DKK3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Pathways
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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Sus scrofa
Analyze
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 13849296
Description: ENCODES a protein that exhibits co-receptor binding (inferred); receptor antagonist activity (inferred); INVOLVED IN adrenal gland development (inferred); negative regulation of aldosterone biosynthetic process (inferred); negative regulation of canonical Wnt signaling pathway (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); intellectual disability (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dickkopf 3 homolog; dickkopf homolog 3; dickkopf-related protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,192 - 47,444,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,192 - 47,444,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,963,036 - 12,009,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBICelera
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
T2T-CHM13v2.01112,054,919 - 12,101,206 (-)NCBIT2T-CHM13v2.0
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)EnsemblGRCm39 Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBIMGSCv36mm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map758.74NCBI
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,672,834 - 175,715,867 (-)NCBIGRCr8
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1166,238,238 - 166,280,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,573,298 - 174,615,607 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,759,295 - 181,801,602 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01174,459,245 - 174,501,581 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2914,409,852 - 14,456,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,372,466 - 14,418,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2135,899,250 - 35,950,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBIUU_Cfam_GSD_1.0
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365286,429,973 - 6,477,218 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247664,041,816 - 4,085,209 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DKK3
2097 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 3 23 1
Low 8 4 5 2 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014641   ⟹   ENSSSCP00000014246
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,239 - 47,444,567 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061517   ⟹   ENSSSCP00000033075
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,638 - 47,444,660 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069339   ⟹   ENSSSCP00000061871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,591 - 47,444,567 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072979   ⟹   ENSSSCP00000061257
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,192 - 47,444,568 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085402   ⟹   ENSSSCP00000064010
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,205 - 47,443,406 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000096272   ⟹   ENSSSCP00000077242
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl247,385,205 - 47,443,406 (+)Ensembl
RefSeq Acc Id: NM_001039749   ⟹   NP_001034838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1247,386,319 - 47,444,568 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661123   ⟹   XP_005661180
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1247,385,581 - 47,444,664 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021082083   ⟹   XP_020937742
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1247,385,244 - 47,444,576 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020937742   ⟸   XM_021082083
- Peptide Label: isoform X2
- UniProtKB: F6Q5E9 (UniProtKB/TrEMBL),   A0A4X1TMF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661180   ⟸   XM_005661123
