TRIM61 (tripartite motif containing 61) - Rat Genome Database

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Gene: TRIM61 (tripartite motif containing 61) Homo sapiens
Analyze
Symbol: TRIM61
Name: tripartite motif containing 61
RGD ID: 1354030
HGNC Page HGNC:24339
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ60274; MGC102996; putative tripartite motif-containing protein 61; ring finger protein 35; RNF35; tripartite motif-containing 61
RGD Orthologs
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384164,954,446 - 164,977,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4164,954,446 - 164,977,668 (-)EnsemblGRCh38hg38GRCh38
GRCh374165,875,598 - 165,898,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,095,048 - 166,118,268 (-)NCBINCBI36Build 36hg18NCBI36
Celera4163,207,628 - 163,230,821 (-)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,629,233 - 161,652,427 (-)NCBIHuRef
CHM1_14165,852,150 - 165,875,369 (-)NCBICHM1_1
T2T-CHM13v2.04168,302,109 - 168,325,338 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15146197   PMID:15489334   PMID:15994318   PMID:21873635   PMID:23251661   PMID:33961781  


Genomics

Comparative Map Data
TRIM61
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384164,954,446 - 164,977,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4164,954,446 - 164,977,668 (-)EnsemblGRCh38hg38GRCh38
GRCh374165,875,598 - 165,898,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,095,048 - 166,118,268 (-)NCBINCBI36Build 36hg18NCBI36
Celera4163,207,628 - 163,230,821 (-)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,629,233 - 161,652,427 (-)NCBIHuRef
CHM1_14165,852,150 - 165,875,369 (-)NCBICHM1_1
T2T-CHM13v2.04168,302,109 - 168,325,338 (-)NCBIT2T-CHM13v2.0
Trim61
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,465,628 - 65,471,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,465,639 - 65,471,175 (-)EnsemblGRCm39 Ensembl
GRCm38865,012,976 - 65,018,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl865,012,987 - 65,018,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,536,875 - 67,542,587 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,941,979 - 67,947,555 (-)NCBIMGSCv36mm8
Celera867,574,361 - 67,582,546 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.52NCBI
TRIM61
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,718,049 - 162,731,305 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,077,831 - 163,090,696 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04156,986,382 - 157,178,424 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,219,528 - 169,220,694 (-)NCBIpanpan1.1PanPan1.1panPan2
TRIM61
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,019,766 - 61,021,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,329,090 - 61,337,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01561,881,617 - 61,890,274 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11561,045,697 - 61,054,333 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,106,850 - 61,115,497 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,480,551 - 61,489,200 (-)NCBIUU_Cfam_GSD_1.0
TRIM61
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,306,850 - 111,308,827 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603791,137,496 - 91,151,497 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TRIM61
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q32.2-35.2(chr4:162013220-189975519)x3 copy number gain See cases [RCV000050649] Chr4:162013220..189975519 [GRCh38]
Chr4:162934372..190828225 [GRCh37]
Chr4:163153822..191133668 [NCBI36]
Chr4:4q32.2-35.2		 pathogenic
GRCh38/hg38 4q26-35.2(chr4:118065569-190042639)x3 copy number gain See cases [RCV000051785] Chr4:118065569..190042639 [GRCh38]
Chr4:118986724..190828225 [GRCh37]
Chr4:119206172..191200788 [NCBI36]
Chr4:4q26-35.2		 pathogenic
GRCh38/hg38 4q27-35.2(chr4:121518223-190062270)x3 copy number gain See cases [RCV000051786] Chr4:121518223..190062270 [GRCh38]
Chr4:122439378..190828225 [GRCh37]
Chr4:122658828..191220419 [NCBI36]
Chr4:4q27-35.2		 pathogenic
GRCh38/hg38 4q31.22-34.1(chr4:147317283-173675559)x3 copy number gain See cases [RCV000051788] Chr4:147317283..173675559 [GRCh38]
