METRN (meteorin, glial cell differentiation regulator)

Gene: METRN (meteorin, glial cell differentiation regulator) Homo sapiens

Analyze

Symbol:

METRN

Name:

meteorin, glial cell differentiation regulator

RGD ID:

1353878

HGNC Page

HGNC:14151

Description:

Predicted to enable hormone activity. Predicted to be involved in glial cell differentiation and positive regulation of axonogenesis. Predicted to act upstream of or within radial glial cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C16orf23; c380A1.2; meteorin; MGC2601

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	715,118 - 719,655 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	715,118 - 719,655 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	765,118 - 769,655 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	705,174 - 707,481 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	705,173 - 707,479	NCBI
Celera	16	965,338 - 967,645 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	687,641 - 689,372 (+)	NCBI		HuRef
CHM1_1	16	765,143 - 767,450 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	719,300 - 723,837 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (IAGP)

idiopathic generalized epilepsy (IAGP)

short-rib thoracic dysplasia 9 with or without polydactyly (IAGP)

tuberous sclerosis 2 (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (EXP)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (EXP)

all-trans-retinoic acid (EXP,ISO)

antimycin A (EXP)

Aroclor 1254 (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

bleomycin A5 (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

cisplatin (EXP)

clobetasol (ISO)

copper(II) sulfate (EXP)

Cuprizon (ISO)

cyclophosphamide (EXP)

cyclosporin A (EXP,ISO)

deguelin (EXP)

dicrotophos (EXP)

dimethylselenide (EXP)

dorsomorphin (EXP)

doxorubicin (EXP)

endosulfan (ISO)

entinostat (EXP)

ethanol (ISO)

exemestane (EXP)

folic acid (ISO)

formaldehyde (EXP)

isoprenaline (ISO)

methyl methanesulfonate (EXP)

oxaliplatin (ISO)

paclitaxel (EXP)

paracetamol (ISO)

PCB138 (ISO)

reactive oxygen species (EXP)

SB 431542 (EXP)

sodium arsenite (EXP)

sunitinib (EXP)

tebufenpyrad (EXP)

tetrachloroethene (ISO)

thifluzamide (EXP)

topotecan (ISO)

trimellitic anhydride (ISO)

tungsten (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (IEA,ISO)

cell differentiation (IEA)

glial cell differentiation (IBA)

nervous system development (IEA)

positive regulation of axonogenesis (IBA,IEA,ISO)

radial glial cell differentiation (IEA,ISO)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA)

Molecular Function

hormone activity (IBA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Generalized-onset seizure (IAGP)

Seizure (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11157797	PMID:12477932	PMID:14702039	PMID:15085178	PMID:15489334	PMID:15616553	PMID:21873635	PMID:26121675	PMID:26760575	PMID:28298427	PMID:28514442	PMID:29117863
PMID:31859449	PMID:32513696	PMID:33867829	PMID:33961781

Genomics

Comparative Map Data

METRN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	715,118 - 719,655 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	715,118 - 719,655 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	765,118 - 769,655 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	705,174 - 707,481 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	705,173 - 707,479	NCBI
Celera	16	965,338 - 967,645 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	687,641 - 689,372 (+)	NCBI		HuRef
CHM1_1	16	765,143 - 767,450 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	719,300 - 723,837 (+)	NCBI		T2T-CHM13v2.0

Metrn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	26,013,545 - 26,016,019 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	26,012,195 - 26,016,057 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,794,571 - 25,797,045 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,793,221 - 25,797,136 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,931,516 - 25,933,990 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,522,171 - 25,524,645 (-)	NCBI		MGSCv36	mm8
Celera	17	26,327,377 - 26,329,803 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.89	NCBI

Metrn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,321,200 - 15,323,218 (-)	NCBI		GRCr8
mRatBN7.2	10	14,816,684 - 14,818,702 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,816,572 - 14,818,701 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,555,693 - 19,557,711 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,044,570 - 19,046,588 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,544,689 - 14,546,707 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	15,164,439 - 15,166,457 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	15,164,439 - 15,166,457 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,977,382 - 14,979,400 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,062,082 - 15,064,100 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,062,081 - 15,064,100 (-)	NCBI
Celera	10	14,485,660 - 14,487,678 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Metrn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,485,482 - 16,488,949 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,485,482 - 16,488,949 (-)	NCBI	ChiLan1.0	ChiLan1.0

METRN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	955,259 - 960,260 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,739,565 - 4,744,730 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	711,828 - 732,711 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	728,365 - 730,423 (+)	Ensembl	panpan1.1		panPan2

METRN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,864,731 - 39,867,729 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,129,730 - 41,132,236 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,208,238 - 40,210,744 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	39,896,842 - 39,899,348 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,857,049 - 39,859,555 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,335,934 - 40,338,440 (-)	NCBI		UU_Cfam_GSD_1.0

Metrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,196,457 - 112,203,500 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	299,237 - 301,399 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936501	294,359 - 296,020 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	295,970 - 301,344 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METRN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	41,061,225 - 41,064,391 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	41,053,722 - 41,064,315 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,413,572 - 41,416,907 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METRN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	633,951 - 637,227 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666068	30,496,275 - 30,501,649 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Metrn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,524,721 - 1,526,984 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,524,641 - 1,526,850 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in METRN
25 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3	copy number gain	See cases [RCV000052367]	Chr16:23141..11296695 [GRCh38] Chr16:73141..11390552 [GRCh37] Chr16:13141..11298053 [NCBI36] Chr16:16p13.3-13.13	pathogenic
GRCh38/hg38 16p13.3(chr16:29941-2560460)x3	copy number gain	See cases [RCV000052368]	Chr16:29941..2560460 [GRCh38] Chr16:79941..2610461 [GRCh37] Chr16:19941..2550462 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:46566-1800860)x3	copy number gain	See cases [RCV000052369]	Chr16:46566..1800860 [GRCh38] Chr16:96566..1850861 [GRCh37] Chr16:36566..1790862 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:46766-3214623)x3	copy number gain	See cases [RCV000052370]	Chr16:46766..3214623 [GRCh38] Chr16:96766..3264623 [GRCh37] Chr16:36766..3204624 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1773349)x1	copy number loss	See cases [RCV000053251]	Chr16:23141..1773349 [GRCh38] Chr16:73141..1823350 [GRCh37] Chr16:13141..1763351 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1712523)x1	copy number loss	See cases [RCV000053252]	Chr16:23141..1712523 [GRCh38] Chr16:73141..1762524 [GRCh37] Chr16:13141..1702525 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1997582)x1	copy number loss	See cases [RCV000053253]	Chr16:46766..1997582 [GRCh38] Chr16:96766..2047583 [GRCh37] Chr16:36766..1987584 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:105429-1499893)x1	copy number loss	See cases [RCV000053267]	Chr16:105429..1499893 [GRCh38] Chr16:155427..1549894 [GRCh37] Chr16:95427..1489895 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3	copy number gain	See cases [RCV000133780]	Chr16:46766..11525516 [GRCh38] Chr16:96766..11619372 [GRCh37] Chr16:36766..11526873 [NCBI36] Chr16:16p13.3-13.13	pathogenic
GRCh38/hg38 16p13.3(chr16:636673-722554)x3	copy number gain	See cases [RCV000134645]	Chr16:636673..722554 [GRCh38] Chr16:686673..772554 [GRCh37] Chr16:16p13.3	benign
GRCh38/hg38 16p13.3(chr16:636673-722554)x1	copy number loss	See cases [RCV000134647]	Chr16:636673..722554 [GRCh38] Chr16:686673..772554 [GRCh37] Chr16:626674..712555 [NCBI36] Chr16:16p13.3	benign
GRCh38/hg38 16p13.3(chr16:46766-1544014)x1	copy number loss	See cases [RCV000134917]	Chr16:46766..1544014 [GRCh38] Chr16:96766..1594015 [GRCh37] Chr16:36766..1534016 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:551385-722554)x3	copy number gain	See cases [RCV000135264]	Chr16:551385..722554 [GRCh38] Chr16:601385..772554 [GRCh37] Chr16:541386..712555 [NCBI36] Chr16:16p13.3	likely benign
GRCh38/hg38 16p13.3(chr16:46766-4247185)x3	copy number gain	See cases [RCV000136687]	Chr16:46766..4247185 [GRCh38] Chr16:96766..4297186 [GRCh37] Chr16:36766..4237187 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:46722-1867327)x1	copy number loss	See cases [RCV000137826]	Chr16:46722..1867327 [GRCh38] Chr16:96722..1917328 [GRCh37] Chr16:36722..1857329 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3(chr16:46766-882211)x1	copy number loss	See cases [RCV000137979]	Chr16:46766..882211 [GRCh38] Chr16:96766..932211 [GRCh37] Chr16:36766..872212 [NCBI36] Chr16:16p13.3	pathogenic\|uncertain significance
GRCh38/hg38 16p13.3(chr16:412341-925326)x3	copy number gain	See cases [RCV000139354]	Chr16:412341..925326 [GRCh38] Chr16:462341..975326 [GRCh37] Chr16:402342..915327 [NCBI36] Chr16:16p13.3	uncertain significance
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3	copy number gain	See cases [RCV000139166]	Chr16:43732..13326806 [GRCh38] Chr16:93732..13420663 [GRCh37] Chr16:33732..13328164 [NCBI36] Chr16:16p13.3-13.12	pathogenic
GRCh38/hg38 16p13.3(chr16:534395-722554)x3	copy number gain	See cases [RCV000140349]	Chr16:534395..722554 [GRCh38] Chr16:584395..772554 [GRCh37] Chr16:524396..712555 [NCBI36] Chr16:16p13.3	benign
GRCh38/hg38 16p13.3(chr16:636673-786508)x3	copy number gain	See cases [RCV000140337]	Chr16:636673..786508 [GRCh38] Chr16:686673..836508 [GRCh37] Chr16:626674..776509 [NCBI36] Chr16:16p13.3	benign
GRCh38/hg38 16p13.3(chr16:650260-722554)x1	copy number loss	See cases [RCV000141130]	Chr16:650260..722554 [GRCh38] Chr16:700260..772554 [GRCh37] Chr16:640261..712555 [NCBI36] Chr16:16p13.3	benign