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TMF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001034838   ⟸   NM_001039749
- Peptide Label: precursor
- UniProtKB: Q2HWR5 (UniProtKB/TrEMBL),   A0A4X1TS89 (UniProtKB/TrEMBL),   A0A5G2QGW8 (UniProtKB/TrEMBL),   A0A8D1RUV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061871   ⟸   ENSSSCT00000069339
RefSeq Acc Id: ENSSSCP00000064010   ⟸   ENSSSCT00000085402
RefSeq Acc Id: ENSSSCP00000033075   ⟸   ENSSSCT00000061517
RefSeq Acc Id: ENSSSCP00000014246   ⟸   ENSSSCT00000014641
RefSeq Acc Id: ENSSSCP00000061257   ⟸   ENSSSCT00000072979
RefSeq Acc Id: ENSSSCP00000077242   ⟸   ENSSSCT00000096272
Protein Domains
Dickkopf N-terminal cysteine-rich


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005037083 UniProtKB/TrEMBL
  ENSSSCG00015046286 UniProtKB/TrEMBL
  ENSSSCG00025030760 UniProtKB/TrEMBL
  ENSSSCG00030020844 UniProtKB/TrEMBL
  ENSSSCG00035018033 UniProtKB/TrEMBL
  ENSSSCG00045024315 UniProtKB/TrEMBL
  ENSSSCG00055024714 UniProtKB/TrEMBL
  ENSSSCG00060056540 UniProtKB/TrEMBL
  ENSSSCG00065023474 UniProtKB/TrEMBL
  ENSSSCG00070011235 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014641 ENTREZGENE
  ENSSSCT00000014641.4 UniProtKB/TrEMBL
  ENSSSCT00000061517 ENTREZGENE
  ENSSSCT00000061517.2 UniProtKB/TrEMBL
  ENSSSCT00000069339.2 UniProtKB/TrEMBL
  ENSSSCT00000072979 ENTREZGENE
  ENSSSCT00000072979.1 UniProtKB/TrEMBL
  ENSSSCT00000085402.2 UniProtKB/TrEMBL
  ENSSSCT00000096272.1 UniProtKB/TrEMBL
  ENSSSCT00005059875.1 UniProtKB/TrEMBL
  ENSSSCT00005059936.1 UniProtKB/TrEMBL
  ENSSSCT00005060017.1 UniProtKB/TrEMBL
  ENSSSCT00005060065.1 UniProtKB/TrEMBL
  ENSSSCT00015062101.1 UniProtKB/TrEMBL
  ENSSSCT00015062349.1 UniProtKB/TrEMBL
  ENSSSCT00025041949.1 UniProtKB/TrEMBL
  ENSSSCT00025042125.1 UniProtKB/TrEMBL
  ENSSSCT00025042253.1 UniProtKB/TrEMBL
  ENSSSCT00030028844.1 UniProtKB/TrEMBL
  ENSSSCT00030028865.1 UniProtKB/TrEMBL
  ENSSSCT00030028874.1 UniProtKB/TrEMBL
  ENSSSCT00035023250.1 UniProtKB/TrEMBL
  ENSSSCT00035023258.1 UniProtKB/TrEMBL
  ENSSSCT00035023269.1 UniProtKB/TrEMBL
  ENSSSCT00045041503.1 UniProtKB/TrEMBL
  ENSSSCT00045041599.1 UniProtKB/TrEMBL
  ENSSSCT00045041715.1 UniProtKB/TrEMBL
  ENSSSCT00045041830.1 UniProtKB/TrEMBL
  ENSSSCT00055048893.1 UniProtKB/TrEMBL
  ENSSSCT00055048998.1 UniProtKB/TrEMBL
  ENSSSCT00055049102.1 UniProtKB/TrEMBL
  ENSSSCT00060077015.1 UniProtKB/TrEMBL
  ENSSSCT00060077023.1 UniProtKB/TrEMBL
  ENSSSCT00060077033.1 UniProtKB/TrEMBL
  ENSSSCT00065031238.1 UniProtKB/TrEMBL
  ENSSSCT00065031251.1 UniProtKB/TrEMBL
  ENSSSCT00070021880.1 UniProtKB/TrEMBL
  ENSSSCT00070021889.1 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk3_Cys2 UniProtKB/TrEMBL
  Dkk3_N UniProtKB/TrEMBL
KEGG Report ssc:664653 UniProtKB/TrEMBL
NCBI Gene DKK3 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 3 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
UniProt A0A286ZNN6_PIG UniProtKB/TrEMBL
  A0A4X1TMF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TS89 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QGW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QUM6_PIG UniProtKB/TrEMBL
  A0A5G2R0H3_PIG UniProtKB/TrEMBL
  A0A8D0K123_PIG UniProtKB/TrEMBL
  A0A8D0K5F9_PIG UniProtKB/TrEMBL
  A0A8D0K6S3_PIG UniProtKB/TrEMBL
  A0A8D0LVQ7_PIG UniProtKB/TrEMBL
  A0A8D0NXN6_PIG UniProtKB/TrEMBL
  A0A8D0P1H0_PIG UniProtKB/TrEMBL
  A0A8D0RLV1_PIG UniProtKB/TrEMBL
  A0A8D0YVV6_PIG UniProtKB/TrEMBL
  A0A8D1I5E7_PIG UniProtKB/TrEMBL
  A0A8D1IB77_PIG UniProtKB/TrEMBL
  A0A8D1IF27_PIG UniProtKB/TrEMBL
  A0A8D1RLA2_PIG UniProtKB/TrEMBL
  A0A8D1RT28_PIG UniProtKB/TrEMBL
  A0A8D1RUV7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FD44_PIG UniProtKB/TrEMBL
  F6Q5E9 ENTREZGENE, UniProtKB/TrEMBL
  Q2HWR5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87323 ENTREZGENE