TRBV6-7 (T cell receptor beta variable 6-7 (non-functional)) - Rat Genome Database

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Gene: TRBV6-7 (T cell receptor beta variable 6-7 (non-functional)) Homo sapiens
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Symbol: TRBV6-7
Name: T cell receptor beta variable 6-7 (non-functional)
RGD ID: 1351484
HGNC Page HGNC:12232
Description: Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane.
Type: pseudo (Ensembl: TR_V_gene)
RefSeq Status: VALIDATED
Previously known as: T cell receptor beta variable 6-7; TCRBV13S8P; TCRBV6S7; TRBV67
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,487,863 - 142,488,295 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,487,863 - 142,488,295 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,143,652 - 142,144,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,856,336 - 141,856,768 (+)NCBINCBI36Build 36hg18NCBI36
Celera7136,986,816 - 136,987,248 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,503,945 - 136,504,377 (+)NCBIHuRef
CHM1_17142,121,835 - 142,122,267 (+)NCBICHM1_1
T2T-CHM13v2.07143,824,609 - 143,825,041 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8206523   PMID:8650574   PMID:21873635  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q34-36.3(chr7:142021716-159325876)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|See cases [RCV000053577] Chr7:142021716..159325876 [GRCh38]
Chr7:142528609..159118566 [GRCh37]
Chr7:141367985..158811327 [NCBI36]
Chr7:7q34-36.3		 pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1		 pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:288
Interacting mature miRNAs:296
Transcripts:ENST00000390373
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 21 55 30 3 126 3 10 2 32 3 229 45 5 2
Below cutoff 251 321 220 51 455 40 199 50 537 54 223 237 11 74 109

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000390373   ⟹   ENSP00000374896
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7142,487,863 - 142,488,295 (+)Ensembl
Reference Protein Sequences
RefSeq Acc Id: ENSP00000374896   ⟸   ENST00000390373
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0A0MS04-F1-model_v2 AlphaFold A0A0A0MS04 1-114 view protein structure


Additional Information

Database Acc Id Source(s)
COSMIC TRBV6-7 COSMIC
Ensembl Genes ENSG00000253188 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000282470 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000390373.2 UniProtKB/Swiss-Prot
  ENST00000631511.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000253188 GTEx
  ENSG00000282470 GTEx
HGNC ID HGNC:12232 ENTREZGENE
Human Proteome Map TRBV6-7 Human Proteome Map
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
NCBI Gene TRBV6-7 ENTREZGENE
PANTHER T CELL RECEPTOR BETA VARIABLE 6-8-RELATED UniProtKB/Swiss-Prot
  T-CELL RECEPTOR BETA CHAIN UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA36912 PharmGKB
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0A0MS04 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 TRBV6-7  T cell receptor beta variable 6-7 (non-functional)    T cell receptor beta variable 6-7  Symbol and/or name change 5135510 APPROVED