GRCh38/hg38 16p13.3(chr16:59980-1221651)x1	copy number loss	See cases [RCV000141384]	Chr16:59980..1221651 [GRCh38] Chr16:109978..1271651 [GRCh37] Chr16:49978..1211652 [NCBI36] Chr16:16p13.3	pathogenic
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3	copy number gain	See cases [RCV000143710]	Chr16:666662..15743104 [GRCh38] Chr16:716662..15836961 [GRCh37] Chr16:656663..15744462 [NCBI36] Chr16:16p13.3-13.11	pathogenic
GRCh37/hg19 16p13.3(chr16:450686-1007236)x3	copy number gain	See cases [RCV000239842]	Chr16:450686..1007236 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3	copy number gain	See cases [RCV000203445]	Chr16:102839..28327676 [GRCh37] Chr16:16p13.3-11.2	pathogenic
GRCh37/hg19 16p13.3(chr16:706802-772110)x4	copy number gain	Breast ductal adenocarcinoma [RCV000207113]	Chr16:706802..772110 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:97494-1257060)x3	copy number gain	Breast ductal adenocarcinoma [RCV000207237]	Chr16:97494..1257060 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:88165-1715454)x1	copy number loss	See cases [RCV000239415]	Chr16:88165..1715454 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:72769-1511716)x1	copy number loss	See cases [RCV000240294]	Chr16:72769..1511716 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:239130-841725)x3	copy number gain	See cases [RCV000240506]	Chr16:239130..841725 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.388T>C (p.Phe130Leu)	single nucleotide variant	not specified [RCV004320331]	Chr16:715867 [GRCh38] Chr16:765867 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:686673-772554)x1	copy number loss	See cases [RCV000449474]	Chr16:686673..772554 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:755749-766588)x3	copy number gain	See cases [RCV000446403]	Chr16:755749..766588 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3	copy number gain	See cases [RCV000446684]	Chr16:69193..90274381 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3-13.2(chr16:78801-9169448)	copy number gain	See cases [RCV000446555]	Chr16:78801..9169448 [GRCh37] Chr16:16p13.3-13.2	pathogenic
GRCh37/hg19 16p13.3(chr16:97133-5122974)x3	copy number gain	See cases [RCV000445663]	Chr16:97133..5122974 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:643377-3125125)x3	copy number gain	See cases [RCV000510815]	Chr16:643377..3125125 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.298G>C (p.Gly100Arg)	single nucleotide variant	not specified [RCV004305952]	Chr16:715777 [GRCh38] Chr16:765777 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)	copy number gain	See cases [RCV000511296]	Chr16:85881..90155062 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3	copy number gain	See cases [RCV000512194]	Chr16:85880..19806921 [GRCh37] Chr16:16p13.3-12.3	pathogenic
GRCh37/hg19 16p13.3-13.2(chr16:85880-9883129)x3	copy number gain	See cases [RCV000510698]	Chr16:85880..9883129 [GRCh37] Chr16:16p13.3-13.2	pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3	copy number gain	See cases [RCV000512138]	Chr16:85881..90155062 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3	copy number gain	See cases [RCV000511360]	Chr16:85880..22442007 [GRCh37] Chr16:16p13.3-12.2	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1498731)x1	copy number loss	not provided [RCV000683740]	Chr16:85880..1498731 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1875694)x1	copy number loss	not provided [RCV000683741]	Chr16:85880..1875694 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-3216551)x3	copy number gain	not provided [RCV000683742]	Chr16:85880..3216551 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3-13.13(chr16:85880-11209288)x3	copy number gain	not provided [RCV000683743]	Chr16:85880..11209288 [GRCh37] Chr16:16p13.3-13.13	pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3	copy number gain	not provided [RCV000738918]	Chr16:88165..90274695 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3	copy number gain	not provided [RCV000738915]	Chr16:61451..90294632 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3	copy number gain	not provided [RCV000738917]	Chr16:88165..90163275 [GRCh37] Chr16:16p13.3-q24.3	pathogenic
GRCh37/hg19 16p13.3(chr16:591586-784800)x3	copy number gain	not provided [RCV000738948]	Chr16:591586..784800 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:610419-776308)x1	copy number loss	not provided [RCV000738955]	Chr16:610419..776308 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:624108-780942)x3	copy number gain	not provided [RCV000738956]	Chr16:624108..780942 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:624108-784800)x3	copy number gain	not provided [RCV000738957]	Chr16:624108..784800 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:682670-784800)x3	copy number gain	not provided [RCV000738959]	Chr16:682670..784800 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:683959-781623)x3	copy number gain	not provided [RCV000738960]	Chr16:683959..781623 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:683959-784800)x3	copy number gain	not provided [RCV000738961]	Chr16:683959..784800 