TRAV35 (T cell receptor alpha variable 35) - Rat Genome Database

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Gene: TRAV35 (T cell receptor alpha variable 35) Homo sapiens
Analyze
No known orthologs.
Symbol: TRAV35
Name: T cell receptor alpha variable 35
RGD ID: 1354276
HGNC Page HGNC:12134
Description: Predicted to be involved in response to bacterium. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex.
Type: gene (Ensembl: TR_V_pseudogene)
RefSeq Status: REVIEWED
Previously known as: TCRAV25S1; TCRAV35S1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,221,896 - 22,222,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,221,896 - 22,222,475 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,689,792 - 22,690,371 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,759,632 - 21,760,211 (+)NCBINCBI36Build 36hg18NCBI36
Celera142,553,326 - 2,553,905 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,807,420 - 2,807,999 (+)NCBIHuRef
CHM1_11422,689,798 - 22,690,377 (+)NCBICHM1_1
T2T-CHM13v2.01416,419,667 - 16,420,246 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8188290   PMID:21873635  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:21919243-22511027)x1 copy number loss See cases [RCV000135132] Chr14:21919243..22511027 [GRCh38]
Chr14:22387418..22980010 [GRCh37]
Chr14:21457258..22049850 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2(chr14:21973760-22442515)x1 copy number loss See cases [RCV000135471] Chr14:21973760..22442515 [GRCh38]
Chr14:22441989..22911507 [GRCh37]
Chr14:21511829..21981347 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:21854413-22495939)x1 copy number loss See cases [RCV000135900] Chr14:21854413..22495939 [GRCh38]
Chr14:22322590..22964922 [GRCh37]
Chr14:21392430..22034762 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
GRCh38/hg38 14q11.2(chr14:22130104-22398359)x1 copy number loss See cases [RCV000138699] Chr14:22130104..22398359 [GRCh38]
Chr14:22598068..22866762 [GRCh37]
Chr14:21667908..21936602 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:22130104-22343431)x3 copy number gain See cases [RCV000138458] Chr14:22130104..22343431 [GRCh38]
Chr14:22598068..22811855 [GRCh37]
Chr14:21667908..21881695 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:22021665-22324997)x3 copy number gain See cases [RCV000138466] Chr14:22021665..22324997 [GRCh38]
Chr14:22489905..22793429 [GRCh37]
Chr14:21559745..21863269 [NCBI36]
Chr14:14q11.2		 benign|likely benign|conflicting data from submitters
GRCh38/hg38 14q11.2(chr14:22021665-22428036)x3 copy number gain See cases [RCV000139203] Chr14:22021665..22428036 [GRCh38]
Chr14:22489905..22897028 [GRCh37]
Chr14:21559745..21966868 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21973759-22428036)x3 copy number gain See cases [RCV000139486] Chr14:21973759..22428036 [GRCh38]
Chr14:22441988..22897028 [GRCh37]
Chr14:21511828..21966868 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:21919182-22398359)x3 copy number gain See cases [RCV000139614] Chr14:21919182..22398359 [GRCh38]
Chr14:22387357..22866762 [GRCh37]
Chr14:21457197..21936602 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21010790-22951814)x3 copy number gain See cases [RCV000140829] Chr14:21010790..22951814 [GRCh38]
Chr14:21478949..23421023 [GRCh37]
Chr14:20548789..22490863 [NCBI36]
Chr14:14q11.2		 uncertain significance
GRCh38/hg38 14q11.2(chr14:21830995-22324997)x3 copy number gain See cases [RCV000142945] Chr14:21830995..22324997 [GRCh38]
Chr14:22299151..22793429 [GRCh37]
Chr14:21368991..21863269 [NCBI36]
Chr14:14q11.2		 pathogenic|likely benign
GRCh38/hg38 14q11.2(chr14:22021665-22398359)x3 copy number gain See cases [RCV000142894] Chr14:22021665..22398359 [GRCh38]
Chr14:22489905..22866762 [GRCh37]
Chr14:21559745..21936602 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21973759-22398359)x3 copy number gain See cases [RCV000142826] Chr14:21973759..22398359 [GRCh38]
Chr14:22441988..22866762 [GRCh37]
Chr14:21511828..21936602 [NCBI36]
Chr14:14q11.2		 likely benign
GRCh38/hg38 14q11.2(chr14:21973759-22324997)x3 copy number gain See cases [RCV000142998] Chr14:21973759..22324997 [GRCh38]
Chr14:22441988..22793429 [GRCh37]
Chr14:21511828..21863269 [NCBI36]
Chr14:14q11.2		 pathogenic|likely benign
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1 copy number loss See cases [RCV000051483] Chr14:19755249..22741281 [GRCh38]
Chr14:20223408..23210490 [GRCh37]
Chr14:19293248..22280330 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:21919243-22442515)x1 copy number loss See cases [RCV000051207] Chr14:21919243..22442515 [GRCh38]
Chr14:22387418..22911507 [GRCh37]
Chr14:21457258..21981347 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2		 pathogenic
GRCh38/hg38 14q11.2(chr14:22021664-22592708)x1 copy number loss See cases [RCV000053682] Chr14:22021664..22592708 [GRCh38]
Chr14:22489904..23061615 [GRCh37]
Chr14:21559744..22131455 [NCBI36]
Chr14:14q11.2		 benign
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:187
Interacting mature miRNAs:188
Transcripts:ENST00000390462
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 26 3 52 1 1
Low 207 616 128 40 912 38 95 5 21 59 86 251 2 71 42
Below cutoff 436 495 299 130 273 89 677 143 208 94 197 406 42 357 368 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000390462
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1422,221,896 - 22,222,475 (+)Ensembl
Protein Sequences
GenBank Protein P0DPF4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DPF4-F1-model_v2 AlphaFold P0DPF4 1-110 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12134 AgrOrtholog
COSMIC TRAV35 COSMIC
Ensembl Genes ENSG00000211814 Ensembl, ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000211814 GTEx
HGNC ID HGNC:12134 ENTREZGENE
Human Proteome Map TRAV35 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
NCBI Gene TRAV35 ENTREZGENE
PANTHER T CELL RECEPTOR ALPHA VARIABLE 22 UniProtKB/Swiss-Prot
  T CELL RECEPTOR ALPHA VARIABLE 39 UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA36816 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART IGv UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt P0DPF4 ENTREZGENE, UniProtKB/Swiss-Prot