CAPN12 (calpain 12) - Rat Genome Database

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Gene: CAPN12 (calpain 12) Sus scrofa
Analyze
Symbol: CAPN12
Name: calpain 12
RGD ID: 13858640
Description: ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH maturity-onset diabetes of the young type 1 (ortholog); type 2 diabetes mellitus (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calpain-12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,565,440 - 47,578,994 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,565,917 - 47,579,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,126,499 - 43,139,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPN12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,565,440 - 47,578,994 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,565,917 - 47,579,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,126,499 - 43,139,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAPN12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,730,192 - 38,744,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,730,187 - 38,769,904 (-)EnsemblGRCh38hg38GRCh38
GRCh371939,220,832 - 39,235,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,912,672 - 43,926,954 (-)NCBINCBI36Build 36hg18NCBI36
Build 341943,912,671 - 43,926,954NCBI
Celera1936,022,825 - 36,037,032 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,667,615 - 35,682,075 (-)NCBIHuRef
CHM1_11939,221,640 - 39,235,595 (-)NCBICHM1_1
T2T-CHM13v2.01941,534,246 - 41,548,645 (-)NCBIT2T-CHM13v2.0
Capn12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,580,890 - 28,593,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,580,847 - 28,592,988 (+)EnsemblGRCm39 Ensembl
GRCm38728,881,465 - 28,893,585 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,881,422 - 28,893,563 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,666,675 - 29,678,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,590,417 - 28,602,345 (+)NCBIMGSCv36mm8
Celera723,443,096 - 23,455,025 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Capn12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,298,571 - 93,311,220 (+)NCBIGRCr8
mRatBN7.2184,171,059 - 84,183,161 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,171,059 - 84,183,119 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,580,975 - 89,593,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,040,078 - 98,052,143 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,336,837 - 91,348,901 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,066,289 - 87,078,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,066,289 - 87,078,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,246,907 - 88,258,966 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,989,000 - 84,001,059 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,066,985 - 84,078,502 (+)NCBI
Celera178,561,187 - 78,573,226 (+)NCBICelera
Cytogenetic Map1q21NCBI
Capn12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468761,015 - 770,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955468761,015 - 771,387 (+)NCBIChiLan1.0ChiLan1.0
CAPN12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,022,279 - 45,036,564 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,892,628 - 46,907,061 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,824,858 - 35,839,633 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,396,099 - 44,409,441 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,394,323 - 44,409,441 (-)Ensemblpanpan1.1panPan2
CAPN12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,342,210 - 114,347,873 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,342,521 - 114,354,482 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,747,505 - 113,759,624 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,944,822 - 114,956,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,942,987 - 114,956,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,518,101 - 114,530,073 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,135,462 - 114,147,615 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,174,114 - 115,186,160 (+)NCBIUU_Cfam_GSD_1.0
Capn12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,237,769 - 13,261,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,403,256 - 1,412,570 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,402,813 - 1,426,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,372,942 - 33,403,800 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,373,372 - 33,385,758 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,323,650 - 11,370,402 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capn12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,113,970 - 12,124,499 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,114,392 - 12,125,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CAPN12
317 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system
High
Medium
Low 3
Below cutoff 6

Sequence


RefSeq Acc Id: ENSSSCT00000003291   ⟹   ENSSSCP00000003209
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,565,440 - 47,578,994 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000092123   ⟹   ENSSSCP00000075058
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl647,565,440 - 47,578,994 (-)Ensembl
RefSeq Acc Id: XM_003481847   ⟹   XP_003481895
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,566,298 - 47,579,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094345   ⟹   XP_020950004
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,565,917 - 47,579,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094346   ⟹   XP_020950005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,565,917 - 47,579,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094347   ⟹   XP_020950006
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,565,917 - 47,578,657 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344647
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1647,566,751 - 47,579,278 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020950005   ⟸   XM_021094346
- Peptide Label: isoform X2
- UniProtKB: A0A8D1S8C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020950004   ⟸   XM_021094345
- Peptide Label: isoform X1
- UniProtKB: A0A8D1S3I3 (UniProtKB/TrEMBL),   F1RI38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020950006   ⟸   XM_021094347
- Peptide Label: isoform X3
- UniProtKB: A0A8D1S3I3 (UniProtKB/TrEMBL),   F1RI38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003481895   ⟸   XM_003481847
- Peptide Label: isoform X4
- UniProtKB: A0A8W4F714 (UniProtKB/TrEMBL),   A0A8D1S3I3 (UniProtKB/TrEMBL),   F1RI38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000003209   ⟸   ENSSSCT00000003291
RefSeq Acc Id: ENSSSCP00000075058   ⟸   ENSSSCT00000092123
Protein Domains
Calpain catalytic   EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002967 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00055027969 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003291.5 UniProtKB/TrEMBL
  ENSSSCT00000092123 ENTREZGENE
  ENSSSCT00000092123.1 UniProtKB/TrEMBL
  ENSSSCT00055055813.1 UniProtKB/TrEMBL
  ENSSSCT00055055918.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.380 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro C2_III UniProtKB/TrEMBL
  Calpain_cysteine_protease UniProtKB/TrEMBL
  Calpain_domain_III UniProtKB/TrEMBL
  Calpain_III UniProtKB/TrEMBL
  Calpain_III_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Peptidase_C2_calpain_cat UniProtKB/TrEMBL
NCBI Gene CAPN12 ENTREZGENE
PANTHER CALPAIN UniProtKB/TrEMBL
  PTHR10183:SF280 UniProtKB/TrEMBL
Pfam Calpain_III UniProtKB/TrEMBL
  Peptidase_C2 UniProtKB/TrEMBL
PRINTS CALPAIN UniProtKB/TrEMBL
PROSITE CALPAIN_CAT UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
SMART calpain_III UniProtKB/TrEMBL
  CysPc UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF49758 UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0A8D1S3I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S8C4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F714 ENTREZGENE, UniProtKB/TrEMBL
  F1RI38 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86172 ENTREZGENE