Chr4:148238435..174596710 [GRCh37]
Chr4:148457885..174833285 [NCBI36]
Chr4:4q31.22-34.1		 pathogenic
GRCh38/hg38 4q31.23-35.2(chr4:148356485-189548183)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051789]|See cases [RCV000051789] Chr4:148356485..189548183 [GRCh38]
Chr4:149277637..190469337 [GRCh37]
Chr4:149497087..190706331 [NCBI36]
Chr4:4q31.23-35.2		 pathogenic
GRCh38/hg38 4q32.2-32.3(chr4:161592038-165721577)x3 copy number gain See cases [RCV000051791] Chr4:161592038..165721577 [GRCh38]
Chr4:162513190..166642729 [GRCh37]
Chr4:162732640..166862179 [NCBI36]
Chr4:4q32.2-32.3		 pathogenic
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q32.1-35.2(chr4:158568335-189975660)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053325]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053325]|See cases [RCV000053325] Chr4:158568335..189975660 [GRCh38]
Chr4:159489487..190828225 [GRCh37]
Chr4:159708937..191133809 [NCBI36]
Chr4:4q32.1-35.2		 pathogenic
GRCh38/hg38 4q32.2-34.1(chr4:162723818-172501433)x1 copy number loss See cases [RCV000053326] Chr4:162723818..172501433 [GRCh38]
Chr4:163644970..173422584 [GRCh37]
Chr4:163864420..173659159 [NCBI36]
Chr4:4q32.2-34.1		 pathogenic
GRCh38/hg38 4q32.3-35.2(chr4:163651681-189975519)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053327]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053327]|See cases [RCV000053327] Chr4:163651681..189975519 [GRCh38]
Chr4:164572833..190828225 [GRCh37]
Chr4:164792283..191133668 [NCBI36]
Chr4:4q32.3-35.2		 pathogenic
GRCh38/hg38 4q32.3-35.2(chr4:164039530-189982708)x1 copy number loss See cases [RCV000053347] Chr4:164039530..189982708 [GRCh38]
Chr4:164960682..190828225 [GRCh37]
Chr4:165180132..191140857 [NCBI36]
Chr4:4q32.3-35.2		 pathogenic
NM_001012414.2(TRIM61):c.155C>T (p.Pro52Leu) single nucleotide variant Malignant melanoma [RCV000060943] Chr4:164969848 [GRCh38]
Chr4:165891000 [GRCh37]
Chr4:166110450 [NCBI36]
Chr4:4q32.3		 not provided
GRCh38/hg38 4q31.21-35.2(chr4:145042668-189975519)x3 copy number gain See cases [RCV000135845] Chr4:145042668..189975519 [GRCh38]
Chr4:145963820..190828225 [GRCh37]
Chr4:146183270..191133668 [NCBI36]
Chr4:4q31.21-35.2		 pathogenic
GRCh38/hg38 4q32.1-32.3(chr4:158387928-166845726)x3 copy number gain See cases [RCV000136603] Chr4:158387928..166845726 [GRCh38]
Chr4:159309080..167766877 [GRCh37]
Chr4:159528530..168003452 [NCBI36]
Chr4:4q32.1-32.3		 pathogenic|uncertain significance
GRCh38/hg38 4q32.3(chr4:164958519-165250486)x3 copy number gain See cases [RCV000135907] Chr4:164958519..165250486 [GRCh38]
Chr4:165879671..166171638 [GRCh37]
Chr4:166099121..166391088 [NCBI36]
Chr4:4q32.3		 benign
GRCh38/hg38 4q31.1-35.2(chr4:138510532-189963195)x3 copy number gain See cases [RCV000136810] Chr4:138510532..189963195 [GRCh38]
Chr4:139431686..190828225 [GRCh37]
Chr4:139651136..191121344 [NCBI36]
Chr4:4q31.1-35.2		 pathogenic
GRCh38/hg38 4q28.3-35.2(chr4:131985253-190095391)x3 copy number gain See cases [RCV000137721] Chr4:131985253..190095391 [GRCh38]
Chr4:132906408..190828225 [GRCh37]
Chr4:133125858..191250527 [NCBI36]
Chr4:4q28.3-35.2		 pathogenic|likely benign
GRCh38/hg38 4q28.1-35.1(chr4:125432943-185761887)x3 copy number gain See cases [RCV000138578] Chr4:125432943..185761887 [GRCh38]
Chr4:126354098..186683041 [GRCh37]
Chr4:126573548..186920035 [NCBI36]
Chr4:4q28.1-35.1		 pathogenic|likely benign
GRCh38/hg38 4q32.1-35.2(chr4:160757699-190091407)x3 copy number gain See cases [RCV000140982] Chr4:160757699..190091407 [GRCh38]
Chr4:161678851..191012562 [GRCh37]
Chr4:161898301..191246543 [NCBI36]
Chr4:4q32.1-35.2		 pathogenic
GRCh38/hg38 4q32.1-33(chr4:155162982-170959553)x1 copy number loss See cases [RCV000141861] Chr4:155162982..170959553 [GRCh38]
Chr4:156084134..171880704 [GRCh37]
Chr4:156303584..172117279 [NCBI36]
Chr4:4q32.1-33		 pathogenic
GRCh38/hg38 4q32.3(chr4:164837643-167576305)x1 copy number loss See cases [RCV000142339] Chr4:164837643..167576305 [GRCh38]
Chr4:165758795..168497456 [GRCh37]
Chr4:165978245..168734031 [NCBI36]
Chr4:4q32.3		 uncertain significance
GRCh38/hg38 4q32.2-32.3(chr4:161590861-165734658)x3 copy number gain See cases [RCV000143095] Chr4:161590861..165734658 [GRCh38]