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:700970-767179)x3	copy number gain	not provided [RCV000738962]	Chr16:700970..767179 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:569754-781623)x3	copy number gain	not provided [RCV000751474]	Chr16:569754..781623 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:569754-847743)x3	copy number gain	not provided [RCV000751475]	Chr16:569754..847743 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:570466-781623)x3	copy number gain	not provided [RCV000751476]	Chr16:570466..781623 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:580124-875402)x1	copy number loss	not provided [RCV000751479]	Chr16:580124..875402 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:747013-781623)x4	copy number gain	not provided [RCV000751482]	Chr16:747013..781623 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:747013-784800)x3	copy number gain	not provided [RCV000751483]	Chr16:747013..784800 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:749057-781623)x4	copy number gain	not provided [RCV000751484]	Chr16:749057..781623 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:61451-1593645)x1	copy number loss	not provided [RCV000751445]	Chr16:61451..1593645 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:450309-951598)x3	copy number gain	not provided [RCV000751466]	Chr16:450309..951598 [GRCh37] Chr16:16p13.3	benign
GRCh37/hg19 16p13.3(chr16:109978-4316797)	copy number gain	Chromosome 16p13.3 duplication syndrome [RCV000767731]	Chr16:109978..4316797 [GRCh37] Chr16:16p13.3	pathogenic
NC_000016.9:g.(?_624055)_(2115656_?)del	deletion	Tuberous sclerosis 2 [RCV000811345]	Chr16:624055..2115656 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-830613)x1	copy number loss	not provided [RCV000846660]	Chr16:85880..830613 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-2053328)x1	copy number loss	not provided [RCV000849039]	Chr16:85880..2053328 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1166355)x1	copy number loss	not provided [RCV001006741]	Chr16:85880..1166355 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1468459)x1	copy number loss	not provided [RCV000848130]	Chr16:85880..1468459 [GRCh37] Chr16:16p13.3	pathogenic
NC_000016.9:g.(?_624055)_(2148005_?)del	deletion	Tuberous sclerosis 2 [RCV001033183]	Chr16:624055..2148005 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:726789-1066511)x1	copy number loss	not provided [RCV002473519]	Chr16:726789..1066511 [GRCh37] Chr16:16p13.3	uncertain significance
NC_000016.9:g.(?_624055)_(2550979_?)dup	duplication	Idiopathic generalized epilepsy [RCV001033790]	Chr16:624055..2550979 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:364182-1186480)x3	copy number gain	not provided [RCV001006744]	Chr16:364182..1186480 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:84485-5251013)x3	copy number gain	not provided [RCV001537890]	Chr16:84485..5251013 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85880-5249457)x3	copy number gain	not provided [RCV001259749]	Chr16:85880..5249457 [GRCh37] Chr16:16p13.3	pathogenic
NC_000016.9:g.(?_624055)_(2153916_?)dup	duplication	Epilepsy [RCV001344085]\|Idiopathic generalized epilepsy [RCV001316565]	Chr16:624055..2153916 [GRCh37] Chr16:16p13.3	uncertain significance
NC_000016.9:g.(?_765584)_(1204036_?)del	deletion	Idiopathic generalized epilepsy [RCV001352399]	Chr16:765584..1204036 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-1468828)	copy number loss	not specified [RCV002052500]	Chr16:85880..1468828 [GRCh37] Chr16:16p13.3	pathogenic
NC_000016.9:g.(?_256302)_(5971108_?)dup	duplication	Familial Mediterranean fever [RCV001877532]\|Fanconi anemia [RCV001877533]\|not provided [RCV001877531]	Chr16:256302..5971108 [GRCh37] Chr16:16p13.3	uncertain significance
NC_000016.9:g.(?_256302)_(4852572_?)dup	duplication	Epilepsy [RCV003113403]\|Idiopathic generalized epilepsy [RCV003109446]\|Saldino-Mainzer syndrome [RCV003113404]	Chr16:256302..4852572 [GRCh37] Chr16:16p13.3	uncertain significance
NC_000016.9:g.(?_256302)_(1843653_?)del	deletion	Idiopathic generalized epilepsy [RCV003109815]	Chr16:256302..1843653 [GRCh37] Chr16:16p13.3	uncertain significance
NC_000016.9:g.(?_256302)_(1657267_?)del	deletion	Saldino-Mainzer syndrome [RCV003116765]\|not provided [RCV003116766]	Chr16:256302..1657267 [GRCh37] Chr16:16p13.3	pathogenic\|no classifications from unflagged records
NC_000016.9:g.(?_256302)_(1918176_?)del	deletion	not provided [RCV003119703]	Chr16:256302..1918176 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.74A>G (p.Tyr25Cys)	single nucleotide variant	not specified [RCV004310408]	Chr16:715363 [GRCh38] Chr16:765363 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:111043-6627459)x3	copy number gain	See cases [RCV002292215]	Chr16:111043..6627459 [GRCh37] Chr16:16p13.3	pathogenic
GRCh37/hg19 16p13.3(chr16:85881-1350186)x1	copy number loss	not provided [RCV002474576]	Chr16:85881..1350186 [GRCh37] Chr16:16p13.3	pathogenic
