGNC:90761	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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