Chr4:162512013..166655810 [GRCh37]
Chr4:162731463..166875260 [NCBI36]
Chr4:4q32.2-32.3		 uncertain significance
GRCh38/hg38 4q28.3-35.2(chr4:134935616-190036318)x3 copy number gain See cases [RCV000143559] Chr4:134935616..190036318 [GRCh38]
Chr4:135856771..190957473 [GRCh37]
Chr4:136076221..191194467 [NCBI36]
Chr4:4q28.3-35.2		 pathogenic
GRCh37/hg19 4q28.3-35.1(chr4:136912336-184253252)x3 copy number gain See cases [RCV000240245] Chr4:136912336..184253252 [GRCh37]
Chr4:4q28.3-35.1		 pathogenic
GRCh37/hg19 4q32.2-34.2(chr4:162344510-177103037)x1 copy number loss See cases [RCV000239855] Chr4:162344510..177103037 [GRCh37]
Chr4:4q32.2-34.2		 pathogenic
GRCh37/hg19 4q26-35.2(chr4:119437495-190904301)x3 copy number gain See cases [RCV000240392] Chr4:119437495..190904301 [GRCh37]
Chr4:4q26-35.2		 pathogenic
NM_001414904.1(TRIM61):c.340C>T (p.Leu114Phe) single nucleotide variant not specified [RCV004314531] Chr4:164969663 [GRCh38]
Chr4:165890815 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.3(chr4:165499415-165907923)x3 copy number gain See cases [RCV000447124] Chr4:165499415..165907923 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q32.3(chr4:165876480-165879671)x3 copy number gain See cases [RCV000448170] Chr4:165876480..165879671 [GRCh37]
Chr4:4q32.3		 benign|likely benign
GRCh37/hg19 4q32.3(chr4:165876480-165889702)x3 copy number gain See cases [RCV000448189] Chr4:165876480..165889702 [GRCh37]
Chr4:4q32.3		 benign
GRCh37/hg19 4q31.3-35.2(chr4:153890440-190957473)x3 copy number gain See cases [RCV000510713] Chr4:153890440..190957473 [GRCh37]
Chr4:4q31.3-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q25-35.2(chr4:109199664-189752726)x3 copy number gain See cases [RCV000511945] Chr4:109199664..189752726 [GRCh37]
Chr4:4q25-35.2		 pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
GRCh37/hg19 4q32.1-35.2(chr4:156465633-190957473)x3 copy number gain See cases [RCV000512542] Chr4:156465633..190957473 [GRCh37]
Chr4:4q32.1-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q32.2-34.3(chr4:162205710-182329883)x1 copy number loss See cases [RCV000512340] Chr4:162205710..182329883 [GRCh37]
Chr4:4q32.2-34.3		 pathogenic
GRCh37/hg19 4q32.1-35.1(chr4:157552397-183831253)x3 copy number gain not provided [RCV000682475] Chr4:157552397..183831253 [GRCh37]
Chr4:4q32.1-35.1		 pathogenic
GRCh37/hg19 4q32.1-35.2(chr4:159492464-190957473)x3 copy number gain not provided [RCV000682478] Chr4:159492464..190957473 [GRCh37]
Chr4:4q32.1-35.2		 pathogenic
Single allele deletion not provided [RCV000677975] Chr4:164428194..173480785 [GRCh37]
Chr4:4q32.2-34.1		 likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q28.1-35.1(chr4:124873497-185278662)x3 copy number gain not provided [RCV000849686] Chr4:124873497..185278662 [GRCh37]
Chr4:4q28.1-35.1		 pathogenic
GRCh37/hg19 4q31.3-35.2(chr4:151174061-190957473)x3 copy number gain not provided [RCV000849098] Chr4:151174061..190957473 [GRCh37]
Chr4:4q31.3-35.2		 pathogenic
GRCh37/hg19 4q32.3-34.2(chr4:165069355-177189728)x3 copy number gain not provided [RCV000846267] Chr4:165069355..177189728 [GRCh37]
Chr4:4q32.3-34.2		 pathogenic
GRCh37/hg19 4q32.3(chr4:165822566-165894496)x1 copy number loss not provided [RCV001005613] Chr4:165822566..165894496 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.3(chr4:164980534-166223066)x3 copy number gain not provided [RCV002472715] Chr4:164980534..166223066 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.1-32.3(chr4:161461677-166911259)x1 copy number loss not provided [RCV002473507] Chr4:161461677..166911259 [GRCh37]
Chr4:4q32.1-32.3		 uncertain significance
GRCh37/hg19 4q32.3-35.2(chr4:165010461-190957473)x1 copy number loss not provided [RCV001005612] Chr4:165010461..190957473 [GRCh37]
Chr4:4q32.3-35.2		 pathogenic
GRCh37/hg19 4q32.1-34.1(chr4:157771352-172496278) copy number loss Autism with high cognitive abilities [RCV001352663] Chr4:157771352..172496278 [GRCh37]
Chr4:4q32.1-34.1		 pathogenic
GRCh37/hg19 4q28.3-32.3(chr4:131303317-168722402)x3 copy number gain not provided [RCV001537926] Chr4:131303317..168722402 [GRCh37]