NM_024042.4(METRN):c.800C>T (p.Ala267Val)	single nucleotide variant	not specified [RCV004081030]	Chr16:717305 [GRCh38] Chr16:767305 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.285C>A (p.Phe95Leu)	single nucleotide variant	not specified [RCV004075940]	Chr16:715764 [GRCh38] Chr16:765764 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.64C>T (p.Arg22Cys)	single nucleotide variant	not specified [RCV004136111]	Chr16:715353 [GRCh38] Chr16:765353 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.721C>T (p.Arg241Cys)	single nucleotide variant	not specified [RCV004221560]	Chr16:717226 [GRCh38] Chr16:767226 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.557G>T (p.Ser186Ile)	single nucleotide variant	not specified [RCV004125841]	Chr16:716984 [GRCh38] Chr16:766984 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.184G>A (p.Ala62Thr)	single nucleotide variant	not specified [RCV004192348]	Chr16:715663 [GRCh38] Chr16:765663 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.335G>A (p.Gly112Asp)	single nucleotide variant	not specified [RCV004192938]	Chr16:715814 [GRCh38] Chr16:765814 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.56C>T (p.Pro19Leu)	single nucleotide variant	not specified [RCV004159892]	Chr16:715345 [GRCh38] Chr16:765345 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.821G>A (p.Arg274His)	single nucleotide variant	not specified [RCV004118346]	Chr16:717326 [GRCh38] Chr16:767326 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.361T>C (p.Trp121Arg)	single nucleotide variant	not specified [RCV004113386]	Chr16:715840 [GRCh38] Chr16:765840 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.708T>G (p.Ile236Met)	single nucleotide variant	not specified [RCV004140260]	Chr16:717213 [GRCh38] Chr16:767213 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.709C>T (p.Arg237Cys)	single nucleotide variant	not specified [RCV004069696]	Chr16:717214 [GRCh38] Chr16:767214 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.806G>T (p.Arg269Leu)	single nucleotide variant	not specified [RCV004179416]	Chr16:717311 [GRCh38] Chr16:767311 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.363G>C (p.Trp121Cys)	single nucleotide variant	not specified [RCV004177027]	Chr16:715842 [GRCh38] Chr16:765842 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.649C>T (p.Arg217Cys)	single nucleotide variant	not specified [RCV004081075]	Chr16:717154 [GRCh38] Chr16:767154 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.640C>T (p.Arg214Cys)	single nucleotide variant	not specified [RCV004089880]	Chr16:717145 [GRCh38] Chr16:767145 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.235G>T (p.Gly79Cys)	single nucleotide variant	not specified [RCV004251855]	Chr16:715714 [GRCh38] Chr16:765714 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.683C>T (p.Ser228Phe)	single nucleotide variant	not specified [RCV004272836]	Chr16:717188 [GRCh38] Chr16:767188 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.278A>G (p.Gln93Arg)	single nucleotide variant	not specified [RCV004267113]	Chr16:715757 [GRCh38] Chr16:765757 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.728G>C (p.Gly243Ala)	single nucleotide variant	not specified [RCV004335330]	Chr16:717233 [GRCh38] Chr16:767233 [GRCh37] Chr16:16p13.3	uncertain significance
GRCh37/hg19 16p13.3(chr16:85881-1657611)x1	copy number loss	not provided [RCV003483253]	Chr16:85881..1657611 [GRCh37] Chr16:16p13.3	pathogenic
NM_024042.4(METRN):c.650G>A (p.Arg217His)	single nucleotide variant	not specified [RCV004424262]	Chr16:717155 [GRCh38] Chr16:767155 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.872C>T (p.Ala291Val)	single nucleotide variant	not specified [RCV004424264]	Chr16:717377 [GRCh38] Chr16:767377 [GRCh37] Chr16:16p13.3	likely benign
NM_024042.4(METRN):c.125G>A (p.Gly42Asp)	single nucleotide variant	not specified [RCV004424254]	Chr16:715604 [GRCh38] Chr16:765604 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.593C>T (p.Thr198Ile)	single nucleotide variant	not specified [RCV004424260]	Chr16:717098 [GRCh38] Chr16:767098 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.344G>C (p.Gly115Ala)	single nucleotide variant	not specified [RCV004424255]	Chr16:715823 [GRCh38] Chr16:765823 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.425G>C (p.Arg142Pro)	single nucleotide variant	not specified [RCV004424257]	Chr16:715904 [GRCh38] Chr16:765904 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.601G>A (p.Val201Met)	single nucleotide variant	not specified [RCV004424261]	Chr16:717106 [GRCh38] Chr16:767106 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.832G>A (p.Glu278Lys)	single nucleotide variant	not specified [RCV004424263]	Chr16:717337 [GRCh38] Chr16:767337 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.408C>G (p.His136Gln)	single nucleotide variant	not specified [RCV004424256]	Chr16:715887 [GRCh38] Chr16:765887 [GRCh37] Chr16:16p13.3	uncertain significance
NM_024042.4(METRN):c.88T>A (p.Cys30Ser)	single nucleotide variant	not specified [RCV004424265]	Chr16:715377 [GRCh38] Chr16:765377 [GRCh37] Chr16:16p13.3	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	3095
Count of miRNA genes:	950
Interacting mature miRNAs:	1186
Transcripts:	ENST00000219542, ENST00000564661, ENST00000567076, ENST00000568223, ENST00000568415, ENST00000570132
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH36609

