Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPCS3 mRNA | CTD | PMID:22079256 | 1,1-dichloroethene | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of SPCS3 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | ISO | Spcs3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SPCS3 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in increased expression of SPCS3 mRNA | CTD | PMID:29097150 | 17beta-estradiol | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of SPCS3 mRNA | CTD | PMID:32145629 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | increases expression | EXP | | 6480464 | Metribolone results in increased expression of SPCS3 mRNA | CTD | PMID:16751804 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | EXP | | 6480464 | Dihydrotestosterone results in increased expression of SPCS3 mRNA | CTD | PMID:29581250 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Spcs3 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Spcs3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SPCS3 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPCS3 mRNA | CTD | PMID:32109520 more ... | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SPCS3 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of SPCS3 protein | CTD | PMID:34186270 | 6-propyl-2-thiouracil | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SPCS3 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of SPCS3 mRNA | CTD | PMID:30047161 | acetamide | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of SPCS3 mRNA | CTD | PMID:31881176 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of SPCS3 gene | CTD | PMID:27153756 | alpha-Zearalanol | multiple interactions | ISO | Spcs3 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SPCS3 mRNA | CTD | PMID:35163327 | amitrole | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of SPCS3 mRNA | CTD | PMID:30047161 | antirheumatic drug | decreases expression | EXP | | 6480464 | Antirheumatic Agents results in decreased expression of SPCS3 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of SPCS3 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SPCS3 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SPCS3 mRNA | CTD | PMID:26238291 | bisphenol A | multiple interactions | ISO | Spcs3 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SPCS3 mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SPCS3 mRNA | CTD | PMID:33670352 | bisphenol A | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SPCS3 mRNA | CTD | PMID:25181051 and PMID:32145629 | cadmium dichloride | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of SPCS3 mRNA | CTD | PMID:33453195 | captan | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Captan results in decreased expression of SPCS3 mRNA | CTD | PMID:31558096 | carbon nanotube | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SPCS3 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SPCS3 mRNA | CTD | PMID:37019170 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of SPCS3 mRNA | CTD | PMID:27594783 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of SPCS3 mRNA | CTD | PMID:19376846 | colforsin daropate hydrochloride | increases expression | EXP | | 6480464 | Colforsin results in increased expression of SPCS3 mRNA | CTD | PMID:16751804 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of SPCS3 mRNA | CTD | PMID:20106945 more ... | DDT | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | DDT results in decreased expression of SPCS3 mRNA | CTD | PMID:30207508 | dibenzo[a,l]pyrene | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | dibenzo(a and l)pyrene results in decreased expression of SPCS3 mRNA | CTD | PMID:25908611 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPCS3 mRNA | CTD | PMID:27188386 | endosulfan | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SPCS3 mRNA | CTD | PMID:29391264 | ethanol | affects splicing | ISO | Spcs3 (Mus musculus) | 6480464 | Ethanol affects the splicing of SPCS3 mRNA | CTD | PMID:30319688 | fenthion | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Fenthion results in decreased expression of SPCS3 mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | ISO | Spcs3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SPCS3 mRNA | CTD | PMID:22206623 | folic acid | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SPCS3 mRNA | CTD | PMID:25629700 | folpet | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | folpet results in decreased expression of SPCS3 mRNA | CTD | PMID:31558096 | glafenine | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Glafenine results in increased expression of SPCS3 mRNA | CTD | PMID:24136188 | isotretinoin | decreases expression | EXP | | 6480464 | Isotretinoin results in decreased expression of SPCS3 mRNA | CTD | PMID:20436886 | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of SPCS3 protein | CTD | PMID:32959892 | methapyrilene | decreases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of SPCS3 mRNA | CTD | PMID:30467583 | methimazole | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of SPCS3 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | decreases expression | EXP | | 6480464 | Methyl Methanesulfonate results in decreased expression of SPCS3 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of SPCS3 mRNA | CTD | PMID:28001369 | nickel atom | increases expression | EXP | | 6480464 | Nickel results in increased expression of SPCS3 mRNA | CTD | PMID:24768652 | nimesulide | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | nimesulide results in increased expression of SPCS3 mRNA | CTD | PMID:24136188 | paracetamol | affects expression | ISO | Spcs3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SPCS3 mRNA | CTD | PMID:17562736 | paracetamol | multiple interactions | ISO | Spcs3 (Mus musculus) | 6480464 | PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of SPCS3 mRNA] | CTD | PMID:29246445 | paracetamol | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of SPCS3 mRNA | CTD | PMID:29246445 | perfluorooctanoic acid | multiple interactions | ISO | Spcs3 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of SPCS3 mRNA | CTD | PMID:35163327 | phenylmercury acetate | increases expression | EXP | | 6480464 | Phenylmercuric Acetate results in increased expression of SPCS3 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPCS3 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | Spcs3 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SPCS3 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SPCS3 mRNA | CTD | PMID:23811191 | potassium chromate | decreases expression | EXP | | 6480464 | potassium chromate(VI) results in decreased expression of SPCS3 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SPCS3 mRNA | CTD | PMID:22079256 | propiconazole | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | propiconazole results in increased expression of SPCS3 mRNA | CTD | PMID:21278054 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPCS3 mRNA | CTD | PMID:27188386 | sodium dichromate | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of SPCS3 mRNA | CTD | PMID:31558096 | sulfadimethoxine | increases expression | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of SPCS3 mRNA | CTD | PMID:30047161 | T-2 toxin | decreases expression | EXP | | 6480464 | T-2 Toxin results in decreased expression of SPCS3 mRNA | CTD | PMID:31863870 | testosterone | multiple interactions | ISO | Spcs3 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SPCS3 mRNA | CTD | PMID:26496021 | testosterone | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of SPCS3 mRNA | CTD | PMID:33848595 | tetrachloromethane | affects expression | ISO | Spcs3 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SPCS3 mRNA | CTD | PMID:17484886 | tetrachloromethane | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SPCS3 mRNA | CTD | PMID:31919559 | thapsigargin | increases expression | EXP | | 6480464 | Thapsigargin results in increased expression of SPCS3 mRNA | CTD | PMID:29453283 | titanium dioxide | increases expression | ISO | Spcs3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of SPCS3 mRNA | CTD | PMID:23557971 and PMID:27760801 | titanium dioxide | decreases expression | ISO | Spcs3 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SPCS3 mRNA | CTD | PMID:29264374 | trichloroethene | increases methylation | ISO | Spcs3 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of SPCS3 gene | CTD | PMID:27618143 | tunicamycin | increases expression | EXP | | 6480464 | Tunicamycin results in increased expression of SPCS3 mRNA | CTD | PMID:22378314 and PMID:29453283 | valproic acid | affects expression | ISO | Spcs3 (Mus musculus) | 6480464 | Valproic Acid affects the expression of SPCS3 mRNA | CTD | PMID:17963808 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of SPCS3 mRNA | CTD | PMID:23179753 and PMID:28001369 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of SPCS3 mRNA | CTD | PMID:25979313 | xylitol | decreases expression | EXP | | 6480464 | Xylitol results in decreased expression of SPCS3 mRNA | CTD | PMID:32275922 | |