Chr4:4q28.3-32.3		 pathogenic
GRCh37/hg19 4q32.3(chr4:165626874-165959108)x3 copy number gain not provided [RCV001834414] Chr4:165626874..165959108 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.3(chr4:165499415-165907923) copy number gain not specified [RCV002053466] Chr4:165499415..165907923 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.1-35.2(chr4:159755174-190225765) copy number gain not specified [RCV002053465] Chr4:159755174..190225765 [GRCh37]
Chr4:4q32.1-35.2		 pathogenic
GRCh37/hg19 4q32.1-35.2(chr4:159174483-190957473)x1 copy number loss See cases [RCV002292401] Chr4:159174483..190957473 [GRCh37]
Chr4:4q32.1-35.2		 pathogenic
NM_001414904.1(TRIM61):c.313A>C (p.Thr105Pro) single nucleotide variant not specified [RCV004111121] Chr4:164969690 [GRCh38]
Chr4:165890842 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.482T>A (p.Val161Asp) single nucleotide variant not specified [RCV004154979] Chr4:164969521 [GRCh38]
Chr4:165890673 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.14C>T (p.Thr5Met) single nucleotide variant not specified [RCV004128173] Chr4:164969989 [GRCh38]
Chr4:165891141 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.406G>C (p.Ala136Pro) single nucleotide variant not specified [RCV004144580] Chr4:164969597 [GRCh38]
Chr4:165890749 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.70A>G (p.Lys24Glu) single nucleotide variant not specified [RCV004155723] Chr4:164969933 [GRCh38]
Chr4:165891085 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.490A>G (p.Met164Val) single nucleotide variant not specified [RCV004143946] Chr4:164969513 [GRCh38]
Chr4:165890665 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.325C>G (p.Gln109Glu) single nucleotide variant not specified [RCV004241750] Chr4:164969678 [GRCh38]
Chr4:165890830 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.449C>T (p.Pro150Leu) single nucleotide variant not specified [RCV004220093] Chr4:164969554 [GRCh38]
Chr4:165890706 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.517A>G (p.Lys173Glu) single nucleotide variant not specified [RCV004266988] Chr4:164969486 [GRCh38]
Chr4:165890638 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.263G>A (p.Arg88Lys) single nucleotide variant not specified [RCV004274243] Chr4:164969740 [GRCh38]
Chr4:165890892 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.224C>T (p.Thr75Ile) single nucleotide variant not specified [RCV004338450] Chr4:164969779 [GRCh38]
Chr4:165890931 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.116G>A (p.Cys39Tyr) single nucleotide variant not specified [RCV004355213] Chr4:164969887 [GRCh38]
Chr4:165891039 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.201C>G (p.Ser67Arg) single nucleotide variant not specified [RCV004365273] Chr4:164969802 [GRCh38]
Chr4:165890954 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.289T>G (p.Cys97Gly) single nucleotide variant not specified [RCV004356051] Chr4:164969714 [GRCh38]
Chr4:165890866 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q32.3(chr4:165746311-166148332)x3 copy number gain not provided [RCV003484209] Chr4:165746311..166148332 [GRCh37]
Chr4:4q32.3		 uncertain significance
GRCh37/hg19 4q26-32.3(chr4:117518683-168174703)x3 copy number gain not provided [RCV003484198] Chr4:117518683..168174703 [GRCh37]
Chr4:4q26-32.3		 pathogenic
GRCh37/hg19 4q32.1-35.2(chr4:161589441-190957473)x1 copy number loss not specified [RCV003986532] Chr4:161589441..190957473 [GRCh37]
Chr4:4q32.1-35.2		 pathogenic
GRCh37/hg19 4q27-35.2(chr4:123399154-190957473)x3 copy number gain not specified [RCV003986533] Chr4:123399154..190957473 [GRCh37]
Chr4:4q27-35.2		 pathogenic
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2		 pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_001414904.1(TRIM61):c.245A>G (p.Gln82Arg) single nucleotide variant not specified [RCV004476040] Chr4:164969758 [GRCh38]
Chr4:165890910 [GRCh37]
Chr4:4q32.3		 uncertain significance
NM_001414904.1(TRIM61):c.208C>A (p.Gln70Lys) single nucleotide variant not specified [RCV004476039] Chr4:164969795 [GRCh38]
Chr4:165890947 [GRCh37]
Chr4:4q32.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:130