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	16	767,254 - 767,447	UniSTS	GRCh37
Build 36	16	707,255 - 707,448	RGD	NCBI36
Celera	16	967,419 - 967,612	RGD
Cytogenetic Map	16	p13.3	UniSTS
HuRef	16	689,146 - 689,339	UniSTS
GeneMap99-GB4 RH Map	16	26.03	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

1736

1625

1279

213

114

128

1644

1102

3718

222

795

1203

100

323

1239

Low

702

1275

445

409

1682

335

2713

1091

197

664

410

881

1549

Below cutoff

145

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AE006464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK057053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK308711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL360260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CS179964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB435052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JC181135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z97653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z98258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000219542 ⟹ ENSP00000219542

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	715,338 - 717,390 (+)	Ensembl

RefSeq Acc Id:

ENST00000564661

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	716,427 - 717,817 (+)	Ensembl

RefSeq Acc Id:

ENST00000567076 ⟹ ENSP00000459900

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	715,641 - 717,477 (+)	Ensembl

RefSeq Acc Id:

ENST00000568223 ⟹ ENSP00000455068

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	715,118 - 719,655 (+)	Ensembl

RefSeq Acc Id:

ENST00000568415 ⟹ ENSP00000457702

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	716,574 - 717,480 (+)	Ensembl

RefSeq Acc Id:

ENST00000570132 ⟹ ENSP00000456647

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	16	715,237 - 717,247 (+)	Ensembl

RefSeq Acc Id:

NM_024042 ⟹ NP_076947

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	16	715,118 - 719,655 (+)	NCBI
GRCh37	16	765,173 - 769,655 (+)	NCBI
Build 36	16	705,174 - 707,481 (+)	NCBI Archive
Celera	16	965,338 - 967,645 (+)	RGD
HuRef	16	687,641 - 689,372 (+)	NCBI
CHM1_1	16	765,143 - 769,625 (+)	NCBI
T2T-CHM13v2.0	16	719,300 - 723,837 (+)	NCBI

Sequence:

show sequence

AAGGCGGCCCCGGCGCTGGGGCTGCGCGGCAGGCGGAGCGGCCGCGGGCTTGGGGGCTTCGCCG
GGGCCGGGCGGCCGGCGCCCCCGGCTGCTCCCGCCGCCGCCCGGACCCGCGCCCCGCCGGGGCA
GCGGTGGTGAGAGCCCCGACTCCCCGGACGCCGCCCGCCGTGCCATGGGGTTCCCGGCCGCGGC
GCTGCTCTGCGCGCTGTGCTGCGGCCTCCTGGCCCCGGCTGCCCGCGCCGGCTACTCCGAGGAG
CGCTGCAGCTGGAGGGGCAGCGGCCTCACCCAGGAGCCCGGCAGCGTGGGGCAGCTGGCCCTGG
CCTGTGCGGAGGGCGCGGTTGAGTGGCTGTACCCGGCTGGGGCGCTGCGCCTGACCCTGGGCGG
CCCCGATCCCAGAGCGCGGCCCGGCATCGCCTGTCTGCGGCCGGTGCGGCCCTTCGCGGGCGCC
CAGGTCTTCGCGGAGCGCGCAGGGGGCGCCCTGGAGCTGCTGCTGGCCGAGGGCCCGGGCCCGG
CAGGGGGCCGCTGCGTGCGCTGGGGTCCCCGCGAGCGCCGGGCCCTCTTCCTGCAGGCCACGCC
GCACCAGGACATCAGCCGCCGCGTGGCCGCCTTCCGCTTTGAGCTGCGCGAGGACGGGCGCCCC
GAGCTGCCCCCGCAGGCCCACGGTCTCGGCGTAGACGGTGCCTGCAGGCCCTGCAGCGACGCTG
AGCTGCTCCTGGCCGCATGCACCAGCGACTTCGTAATTCACGGGATCATCCATGGGGTCACCCA
TGACGTGGAGCTGCAGGAGTCTGTCATCACTGTGGTGGCCGCCCGTGTCCTCCGCCAGACACCG
CCGCTGTTCCAGGCGGGGCGATCCGGGGACCAGGGGCTGACCTCCATTCGTACCCCACTGCGCT
GTGGCGTCCACCCGGGCCCAGGCACCTTCCTCTTCATGGGCTGGAGCCGCTTTGGGGAGGCCCG
GCTGGGCTGTGCCCCACGATTCCAGGAGTTCCGCCGTGCCTACGAGGCTGCCCGTGCTGCCCAC
CTCCACCCCTGCGAGGTGGCGCTGCACTGAGGGGCTGGGTGCTGGGGAGGGGCTGGTAGGAGGG
AGGGTGGGCCCACTGCTTTGGAGGTGATGGGACTATCAATAAGAACTCTGTTCACGCAAGCTGC
TGTGGACCTGGTCTCCTGTGTCCAGCCCAGCCTTGGGCCTGCCTCGCAGCTGTGAGGATGGCTC
CAATTCCTGCCTCCTGGCGGGAGACTGAGGCTCAGGGGAATGGTATCTTGTTCAAGACCATTTG
GCAACTGAGAGGGAGAGCAGATGTCAGGAGGAGCTACACCCACATTCCGGGGAGGGGCCGCTGC
TGGGTGGGGGGCACGTGGGGACCTGCACTCATGCAAGCTTCTGCTCTGCTGCACCCACCAGCCC
CGTCCTTGCCCGCACCCTTGCCTGCTTCCCTGGCTGGCTCCCACTTGCCTCCCGTGCCAGGTGC
TTCTGGGGCTCAGCAGGAGAGGAAAGGGGCAGAGGGGCATAGGGTCCCTCGGGTACGGTGGGGG
CAGGCGGGCGCACAGCGCTCCGGCTCTGAGCCAGGCCTGTGAGGGAAGGGGCTGCAGGCTGGCA
GGGTGCCGACTTCCCCCATGGCTGCTGTGAGCCCGCAGAGTCATCCTTGGCCCCGTCCCGCCCT
TGGGGAAGAATGGGCCCCTCTGTCCTCAGGCCCCTTCGACGTGCTGAGCATCCAGACGTGGCGA
GGAGCCCGAAGGGTGTGGGGTCCCCTCTGCAGGGTCCTGCTTGTTGCCTGTTTCCGGCGGGCGG
GGTGCACAATGGGGTCTCTAAGGACCGTTTCCCGCCACTGGCCCCATTGTCACTGTCTCCGCCT
TCCTCCTCGGCCTTTCAGCCGCATAAAGGGCCAGTGAGGTTTGGGACAGCCACAGCCCAAGGCT
CCGAGGCTAAAAGCCCCTGGGTGGGGGTGTTCCAGGACACCTGGCCCTGTGTGAGCTGCCTCCT
CTCACCCCAACCCCTCGGATCCTGGGAAAGAGACAGCCATGGCTCAAGGGCCAGGGACCCCTGG
GCTGAGCCCCAGAAATGGCTTTCCATTCTCGCCTGGGCCGGGGTGGGGGTGGAGGCCAGAGGCC
CTGCCCAGGCAGATGAAGCCCCCAGCTTTCAAGGGGGAAACTGAGGCTGTGTGAGGGACACAGC
TGTGCAGGGCCCACAAACACGGTCCTTTCTCTAGGTTAGCGGATGCAGATGCCTGATGAGTGCC
ATGCCCTCTGTGGACACCTGGGGAGGGGGGTCACCTCCAGCGCCGCCCTGGGACTTCCACTGCA
CGTGCAAGAGACTTACCCTTTCACACAGATCACCTGCCTGCCGCAGGGCTGATGAGGATGGGTG
AGGAGCGCAGCCACTGGGTGTCATGCACTGTGGGGGTTCTCCCACCTTCTGCCCCTCCTCAGGT
TCCTTGCTGCTTCTCTCCTCTCCCAACTGTGGCACGCTGAGGGCTCAGGCACAGGACCGCTCCT
CTGGGGCAGCCTCCAATAACCCTTGGACAACCTCCACTTTTTCATCTTCAGCCCTGACCACTCC
CTGGGGCCCATAGCCTTACATCCATCTGCCCCCAGCCCAAACACTTCTGCAAACACTAGAAAAG
GAGGTAGCCCGTGTGCCCTCCTGCACCGCCTCCTCCACTCCTGTCTTGGAGAGGCTTTCCCGTG
GGCCGAGCAACCCCCTTACCTTTGGCACTTGCCCTGATTCTCTGGCCAGCTTCCTACAACCTCT
CCTTTTCAGCCACACCCAAGTCCACCTGTTCACAAACACCCTGGGCTGGGCCCTGGCCGAACCC
TGGCTTCTACCTACCTGTCTCAGGAAGTGCCTGAGCCTTGCACCTACAGACCCTCCCAGAGAAA
GCCCTGGCTTTGCAACCAGCTGTCTTCTCATGAGACACAGGGCCACAGGAGCACCACGGTGCCC
AAATGGGTCTTGGAGCATTAGACCAGGGGCTTCATGCCTGCCCTGGGGACAGGTGGCCAAAGTG
GCATGGGAGATAGGGAGACAGTGTGGGTGAGCAGGTGGGCAGGAGCTACAGGAGCCTGGGGCCT
GTGGATCACAGACACCGCCAGGCAAGTGCCAGTTCACACAGGTACAGGTGGCTGCAGAGTGCCC
AAAGGCCAAGCAGCAGAGTGCCTGGTGTGGACGGGAGAGGAGTGGGGAGGTTGGGCGCAGTGGC
TCACGCCTGTAATCCCAACACTTTGGGAGGCCCAGGCAAGCAGATCATGAGGTCAGGAGATGGA
GACCATCCTGGCCAACATGGTGAAACCGTCTCTAATAAAACACAAAAAATTAGCCAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_076947	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH00662	(Get FASTA)	NCBI Sequence Viewer
	AAK61247	(Get FASTA)	NCBI Sequence Viewer
	CAL15420	(Get FASTA)	NCBI Sequence Viewer
	CAZ68030	(Get FASTA)	NCBI Sequence Viewer
	CDM21925	(Get FASTA)	NCBI Sequence Viewer
	EAW85747	(Get FASTA)	NCBI Sequence Viewer
	EAW85748	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000219542.3
	ENSP00000455068
	ENSP00000455068.1
	ENSP00000456647.1
	ENSP00000457702.1
	ENSP00000459900.1
GenBank Protein	Q9UJH8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_076947 ⟸ NM_024042
- Peptide Label:	precursor
- UniProtKB:	Q9UJH9 (UniProtKB/Swiss-Prot), Q9UJH8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGFPAAALLCALCCGLLAPAARAGYSEERCSWRGSGLTQEPGSVGQLALACAEGAVEWLYPAGA LRLTLGGPDPRARPGIACLRPVRPFAGAQVFAERAGGALELLLAEGPGPAGGRCVRWGPRERRA LFLQATPHQDISRRVAAFRFELREDGRPELPPQAHGLGVDGACRPCSDAELLLAACTSDFVIHG IIHGVTHDVELQESVITVVAARVLRQTPPLFQAGRSGDQGLTSIRTPLRCGVHPGPGTFLFMGW SRFGEARLGCAPRFQEFRRAYEAARAAHLHPCEVALH hide sequence