Interacting mature miRNAs:133
Transcripts:ENST00000329314
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH103332  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map4q32.3UniSTS
GeneMap99-GB4 RH Map4657.9UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2 19 12 1 1 149 11
Low 661 1136 1280 51 897 51 1156 406 1472 125 699 1142 3 1 853 603 1
Below cutoff 1547 1496 349 428 720 318 2158 1195 2132 226 525 395 116 338 1367 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000329314   ⟹   ENSP00000332288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4164,954,446 - 164,977,657 (-)Ensembl
RefSeq Acc Id: ENST00000508856   ⟹   ENSP00000498736
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4164,968,374 - 164,977,668 (-)Ensembl
RefSeq Acc Id: ENST00000710271   ⟹   ENSP00000518164
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4164,968,281 - 164,977,657 (-)Ensembl
RefSeq Acc Id: NM_001012414   ⟹   NP_001012414
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384164,954,446 - 164,977,657 (-)NCBI
GRCh374165,875,598 - 165,898,818 (-)RGD
Build 364166,095,048 - 166,118,268 (-)NCBI Archive
Celera4163,207,628 - 163,230,821 (-)RGD
HuRef4161,629,233 - 161,652,427 (-)RGD
CHM1_14165,852,150 - 165,875,369 (-)NCBI
T2T-CHM13v2.04168,302,109 - 168,325,316 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001414904   ⟹   NP_001401833
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384164,968,281 - 164,977,657 (-)NCBI
T2T-CHM13v2.04168,315,940 - 168,325,316 (-)NCBI
RefSeq Acc Id: XM_054349976   ⟹   XP_054205951
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04168,316,246 - 168,325,338 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012414   ⟸   NM_001012414
- Peptide Label: isoform 2
- UniProtKB: Q5EBN2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000498736   ⟸   ENST00000508856
RefSeq Acc Id: ENSP00000332288   ⟸   ENST00000329314
RefSeq Acc Id: NP_001401833   ⟸   NM_001414904
- Peptide Label: isoform 1
- UniProtKB: A0A494C0U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054205951   ⟸   XM_054349976
- Peptide Label: isoform X1
- UniProtKB: A0A494C0U7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000518164   ⟸   ENST00000710271
Protein Domains
B box-type   B30.2/SPRY   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EBN2-F1-model_v2 AlphaFold Q5EBN2 1-209 view protein structure

Promoters
RGD ID:6868828
Promoter ID:EPDNEW_H7579
Type:initiation region
Name:TRIM61_1
Description:tripartite motif containing 61
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384164,977,631 - 164,977,691EPDNEW
RGD ID:6802678
Promoter ID:HG_KWN:49406
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:UC003IQW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364166,117,986 - 166,118,486 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24339 AgrOrtholog
COSMIC TRIM61 COSMIC
Ensembl Genes ENSG00000183439 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000329314 ENTREZGENE
  ENST00000329314.6 UniProtKB/Swiss-Prot
  ENST00000508856.2 UniProtKB/TrEMBL
  ENST00000710271 ENTREZGENE
  ENST00000710271.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000183439 GTEx
HGNC ID HGNC:24339 ENTREZGENE
Human Proteome Map TRIM61 Human Proteome Map
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY/PRY_TRIM60 UniProtKB/TrEMBL
  SPRY_dom UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:391712 UniProtKB/Swiss-Prot
NCBI Gene 391712 ENTREZGENE
OMIM 619417 OMIM
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIPARTITE MOTIF-CONTAINING PROTEIN 61-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PRY UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134868214 PharmGKB
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PRY UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A494C0U7 ENTREZGENE, UniProtKB/TrEMBL
  Q5EBN2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 TRIM61  tripartite motif containing 61  RNF35  ring finger protein 35  Data merged from RGD:1349960 737654 PROVISIONAL
2011-07-27 TRIM61  tripartite motif containing 61  TRIM61  tripartite motif-containing 61  Symbol and/or name change 5135510 APPROVED