RefSeq Acc Id:

ENSP00000456647 ⟸ ENST00000570132

RefSeq Acc Id:

ENSP00000219542 ⟸ ENST00000219542

RefSeq Acc Id:

ENSP00000459900 ⟸ ENST00000567076

RefSeq Acc Id:

ENSP00000457702 ⟸ ENST00000568415

RefSeq Acc Id:

ENSP00000455068 ⟸ ENST00000568223

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9UJH8-F1-model_v2	AlphaFold	Q9UJH8	1-293	view protein structure

Promoters

RGD ID:

6793264

Promoter ID:

HG_KWN:22644

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000109074

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	16	704,781 - 705,562 (+)	MPROMDB

RGD ID:

7230833

Promoter ID:

EPDNEW_H21163

Type:

initiation region

Name:

METRN_1

Description:

meteorin, glial cell differentiation regulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H21164

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	16	715,118 - 715,178	EPDNEW

RGD ID:

7230839

Promoter ID:

EPDNEW_H21164

Type:

initiation region

Name:

METRN_2

Description:

meteorin, glial cell differentiation regulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H21163

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	16	716,378 - 716,438	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:14151	AgrOrtholog
COSMIC	METRN	COSMIC
Ensembl Genes	ENSG00000103260	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000219542.3	UniProtKB/TrEMBL
	ENST00000567076.5	UniProtKB/TrEMBL
	ENST00000568223	ENTREZGENE
	ENST00000568223.7	UniProtKB/Swiss-Prot
	ENST00000568415.1	UniProtKB/TrEMBL
	ENST00000570132.1	UniProtKB/TrEMBL
GTEx	ENSG00000103260	GTEx
HGNC ID	HGNC:14151	ENTREZGENE
Human Proteome Map	METRN	Human Proteome Map
KEGG Report	hsa:79006	UniProtKB/Swiss-Prot
NCBI Gene	79006	ENTREZGENE
OMIM	610998	OMIM
PANTHER	METEORIN-LIKE PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR28593:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA25537	PharmGKB
UniProt	H3BSC8_HUMAN	UniProtKB/TrEMBL
	H3BUM1_HUMAN	UniProtKB/TrEMBL
	I3L2T3_HUMAN	UniProtKB/TrEMBL
	J3KMW6_HUMAN	UniProtKB/TrEMBL
	METRN_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9UJH9	ENTREZGENE
UniProt Secondary	Q9UJH9	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar

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Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar